Digital Commons Network^™

Non-Enzymatic Glycoxidation Reports On Society, Environment And Biology To Inform On Enduring Cancer Disparities, Fariha Imtiaz, Boxiao Ding, Bradley A. Krisanits, Katherine A. Walter, Lindsay L. Peterson, Susan Steck, Marvella E. Ford, Gayenell Magwood, Victoria J. Findlay, David Turner

Annual Research Day

Background: Despite advancements in cancer treatment, disparities in incidence and mortality persist among different races and ethnicities. These disparities are influenced by an intricate interplay between environmental, biological and social factors that underscore the need for a multifaceted approach to understand this relationship. Objective/Aim: To show that advanced glycation end products (AGEs) due to non-enzymatic glycoxidation represent informative and functional markers that report on the combined impact of environmental, biological and social factors on enduring cancer disparities. Methods: To address this objective, a more holistic approach to disparities research was used ranging from basic research, population-based investigations, preclinical and clinical …

Learning Curve And Patient Outcomes Of Minimally Invasive Esophagectomy: One Surgeon’S 10-Year Experience, Moamad Chehab M.D., Cody Tragesser M.D, Franklin Geroudis M.D., Rebecca Deitch M.D., Anthony Cassano M.D., Rachit Shah M.D.

Annual Research Day

Objective: To examine the learning curve of one surgeon performing minimally invasive esophagectomy (MIE) over a 10-year period since the beginning of their practice with a focus on patient outcomes. Methods: This is a retrospective study of all patients undergoing MIE for malignancy by one surgeon at an academic high-volume tertiary center over a 10-year period (10/2012 to 9/2022). Patients were stratified into 2 equal groups based on chronological order and termed Early MIE and Late MIE. Primary outcomes included operative measures and patient outcomes over a 1- year period post-operatively. Results: A total of 128 patients were identified, divided …

Post Opera, Suzy Lykins

Theses and Dissertations

Post Opera is a spell and work of embodied research which explores medicalization, desire, labor, and belief. Through methods of performance, sound, text and installation, I facilitate encounters of trans-femininity, spiritual power and connectivity. An opening wound, a set of psychic scalpels, sutures and bandages prepare this text for your consumption, take care to digest her well.

Maternal-Infant Attachment, Depression, Anxiety, And Breastfeeding Self-Efficacy Among Marginalized Populations, Leslie B. Lantz, Merilyn Arikkat, Amy Salisbury, Sara Moyer, Sally Russell, Leroy Thacker, Candice Gault, Josselyn Valenzuela, Kimberly Cruz-Lopez, S Bodnar-Deren, Patricia Kinser

School of Nursing Publications

No abstract provided.

Vcu's Yellow Brick Road: Connection, Safety, & Navigation, Karen Bjork, Robert Chisley, Samuel Kessler, Taylor Mackillop, Sarah Midkiff

The Grace E. Harris Leadership Institute Publications

Yellow Brick Road is an initiative designed to strengthen the connection between Virginia Commonwealth University (VCU) and downtown Richmond by promoting outdoor activity, sustainable mobility, and shared community experiences. The project aims to enhance the health and well-being of students, faculty, and staff through walking meetings and a proposed VCU-branded e-bike fleet, while also deepening VCU’s engagement with the urban community through events such as the UNCOMMON Street Festival. Together, these efforts reflect VCU’s vision as a university fully embedded in the city, guided by the question: How can VCU thrive with Richmond, not apart from it?

The Compass, Summer 2025

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

News Mediated Reporting And Governmental Narratives About The Enforcement Of Elite Criminality: Exploring The Social Construction Of Financial Frauds And Discrepancies In Punishment, Dominic J. Zicari

Theses and Dissertations

This study examines how financial crime enforcement decisions are socially constructed through a qualitative content analysis of news articles and government communications pertaining to two specific cases: the Enron scandal of 2001 and the subprime mortgage crisis of 2008. The study was guided by a theoretical framework that utilizes Barak’s (2017) theory of state-routinized crime control. The rigorous analysis of 394 news articles and government communication documents revealed that the media and the state rarely framed the subprime mortgage crisis as a criminal issue. Although the Enron scandal was frequently described as financial crime, journalists and government communicators were often …

Sex-Specific Regulation Of Mash And Hepatocellular Carcinoma: A Role Of Sphk2 In Females, Bria Pierre

Theses and Dissertations

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is characterized by excessive fat accumulation in the liver, with metabolic dysfunction-associated steatohepatitis (MASH) representing a more severe form that can progress to cirrhosis or hepatocellular carcinoma (HCC). The sphingosine kinases and the S1P signaling pathway are key regulators of MASH and HCC progression. While much is known about the mechanisms contributing to MASH-HCC in males, less is known for females. Nevertheless, we previously identified sphingosine Kinase 2 (SphK2) to protect females from MASH-driven HCC. This study first performed differential gene expression analysis on human liver cohorts to examine sex-specific differences in gene expression …

The Diseased Extracellular Matrix In Chronic Obstructive Pulmonary Disease Modeling, Leigh-Ann M. Antczak

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world, with an increasing prevalence as the world’s population ages. In the distal regions of the lungs, COPD is characterized by progressive emphysema due to an imbalance of proteases that continuously degrade essential extracellular matrix (ECM) proteins within the alveolar walls, causing fatal tissue impairment. This dissertation examines the unique properties of this diseased lung ECM in two parts: (1) As a key constituent in inflammatory signaling that leads to increased inflammation and progression of COPD, and (2) as a tool in three-dimensional (3D) in …

Smear Layer Removal By Irrigation Adjuncts: A Scanning Electron Microscopy Study, Triet D. Vuong

Theses and Dissertations

Purpose: This study aimed to compare the intracanal smear layer removal ability of two adjunctive irrigation modalities: the AdvErL EVO laser, the GentleWave^® Procedure, and their combination, after minimally invasive canal instrumentation.

Methods: Forty molars were accessed, the mesiobuccal canals of maxillary and mandibular molars were prepared up to apical size 25.04 using rotary instrumentation, then irrigated using: conventional needle irrigation (CNI), laser-assisted irrigation (LAI), the GentleWave^® Procedure (GWP), and LAI followed by GWP (LAI+GWP). The teeth were then decoronated and split longitudinally. One-half of each root was selected for preparation and analysis under scanning electron microscope. Blinded …

The Bacteriostatic, Regenerative, And Immunomodulatory Properties Of Extracellular Matrix Particles For Lung Injury, Keera P. Rhoads

Theses and Dissertations

Acute respiratory distress syndrome (ARDS) is a prevalent, life-threatening lung condition, affecting nearly 200,000 Americans annually, with a 40% international mortality rate. There is no cure for ARDS, and current pharmacological treatments have limited effectiveness. Symptoms can be mitigated with mechanical ventilation, though this often leads to ventilator-induced lung injuries (VILI) and puts critically ill patients at risk of infections, including ventilator-associated pneumonia (VAP). A promising therapeutic is the extracellular matrix (ECM), a complex network of structural proteins and bioactive molecules that has been shown to have anti-inflammatory properties and prevent fibrosis. We aim to utilize the regenerative and immunomodulatory …

Sink Into Serenity: Exploring The Healing Properties Of Bathing Culture, Kristopher P. Mckeever

Theses and Dissertations

In an effort to deconstruct the ideas of privacy as they’re understood in the west, this project’s concept revolves around levels of transparency and how that can eliminate barriers and feelings of shame surrounding the human body, fostering a greater sense of community through shared vulnerability.

Identification Of Mechanisms Associated With Electronic Nicotine Delivery System Use For Weight Control In Young Adults, Gabrielle Maldonado

Theses and Dissertations

Electronic nicotine delivery system (ENDS) use continues to rise among young adults in the United States, raising public health concerns as the harmful effects of ENDS continue to rise while tailored cessation programs lag. Weight control motives may drive ENDS initiation and frequent use, particularly among sexual and gender minority (SGM) populations, who report higher ENDS use, body dissatisfaction, and disordered eating behaviors than those who identify as heterosexual and cisgender. Understanding these behaviors, their mechanisms, and at-risk populations is critical for improving public health. Seven hundred and eight young adults (ages 18–30; M = 26, SD = 3.3) reporting …

Financial Health Literacy Of Community-Dwelling Older Adults: A Qualitative Research Study, Kimberly Davis

Theses and Dissertations

Background: Financial health literacy (FHL) is an emerging concept with unique application to older adults. Multiple complexities converge in older age that create increased financial vulnerability (e.g., retirement, chronic disease). However, low financial and health literacy are common in older adults, impacting their ability to self-manage. The AWV’s focus on prevention offers an opportunity to incorporate a proactive approach to financial-related assessment. This study will explore the perceived value of assessing FHL in primary care settings and the financial-related barriers and facilitators to implementing the personalized prevention plan.

Methods: The conceptual framework was guided by the Individual and Family Self-Management …

Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher

Master of Science in Forensic Science Directed Research Projects

Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …

Impact Of Substrates And Deposition Time On Bacteria Associated With Saliva Samples And Its Implication On A Bacterial Signature-Based Body Fluid Identification Method, Olisdey Galano Cruz

Master of Science in Forensic Science Directed Research Projects

Traditional serological methods for body fluid detection are limited by poor specificity and sensitivity, lacking confirmatory capability and thereby increasing the risk of false positives that may compromise the integrity of forensic investigations. While molecular methods such as mRNA, miRNA, and DNA methylation offer improved specificity, they are often hindered by marker instability and operational complexity in routine forensic workflows. Bacterial signature profiling has emerged as a promising alternative, offering enhanced stability, abundance, and compatibility with existing DNA workflows. However, its forensic implementation requires further validation. This study evaluated the effects of substrate type and storage time on the salivary …

Novel Time-Since-Deposition Signatures For Canine Blood; Implications For Animal Cruelty Investigations, Alysia M. Townsley

Master of Science in Forensic Science Directed Research Projects

Dogfighting is a felony in all 50 states and is often tied to other organized crime activities including gambling, narcotics, and weapons trafficking. Because of the clandestine nature of dogfighting crimes, it may be necessary to determine the age of blood samples from suspected events, not just the source. In this study, flow cytometry was used to identify cellular autofluorescence signatures for estimating TSD (time-since-deposition) in canine blood deposits up to 6 months old. To accomplish this, blood was taken from canines of various chronological ages and breeds, then deposited to create TSD samples ranging between 1 day and 180 …

Transforming Numbers And Narratives Into Impact At The Richmond Ed Fund, Jasmine C. Brown, Rochelle Clarke, Truc-Mai Nguyen

Doctor of Education Capstones

The Richmond Ed Fund (REF) has been a nonprofit partner to Richmond Public Schools (RPS) for over two decades. During this time, they provided valuable support through enrichment programs, scholarships, and teacher development to the RPS community. In 2019, the organization shifted its focus from direct program operation to major gifts fundraising to align with the RPS strategic plan’s five priorities. To better reflect its renewed mission and enhance its visibility within the community, in 2024 REF underwent a major rebranding focused on expanding impact, increasing collaboration, and fostering innovation. The Executive Director of REF submitted a Request for Partnership …

Elements Of A Talent Information System For The Shenandoah Valley Partnership, Jake Thompson

Master of Urban and Regional Planning Capstone Projects

This study examines the development of a comprehensive talent information system for the Shenandoah Valley Partnership (SVP), addressing the region’s prioritized need for talent attraction and retention. Through a mixed-methods approach combining literature review, demographic analysis, and qualitative interviews with comparable regional economic development organizations, the research identifies effective strategies for collecting, managing, and analyzing workforce data. The Shenandoah Valley region, comprising twelve localities in Virginia, faces challenges in educational attainment and healthcare provision despite possessing significant natural and cultural assets. Findings reveal three key components for effective talent information systems: (1) ambassador programs that provide qualitative insights on regional …

Navigating Preservation And Memorialization In Contested Spaces: A Case Study Of The Richmond Community Hospital And The Legacy Of Sarah Garland Boyd Jones, Rebecca M. Skatoff

Master of Urban and Regional Planning Capstone Projects

This plan develops a strategic framework to address the complexity of navigating preservation and memorialization in contested spaces, using the Richmond Community Hospital as a case study. Rooted in the legacy of Sarah Garland Boyd Jones, the first African American woman certified to practice medicine in Virginia, this plan examines the intersection of racial equity, cultural heritage, and land-use planning. The Richmond Community Hospital case study raises broader questions about how African American cultural heritage sites are preserved to confront erasure, ensure an accurate historical record, and promote historical literacy for current and future generations. Conducted with reflective practice, this …

Exploring The Stem Career Identity Development Of Black Women Across Their Lifespan, Veronica Hurd

Theses and Dissertations

Although STEM is the fastest-growing career sector, Black women are grossly underrepresented as they account for 2.5% of the workforce. Research highlights that this underrepresentation is due to racialized structures in K-12, postsecondary, and career settings that restrict Black girls’ and women’s STEM opportunities. While macrosystems such as hegemonic ideologies, attitudes, and social conditions shape Black girls’ and women’s opportunities in STEM, they continue to persist and achieve their career goals. To explore these barriers and Black women’s persistence in this industry, this study draws from the autobiographical memories of 10 Black women in the field or formerly in the …

Multitask Learning For Named Entity Recognition And Relationship Extraction, Adrienne D. Hembrick

Theses and Dissertations

Information Extraction (IE) is a fundamental task in Natural Language Processing (NLP), involving the identification of structured information from unstructured text. Two core components of IE—Named Entity Recognition (NER) and Relation Extraction (RE)—are widely used to extract key concepts and the relationships between them across various domains. However, the sequential dependency of RE on the output of NER makes it vulnerable to error propagation: inaccuracies in entity recognition can negatively affect downstream relation extraction.

To mitigate this issue, Multitask Learning (MTL) has been proposed as an approach that jointly models NER and RE, aiming to improve overall performance and reduce …

Expanding The Performance And Functionality Of Air-Jet Dry Powder Inhalers Across Multiple Applications, Ghali H. Aladwani

Theses and Dissertations

This dissertation aims to expand the performance and functionality of air-jet dry powder inhaler (DPI) applications through the development of a next-generation, mesh-nebulizer-based, and scalable spray dryer for the production of pharmaceutical aerosols, along with new spray-dried formulation production methods, novel formulations, and new air-jet DPI components for aerosol delivery to both infants and adults. The first aim focused on the development of a custom small-particle spray drying system capable of integrating vibrating mesh nebulizer technologies in various configurations for the production of excipient enhanced growth (EEG) formulations. This flexible system enabled efficient production of both small- and large-particle powders …

The Influence Of The Covid-19 Pandemic On Student Engagement At A Historically Black University, John C. Travis

Theses and Dissertations

This study examined student engagement across three NSSE administrations at an HBCU—pre-COVID (2018), during COVID (2019), and post-COVID (2022). Engagement was analyzed across four themes: Academic Challenge, Learning with Peers, Experiences with Faculty, and Campus Environment. Results showed that Learning with Peers declined significantly over time, with the largest drop between 2018 and 2022, reflecting pandemic-related disruptions to peer interaction. No significant year effects emerged for the other themes. Two-way MANOVAs indicated that gender, first-generation status, and major did not significantly predict engagement, nor did they interact with year. In contrast, classification emerged as the most consistent predictor, with upper-division …

Using A Dimension Reduction Approach To Parse Heterogeneity In Dietary Restriction, Amanda Makara

Theses and Dissertations

Dietary restriction, the problematic reduction of caloric or macronutrient intake, is a critical eating behavior occurring transdiagnostically across eating disorders and subclinical disordered eating. The definition of dietary restriction is highly heterogeneous, and restriction is often conflated with other distinct constructs, such as dietary restraint. The current practices related to the definition and measurement of dietary restriction have notable flaws, negatively impacting the ability to identify and establish risk, diagnosis, and treatment of eating disorders. There is also limited evidence that commonly-used dietary restriction measures can validly predict food choice and objective intake. These issues raise questions about whether dietary …

Transforming From Outsider To Insider: A Study On New Employee Acculturation To Boost Retention, Laura Davinci, Kathleen Denman, Aaron Gilley, Vickisha Harris, Alyssa Reddy

Doctor of Education Capstones

This dissertation in practice addresses the problem of practice at the National Defense University (NDU) concerning workplace morale, with a focus on new employees (defined as those employed for two years or less). NDU, a unique professional military education institution with a diverse mix of military, civilian, and contractor personnel, sought strategies to improve employee acculturation and foster a more positive command climate. This study explores the impact of current orientation practices on new employees' sense of belonging and morale. Through qualitative research methods, including 17 interviews, a survey sent to all new employees, orientation observations, and artifact analysis, the …

Agility In Professional Associations: Using Improvement Science To Align Nirsa’S Communication Strategy With Member Needs, Stephanie L. Hart, Kimberly A. Bradley, Lisa M. Gwyn, Joanna A. Liebelt, Denise K. Miller

Doctor of Education Capstones

This intrinsic case study delved into how NIRSA, a leading Association for Campus Recreation, and its members could effectively engage with one another to best support the members' needs. Leveraging the principles of improvement science, we rigorously assessed the root causes of misalignments between NIRSA and its members. This process allowed us to develop a theory of change that supports organizational alignment and engagement and satisfies members' needs. We found that change concepts like agility to pivot, in addition to inclusive and responsive communication strategies, would support members in navigating the evolving landscape of the campus recreation industry and amplify …

Uncovering Graduate Student Achievement At Virginia Commonwealth University: An Exploration Of Academic Advising & Administrative Processes, Kenzel Hill, Elizabeth Howley, Madeline Schutt, Michelle Blackwell

Doctor of Education Capstones

Virginia Commonwealth University's (VCU) Graduate School submitted a Request for Partnership, with the problem being a lack of consistency and formal advising standards for graduate students across various academic units at VCU. As a result, the Graduate School observed an impact on student success, including retention and graduation of graduate students. A capstone team was constructed to determine, through focus group interviews, surveying, and document analysis what the best practices for graduate student advising are and what the administrative processes and challenges that program directors, support staff, and faculty face in administering their graduate programs and advising. Findings suggest that …

Professional Learning Partnerships: An Exploratory Study Into How Institutions Of Higher Education Can Support Pk–12 Educators, Eleonore E. Cardinell, Nora Bryant, Danielle Terrell, Alexandra Javna, Megan Wood

Doctor of Education Capstones

Dr. Jonathan Becker, a Virginia Commonwealth University (VCU) Associate Professor in the School of Education (SOE), submitted a request for assistance from a Doctorate of Educational Leadership team at VCU. Dr. Becker was tasked with establishing a professional studies program that would offer non-credit bearing professional learning experiences to PK–12 educators. The VCU SOE wanted to learn how to design an accessible and relevant non-credit bearing program for PK–12 educators that maximized the value of the VCU SOE while generating revenue. To support the VCU SOE, the team conducted research using an exploratory sequential mixed methods model. The team gathered …

Innovative Secondary School Scheduling Practices To Positively Impact Student Outcomes In West Point Public Schools, Jessica Burdette, Sydney B. Lilly, Mark A. Strickler

Doctor of Education Capstones

Utilizing the principles of improvement science through a critical pragmatic approach, this study aimed to promote West Point Public School (WPPS) student success through researching secondary school scheduling practices. The primary theory of change for this study stated that if instructional time is maximized, all WPPS students will be given the opportunity to experience academic success and increase achievement. Three key research questions emerged as we analyzed the problem of practice: How can WPPS structure a secondary school day schedule to ensure every student has the best opportunity to succeed within the system? How can WPPS incorporate research-based strategies for …