Digital Commons Network^™

A Comparison Of Computer- And Interviewer-Administered Measures To Identify Heavy/Problem Alcohol And Other Drug Use In Primary Care Patients, David J. Pomm

Theses and Dissertations

Substance use is a leading cause of morbidity and mortality that is under-identified in primary care settings. Screening for substance use in primary care requires an efficient and accurate approach. Exploring methods to collect sensitive and accurate data about substance use and related problems is important to inform research practice and clinical care. Using RCT data comparing computerized and therapist delivered brief intervention for substance use problems, the present study had a unique opportunity to compare computerized anonymous and confidential surveys to a confidential, interviewer-administered assessment in a sample of N = 540 males and females at risk for heavy/problem …

Black Women And Body Image: Implications Of The Racialized Beauty Aesthetic, Rachel L. Boutte

Theses and Dissertations

Black women have the highest prevalence of overweight and obesity relative to any other demographic group in the United States, however current weight management interventions appear least effective for them. Although several hypotheses have been proposed to explain these outcomes, few studies have collected data to evaluate how well they fit the lived experiences of Black women. In particular, the potential roles of body image and body dissatisfaction in the development and maintenance of overweight and obesity in Black women are not well understood. Extant literature largely reports that Black women are inoculated from body dissatisfaction due to cultural factors, …

Design Hub: Activating Community By Design, Ed Williams

Theses and Dissertations

MOTIVATION

At the turn of the century, Robert Putnam (2000, 27) wrote “...a powerful tide bore Americans into ever deeper engagement in the life of their communities, but a few decades ago that tide reversed and we were overtaken by a treacherous rip current.” Putnam is describing a loss of “social capital” throughout American society. Research suggests that many of our contemporary issues are the result of a decline in “social capital,” or “community.”

This pervasive lack of community is thought to be detrimental to “educational performance, safe neighborhoods, equitable tax collection, democratic responsiveness, everyday honesty, and even our health …

Exosomes As Systemic Mediators Of Nanotube Induced Neurotoxicity, Christopher G. Canal

Theses and Dissertations

Extra-pulmonary effects of nanoparticle inhalation have been well documented; however, mechanisms for conveying peripheral bioactivity remain elusive. Recent studies point to indirect molecular mediators shed into the circulation. Protein and lipid alternatives to cytokines or chemokines have been proposed, yet the diversity among responses suggests a broader assemblage of factors. Recently we have proposed proteolytic fragment peptides as an additional source of bioactivity, which interestingly were significantly associated with exosomal proteins after enrichment analysis. Here we tested whether modeled exposure to multi-walled carbon nanotubes (MWCNT) could alter the composition and bioactivity of circulating exosomes. Male C57BL/6 mice were exposed by …

Adverse Childhood Experiences In Children Presenting To Integrated Pediatric Primary Care, Irene A. Jacobs

Theses and Dissertations

The prevalence of adverse childhood experiences (ACEs) has created a significant public health concern in the United States. A vast body of literature examining adult populations has displayed a dose-response association between cumulative ACEs and chronic illnesses (Chapman et al., 2004; Felitti et al., 1998). ACEs research conducted with children and adolescents has indicated higher ACE scores associated with learning and behavioral problems (Burke et al., 2011), health risk behaviors (Garrido et al., 2018), and mental health challenges (Mackner et al., 1997). However, ACEs research and subsequent interventions have largely relied upon retrospective data retrieved from adults (Felitti et al., …

Competing Models Of Exposure To Community Violence Among Urban Youth: Dimensional Versus Person-Centered Approaches, Sarah K. Pittman

Theses and Dissertations

Exposure to community violence is prevalent among urban youth residing in neighborhoods with high rates of crime and violence. Although there is strong evidence suggesting that community violence exposure is associated with negative consequences on youth development, there are inconsistencies in theories and evidence regarding the nature of these associations. Methodological limitations of dimensional approaches to conceptualizing exposure, including the assumption that adolescents are similar in their frequency and patterns of exposure, likely contribute to the inconsistencies in findings of associations. Recently, person-centered methods have been used to elucidate associations between community violence exposure and consequences on adolescent development. However, …

Effects Of A Self-Advocacy Intervention On The Abilities Of College Students With Intellectual And Developmental Disabilities To Request Academic Accommodations, Katherine R. Brendli

Theses and Dissertations

Students with intellectual and developmental disabilities (IDD) are pursuing college at higher rates than ever before. However, many of these students experience barriers to success in college and need to self-advocate for their needs, such as requesting academic accommodations. This study examined the effects of a virtually delivered self-advocacy intervention package on the abilities of college students with IDD to request their academic accommodations. This is the first study to virtually implement a modified version of the Self-Advocacy and Conflict Resolution strategy with college students with IDD. Using a single-subject multiple-probe across participants design, this study was implemented with three …

Investigation Of Molecular Mechanisms Of Liver Preservation Injury: A Complication Preceding Organ Transplantation, Ria C. Fyffe-Freil

Theses and Dissertations

Of the over 108,000 American awaiting a life-saving organ transplant today, over 12,000 (11%) of those need a new liver (OPTN, 2020). Last year, only 35% of patients on the waiting list for an organ were transplanted. Improving the quality of marginal organs by preventing or reversing preservation injury could vastly increase the number of transplants performed. Washout of circulating blood during liver procurement with cold University of Wisconsin solution flushes out any endogenous pro-survival signaling molecules. We investigated lysophospholipid (LPL) surface receptors (G-protein coupled receptors for lysophosphatidic acid (LPA) and sphingosine- 1-phosphate (S1P)) and their role in protecting hepatocytes …

Development And Validation Of Predictive Risk And Multiple Criteria Decision Analysis Models To Evaluate Cardiovascular Outcomes Among Cancer Patients, Purva N. Parab

Theses and Dissertations

Objective: The objectives of our study were to characterize the study population with cancer and cardiovascular diseases (CVD) both as compared to those without and to build a predictive model using machine learning (ML) algorithms that can predict the risk of CVD in cancer patients. In addition, our objective was also to evaluate characteristics associated with cardiotoxic adverse events of breast cancer therapies and develop a multiple criteria decision analysis (MCDA) model to conduct benefit-risk assessment of breast cancer therapy regimens. Methods: We used Medical Expenditure Panel Survey (MEPS) and FDA Adverse Events Reporting System (FAERS) 2005-2015 files along with …

An Online Mindfulness Training For Improved Eudaimonic Well-Being And Sleep Outcomes In Caregivers: A Preliminary Study, Tarah L. Raldiris

Theses and Dissertations

As the United States population continues to age, the number of older adults with dementia is projected to rise. Much of the care for those with dementia is provided by unpaid, informal caregivers who are typically family members. Unfortunately, these informal caregivers express significantly higher levels of negative psychological and physical health outcomes compared to non-caregivers. One potential pathway for improving caregiver outcomes may be through increased mindfulness. Using a two-week, online-based mindfulness training program and a structurally equivalent cognitive reappraisal training program, study aims were to: 1.) investigate the acceptability and feasibility of using an online intervention format for …

Characterizing Patterns Of Cannabis Use And Related Health Effects Among Young Adults Using Ecological Momentary Assessment, Alyssa Rudy

Theses and Dissertations

Introduction: Rapid changes in cannabis use policy and prevalence, particularly among young adults, and the lack of information regarding cannabis harms warrant investigation regarding the daily use patterns of cannabis users. Little is known regarding how variability in cannabis use frequency and administration method use patterns may be associated with differential acute cannabis-related health effects (i.e., subjective intoxication and respiratory symptoms). The purpose of the study was to characterize daily and weekly cannabis use patterns and associated cannabis-related intoxication and respiratory symptoms and test the interactions of cannabis use frequency and cannabis administration method use on cannabis-related intoxication and respiratory …

Differential Identification Of Hyperacusis And Misophonia: Implications Of Discrete Decreased Sound Tolerance (Dst) Condition Subtypes, Rachel E. Wallace

Theses and Dissertations

Hyperacusis and misophonia are two conditions of decreased sound tolerance (DST) studied in the psychological literature due to their association with psychological symptoms and mechanisms. DSTs are differentiated from normal sound sensitivity due to the reported impairment and distress individuals experience. Researchers suggest that DSTs are differentiated by types of sounds and emotional reactions elicited, such that hyperacusis is a fear and pain response to ordinary environmental sounds perceived as uncomfortably loud, and misophonia is an anger and disgust response to human-made sounds, but these distinctions, and associated characteristics, have not been empirically demonstrated. Undergraduate students (N = 1572) …

The Pseudomonas Aeruginosa Interactome: Insights Into Srna-Mediated Regulatory Networks, Christine M. Van Duyn

Theses and Dissertations

Pseudomonas aeruginosa is a Gram-negative bacterium found in various environmental niches including soil, water, hospital environments, and within a broad range of hosts. It is well known for its metabolic versatility and intrinsic and acquired resistance to a variety of antimicrobial agents. Moreover, this bacterium has a remarkable ability to adapt and survive in suboptimal environments by altering its transcriptional profile in response to nutrient deprivation, changes in temperature and pH, osmotic stress, the presence of reactive oxygen species (ROS), and exposure to antibiotics and host defenses. P. aeruginosa colonizes individuals with compromised immune systems and severe burn injuries and …

Interpersonal Competency Configurations And The School Adjustment Of Early Adolescents With Disabilities: A Person-Centered Approach, Brittany I. Sterrett

Theses and Dissertations

The transition to middle school is a critical time in adolescence. The more complex school environment provides opportunities for growth and challenges for students with disabilities. Although special education strives to provide individualized supports to students with disabilities through data-based decision-making, the tools used to understand and meet the needs of these students are often unresponsive to the dynamic nature of development and student adjustment as they age. Grounded in developmental science, this study sought to create a data collection framework through a person-centered approach to inform the individualization process. Specifically, this study: 1) explored a decision process that allows …

Development Of A Screening Assay For Type Iii Secretion System Inhibitors And High Throughput Screening Campaign Of Inhibitors Of Prp Of Staphylococcus Aureus, Heather A. Pendergrass

Theses and Dissertations

Antibiotics inhibit the growth or survival of bacteria by targeting their essential functions.¹ Due to weaknesses in traditional antibiotics and the increasing prevalence of antibiotic resistance genes, virulence factors are being targeted for therapeutic treatment of bacterial infection.² We have developed an assay to quantify and observe type III secretion system (T3SS) activity. The type III secretion system (T3SS) is a virulence factor present in some Gram-negative pathogens including enteropathogenic and enterohemorrhagic E. coli (EPEC and EHEC, respectively),³ and others.^4–9 The T3SS between EPEC and EHEC are highly conserved and share over 90% sequence identity with …

A Longitudinal Test Of Mexican Teen Mothers’ Cultural Characteristics And Children’S Language Skills Via Mothers’ Language, Arlenis A. Santana

Theses and Dissertations

The current study includes 204 Mexican teen mothers and their children from a larger study who were interviewed when children were 3 years old (Wave 4; W4), 4 years old (W5), and 5 years old (W6). The current study is guided by the integrative model of developmental competencies (García Coll et al., 1996), which suggests that parents’ adaptive cultural characteristics and exchanges with their children inform children’s developmental competencies. Thus, the current study examined whether teen mothers’ adaptive cultural characteristics (i.e., familism values, language competency pressures, and involvement in Mexican culture and U.S. mainstream culture) at W4 informed mothers’ Spanish …

Dating Violence Victimization And Posttraumatic Stress Outcomes Among Urban Adolescents: The Moderating And Mediating Role Of Positive Outlook, Carine Leslie

Theses and Dissertations

Adolescent dating violence occurs far too frequently in early adolescence and is related to adverse mental health outcomes, including posttraumatic stress symptoms. One focus within this literature has been to determine and better understand how protective processes may function in influencing relations between risk factors and dating violence victimization. A protective factor that has not been explored in the dating literature is positive outlook. The current short-term longitudinal study investigated whether dating violence victimization at Time 1 predicted posttraumatic stress symptoms at Time 2 among African American middle school students and examine whether positive outlook moderated or mediated this relation. …

Comorbidity In Context: Identifying Patterns Of Depressive And Anxiety Symptoms In African American Early Adolescents, Kathryn Behrhorst

Theses and Dissertations

Depression and anxiety during adolescence includes symptoms of irritability, sleeplessness, feelings of guilt or worthlessness, worry, avoidance, and/or restlessness. Anxiety and depressive symptoms are often comorbid and are associated with impairments across academic, social, and emotional areas of functioning. No studies to date have examined patterns of depressive and anxiety symptoms together for African American adolescents using person-centered analyses. The current study examined patterns of symptoms and domains of anxiety and depression during early adolescence using latent profile analyses (LPA). A sample of 196 African American early adolescents in grades six through eight (M_age = 12.6; 50% female) were …

Community Input On An Enhanced Care Planning Tool Addressing Health Behaviors, Mental Health Needs, And Social Risks, Kristen O'Loughlin, Hannah Shadowen, Paulette Lail Kashiri, Alex Krist

Graduate Research Posters

Background: Many patients with multiple chronic conditions (MCC) have social risks, mental health needs, and/or unhealthy behaviors. These interfere with their ability to manage their MCC. A care planning tool was created to help address these needs; this study solicited feedback from stakeholder groups and incorporated it into improving the tool.

Methods: Instrument: The Enhanced Care Planning (ECP) tool screens patients for social risks, mental health needs, and unhealthy behaviors. They are shown where their responses revealed risk, then select 1-2 to improve upon. Next, patients set personal goals and select strategies to support them. Patients are supported by …

Multilevel Variance Components And Brain Volume Mediation Of Life Stress On Post-Traumatic Stress Disorder Symptoms In Children Via Regularization, Daniel Bustamante, Michael C. Neale

Graduate Research Posters

Alterations of volume in brain regions of interest (ROIs) are associated with post-traumatic stress disorder (PTSD). Most of the extant neuroimaging research in PTSD has studied adults. The present study extends this research by using data from children (N=11,869, M age =9.92) from the ABCD study, a multisite longitudinal long-term study of brain development and childhood health in the U.S. Traumatic events (TEs) and PTSD symptoms were measured through the K- SADS for DSM-5. Values of brain ROIs were assessed using structural MRI measures. The unidirectional model was able to detect the small differences from site variance in sMRI mediators …

Differences In Treatment For Substance Use Disorders By Insurance Status: Self-Help Only Versus Outpatient Medical Treatment, Huyen Pham, Lauryn Walker Phd Rn, Andrew J. Barnes Phd, Peter Cunningham Phd

Graduate Research Posters

Background: The role of insurance on substance use disorders (SUD) treatment utilization generally is poorly understood and still less is known on how insurance status relates to the use of evidence-based treatment (i.e., medicalization approach) compared to other treatments, like single self-help groups, where the research on effectiveness is less supportive. This study examines associations between health insurance and any SUD treatment utilization as well as use of single self- help versus medicalization approach.

Methods: A cross-sectional study design was used. Data were from the 2015-2017, public use National Surveys on Drug Use and Health (NSDUH). Adjusted logistic regressions were …

Perceptions Of Using Smart Speaker Technology For Improving The Health And Wellness Of Older Adults Living In A Low-Income Community, Brooke Saba Mcdowell, Jane Chung, Johnathan Bennett

Graduate Research Posters

There is a growing interest in the usage of smart speakers in various settings with older adults for improved quality of life and health. Residents who live within a low-income housing development may benefit from the use of smart speaker technology for creating a more engaging and healthier lifestyle. Because technology acceptance is critical; this study aims to examine smart speaker acceptance among low-income senior housing residents. A cross-sectional survey (n=46) was conducted to assess smart speaker acceptance, perceived usefulness, perceived ease, and privacy concerns. Individuals were recruited through varying methodologies, including group information sessions, sign-up sheets, word of mouth, …

Investigating The Role Of Aeg-1 In Mouse Models Of Pain, Bryan Mckiver, Wisam Toma, Deniz Bagdas, Devanand Sarkar, M. Imad. Damaj

Graduate Research Posters

Background: Astrocyte Elevated Gene 1 (AEG-1) is a multifunctional protein shown to be a regulator of transcription and multiple intracellular signaling pathways. The role of AEG-1 in cellular inflammation appears to be primarily facilitated by its direct interaction with the transcription factor NFκB, transcriptional regulator of inflammatory cytokines. May be have a potential role in models of pain, particularly chronic inflammatory and chemotherapy induced peripheral neuropathy (CIPN). Methods: C57BL6/J male and female mice, 8-14 weeks old. AEG-1 wild type (WT) and global knockout (KO) male and female mice, 8-14 weeks old. Chronic Inflammatory Pain induced via i.pl. injection of 50% …

Development Of An R Script For Simple Lipidomic And Metabolomic Data Analysis, Suad Alshammari, Joshua M. Morriss, Daniel Contaifer, Dayanjan S. Wijesinghe, Monther Alsultan

Graduate Research Posters

Background: Metabolomic and lipidomic studies generate vast quantities of data that are often analysed in a closed software environment with little to no access to the underlying algorithms. As a result, data processed via different software pipelines yield different results thus leading to a widespread problem of low reproducibility within these fields. To address this problem, we are developing LipidAnalyst; an R based lipidomics software pipeline. As a part of this project, we are creating a simple statistical analysis and graphing module in R to generate accurate, reproducible, high-resolution figures.

Methods: R scripts were developed under version 3.5.3 with the …

Centering High Risk Pregnancies Interprofessionaly (Chrpi) To Reduce Racial Disparities In Pregnancy Outcomes, Dongjin Suh B.S., Dhruv Srinivasachar B.S., Wintwar Phyo B.S., Asma Khan B.S., Sarah H. Milton, M.D.

Graduate Research Posters

Background:

Despite the steady rise in use of prenatal care, significant racial disparities exist in pregnancy-related outcomes. This calls for innovative prenatal care to improve pregnancy outcomes in racial minorities. CHRPI is an innovative prenatal care model designed to address risk factors and manageable conditions particularly prevalent in African Americans that threaten their course of pregnancy.

Methods:

CHRPI is an outpatient model (Fig. 1) that will accept pregnant moms with risk-factors outlined by the ACOG. They are initially evaluated by a Maternal Fetal Medicine physician where management is outlined. Then, patients are placed in groups of 4 according to their …

Predicting Caregiver Burden Over The First 4 Months After Tbi In Latin America: A Multi-Site, Multi-Country Study, Mickeal Pugh Jr., Paul B. Perrin, Yaneth Rodriguez, Silvia Olivera, Maria Cristina Quijano, Juan Carlos Arango-Lasprilla

Graduate Research Posters

Disparities in TBI exist between developed and developing regions, and this neurological condition typically requires caregivers to provide aid and functional support for those with TBI (Hyder, Wunderlich, Puvanachandra, Gururaj, & Kobusingye, 2007). Latin America, among these global regions, has elevated risks of both sustaining TBI and poorer post-TBI functioning (Bonow et al., 2018). Previous literature has shown the poor cognitive, mental health, and social functional outcomes following the injury (Deloche, Dellatolas, & Christensen, 2000), but research has minimally explored both longitudinal trends of these outcomes, and if functional outcomes of the injury differentially predict caregiver burden. The aim of …

Daily Sleep Quality Is Associated With Daily Cognition In Late-Life, Emily K. Donovan, Joseph M. Dzierzewski, Constance H. Fung, Karen R. Josephson, Cathy A. Alessi, Jennifer L. Martin

Graduate Research Posters

Background: Older adults often face sleep disturbance or cognitive decline that goes beyond the scope of normal aging. The present study examined the relationship between self-reported sleep quality and self-reported daytime attention in a community-dwelling sample of older men at the between-persons and within-persons levels of association.

Methods: Thirty-eight participants (M age =75.36 years, SD age =7.51 years, range=66-90 years) completed a twice-daily sleep diary for one week. Sleep quality and attention were assessed using a single-item 0-10 rating scales from the morning diary (“How was the quality of your sleep last night?”) and from the evening diary (“How was …

An Examination Of Virginia Wic Staff’S Attitudes And Knowledge Towards The Brush, Book, Bed Oral Health Program, Tia Jackson, Tegwyn H. Brickhouse, Lizbeth Snead, Natalie Pennywell

Graduate Research Posters

Introduction: Families who are low income and have low oral health literacy tend to have poor oral health. The Brush, Book, Bed (BBB) program helps caregivers establish a consistent night routine for their children that includes brushing teeth, reading, and an age-appropriate bedtime. BBB has been shown to increase oral hygiene behaviors and therefore oral health outcomes. Studies have shown that children who participate in Women, Infants, and Children, (WIC) programs are more likely to access dental services. This study examined local Richmond, Virginia (VA) WIC staff on their current oral health knowledge and views on implementing BBB.

Methods: A …

Prevalence Of Mental Health Disorder Symptoms And Rates Of Help-Seeking Among University-Enrolled, Black Men, Kofoworola D. A. Williams, Amy Adkins, Sally I-Chun Kuo, Jessica G. Larose, Shawn O. Utsey, Jeanine P. D. Guidry, Danielle Dick, Spit For Science Working Group, Kellie E. Carlyle

Graduate Research Posters

Background. Black men in college represent a subgroup of emerging adults who are at increased risk of developing mental health disorders (MHDs), such as anxiety and depression. Such risk has been attributed to disproportionate experiences with everyday racial discrimination and high levels of psychological distress. Despite being at higher risk, university-enrolled, Black men are not utilizing mental health or health resources at optimal rates. The current evidence base describing prevalence of MHDs and health services utilization among Black men in college is limited. The present study addresses this by examining mental health prevalence among university-enrolled, Black men and their rates …

Life Satisfaction: Measurement Invariance And Correlations With Adolescent Adjustment, Sarah K. Pittman, Robert F. Valois, Albert D. Farrell

Graduate Research Posters

Background

Low life satisfaction during adolescence has been associated with adjustment problems. There are few well-validated measures available to assess adolescents’ life-satisfaction. The purpose of this study was to investigate the structure of the Life Satisfaction Scale, evaluate its measurement invariance across sex and race/ethnicity, and investigate its associations with related constructs.

Methods

Participants were 3,340 adolescents from rural middle schools in Florida. Half the participants were female, 51% were White, 15% were Black, and 22% were Latinx. Adolescents completed the Life Satisfaction Scale, the Children’s Report of Exposure to Violence scale, and the Problem Behavior Frequency Scale.

Results

Confirmatory …