Perovskite Thin Films Annealed In Supercritical Fluids For Efficient Solar Cells, Gilbert Annohene

Theses and Dissertations

In the field of photovoltaics, scientists and researchers are working fervently to produce a combination of efficient, stable, low cost and scalable devices. Methylammonium lead trihalide perovskite has attracted intense interest due to its high photovoltaic performance, low cost, and ease of manufacture. Their high absorption coefficient, tunable bandgap, low-temperature processing, and abundant elemental constituent provide innumerable advantages over other thin film absorber materials. Since the perovskite film is the most important in the device, morphology, crystallization, compositional and interface engineering have been explored to boost its performance and stability. High temperatures necessary for crystallization of organic-inorganic hybrid perovskite films …

A Mixed Methods Approach To Examine Racial Disparities In Adherence To Surveillance Mammography Among Breast Cancer Survivors, Megan C. Edmonds

Theses and Dissertations

PURPOSE: Annual surveillance mammography is a critical part of routine cancer care for breast cancer (BC) survivors; reducing mortality by 39%. However, disparities exist with regard to adherence to surveillance mammograms among BC survivors; Black women are 44% less likely to adhere than their White counterparts. Despite the existence of this racial disparity for over a decade, little is known about factors that explain reasons for Black BC survivors’ non-adherence. This is because most studies have not evaluated the role of healthcare delivery or psychosocial factors. Guided by the Behavioral Model for Vulnerable Populations, the purpose of this mixed methods …

The Just Host: Addressing The Wage Structure Problem In The Tourism Industry, Bill Farley

Theses and Dissertations

Since the early 1990’s, tourism development has been promoted to replace employment lost to downsizing, outsourcing and automation in both urban and rural America. These efforts are actively supported by state and local chambers of commerce. However, despite the enthusiasm for tourism within city halls and business membership organizations, planning theorists have expressed concerns about the wage structure of the industry. Specifically, given the significant public investment in the industry, planners are being asked by some theorists to consider the distribution of economic benefits between labor and capital. This dissertation explores this issue and concludes with a study focused on …

The Therapeutic Potential Of Glycosaminoglycan Directed Metalloglycomics: Elucidating New Targets And Mechanisms For Polynuclear Platinum Complexes, James D. Hampton

Theses and Dissertations

Cancer remains a serious clinical problem and in order to continue to improve patient health outcomes, novel treatment strategies must continue to be developed. Platinum chemotherapies remain as one of the most widely successful classes of cancer therapeutic, with over 50% of cancer patients receiving a platinate at some point over the span of their treatment. However, intrinsic and extrinsic resistances limit their effectiveness, long term efficacy, and broad applicability to multiple cancer subtypes. Therefore, the development of new agents and strategies which can overcome these limitations are crucial for patient health. To this end a novel class of polynuclear …

A Non-Inferiority Randomized Controlled Trial Comparing Behavioral Sleep Interventions In Women Veterans: A Secondary Analysis Of Pain Outcomes, Scott Ravyts

Theses and Dissertations

Women are disproportionally more likely to experience both insomnia and chronic pain. While these two conditions frequently co-occur, a wealth of literature suggests that insomnia is a stronger predictor of pain than pain is of insomnia. Preliminary research indicates that sleep apnea may also lead to adverse pain outcomes, with the combination of insomnia and sleep apnea contributing to an adverse synergistic effect on pain. Despite the clinical implications of such findings, knowledge regarding the interrelations between sleep disorder complexity and pain remain limited, especially among women. Additionally, interventions seeking to improve pain by targeting insomnia have yielded inconsistent results …

An Exploration Of Teacher Residents’ Perception Of Culture And Their Use Of Culturally Responsive Pedagogy, Jodi Larson

Theses and Dissertations

Urban teacher residency (UTR) programs place residents in urban schools labeled “hard-to-staff” or “under-resourced.” Enrollment in residency schools tends to be majority Brown or Black students from various cultures. Teacher residents are from diverse backgrounds and races who have a commitment to teach in Title 1 schools with the support of a residency program that coaches them how to teach using culturally relevant pedagogy. Their journeys are unique from typical student teaching experiences because they co-teach with an experienced teacher for a full school year while attending university classes on pedagogy and theory. This qualitative case study followed seven elementary …

Modeling Substance Use And Mental Disorder Comorbidity Using Latent Variable And Network Approaches, Courtney T. Blondino

Theses and Dissertations

Introduction. Substance use disorder (SUD) is a common condition that affects millions of Americans. Addressing SUD has been complicated by comorbid mental disorders and co-occurring substance use. Consequently, detailing and addressing SUD and comorbid SUD represent an important goal to improve the health of Americans.

Objective. The research goal of this dissertation was to characterize the comorbidity between substance use, including tobacco use, and mental disorder symptoms measured as negative affect and externalizing symptoms in a population-based sample using latent variable and network approaches.

Methods. Waves 1 – 3 from the Population Assessment of Tobacco and Health Study were used. …

Single-Molecule Investigation Of I-Motif Folding And Dynamics In Bioinspired Dna Platforms, Anoja Megalathan

Theses and Dissertations

Although the canonical right-handed B-DNA is the predominant form of DNA in cells, DNA can adopt other secondary structures such as hairpins, G-quadruplexes (G4), and intercalated motifs (i-motif). These secondary structures are typically formed in the regions with repeat sequences. Among many secondary structures DNA can adopt, G-quadruplexes and i-motifs (tetraplex structures formed in the G-rich and C-rich sequences, respectively) caught significant research interest in recent years due to the prevalence of G-rich and C-rich sequences in the human genome. While G-quadruplexes are extensively studied, little is known about i-motifs – especially their formation and stability under cellular environments. For …

Genetics And Alcohol Interventions In Youth, Zoe E. Neale

Theses and Dissertations

Alcohol is the most commonly used substance among youth, and risky alcohol use is associated with harmful consequences such as accidents, academic consequences, and physical and emotional health problems. Alcohol use disorders are approximately 50% heritable, yet most efforts to prevent and intervene upon youth alcohol use focus only on environmental factors. Furthermore, current prevention and intervention programs tend to have modest effects and are not uniformly effective for all individuals. Gene-by-intervention (GxI) studies offer an opportunity to expand current understanding of interventions by examining whether underlying genetic risk may contribute to differential program effects. Much of the current GxI …

Preclinical Pharmacokinetic Studies Of Pterostilbene, And Its Human Pharmacokinetic Prediction Using Physiologically Based Pharmacokinetic Modeling, Palak S. Phansalkar

Theses and Dissertations

This dissertation research aimed to determine the preclinical pharmacokinetics of pterostilbene in vitro and develop a physiologically based pharmacokinetic (PBPK) model to simulate the animal and human PK profiles for pterostilbene. The in vitro PK characteristics of pterostilbene, including Caco-2 cell permeability, plasma protein binding, and metabolic stability were determined using rat and human intestinal & hepatic S9 subcellular fractions. The in vitro metabolic parameters determined in rat subcellular fractions were extrapolated to in vivo values to predict the oral bioavailability (F_oral) in rats. The predicted F_oral was found to be 43.0 %, which is similar to …

Analyzing Electronic Health Records With Time-To-Event Endpoints: Propensity Scores And Semiparametric Approaches, Jonathan W. Yu

Theses and Dissertations

For analyzing large electronic health records (EHR) with time-to-event endpoints, such as in kidney transplantation, a major challenge is to provide an accurate risk analyses, while accounting for a multitude of epidemiological and statistical complexities. Motivated by a right-censored kidney transplantation EHR dataset derived from the United Network of Organ Sharing (UNOS), this dissertation, through a culmination of two interrelated yet distinctly different projects, focuses on developments of novel statistical procedures and methodologies to address some pressing issues arising in EHR-based research. In the first project, we aim to decouple the causal effects of treatments (here, studying subgroups, such as …

Owning Our Story: An Interior Exploration To Foster Self-Reflection, Hannah Bulow

Theses and Dissertations

With emerging technologies in the 21st century, Millennial and Gen Z adults have a complicated relationship with these new technologies when it comes to creating and sustaining personal relationships (Dalessandro, 2018). When persons aged 18-35 forged new relationships without the presence of technology, relationships were more organic, natural, and led to less conflicts. Neuroimaging of the brain has also shown that neurocognitive development during early adolescence and adulthood contributes to self-consciousness and vulnerability. Adolescents are called to develop their own identity separate from their parents and understanding how others are actually evaluating them (Sebastian, 2008)

Brene Brown states that most …

Structural Reorganization Of The Cisternal Organelle In Neuroinflammatory Disease, Myshak S. Abdi

Theses and Dissertations

The axon initial segment (AIS), an axonal sub compartment located immediately distal to the soma, is an important structure in mediating action potential generation and modulation. The morphology of this domain can be altered by a wide variety of activity-dependent, environmental, and pathological triggers. Dysregulation of axonal calcium (Ca²⁺) concentrations, and subsequent enzymatic degradation of AIS cytoskeletal architecture have been reported to underlie structural modifications of the AIS. Moreover, pharmacological inhibition of neuronal Ca²⁺ channels have been shown to mitigate the disruptive effects of neuroinflammation on AIS structural integrity. Here we investigate the Cisternal Organelle (CO), a …

Interpersonal Trauma And Mental Health Among Lgbq+ College Students: Examining Social Support And Trauma-Related Drinking As Mediators, Eryn Delaney

Theses and Dissertations

Despite the increased risk of childhood, adulthood, and lifetime interpersonal trauma among LGBQ+ individuals, existing research that has examined the influence of interpersonal trauma on mental health has primarily focused on LGBQ+ adolescents and samples of LGBQ+ community-based adults, and less on LGBQ+ emerging adults in college. Additionally, limited work has focused on mechanisms that might explain the relations between these variables. Thus, the current study tested the relations between interpersonal trauma (i.e., childhood sexual abuse, adulthood sexual victimization, and lifetime physical assault and IPV) and mental health outcomes (i.e., anxiety symptoms, depressive symptoms, and PTSD symptoms), and examined social …

Conformational Modulation Of Α-Helical N-Acetylated Α-Synuclein, Ricardo Fernandez

Theses and Dissertations

Human N-acetylated α-synuclein (^NAcαSyn) has long been accepted as an intrinsically disordered protein (IDP) predominantly found in terminal nerve regions in healthy subjects. ^NAcαSyn structural fluidity enables the formation of transient or dynamic assemblies. Some of these assemblies may serve functional, yet undefined purposes. ^NAcαSyn is highly susceptible to the surrounding environment, leading to misfolding under high cytosolic oxidative stress conditions, which in turn assemble in the form of toxic oligomers or amyloid fibrils. These ^NAcαSyn inclusions along with their accretion and migration within neurons, are pathological hallmarks of Parkinson’s disease (PD), dementia, and multiple …

Copper Sulfide Manganese Nanoparticles For Multimodality Imaging And Therapy, Ali S. Gawi Ermi

Theses and Dissertations

Abstract

COPPER SULFIDE MANGANESE NANOPARTICLES FOR MULTIMODALITY IMAGING AND THERAPY

By Ali S. Gawi Ermi, MSc

Inorganic nanoparticles (NPs) are compatible with metal-based multi-modality molecular imaging and targeted therapy. Copper sulfide nanoparticles (CuS NPs) are attractive photoacoustic and photothermal agents and are amenable to incorporation of radionuclides and paramagnetic elements to facilitate image-guided therapy. The aim of this work is to develop manganese (Mn)- doped CuS NP, intrinsically radiolabeled with radionuclides such as (Zirconium-89 (⁸⁹Zr), Copper-64/67 (^64/67Cu) and Manganese-52/55 (^52/55Mn)). This novel approach combines Photoacoustic (PA), Positron emission tomography (PET), Single-photon emission computed tomography …

Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce

Theses and Dissertations

Climate change has been identified as a defining issue of this century (United Nations, n.d.). Climate change impacts human wellbeing including mental health. While much research has focused on the way that the effects of climate change cause increases in common mental disorders, mental health is not just the absence of these disorders (World Health Organization, 2014). Non-pathologized mental health responses to climate change, such as the grief and loss that results from climate change impacts, are a growing consideration for researchers. Solastalgia, or the distress experienced in the absence of the solace once provided by the environment in the …

Streptococcus Sanguinis: The Good, The Bad, And The Metal-Binding Lipoprotein, Cody Murgas

Theses and Dissertations

Streptococcus sanguinis is an opportunistic bacterium living beneficially in the human mouth. When S. sanguinis gains access to the bloodstream, it can result in colonization on damaged tissue and generate heart valve vegetations that can develop into infective endocarditis. It has been suggested that Mn and Fe are cofactors in the pathogenic capacity of this bacterium, and that these redox active metals are imported by the metal binding lipoprotein S. sanguinis adhesin B (SsaB). The SsaB lipoprotein is an integral part of SsaACB, an ATP-binding cassette (ABC) transport system in S. sanguinis. When SsaB is deleted, the resulting strain displays …

Theorizing #Girlboss Culture: Mediated Neoliberal Feminisms From Influencers To Multi-Level Marketing Schemes, Frankie Mastrangelo

Theses and Dissertations

I define girlboss feminism as emergent, mediated formations of neoliberal feminism that equate feminist empowerment with financial success, market competition, individualized work-life balance, and curated digital and physical presences driven by self-monetization. I look toward how the mediation of girlboss feminism utilizes branded and affective engagements with representational politics, discourses of authenticity and rebellion, as well as meritocratic aspiration to promote cultural interest in conceptualizing feminism in ways that are divorced from collective, intersectional struggle. I question the stakes involved in reducing feminist interrogations and commitments to discourses of representation, visibility, and meritocracy. I argue that while girlboss feminism may …

Inclusive Academic Education & Vocationally-Oriented Transition Predictors’ Association With Post-Secondary Outcomes Of Youth With Intellectual And Developmental Disabilities, Joshua P. Taylor

Theses and Dissertations

Despite efforts through legislation to increase the engagement of individuals with intellectual and developmental disabilities (IDD) in competitive integrated employment (CIE) and post-secondary education, outcomes remain poor. However, recent policy has emphasized CIE as a preferred outcome and created new opportunities to engage individuals with IDD in post-secondary education. Likewise, research into the transition of youth with disabilities has revealed several predictors of post-school success including inclusive education and a variety of vocationally-oriented experiences. Previous research had not determined whether students with IDD received both inclusive academic education and vocational transition experiences or how these predictors might interact. The purpose …

Interventions To Slums And Informal Settlements: A Case Study Of The Integrated Housing Development Program In Addis Ababa, Ethiopia, Nathan Teklemariam

Theses and Dissertations

Rapid urbanization is currently taking place in developing regions that have yet to address already existing and persistent inequities within their urban centers. There is perhaps no urban policy issue more critical for governments of the global South than the elimination of slums and informal settlements, along with the development of equitable access to affordable housing for low-income residents. Ethiopia has taken on this challenge through its Integrated Housing Development Program (IHDP), which incorporates slum clearance and resettlement through a government-led development of condominium housing targeting those displaced and other low and middle-income residents in the city.

Since the launch …

Expand Your Horizon: Investigating An Online Intervention For Weight Bias Internalization, Alexandria Davies

Theses and Dissertations

Weight bias internalization (WBI; i.e., self-directed weight stigma or the degree to which individuals apply negative weight-based stereotypes to themselves), is problematic because it is associated with increased stress, emotional eating, healthcare avoidance, and exercise avoidance. Thus, WBI exacerbates health disparities and there is an urgent need to create treatments that address this concern. The current study examined the preliminary effectiveness of a previously developed online body gratitude journaling intervention (i.e., Expand Your Horizon) compared to an active control writing condition in emerging adult women with WBI. Racially/ethnically diverse women (N=100; n=49) or Expand Your Horizon ( …

The Algorithmic Mashrabiya: Reimagining The Traditional Islamic Screen, Ahmed Nour

Theses and Dissertations

Traditionally, a mashrabiya was an ornate wooden structure attached to the side of an Arabian building or house, with small, intricately patterned openings to provide both ventilation and privacy for the people inside. The patterns, following the geometric rules of Islamic ornament, lent a distinctive appearance to buildings in the region. A mashrabiya converted the house into a safe, private sanctuary, providing a magical scene inside, characterized by linear sun rays, filtered points of light and shadow. Over time, as building technology changed and the number of skilled craftsmen dwindled, the traditional mashrabiya has all but vanished. The aim of …

Third Culture Kids - Playing To Heal, Amna Sana

Theses and Dissertations

With increased globalization and a large expat population, Qatar is home to increasing numbers of Third Culture Kids (TCKs). TCKs are children who live in a country where their parents are non-native, children who grow up between cultures. Young TCKs, especially children between the ages of three and seven, do not possess the skills to adequately vocalize their feelings, but fortunately, play therapy allows them to articulate problems and feelings on their own terms. This thesis addresses the emotional hurdles facing TCKs, using concepts derived from play therapy and offering a series of interactive objects designed to reflect emotional expression …

Western Clinicians’ Diagnostic Accuracy Of Culture-Bound Syndromes, Lisa Y. Chung

Theses and Dissertations

Culture-bound syndromes are of increasing importance in today’s more diverse world. The current study measured the ability of clinicians trained in a western setting to accurately diagnose culture-bound syndromes from cultures outside of their background. Eight-four clinicians were recruited through the American Psychological Association (APA) membership directory. All recruited clinicians were asked to read three vignettes. In two vignettes a patient was suffering from either Hwabyung or Ataque de Nervios and the third vignette represented a control GAD vignette. The clinicians were asked to diagnose the patient in the vignette, to explain what information informed their diagnosis, to complete two …

Kaleidoscope Wellness | Destigmatizing Mental Health For Teens By Design, Rhode L. Baptiste

Theses and Dissertations

Motivation

Mental health is a global public health crisis. (Marcus et. al, 2012; WHO, 2020). Although there is a growing acceptance of the complexities surrounding mental illness, care delivery for adolescents with mental health concerns remains highly stigmatized, which contributes to delays in care (Hoisington et. al, 2019; Burns & Birrell, 2014). Half of all mental illnesses can be detected prior to the age of 14 (National Alliance for Mental Health, 2020). While research exploring how the physical health care environment impacts health and well-being for patients has evolved immensely over the past two decades, research on how facility design …

The Institute For Storytelling & Healthcare Design Research, Ruth E.P. Deibler

Theses and Dissertations

STORYTELLING, HEALTHCARE, INTERIOR DESIGN EDUCATION & GROUNDED THEORY RESEARCH:

THE TRIFECTA OF TRANSFORMATIONAL CHANGE IN HEALTHCARE DESIGN

Policy And Practice Brief 7: Special Considerations For Access Testing During Covid-19, Carolyn N. Waters, Merc English Learner Research & Evaluation Team, Virginia Commonwealth University

MERC Publications

Because of the COVID-19 pandemic, in-person instruction in Virginia public schools was suspended in March 2020 for the remainder of the school year. In 2020-2021, Virginia schools offered an evolving range of virtual, hybrid, concurrent, and face-to-face instruction. Despite the challenges of schooling during the pandemic, federal high-stakes testing mandates remained in place in 2020-2021, and all students identified as English learners (ELs) were still required to take the annual assessment of English language proficiency (ELP), the WIDA ACCESS for ELLs©. Since this test cannot be administered remotely, ELs participating in virtual schooling were expected to return to school buildings …

Will They Stay Or Will They Go? Analysis Of The 2019 Doe Working Conditions Survey, Jonathan D. Becker, Valerie Robnolt, Kasey Dye, Erica Ross

MERC Publications

This report is part of the MERC Teacher Retention study. This study was designed to identify patterns of teacher retention in the MERC region and to determine the school and system-level factors driving them. The study also provides an overview of state and regional policies and programs relevant to teacher retention, and includes evaluations of existing policies and initiatives to determine efficacy and cost benefit. Teacher shortages continue to be a problem in the United States. While a range of policy solutions have attempted to stem the loss of teachers, at the base of many of these efforts is the …

The Same Flight, Laura Bender

Mighty Pen Project Anthology & Archive

After 9/11, a navy chaplain prepares for war.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.