Digital Commons Network^™

Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila R. Kunuthuru, Laura Graham, Harry D. Bear Md, Phd

UROP Posters

Breast cancer has the highest incidence rate of all cancers globally in women, and those of African descent, especially West African females, face higher rates of triple-negative breast cancer (TNBC), a more aggressive form of breast cancer. Immunotherapy for breast cancer is a relatively new treatment option, and research is ongoing to identify the best combination treatments for increasing survival of those diagnosed with TNBC. Eganelisib (IPI-549: a PI3K-gamma inhibitor that works to shift M2 macrophages to M1 to augment T cell function) with other combinatory treatments has shown promising results in reducing tumor growth and increasing survival in mice. …

Spanish Translation And Psychometric Validation Of A Measure Of Acculturative Stress Among Latinx Immigrants In The Usa, Ria Grover, Kritzia Merced, Chimdindu Ohayagha, Isis Garcia-Rodriguez,, Oswaldo Moreno, Paul B. Perrin

UROP Posters

BACKGROUND: In the U.S., the Latinx community is growing at a faster rate than any other racial and ethnic minority group. Members of this community have been found to experience a number of acculturative stressors after immigrating including xenophobia, racism, and discrimination. Although several scales have been created in recent years to measure acculturative stress in Spanish-speaking immigrants, they are long, do not have nuanced subscales, or have not been validated in an extremely diverse sample of Latinx immigrants.

OBJECTIVE: The purpose of the current study was to translate and psychometrically validate the Riverside Acculturative Stress Inventory (RASI) in a …

Neonatal Blood Methylation Marks Associated With Obstetric Pain Relief, Charles J. Tran, Lin Y. Xie, Christina Hultman, Edwin Van Den Oord, Karolina A. Aberg

UROP Posters

The placenta, responsible for intrauterine development, can facilitate modifications within the placental epigenome in response to changes in the mother. In turn these changes have the potential to also influence the neonate¹. Pain relief during delivery is widely used and frequently involves the use of nitrous oxide (N₂O, commonly referred to as laughing gas), and pudendal blocks. These treatments, alone or in combination, are generally accepted as safe methods of providing pain relief to mothers. However, laughing gas and local anesthetics such as the ones used during pudendal blocks have been known to cross the placental …

Covid-19 Impact And The Association Between Sociodemographic, Social Support, Depression, And Anxiety In The Mindful Moms Program, Ashley Nguyen

UROP Posters

Background: The Covid-19 Pandemic lockdown resulted in lessened social support and a higher incidence of depressive symptoms in the United States. Low-income families were more likely to have experienced negative impacts on income, access to mental health treatment, stress, and discord within the family, and higher anxiety scores during the pandemic. Minority groups had higher COVID-19 incidence and mortality rates. More than 1 in 5 pregnant women in the United States experience clinically significant depressive symptoms, with marginalized populations carrying a greater burden. Maternal depression is linked to poor maternal and child health outcomes.

Depression scores of pregnant individuals during …

Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer

UROP Posters

The anterior cruciate ligament (ACL) connects to bone via structurally complex insertions known as entheses that translate load from elastic ligament and stiff bone via gradients in organization, composition, and cell phenotype [1]. These gradients are not recreated in graft repair or engineered replacements, yielding limited repair options and high failure rates [2]. Previously, we developed a culture system that uses a tensile-compressive interface to guide ligament fibroblasts to develop early postnatal-like entheses by 6 weeks [3]; however, cells used were isolated from the entirety of the neonatal bovine ACL from bone to bone and likely contained multiple cell phenotypes …

Developing A Model Of Aged Decellularized Muscle Matrix With Advanced Glycation Cross-Linking, Ammar Jawad, Scott Pennebaker, Lucas C. Olson, Tri M. Nguyen, Barbara D. Boyan, Zvi Schwartz, Michael J. Mcclure

UROP Posters

Volumetric muscle loss (VML) has been found to overwhelm muscle regeneration, resulting in loss of long-term muscle functionality. Decellularized muscle matrices (DMMs) provide an effective environment for muscle regeneration; however, the age of their source has not been adequately explored for clinical translation. Advanced glycation end-products (AGEs) are chemical cross-links that contribute to the aging process by accumulating on collagen fibers, resulting in a stiffening of the collagenous matrix and an increase in inflammation via the receptor for advanced glycation end-products (RAGE). In previous experiments, we found increased levels of AGE-specific cross-links within DMMs in old mice compared to young …

A Personal History Of The Department Of Biology, Margaret L. May

VCU University History Books

Former faculty member Margaret May recounts the history and development of the Department of Biology at Virginia Commonwealth University.

Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester

Theses and Dissertations

One of the largest discrepancies between preclinical and clinical assessment of pain and analgesia is the type of behavioral endpoint used. Although most preclinical research has historically focused on drug effectiveness to block reflexive withdrawal behaviors stimulated by a noxious stimulus, increasing evidence shows that drug-induced restoration of pain-depressed behaviors provides increased clinical translation with decreased susceptibility to false-positives. Accordingly, the first portion of this dissertation designed a behavioral battery that featured pain-depressed behaviors as well as more conventional pain-stimulated behaviors for testing candidate analgesics in male and female mice. The main findings are as follows. (1) Intraperitoneal injection of …

The Experiences Of Religiously And Spiritually Diverse Counselors And Psychotherapists Who Work With Survivors Of Sexual Violence, John M. Waters

Theses and Dissertations

The purpose of this qualitative study was to examine the lived experiences of religiously and spiritually diverse counselors and psychotherapists who work with survivors of sexual violence. The researcher used a transcendental phenomenological approach to understand how the participants engaged their religious and/or spiritual identity to cope with the traumatic stress that accompanies continuous exposure to their clients’ trauma narratives over time. As the only study that has examined these phenomena qualitatively, the present study aimed to enhance counselors and counselor educators’ understanding of the ways that religiously and spiritually diverse counselors make meaning of their experiences. The researcher collected …

Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe

Theses and Dissertations

Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …

Development And Validation Of A Volunteer Adult Literacy Tutor Perception Feedback Scale, Robert Craig

Theses and Dissertations

This exploratory study developed and validated a Volunteer Adult Literacy Tutor Perception Feedback Scale (VALTPFS). The VALTPFS is a self-report questionnaire that measures the perceptions of one-on-one adult literacy tutors about their values, knowledge sharing, and satisfaction. This instrument is designed to assess the perceptions of adults who volunteer to provide literacy instruction to tutees who are U.S. born native English language speaking adults. The theoretical framework used to inform the development of the VALTPFS is the community of practice (CoP). The CoP framework was used to identify subscales from instruments with established psychometric credentials to operationalize the VALTPFS. As …

Therapeutic Approaches For Respiratory Distress Syndrome, Franck J. Kamga Gninzeko

Theses and Dissertations

Respiratory distress syndrome (RDS) is characterized by shortness of breath and low oxygen levels. RDS affects the neonatal and adult populations. In the neonatal population, RDS can be classified as NRDS (Neonatal respiratory distress syndrome), while in adults, it is known as ARDS (acute respiratory distress syndrome). This dissertation examines a therapeutic approach to NRDS and a mechanistic approach to ARDS with in vivo and in vitro models of lung injury. NRDS is characterized by a deficiency or lack of surfactant. Surfactant is an essential compound composed of phospholipids and proteins to prevent the lungs from collapsing. There are several …

Race, Weight, Gender And The Embodied (Odied, Odied) Consciousness Of Big-Bodied Black Women Educators: A Phenomenological Study, Kendra D. Johnson

Theses and Dissertations

Big-Bodied Black women in the United States have perpetually navigated the veritable dichotomy of being hyper-visible and invisible (Beauboeuf-Lafontant, 2003; Fleetwood, 2001; Strings, 2019). Fat Black female bodies have borne the burden of exaggerated tropes and exploitation throughout history, stripping them of their femininity and humanity and resulting in a unique form of objectification (Strings, 2019). Inconsistent messages about BBWs, their bodies, and their value in society have endured for generations. They have been essential in constructing the controlling images of Black womanhood in the U.S. (Collins, 2000). The controlling images all evoked thoughts about the suitability of Black women …

Effect Of Clear Aligner Attachment Design On Extrusion Of Maxillary Lateral Incisors: A Randomized Clinical Trial, Justin Groody

Theses and Dissertations

Introduction: The aims of this randomized clinical trial were to compare the efficacy of extrusion of maxillary lateral incisors among “optimized”, rectangular “horizontal”, rectangular horizontal “incisally beveled”, rectangular horizontal “gingivally beveled” attachments, and to provide a clinically relevant recommendation for attachment planning for extrusion of maxillary lateral incisors during aligner treatment.

Methods: 30 16-to-58 year old Invisalign patients and 56 maxillary lateral incisors requiring extrusion were randomly allocated to one of four attachment groups (optimized, horizontal, incisally beveled, and gingivally beveled). Participants were recruited from two private practice offices and the Virginia Commonwealth University School of Dentistry. The outcome assessor …

Culturally Relevant Coping Strategies Within Bicultural Latine College Students In The Face Of Anti-Immigrant Sentiment And Policy, Cindy M. Hernandez

Theses and Dissertations

Despite their protective potential against anti-immigrant sentiment and policy, the connections between bicultural identity development and culturally relevant coping among temporarily documented Latinx college students remain unstudied. Therefore, this study (a) describes culturally relevant coping strategies used by bicultural Latinx college students, (b) examines the role cultural identity plays in bicultural Latinx college students’ coping strategies, and (c) illuminates the role institutional level systems play in liminally-documented college students’ coping with anti-immigrant sentiment and policy. Participants in this study included 16 Latine college students (M_age = 21.19, SD = 3.21) with DACA (n = 14) or TPS (n = …

Less Water, More Holy: Tools For Sustainable Ablution, Faheem Khan

Theses and Dissertations

Prayer is an important part of life for many people, whether it takes the form of meditation or talking to God. Muslims pray five times a day, and before each prayer, they first clean themselves by performing ritual ablution (wudu). The eight-step purification process of wudu cleanses the body from head to toe. The Hadiths of Sahih al-Bukhari and Sahih Muslim tell us the Prophet Muhammad ﷺ needed just one mudd of water (650ml) to complete wudu, but most people consume many times that amount—four-to-seven liters is more common today.

To visualize and better understand the nature …

Use Of Passive Immobilization During Oral Conscious Sedation: Parental Perceptions And Utilization By Pediatric Dentists In The United States, Jennifer N. Levine

Theses and Dissertations

Use of Passive Immobilization During Oral Conscious Sedation: Parental Perceptions and Utilization by Pediatric Dentists in The United States, Levine J, Caudill, C (Virginia Commonwealth University School of Dentistry, Richmond, VA)

Research supported by the Alexander Fellowship

Purpose: To assess change in parental attitudes of passive immobilization after viewing an informational video and evaluate how pediatric dentists are currently using passive immobilization during oral conscious sedations (OCS).

Methods: A survey consisting of six statements on a 5-point Likert scale was completed by parents at their child’s OCS consultation appointment before and after viewing an educational video demonstrating benefits of passive …

The Effect Of Crowding On The Accuracy Of 3d Printed Aligners, Tonya Spangler

Theses and Dissertations

Purpose: To evaluate the accuracy of three-dimensionally (3D) printed aligners compared to conventional vacuum-formed thermoplastic aligners with varying levels of dental crowding.

Methods: Digital intraoral scans of 10 different cases were assigned to their respective groups (n=10, each, 30 total) as follows: no crowding (control), moderate crowding, and severe crowding. Using 3Shape software, digital aligner samples were created in standard tessellation language (STL) file format and randomly 3D printed. The same STL files of each case were also sent to a dental laboratory for the fabrication of vacuum-formed samples, which is the current technology used for manufacturing aligners. The intaglio …

Building A School Culture Of Success For Multilingual Learners: A Multiple Case Study Of Perspectives From Secondary School Leaders, John P. Marshall

Theses and Dissertations

The present study seeks to address achievement and opportunity gaps for Multilingual Learners (MLs) by studying secondary schools who have established a school culture that prioritizes ML support and success. It draws on existing literature in the fields of ML best practices, educational leadership, and school culture research to study case schools in order to distill from their lived experiences recommendation for practitioners. The author used a multiple case study methodology to delve into four case schools identified as exemplars of cultures for ML success. The author used in-depth qualitative interviews to find out if leaders in any secondary schools …

Associations Between Years Of Teaching Experience And Classroom Management Practices, Responsivenss, And Acceptability To A Coaching Intervention, Nicole M. Peterson

Theses and Dissertations

This study aimed to bridge the research-to-practice gap related to in-service supports and professional development by identifying factors associated with teacher use of evidence-based classroom management practices and responsiveness to a coaching intervention. Years of teaching experience was identified as a teacher-level intervention determinant with a strong research base in the classroom management literature; however few studies used direct observation of behavior to report difference among teacher behavior. This study used quantitative statistical methods to analyze data from a multi-year parent study investigating the effects of a coaching intervention (BEST in CLASS-Elementary) aimed at increasing the use of evidence-based practices …

Exploring Digital Equity Through Parent Perceptions Of Students’ Use Of 1:1 Devices: A Mixed Methods Approach, Joy Washington

Theses and Dissertations

Over the last two decades, 1:1 initiatives, in which each child in a school building is provided a school-issued device, have increased dramatically around the world. However, the outcomes of such programs are not always clear and studies regarding 1:1 one programs have found mixed results. It is important to ensure that1:1 initiatives are equitable and do not perpetuate the digital divide. Many studies exist that examine use of 1:1 devices in schools from a teacher or student perspective. However, only a few studies examine the experience of 1:1 initiatives from a parent perspective and also focus on equity. The …

Improving Feature Learning Capability And Interpretability Of Unsupervised Neural Networks, Chathurika S. Wickramasinghe Brahmana

Theses and Dissertations

The motivation for this dissertation is two-prong. Firstly, the current state of machine learning imposes the need for unsupervised Machine Learning (ML). Secondly, once such models are developed, a deeper understanding of ML models is necessary for humans to adapt and use such models.

Real-world systems generate massive amounts of unlabeled data at rapid speed, limiting the usability of state-of-the-art supervised machine learning approaches. Further, the manual labeling process is expensive, time-consuming, and requires the expertise of the data. Therefore, the existing supervised learning algorithms are unable to take advantage of the abundance of real-world unlabeled data. Thus, relying on …

Temporal Disambiguation Of Relative Temporal Expressions In Clinical Texts Using Temporally Fine-Tuned Contextual Word Embeddings., Amy L. Olex

Theses and Dissertations

Temporal reasoning is the ability to extract and assimilate temporal information to reconstruct a series of events such that they can be reasoned over to answer questions involving time. Temporal reasoning in the clinical domain is challenging due to specialized medical terms and nomenclature, shorthand notation, fragmented text, a variety of writing styles used by different medical units, redundancy of information that has to be reconciled, and an increased number of temporal references as compared to general domain texts. Work in the area of clinical temporal reasoning has progressed, but the current state-of-the-art still has a ways to go before …

Graduate School's Transformative Awakening: An Arts-Based Autoethnography, Roxanne L. Brown

Theses and Dissertations

This is an autoethnographic journey of a 30-year veteran art teacher through graduate school during the 2016 presidential campaign, election, presidency, #MeToo movement, a global pandemic, Black Lives Matter (BLM), virtual teaching and grading during a pandemic. My narrative includes an account of my transformative academic, social, and personal experiences and how they have informed my teaching practice. They include a collection of visual representations I created during my graduate school journey.

The Value Of Educating Teachers, Coaches, And Athletic Trainers On The Management Of Dental Trauma., Laura Satoski

Theses and Dissertations

Purpose: The aim of this study is to investigate the baseline knowledge and assess the benefit of educating teachers, coaches, and athletic trainers about the management of sports-related dental injuries.

Methods: Teachers, coaches, and athletic trainers working in youth sports activities across the city of Richmond and the Greater Richmond Region were recruited via email. Participants answered a pre-seminar survey to evaluate their baseline knowledge and determine whether they experienced dental trauma with their athletes previously. The survey also indicated whether they participated in a public or private sports facility. The participants watched a pre-recorded virtual seminar educating them on …

The Abuse Liability Profile Of An Unflavored, Sucralose-Sweetened, Electronic Cigarette In Combustible Cigarette Smokers, Sarah F. Maloney

Theses and Dissertations

The purpose of this study was to examine the effects of sucralose and nicotine in otherwise unflavored PG/VG ECIG liquid solutions, via a 30-watt ECIG, using multiple measures predictive of abuse liability to provide a basic understanding of the effects of sweeteners and perceived sweetness on ECIG abuse liability in reference to combustible cigarettes. Fourteen dependent smokers completed five independent study sessions that were within-subject, Latin-square ordered, and were identical in regards to all aspects but the product used. In each session, participants were given either their own brand of cigarettes or one of the four ECIG conditions: 0 mg/mL …

The Civil Right To Belong: A Case Study On Immigrant Integration Of Muslim Students In Educational Institutions, Mamoona H. Siddiqui

Theses and Dissertations

Constitutional equal protection values serve as social integration policies for new Americans and generations that follow. They promise equal opportunity, fair treatment, protection from unlawful discrimination, and freedom to preserve cultural identities in their new communities. However, in times of national security crises and political polarization, the disjuncture in the way equal protection doctrines have been historically implemented often reflect deep-rooted inequities that impact underrepresented communities. American Muslims are one such community in which members have experienced anti-Muslim and anti-immigrant sentiment particularly after 9/11 and political polarization on immigration and civil rights policies. The study explores the equal protection doctrine …

Childhood Reliquary De Una Catracha/Mexi Entre Nopales, Juliana Bustillo

Theses and Dissertations

Childhood Reliquary De Una CatrachaMexi Entre Nopales is a multisensory based installation consisting of three large and six medium scale mixed media paintings with performance. It is informed by my upbringing in Boyle Heights in the projects during the 90s, followed by East LA in the mid 2000s. It is the reliquary for my discomfort in institutional spaces and why I have found comfort in dystopian-like installations. This is the landscape in which I exist, regardless of where I am now. It is where I place my work. It is the context in which I celebrate the powerful delicacy of …

Peri-Implantitis Incidence And Effect Of Supportive Periodontal Therapy On Outcomes: Retrospective Cohort Study, Michael Ha

Theses and Dissertations

Purpose: Management of peri-implantitis is becoming an increasing component of dental practice. Dental implants can develop peri-implantitis lesions which occur in a non‐linear and accelerating pattern compared to a gradual periodontitis lesion. It is crucial to diagnose and treat this disease early, or ideally prevent it. Contemporary implants have a rough surface texture which is difficult to properly decontaminate as a crucial component for treatment prognosis. Evidence on the long-term effects of Periodontal implant maintenance therapy (PIMT) on implants is limited. This study aims to investigate the effect of periodontal maintenance on peri-implant tissue health.

Methods: A retrospective chart review …

An Exploration Of Differences In Veteran Suicidality, Philip A. Weisbrod

Theses and Dissertations

Suicide is an important issue of public health, with Veteran suicide being a somewhat unique sub-populous at high risk. This research aims to explore the factors involved in Veteran suicidality that may raise or lower one’s risk. This analysis was conducted with the National Survey for Drug Use and Health (NSDUH) 2020 (N=1173) dataset through use of Binary Logistic Regression (BLR). The analysis showed that having a Major Depressive Episode (MDE) in the past year was the greatest predictor of increased suicidality, while marriage was the strongest buffer by decreasing the likelihood of suicidality increasing. Being a War on Terror …