Digital Commons Network^™

Cost-Effectiveness Analysis Of Combined Cognitive And Vocational Rehabilitation In Patients With Mild-To-Moderate Tbi: Results From A Randomized Controlled Trial, Emilie Isager Howe, Nada Andelic, Silje C R Fure, Cecilie Røe, Helene L. Søberg, Torgeir Hellstrøm, Øystein Spjelkavik, Heidi Enehaug, Juan Lu, Helene Ugelstad, Marianne Løvstad, Eline Aas

Family Medicine and Population Health Publications

Background

Traumatic brain injury (TBI) represents a financial burden to the healthcare system, patients, their families and society. Rehabilitation interventions with the potential for reducing costs associated with TBI are demanded. This study evaluated the cost-effectiveness of a randomized, controlled, parallel group trial that compared the effectiveness of a combined cognitive and vocational intervention to treatment as usual (TAU) on vocational outcomes.

Methods

One-hundred sixteen participants with mild-to-moderate TBI were recruited from an outpatient clinic at Oslo University Hospital, Norway. They were randomized to a cognitive rehabilitation intervention (Compensatory Cognitive Training, CCT) and Supported Employment (SE) or TAU in a …

Cystic Fibrosis And Sleep Circadian Rhythms, Mariam Louis, Peter Staiano, Lavender Micalo, Nauman Chaudary

Internal Medicine Publications

Cystic fibrosis (CF) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to unusual water and chloride secretion across epithelial surfaces. The lungs are responsible for most morbidity, though other organs are frequently affected. Sleep abnormalities have long been recognized in CF. Abnormal ventilation and oxygenation, sinus disease, deconditioning due to muscle weakness and recurrent infections, and inflammation have been thought to play a role in sleep disorders in CF. However, there is evidence that CFTR gene dysregulation can affect circadian rhythms in CF. Early recognition and treatment of circadian rhythms may improve …

Effect Of Interleukin-1 Blockade With Anakinra On Leukocyte Count In Patients With St-Segment Elevation Acute Myocardial Infarction, Marco Giuseppe Del Buono, Juan I. Damonte, Cory R. Trankle, Dinesh Kadariya, Salvatore Carbone, Georgia Thomas, Jeremy Turlington, Roshanak Markley, Justin M. Canada, Giuseppe G. Biondi‐Zoccai, Michael C. Kontos, Benjamin W. Van Tassell, Antonio Abbate

Internal Medicine Publications

Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-β regulates leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial infarction. However, the effect of IL-1 blockade with anakinra on leukocyte count in patients with STEMI is unknown. We reviewed the white blood cell (WBC) and differential count of 99 patients enrolled in a clinical trial of anakinra (n = 64) versus placebo (n = 35) for 14 days after STEMI. A complete blood cell count with differential count were obtained at …

Calpain-Mediated Protein Targets In Cardiac Mitochondria Following Ischemia–Reperfusion, Ling Li, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky, Belinda Willard, Qun Chen

Internal Medicine Publications

Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury during ischemia (ISC)–reperfusion (REP) by improving mitochondrial function. However, the protein targets of CPN1/2 activation during ISC–REP are unclear. CPN1/2 include a large subunit and a small regulatory subunit 1 (CPNS1). Genetic deletion of CPNS1 eliminates the activities of both CPN1 and CPN2. Conditional cardiomyocyte specific CPNS1 deletion mice were used in the present study to clarify the role of CPN1/2 activation in mitochondrial damage during ISC–REP with an emphasis on identifying the potential protein targets of CPN1/2. …

Evidence-Based Cardiovascular Magnetic Resonance Cost-Effectiveness Calculator For The Detection Of Significant Coronary Artery Disease, Ankur Pandya, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y. Kwong, Rafidah Abu Bakar, John D. Grizzard, Alexander E. Merkler, Ntobeko Ntusi, Steffen E. Peterson, Nina Rashedi, Juerg Schwitter, Joseph B. Selvanayagam, James A. White, James Carr, Subha V. Raman, Orlando P. Simonetti, Chiara Bucciarelli-Ducci, Lilia M. Sierra-Galan, Victor A. Ferrari, Mona Bhatia, Sebastian Kelle

Radiology Publications

Background
Although prior reports have evaluated the clinical and cost impacts of cardiovascular magnetic resonance (CMR) for low-to-intermediate-risk patients with suspected significant coronary artery disease (CAD), the cost-effectiveness of CMR compared to relevant comparators remains poorly understood. We aimed to summarize the cost-effectiveness literature on CMR for CAD and create a cost-effectiveness calculator, useable worldwide, to approximate the cost-per-quality-adjusted-life-year (QALY) of CMR and relevant comparators with context-specific patient-level and system-level inputs.

Methods
We searched the Tufts Cost-Effectiveness Analysis Registry and PubMed for cost-per-QALY or cost-per-life-year-saved studies of CMR to detect significant CAD. We also developed a linear regression meta-model (CMR …

Wses/Gais/Wsis/Sis-E/Aast Global Clinical Pathways For Patients With Skin And Soft Tissue Infections, Massimo Sartelli, Federico Coccolini, Yoram Kluger, Ervis Agastra, Fikri M. Abu-Zidan, Ashraf El Sayed Abbas, Luca Ansaloni, Abdulrashid Kayode Adesunkanmi, Goran Augustin, Miklosh Bala, Oussama Baraket, Walter L. Biffl, Marco Ceresoli, Elisabetta Cerutti, Osvaldo Chiara, Enrico Cicuttin, Massimo Chiarugi, Raul Coimbra, Daniela Corsi, Francesco Cortese, Yunfeng Cui, Dimitris Damaskos, Nicola De’Angelis, Samir Delibegovic, Therese M. Duane, Paola Fugazzola, Joseph M. Galante, Wagih Ghnnam, George Gkiokas, Carlos Augusto Gomes, Ewen A. Griffiths, Timothy C. Hardcastle, Andreas Hecker, Torsten Herzog, Aleksandar Karamarkovic, Vladimir Khokha, Peter K. Kim, Jae Il Kim, Andrew W. Kirkpatrick, Victor Kong, Renol M. Koshy, Kenji Inaba, Arda Isik, Rao Ivatury, Francesco M. Labricciosa, Yeong Yeh Lee, Ari Leppäniemi, Andrey Litvin, Davide Luppi, Ronald V. Maier, Athanasios Marinis, Sanjay Marwah, Cristian Mesina, Ernest E. Moore, Frederick A. Moore, Ionut Negoi, Iyiade Olaoye, Carlos A. Ordoñez, Mouaqit Ouadii, Andrew B. Peitzman, Gennaro Perrone, Tadeja Pintar, Giuseppe Pipitone, Mauro Podda, Kemal Raşa, Julival Ribeiro, Gabriel Rodrigues, Ines Rubio-Perez, Ibrahima Sall, Norio Sato, Robert G. Sawyer, Vishal G. Shelat, Michael Sugrue, Antonio Tarasconi, Matti Tolonen, Bruno Viaggi, Andrea Celotti, Claudio Casella, Leonardo Pagani, Sameer Dhingra, Gian Luca Baiocchi, Fausto Catena

Surgery Publications

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections.

Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs.

An extensive non-systematic review was conducted using the PubMed and MEDLINE …

Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction, Teja Devarakonda, Adolfo G. Mauro, Chad Cain, Anindita Das, Fadi N. Salloum

Internal Medicine Publications

Relaxin is a pleiotropic hormone shown to confer cardioprotection in several preclinical models of cardiac ischemia-reperfusion injury. In the present study, the effects of up-regulating relaxin family peptide receptor 1 (RXFP1) via adeno-associated virus serotype 9 (AAV9) vectors were investigated in a mouse model of myocardial infarction. AAV9-RXFP1 vectors were generated and injected in adult male CD1 mice. Up-regulation of Rxfp1 was confirmed via quantitative polymerase chain reaction, and overexpressing animals showed increased sensitivity to relaxin-induced ventricular inotropic response. Overexpressing animals also demonstrated reduced infarct size and preserved cardiac function 24 hours after ischemia-reperfusion. Up-regulation of RXFP1 via AAV9 vectors …

Rpop: Robust Pet-Only Processing Of Community Acquired Heterogeneous Amyloid-Pet Data, Leonardo Iaccarino, Renaud La Joie, Robert Koeppe, Barry A. Siegel, Bruce E. Hilner, Constantine Gatsonis, Rachel A. Whitmer, Maria C. Carrillo, Charles Apgar, Monica R. Camacho, Rachel Nosheny, Gil D. Rabinovici

Internal Medicine Publications

The reference standard for amyloid-PET quantification requires structural MRI (sMRI) for preprocessing in both multi-site research studies and clinical trials. Here we describe rPOP (robust PET-Only Processing), a MATLAB-based MRI-free pipeline implementing non-linear warping and differential smoothing of amyloid-PET scans performed with any of the FDA-approved radiotracers (18F-florbetapir/FBP, 18F-florbetaben/FBB or 18F-flutemetamol/FLUTE). Each image undergoes spatial normalization based on weighted PET templates and data-driven differential smoothing, then allowing users to perform their quantification of choice. Prior to normalization, users can choose whether to automatically reset the origin of the image to the center of mass or proceed with the pipeline with …

The Effects Of Celiac Disease On Oral Health In Children And Adults, Marissa Balducci, Katarina Jones

Dental Hygiene Student Scholarship

Objectives: Celiac disease (CD) is an autoimmune disorder characterized by intolerance to dietary gluten in genetically predisposed subjects. To ensure affected patients receive optimal dental care, it is necessary for dental professionals to recognize the oral manifestations of celiac disease in both children and adults. Upon associating oral conditions with celiac disease, the dental provider should be able to present recommendations to the patient, contributing to an improvement in their oral health.

Methods: This review of the literature used PubMed to identify relevant professional research articles with publication after 2017. MesH terms utilized in the search process were …

How Effective Are Eco-Friendly Dental Hygiene Products In Preventing Carious Lesions And Improvement In Overall Oral Health, Mary Claryns Truz, Destiney Coles

Dental Hygiene Student Scholarship

Objectives: The purpose of this review of literature is to measure the effectiveness, and future of eco-friendly¹ dental hygiene products in the dental field. As the manufacturing of products from food to technology increases over time, so does the sentiment for environmental practices. The numerous organizations that push for more sustainable initiatives in modern-day society continue to increase over time. The efforts for sustainable practices can be seen in the field of dentistry through dental hygiene products. These products range from compostable toothbrushes, waste-free toothpastes to organic floss advertised for use by the public. In reviewing the efficacy of …

Hydroxyapatite Toothpaste On Caries Prevention In Children, Samantha Richardson, Kelly Vaughan

Dental Hygiene Student Scholarship

Are Hydroxyapatite Toothpastes The Answer To Fluoride Free Patients?

Richardson, Samantha 1 and Vaughan, Kelly 2

Dental Hygiene Program, Virginia Commonwealth University

Abstract:

Objectives/Aims: With the rising trend to become more clean with our ingredient lists, we are facing more patients refusing fluoride treatments and fluoridated toothpastes. This trend has been prevalent in our younger generations due to parents only wanting the purest natural ingredients for their children and now declining fluoride application. The goal of this literature is to find a safe alternative toothpaste that will be just as effective as fluoride.

Methods: This review of literature has been …

Free, Fair, And Fabulous: Five Data Tools To Support Open And Reproducible Research At Your Institution, Christine Nieman, Katie Pierce Farrier, Elizabeth Roth, Sean Corning

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

With more publishers and funders requiring data management and sharing plans, it is important for librarians, researchers, and support staff to be aware of the tools available to help them skillfully manage research data. There are a wide variety of tools available, both free and paid, that can work with data but selecting an affordable, accessible tool can be a barrier to use.

Description

This poster seeks to promote awareness of freely available tools for data management, wrangling, and sharing for use in daily work and research projects. The poster will review five data tools (DMPTool, NIH Common Data …

Optimization Of An Automated Algorithm For Analysis Of Spontaneous Rhythmic Bladder Contractions During Urodynamics Testing, Isabelle Pummill, Rui Li, Zachary Cullingsworth, Adam Klausner, John Speich

Summer REU Program

No abstract provided.

The Impact Of Library Instruction On Medical Student Information Seeking Behavior, Angela Barr

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

To describe initial efforts to impact the information seeking behaviors of medical students during Grand Rounds exercises completed in their first and second years of pre-clinical education.

Description

Librarians received student responses to an information literacy question that is embedded in the Grand Rounds activity and analyze the data as follows. Sources were tallied and grouped according to resource type. Next, librarians attempted to assess the quality of certain sources. Third, search terms provided by students were aggregated and analyzed to determine frequency of use. Finally, a DML librarian-educator presented the compiled data to the entire class, making suggestions …

Research Outside The Library: Perspectives Beyond The Scholarly Literature, Lara Sapp, Carolyn Schubert, Liz Chenevey

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Assignments in the health and behavioral sciences disciplines typically require students to locate peer-reviewed articles. However, relevant stakeholder perspectives cannot be gained if students only rely on scholarly literature, books, and other library-supported resources. This lightning talk will discuss an assignment that “took students beyond the library” to discover established knowledge and gaps related to their research. The purpose of the assignment was to help them uncover problems, issues, and questions that might guide the direction of their projects.

Description

Students in an Honors course, designed to support their research project proposals, were required to locate and interview three …

This Is How We'll Do It: Considerations In Creation Of A Literature Search Best Practices Guideline, Kerry Sewell, Heidi Reis, G.J. Corey Harmon

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Literature searching skills and approaches among librarians may vary considerably, based upon the ways that literature searching is taught in formal and informal education. Informal observation of the literature search assistance approaches among health sciences librarians in the Information and Research Services department in Lapus Library indicated that patrons requesting such service might receive varying levels of service. This poster describes the creation of a best practices guideline for literature search assistance to address differential levels of service and build consensus about best practice when consistent pre- or in-service training in this area is missing.

Description

The Literature Search …

A Validation Study To Optimize Literature Searching For Interprofessional Education Studies In Pubmed, Sophie Nachman, Rebecca Carlson

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Objective

As there is exponential growth in the publication of interprofessional education (IPE) research studies, it has become more difficult to quickly find relevant papers and stay abreast of all the latest research. Accordingly, this poster addresses the development, evaluation, and validation of search hedges for IPE studies in PubMed, to improve future access to and synthesis of IPE research. The comprehensive, validated sets of search terms provide expert guidance to make it easier for educators and researchers to find IPE publications.

Methods

The search hedges were created for PubMed using relative recall methodology; the research process followed the guidance …

Giving It All You’Ve Got: The Value Of Extending Hours In An Academic Health Sciences Library, G.J. Corey Harmon, Kerry Sewell

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Objective

University libraries’ student satisfaction surveys regularly reveal student demand for increased operating hours to accommodate student learning. While academic libraries may provide extended hours, use of such models in academic health sciences libraries appears to be less widely adopted, perhaps due to budgetary concerns and lower general gate counts than academic library counterparts that may already provide extended hours. In the face of student demands, our institution shifted its budget to provide an additional 10 weekend hours, between Friday and Sunday, to help meet these demands. This study assessed the return on investment for those increased hours by tracking …

Mapping It Out: Developing A Library Internship Program, Emily Hurst, Roy E. Brown, John Cyrus

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Newly graduated librarians often do not possess the knowledge and skills essential to practicing in a health sciences library. This mismatch in experience and expectations stems from a lack of exposure to health sciences librarianship and the typically general nature of graduate education in library and information science. This gap in skills and understanding stems from a lack of opportunities to develop in these areas. At the same time, many experienced health sciences librarians do not have the supervisory roles as a regular part of their work, resulting in fewer opportunities to build managerial skills and experience. In 2019 …

Adventures By Stepping Out Of The Library, Helen-Ann Brown Epstein

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

As a solo hospital librarian with a totally digital library, I am free to step out of the Library. Also, the Library organizationally placed on the Clinical Learning Team presents many interesting adventures for an information professional.

Description

This Lightning Talk will describe an ambitious daily rounding schedule, a month of direct observing to help out during the COVID period, active participation on the Nursing Research Council and Family and Patient Education Committee, work with the Nurse Residents and advising a vendor on a new product.

Conclusions

By stepping out of the Library, the Librarian can show support and …

Successes And Challenges Of Being Interim Leaders During A Pandemic, Roy E. Brown, John Cyrus, Emily Hurst

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Assuming an interim leadership role presents personal opportunities for professional growth and organizational challenges. These challenges may stem from the temporary nature of the position and a lack of clear direction or decision-making authority. External forces, in this case the COVID-19 pandemic, also contribute to interim leaders' challenges. Library administration at a large public research university with multiple interim positions worked to identify potential challenges and possible solutions for those designated to interim leadership roles.

Description

This session will describe a plan created to facilitate the transition into and out of interim positions, set expectations for these roles, and …

Roll For Initiative! 101 Just Leveled Up: Choosing Intentionality In Course Redesign, Jennifer Monnin, Faythe Thurman, Kelly Diamond, Celia Shi, David Roth, Virginia Desouky

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background:

As demand for the health sciences (HS) section of the Library's introductory credit-bearing information literacy course outpaced available course seats and after a change to the course registration software made the section difficult to locate, a need was identified to update the coursework to be more relevant to HS students' specific learning needs. Three HS librarians and the Libraries' Office of Curriculum and Instructional Support (OCIS) collaborated to revamp this section to better meet the needs of future healthcare professionals. The revamped coursework was instituted beginning Fall 2021, and in Fall 2022 the section became its own unique class. …

Setting Off On A New Path: Reimaging A Library Department Annual Report, Jackson Hoch, Roy E. Brown, Emily Hurst

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Academic libraries annually produce reports highlighting the previous year's achievements while highlighting new resources, services, and programs. These are intended to communicate with different groups with different interests. The library in these reports must discuss what was done and how those activities provided value to the community of users. The librarians at a large public research university debated the effectiveness of the annual report produced within their department. An internship project was created to rethink the department’s annual report and develop a plan to determine its effectiveness. The project intended to allow the intern to learn more about how …

Book It Forward: An Engaging Community Project, Jessica Bauer, M. J. Tooey

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

A two-fold need was identified in our community:

1. Parents and caregivers frequently have a need to do something with books their children have outgrown or left behind.
2. Many schools and daycare centers in the local community served by our university don’t have adequate books and reading materials for students and have a need to boost their libraries. Working with the university’s Community Engagement Center, the library launched a two-month book collection drive on campus.

Description

Staff from across the library created announcements and graphics promoting the drive and developed criteria for accepted donations. The team reached out to contacts …

Online Escape Rooms: What Do The Students Think?, Emily Gorman

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Objective

Gamification is an increasingly popular teaching method for enhancing student engagement during instruction. Multiple learning games have been used over the last several years to introduce first-year pharmacy students to library and drug information resources. The purpose of this study was to evaluate the efficacy of an online escape room-style game and to investigate student perspectives on this style of learning.

Methods

A librarian developed an online escape room-style learning game and facilitated the activity with first-year pharmacy students as part of their introductory laboratory course in Fall 2020. The escape room was adapted from a previously successful in-person …

Adventuring Into A University Common Read Program, Emily Hurst

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Background

Each year a selection committee at a large urban university selects a book for all first year students. Books are sent out to students and then the title is used throughout many freshman level classes. Librarians are involved in the selection of the book, the creation of a resource guide with related information, and the creation of potential programs to support the themes and topics addressed in the book. The largest event is organized through the common read program and involves a lecture to the university community from the book author. For many years the book and common read …

The Self-Taught Marketers Guide To Creating An Annual Report, Everly D. Brown, Patrick T. Waugh, Tara R. Wink

Mid-Atlantic Chapter of the Medical Library Association (MAC- MLA) Annual Meeting Posters/Presentations

Objective

To produce an easy-to-read, visually appealing, 1-4 page annual report for the University of Maryland, Baltimore’s Health Sciences and Human Services Library (HSHSL). The report should be a mix of interesting statistics, highlights, stories, quotes, and photographs to promote the HSHSL’s annual accomplishments to the campus.

Methods

We gather all of the stories and statistics we think will be eligible material for the annual report, pulling content and ideas from: newsletters, workshops, blog posts, events, exhibits, and meetings with division and department heads. An annual report committee and visual designer decide upon the top stories and statistics, focusing upon …

Foxos Modulate Proteasome Activity In Human-Induced Pluripotent Stem Cells Of Huntington’S Disease And Their Derived Neural Cells, Jefin Jose

VCU's Medical Journal Club: The Work of Future Health Professionals

FOXO transcription factors have been implicated in modulating proteasome activity. Liu et al. found that Huntington's disease-induced pluripotent stem cells (HD iPSCs) exhibited greater proteasome activity as well as greater FOXO1 and FOXO4 expression. To determine a possible causal relationship, Liu et al. performed shRNA knockout of these two transcription factors and found that only FOXO4 mediated proteasome activity in pluripotent stem cells. Overexpression of FOXO4 rescued proteasomal defect in HD iPSCs-derived neural progenitor cells (NPCs). Overall, Liu et al. found that FOXO4 specifically modulated proteasome activity in HD iPSCs and their derived NPCs.

Slow-Stroke Back Massage Compared With Music Therapy For Leukemia-Related Pain And Fatigue: A Randomized Controlled Trial, Rhea Tammireddi

VCU's Medical Journal Club: The Work of Future Health Professionals

This presentation focused on the effects of nonpharmacological treatments for leukemia-related pain and fatigue. These types of treatments are becoming more prevalent in today's times due to the risk of opioid addictions with increased pain medications. The study looked at two treatments: slow-back massage therapy and music therapy. Both treatments offer various advantages physically and emotionally. The study separated 114 adults with acute myeloid leukemia into the two treatments group and a control group of standard treatment. The results showed back massage therapy had a stronger and longer effect on the reduction of pain and fatigue.

Anti-Gd2 Antibody Dinutuximab Inhibits Triple-Negative Breast Tumor Growth By Targeting Gd2+ Breast Cancer Stem-Like Cells, Nasser Al-Abdulaly

VCU's Medical Journal Club: The Work of Future Health Professionals

Triple negative breast cancer is an aggressive subtype of breast cancer characterized by its lack of estrogen and progesterone receptors, as well as no or low levels of human epidermal growth factor 2. Ly et al. found that the ganglioside GD2 is highly expressed in a stem cell-like population of triple negative breast cancer tumor and helps with cell adhesion and migration. Using a xenograft model, the researchers determined that targeting this cell population with dinutuximab (anti-GD2 antibody) could prevent tumor growth and metastasis.