Digital Commons Network^™

Commonwealth Times 2004-10-04

Commonwealth Times, 1969-

No abstract provided.

Richmond Music Journal (2004-10/2004-11)

Richmond Music Journal

No abstract provided.

Commonwealth Times 2004-09-30

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-09-23

Commonwealth Times, 1969-

No abstract provided.

Bioinformatic Analysis Of A Mammalian Bip Gene For Insertion Into Green Algae And Comparison Of Its Possible Effects On The Synthesis Of A Mammalian Antibody, Katrina Ghazanfar

Theses and Dissertations

This dissertation describes a study utilizing bioinformatics to analyze homologues of a molecular chaperone, glucose-regulated protein 78 (grp 78), also known as BiP. The selected homologous proteins originate from organisms of infinitely diverse genera. Comparisons of protein sequence yielded the first clues of a common ancestry among these proteins. Furthermore, protein molecular weights, isoelectric points, N-terminal amino acids and half-lives of a known homolog and a non-homologous protein were examined. Additionally, electroporation, a state-of-the-art plasmid insertion technique, was explored using Chlamydomonas reinhardtii, a green alga, as the recipient of a parent plasmid, pSP124S. Distinctive hypertonic solutions and three separate field …

Commonwealth Times 2004-09-16

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-09-02

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-08-30 Fall Student Guide 2004

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-26

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-22

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-15

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-08

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-05

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-04-01

Commonwealth Times, 1969-

No abstract provided.

Richmond Music Journal (2004-04)

Richmond Music Journal

No abstract provided.

Commonwealth Times 2004-03-08

Commonwealth Times, 1969-

No abstract provided.

Richmond Music Journal (2004-03)

Richmond Music Journal

No abstract provided.

Commonwealth Times 2004-02-26

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-02-23

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-02-16

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-02-12

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-02-09

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-02-02

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-01-29

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2004-01-22

Commonwealth Times, 1969-

No abstract provided.

Moderate Mutation Rate In The Sars Coronavirus Genome And Its Implications, Zhongming Zhao, Haipeng Li, Xiaozhuang Wu, Yixi Zhong, Keqin Zhang, Ya-Ping Zhang, Eric Boerwinkle, Yun-Xin Fu

Psychiatry Publications

Background The outbreak of severe acute respiratory syndrome (SARS) caused a severe global epidemic in 2003 which led to hundreds of deaths and many thousands of hospitalizations. The virus causing SARS was identified as a novel coronavirus (SARS-CoV) and multiple genomic sequences have been revealed since mid-April, 2003. After a quiet summer and fall in 2003, the newly emerged SARS cases in Asia, particularly the latest cases in China, are reinforcing a wide-spread belief that the SARS epidemic would strike back. With the understanding that SARS-CoV might be with humans for years to come, knowledge of the evolutionary mechanism of …

Calcium And Glycolysis Mediate Multiple Bursting Modes In Pancreatic Islets, Richard Bertram, Leslie S. Satin, Min Zhang, Paul Smolen, Arthur Sherman

Pharmacology and Toxicology Publications

Abstract

Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period of 10–60 s. In some cases, however, the bursts are episodic, clustered into bursts of bursts, which we call compound bursting. Consistent with this are recordings of free Ca²⁺ concentration, oxygen consumption, mitochondrial membrane potential, and intraislet glucose levels that exhibit very slow oscillations, with faster oscillations superimposed. We describe a new mathematical model of the pancreatic β-cell that can account for these multimodal patterns. The model includes the feedback of …

Clinical Review: Hemorrhagic Shock, Guillermo Gutierrez, H. David Reines, Marian E. Wulf-Gutierrez

Surgery Publications

This review addresses the pathophysiology and treatment of hemorrhagic shock – a condition produced by rapid and significant loss of intravascular volume, which may lead sequentially to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. Hemorrhagic shock can be rapidly fatal. The primary goals are to stop the bleeding and to restore circulating blood volume. Resuscitation may well depend on the estimated severity of hemorrhage. It now appears that patients with moderate hypotension from bleeding may benefit by delaying massive fluid resuscitation until they reach a definitive care facility. On the other hand, …

A Review Of The Physiological And Immunological Functions Of Biliary Epithelial Cells: Targets For Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis And Drug-Induced Ductopenias, Chih-Te Wu, Paul A. Davis, Vellmir A. Luketic, M. Eric Gershwin

Internal Medicine Publications

Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified …

Palifermin For Oral Mucositis After Intensive Therapy For Hematologic Cancers, Ricardo Spielberger, Patrick Stiff, William Bensinger, Teresa Gentile, Daniel Weisdorf, Tarun Kewalramani, Thomas Shea, Saul Yanovich, Keith Hansen, Stephen Noga, John Mccarty, C. Frederick Lemaistre, Eric C. Sung, Bruce R. Blazar, Dieter Elhardt, Mon-Gy Chen, Christos Emmanouilides

Internal Medicine Publications

BACKGROUND: Oral mucositis is a complication of intensive chemotherapy and radiotherapy with no effective treatment. We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy. METHODS: This double-blind study compared the effect of palifermin with that of a placebo on the development of oral mucositis in 212 patients with hematologic cancers; 106 patients received palifermin (60 microg per kilogram of body weight per day) and 106 received a placebo intravenously for three consecutive days immediately before the initiation of conditioning therapy (fractionated total-body irradiation plus high-dose chemotherapy) and after autologous …