Digital Commons Network^™

In-Between Echoes, Jiayi Liang

Theses and Dissertations

In this dissertation, I explore memory, diaspora, labor, and intergenerational trauma through constructed photography and experimental film. Informed by Homi K. Bhabha’s concept of the Third Space, I examine how identity is shaped through displacement, cultural negotiation, and inherited memory. Drawing from my relationship with my grandmother and my experience as a Chinese woman living in diaspora, I consider labor as both survival and care, tracing how domestic gestures and emotional structures continue across generations. Through collage, reconstruction, and animation, I rework fragments of family archives, colonial landscape imagery, and personal photographs to address grief, racialized perception, belonging, and the …

An Indigenous Sovereign Approach: Developmental Strategies And Guidelines For The Berger-Patawomeck Preserve Trail Network, Lauren N. Usher

Master of Urban and Regional Planning Capstone Projects

This planning document serves the Patawomeck Tribe's cultural, environmental, and sovereign needs by providing research and recommendations to sustainably steward ancestral lands through integrated Indigenous and Western practices. The plan adapts sustainable design strategies to guide trail maintenance and activities within the Berger-Patawomeck Preserve, examining Traditional Ecological Knowledge (TEK) alongside Western practices. A decolonized, sovereign lens guided the mixed research methods drawing on legal, regulatory, planning, and ethical frameworks to strengthen tribal health, education, and sovereignty. The research explores local ecology, Indigenous culture, and implementational strategies. The ecological findings document the Preserve's sensitive resources, including the Coastal Piedmont transition zone, …

Staging Violence With Intentionality, Toby O'Brien

Theses and Dissertations

This thesis examines the role of the fight choreographer in the theatre while addressing the potential issues staged violence has in distracting an audience from the intended narrative of the play. Avoiding the instruction manual approach of stage combat in favor of expounding on the theory of violent entertainment, I have constructed a thesis that informs the reader of certain types of violence found in both classical and modern productions and have researched the psychological ramifications of violent spectatorship and the necessity for content acknowledgements as well as consideration for the performer’s well-being. By exploring the history of violent entertainment …

An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant

Theses and Dissertations

This dissertation develops an integrated data-driven framework to analyze vessel navigation and ecological risk in the United States Arctic from 2010 to 2019. As environmental change and maritime activity increase in the region, understanding how vessels respond to dynamic conditions and how those responses interact with marine ecosystems has become increasingly important. A central theme of this dissertation is the treatment of vessel speed as both an observed outcome and a decision variable reflecting trade- offs among operational, environmental, and ecological factors. The first chapter develops a predictive framework for vessel speed over ground (SOG) using Gaussian Process Boosting (GPBoost), …

Gz17.602, A Combination Of Three Nutraceuticals, Interacts With Carboplatin And Etoposide To Kill Neuroblastoma, Michael R. Booth

Theses and Dissertations

This study examined the efficacy of GZ17.602, a combination of Harmine, Isovanillin, and Curcumin as a therapeutic for MYCN-amplified Neuroblastoma, both alone and in combination with standard of care chemotherapeutics. This was done due to the low survival rate associated with these neuroblastomas, the large degree of morbidity associated with current treatments, previous experiments in the Dent lab having shown 602 as effective for killing cancers of other types, and the current lack of understanding of the biology of GZ17.602 in solid pediatric cancers. Due to the GZ17.602 components being present at different concentrations in tumors than those administered, the …

My Mouth Is A Glutton, My Mouth Is A Lover., Cole Kamerick Eller

Theses and Dissertations

This thesis is a reflection on my relationship with jewelry. I discuss the impact of jewelry

and its materials. What are the ramifications of these objects? Politically, socially, and

spiritually. I reflect on material agency, cultural unconscious, and value systems, and

how I relate to jewelry, my love for it, and my grief for it. This work is the result of ritual

and impulse. The writing is my reflection on the results of that ritual.

Daisyworld, Eva Foldy

Theses and Dissertations

Daisyworld explores how painting can represent ecological and sociopolitical crisis without relying on narratives of total collapse as a catastrophic end, instead framing the present as a condition of ongoing, uneven transformation. Drawing on ecological models of adaptation, interdependence, and planetary self-regulation, it uses plant fasciation as both a biological reference and speculative metaphor for distorted yet generative forms of survival. Situating painting within a broader history of visual culture, it examines how images function as accessible systems of knowledge while challenging colonial and human-centered modes of representation. In dialogue with contemporary, systems-based artistic practices, the project repositions painting as …

Tangled Up In Blues, Clara B. Deweese

Theses and Dissertations

Martin Buber’s philosophy teaches us that when our masks fall and our armor’s unveiled, we discover humanity shared. Tangled Up in Blues unpacks the snapshot photographic practice I’ve had for years, which documents my mutually uplifting relationships, and is presented for my thesis exhibit through a painterly technique that deconstructs and reconstructs  the images onto wood panels using laser transfer. As we navigate a distracted and fragmented society made of greed and bigotry, cherishing the deep connections and shared memories brings us optimism.

There Is A Puddle In Stonehenge, Nathaniel Newcomb

Theses and Dissertations

I began by making what I called "furniture": finding discarded logs and using a chainsaw, I milled out slabs of wood far larger than any normal board or beam, and gave them the function of chair, table, shelf. Sometimes it was a "shelf" in name only, and was commentary on furniture. In my practice, using discarded wood is necessary for the sake of the earth; making original pieces is necessary for the sake of my soul. I am reminded of megaliths when I erect these enormous forms in wood. I make intuitively, and like the meaning of megaliths, obscured by …

Sensory Constellations, Madaline K. Gardner

Theses and Dissertations

This thesis situates neurodiversity within the field of fine arts by integrating disability studies, institutional critique, and material practices in painting and printmaking. Through visual analysis and studio-based research, the project examines how tactile engagement, color relationships, and repetitive mark-making can articulate embodied experiences of neurodivergence. It challenges dominant institutional frameworks that pathologize neurodivergent behaviors by reframing stimming as a generative and communicative practice. The resulting body of work includes both image-making and the creation of tactile objects designed to facilitate sensory interaction. The thesis proposes alternative ways of understanding artistic practice and accessibility within art institutions.

All Other Ground Is Sinking Sand, Kevin Hopkins

Theses and Dissertations

My thesis project, All Other Ground Is Sinking Sand, is a body of work that frames soft sculpture as "prophetic charm" and collaborative performance as the ceremony that charges them. In this essay, I will explore the conceptual chronology of the charms, their connection to the notion of décalage, and their potential to compel witnesses toward the immediate liberation of queer, Black individuals.

With my research centered on the necessity of shifting cultural responses to enduring racial trauma, I focus my work on deconstructing Black hypermasculine archetypes shaped by white supremacy and unpacking the tension between individual autonomy and social …

Cb1 Allosteric Modulation: Preclinical Insights Into Therapeutic Potential And Misuse Liability, Mohammed A. Mustafa

Theses and Dissertations

Cannabinoid type-1 (CB1) allosteric modulators represent a promising approach to modulate CB1 receptor signaling by binding to distinct receptor sites, without producing adverse cannabimimetic and dependence-related effects associated with Δ9-tetrahydrocannabinol (THC) and other CB1 agonists. This dissertation investigates the pharmacological, behavioral, and dependence-related profiles of CB1 allosteric modulators for their therapeutic potential and misuse liability. Presented here, the chiral CB1 positive allosteric modulator (PAM) ZCZ011 was resolved into its R- and S-enantiomers and characterized across in vitro and in vivo assays. Both enantiomers enhance CB1 agonist activity and produce intrinsic effects in vitro. Behaviorally, they produce antinociceptive effects in the …

Algorhythm: Commodification Of Hobbies On Social Media Platforms, Fariha Ahmed

Theses and Dissertations

Forcing the world online, the COVID-19 pandemic appeared to turn social-media-based hobbies into income-generating cash cows. Digital creative spaces became sites of capitalist logic where hobbyists came to operate as both laborers and commodities. Profit-focused algorithms operate imperceptibly, shaping creative behavior and decision-making in ways that are difficult to recognize, and even harder to resist. This thesis asks how algorithmic participation on platforms such as Instagram conditions a hobbyist, and how that conditioning can be made legible to audiences who inhabit such platforms without always seeing them. Using autoethnography, I position myself as both researcher and subject to document the …

From Cultural Binaries To Coexistence: A Graphic Autoethnography Of Individualism And Collectivism In An International Context, Shahad Alsubaie

Theses and Dissertations

This arts-based autoethnographic study investigates individualism and collectivism, specifically through my study-abroad experience traveling from Saudi Arabia to the United States. Through arts-based reflective practice, I depicted the diasporic experience of being ontoepistemologically collectivistic while navigating a primarily individualistic society. I use the medium of a graphic memoir to illustrate and develop frameworks of confluence that embrace the two distinct cultural orientations simultaneously. This arts-based self-study not only contributes to the body of transnational scholarship but also serves as a reference for international students, researchers, and educators to use arts-based subgenres and data analysis methods to gain better insights into …

Tried For A Flower And Made The Sun, Megan Koeppel

Theses and Dissertations

My thesis work celebrates natural color, honors traditional hand processes, and gently questions the often gendered divisions between different material disciplines. I emphasize the continued relevance of these ancient tacit traditions through exposed seams and stitches. I create a color palette entirely derived from plants and insects, sharing the many shades that come from natural dyes. I create wall mounted and installation based works that soften the edge of distinction between painting, sculpture and textile.

My research includes the history of soft sculpture and American quilting, paired with the stories and chemistry of natural color. With a process closely related …

Contours Of Duration: Movement Authored Through Form—A Behavior Archive, Jood Senussi Elbeshti

Theses and Dissertations

Insect anatomy offers an elegant example of motion derived from structure. Inspired by insect movement, Contours of Duration employs a cam-and-follower system consisting of moving, leg-like parts, designed to engage a series of rotating cams, such that the shape of each cam’s surface activates the legs in unique ways, generating repetitive movement, and demonstrating how geometry produces distinct motion behaviors over time. Through iterative experimentation and controlled variation, trace emerges as a central methodology, whereby movement, over time, creates a distinct pattern of marks, making motion legible and reflecting how subtle changes to surface and form generate different behavioral outcomes. …

Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha

Theses and Dissertations

Background and Objectives: Immigrants in the United States undergo acculturation — a process of sociocultural and behavioral adaptation to the host country. Increasingly, behavioral adaptations have been associated with cardiometabolic health and chronic disease risk. Metabolic syndrome (MetS), a cluster of conditions including abdominal obesity, elevated blood pressure, impaired fasting glucose, elevated triglycerides, and reduced HDL cholesterol, is a major risk factor for type 2 diabetes mellitus, cardiovascular diseases and other chronic diseases, including cancer. Despite the growing immigrant population in the U.S., the role of diet and dietary acculturation in MetS development remains poorly understood in this population. This …

24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim

Theses and Dissertations

Physical frailty is a prevalent geriatric syndrome characterized by age-related decline across multiple physiological systems. Physical frailty is associated with an elevated risk of adverse health outcomes, including chronic disease progression and all-cause mortality, representing a significant and growing public health concern. Disrupted circadian rest-activity rhythms (RARs) are increasingly recognized as clinically meaningful markers of physical frailty in older adults. However, the extent to which biological sex and social determinants of health (SDoH), particularly social capital, contribute to or modify the associations between RARs and physical frailty remains underexplored.

Therefore, this dissertation summarizes the existing literature on age-related changes in …

Mediator: Ornament As A Visual Language Of The Transcendent, Selma Fejzullaj

Theses and Dissertations

Adolf Loos’s declaration that “ornament is a crime” defined modernist design, establishing a legacy that dismisses ornamentation as wasteful and regressive. This research questions that legacy by repositioning aesthetics as a divinely grounded value, inspired by the Qur’anic vision of Paradise. In this celestial realm, beauty is not wasteful but a manifestation of divine perfection. Conceptually, the project reclaims ornament as a vital tool for contemplating metaphysical themes. Materially, it reimagines glass, shifting it from modernist "radical honesty" to a medium of layered depth. Recombining traditional Islamic ornamentation practices such as Girih and Chaharbagh, the project evokes the Qur’anic vision …

Local Lung Delivery Of Ginkgetin For Therapeutic Intervention In Lung Fibrosis, Cimone L. Richardson

Theses and Dissertations

Lung fibrosis (LF) is a progressive, irreversible pathological condition in the lungs that is ultimately fatal. Current drug treatments (nintedanib, pirfenidone, and nerandomilast) slow disease progression but cause significant systemic adverse effects due to oral administration. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, may play a role in LF progression and represent a novel anti-LF target. Ginkgetin (GKT), a natural biflavonoid, is a potent TRPV4 inhibitor with anti-inflammatory and antioxidative properties. Local lung delivery could achieve high local lung concentrations while minimizing systemic exposure. Accordingly, this project evaluates GKT's therapeutic intervention efficacy in LF via local lung …

Discrete Cell Signaling Differences Cause Female-Dominant Il-33 Responses In Mast Cells, Tania D. Maldonado

Theses and Dissertations

Many allergic diseases are more common and severe in women than in men. A key component of allergic inflammation is IL-33, a cytokine released by epithelial cells after allergen exposure. Because mast cells are a central early responder in allergic disease and are activated by IL-33, we investigated sex differences in mast cell responses to IL-33. We first found that male mast cells expanded poorly in standard RPMI-based culture media containing phenol red, which has estrogenic properties. Male cells also responded poorly to IL-33 when cultured with in media containing phenol red. In contrast, female mast cells expanded 3-fold less …

Climate, Biogeography, And Dispersal: A Unifying Framework For Ameri-Caribbean Dry Forests, Pablo Lopez Bustamante

Theses and Dissertations

Seed dispersal is a crucial ecological function that enables plants to alter their distributional range, avoid intense competition and natural enemies near the parent plant, and recover from disturbances. These processes shape species and functional composition of forests. Wind has traditionally been considered the dominant dispersal mechanism in Ameri-Caribbean dry forests, yet growing evidence suggests that other dispersal mechanisms also play significant roles in this ecosystem, responding differently to biotic and abiotic conditions. Still, how dispersal syndrome composition influences plant communities, the ecological drivers underlying these patterns, and the effects of climate change on dispersal syndrome dominance remain poorly understood. …

Sex In Plants: Birth, Death, And Trying To Survive In Changing Climates, Elena M. Meyer

Theses and Dissertations

Plant mating systems are key determinants of fitness. Angiosperms exhibit a wide variety of reproductive strategies, including self-fertilization (or selfing), outcrossing, and mixed mating. It has been estimated that up to 43% of plant species are capable of selfing, and selfing has been hypothesized to provide reproductive assurance where opportunities for mating may be limited, such as in marginal environments. However, questions regarding the overall distribution of selfing rates across angiosperms, the maintenance of mixed mating in the face of inbreeding depression, and the impact of self-fertilization on diversification rates remain incompletely resolved. Here, we explore the dynamics of self-fertilization …

Real-Life Health Applications Of Wireless Sensing Using Edge Devices, Md Touhiduzzaman

Theses and Dissertations

Wireless sensing has emerged as a transformative paradigm that leverages ubiquitous radio-frequency signals for environmental perception and human activity recognition beyond their primary role in data communication. Unlike wearable sensors and camera-based systems, wireless sensing offers a non-intrusive, privacy-preserving, and cost-effective alternative that operates seamlessly under low-lighting conditions, through walls, and in non-line-of-sight (NLoS) scenarios. The growing availability of edge computing devices further enables real-time on-device data processing, making wireless sensing solutions highly suitable for in-home health monitoring and smart living applications. This dissertation investigates real-life health applications of wireless sensing through four completed systems, each addressing a distinct challenge …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

The Importance Of Hippotherapy: Improving The Lives Of The Disabled Through Alternative Therapy, Jennifer N. Stapleton

UROP Posters

For centuries, horses have been suggested as “healers” and “helpers,” although it wasn’t until the 1900s that horseback riding was scientifically proven as a treatment and rehabilitation method. The exploitation of hippotherapy, the implementation of the three-dimensional pelvic movement stimulated by the oscillation and gait of the horse to combat symptoms of diseases and disorders, has since become a flourishing field of study, but one that is often overlooked. Benefits of hippotherapy often include increased motor neuron function, facilitating proper anatomical alignment, and reducing spasticity. This research analyzes the diverse and dynamic nature of treatment that hippotherapy facilitates, exploring the …

Determining Genes Involved In Recovery From Chemotherapy In 4t1, Emt6, And Eo771 Breast Cancer Cells, Akash Jagdeesh, Joseph Landry Ph.D.

UROP Posters

Breast cancer is one of the most common types of cancer, and often has poor prognosis. Traditional treatments for breast cancer include chemotherapy, which involves a chemical attack on all growing cells within the body. However, these treatments are not 100% effective, and patients might experience recurrence in their cancer months or years after achieving remission. Cancer cells can evade chemotherapy through five mechanisms: senescence, quiescence, cytoprotective autophagy, and apoptosis/necroptosis suppression. Prior studies have conducted CRISPR screens and experiments involving inhibition of epigenetic regulators, to alter the regulation of genes that can contribute to breast cancer chemotherapy resistance. This study …

Establishment Of A Conditionally Replicating Guinea Pig Cytomegalovirus Model For Molecular Characterization Of Latency, Akshay R. Molakalapalli, Saketh Majeti, Michael A. Mcvoy, Jian Ben Wang

UROP Posters

Human cytomegalovirus (HCMV) is a member of the Herpesviridae that establishes life-long latent infections that pose risks of life-threatening disease upon reactivation in immunocompromised individuals. Understanding the molecular mechanisms that govern the latent state is critical for developing effective treatments. However, molecular characterization has been impeded by the scarcity of latently infected cells in vivo and the inability of current in vitro models to support the expansion of clonal latent cell lines. To address these limitations, we developed a novel cell culture model utilizing a conditionally replicating guinea pig cytomegalovirus, a relative of HCMV that mimics HCMV pathology and provides …

Did Our Prehistoric Ancestors Engage In Mortuary Practices?, Regina E. Mcrae

UROP Posters

Abstract

Mortuary practice is defined as how humans dispose of and treat their dead. We are familiar with elaborate burials such as the entombment of pharaohs in the pyramids at Giza; Necropolises of the Valley of the Kings and Queens; the Mausoleum at Halicarnassus; the Taj Mahal in India; Viking funeral pyres on boats; and the modern jazz funerals of New Orleans. Caring for our dead is believed to be a modern concept, practiced by Homo Sapiens. However, archeological excavations and scientific analyses show burial practices predate modern man, practiced by our ancient ancestors such as Neanderthal, Homo Naledi, and …

Using Nature-Inspired Sustainable Design Via Biomimicry Of The Peregrine Falcon To Improve The Development Of Japan’S F-X Fighter Jet, Tvisha Datta

UROP Posters

Modern fighter jets face a persistent challenge when it comes to improving aerodynamic efficiency without having to sacrifice high-speed performance or long-term sustainability. These aircraft rely heavily on high thrust and agility, and in doing so, they consume substantial amounts of fuel due to aerodynamic drag and limited energy efficiency. As a result of these constraints, advanced military defense development projects, such as Japan’s Mitsubishi F-X fighter jet program, have been delayed. This highlights the need for more sustainable solutions. Biologically inspired design, or biomimicry, has emerged as a potential and promising alternative. The peregrine falcon, notably the fastest bird …