Digital Commons Network^™

Virginia Commonwealth University Commencement Program [2013], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Fyn-Dependent Gene Networks In Acute Ethanol Sensitivity, Sean P. Farris, Michael F. Miles

Pharmacology and Toxicology Publications

Studies in humans and animal models document that acute behavioral responses to ethanol are predisposing factor for the risk of long-term drinking behavior. Prior microarray data from our laboratory document strain- and brain region-specific variation in gene expression profile responses to acute ethanol that may be underlying regulators of ethanol behavioral phenotypes. The non-receptor tyrosine kinase Fyn has previously been mechanistically implicated in the sedative-hypnotic response to acute ethanol. To further understand how Fyn may modulate ethanol behaviors, we used whole-genome expression profiling. We characterized basal and acute ethanol-evoked (3 g/kg) gene expression patterns in nucleus accumbens (NAC), prefrontal cortex …

Contribution Of Nadph Oxidase To Membrane Cd38 Internalization And Activation In Coronary Arterial Myocytes, Ming Xu, Xiao-Xue Li, Joseph K. Ritter, Justine M. Abais, Yang Zhang, Pin-Lan Li

Pharmacology and Toxicology Publications

The CD38-ADP-ribosylcyclase-mediated Ca2+ signaling pathway importantly contributes to the vasomotor response in different arteries. Although there is evidence indicating that the activation of CD38-ADP-ribosylcyclase is associated with CD38 internalization, the molecular mechanism mediating CD38 internalization and consequent activation in response to a variety of physiological and pathological stimuli remains poorly understood. Recent studies have shown that CD38 may sense redox signals and is thereby activated to produce cellular response and that the NADPH oxidase isoform, NOX1, is a major resource to produce superoxide (O2·−) in coronary arterial myocytes (CAMs) in response to muscarinic receptor agonist, which uses CD38-ADP-ribosylcyclase …

Association Study Of 167 Candidate Genes For Schizophrenia Selected By A Multi-Domain Evidence-Based Prioritization Algorithm And Neurodevelopmental Hypothesis, Zhongming Zhao, Bradley T. Webb, Peilin Jia, T. Bernard Bigdeli, Brion S. Maher, Edwin Van Den Oord, Sarah Bergen, Richard L. Amdur, Francis A. O'Neill, Dermot Walsh, Dawn L. Thiselton, Xianging Chen, Carlos N. Pato, The International Schizophrenia Consortium, Brien P. Riley, Kenneth S. Kendler, Ayman H. Fanous

Psychiatry Publications

Integrating evidence from multiple domains is useful in prioritizing disease candidate genes for subsequent testing. We ranked all known human genes (n = 3819) under linkage peaks in the Irish Study of High-Density Schizophrenia Families using three different evidence domains: 1) a meta-analysis of microarray gene expression results using the Stanley Brain collection, 2) a schizophrenia protein-protein interaction network, and 3) a systematic literature search. Each gene was assigned a domain-specific p-value and ranked after evaluating the evidence within each domain. For comparison to this ranking process, a large-scale candidate gene hypothesis was also tested by including genes with Gene …

A Cohort Study Evaluation Of Maternal Pcb Exposure Related To Time To Pregnancy In Daughters, Chris Gennings, Caroline Carrico, Pam Factor-Litvak, Nickilou Krigbaum, Piera M. Cirillo, Barbara Cohn

Biostatistics Publications

Background Polychlorinated biphenyls (PCBs) remain ubiquitous environmental contaminants. Developmental exposures are suspected to impact reproduction. Analysis of mixtures of PCBs may be problematic as components have a complex correlation structure, and along with limited sample sizes, standard regression strategies are problematic. We compared the results of a novel, empirical method to those based on categorization of PCB compounds by (1) hypothesized biological activity previously proposed and widely applied, and (2) degree of ortho- substitution (mono, di, tri), in a study of the relation of maternal serum PCBs and daughter’s time to pregnancy.

Methods We measured PCBs in maternal serum samples …

True Single Search: The Good, The Bad, And The Ugly, Margaret T. Kidd

VCU Libraries Faculty and Staff Presentations

Since the advent of Google, the trend in search engines has been to try to provide as many types of information as possible from a single location. Libraries are no exception, with discovery tools such as Primo and Summon becoming more and more popular. This presentation discusses the pros and cons of using Primo in relation to finding manuscripts and archives materials.

Independent Animation: Exploring The Fine Line Between Inspiration And Imitation, Rebekah Rifareal

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

I came into VCU hoping to eventually go into independent animation. The UROP opportunity popped up and it sounded great and I thought, “Hey, this is something that I’ve been wanting to do.” I read the book The Evolution of Calpurnia Tate (which is a children’s book that I’m basing my animation off of) as I was coming into school freshman year and I thought it would be great to do a project on it. So, I wrote up a proposal and people liked it!

Mexican Health Paradox, Merit George

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Despite the broad array of research that exists on the Hispanic health paradox, no single explanation has been marked as the dominant reason for the disparities in life expectancy that exist between Mexican Americans and other Hispanic and non-Hispanic ethnic groups. This indicates that researchers must adopt a more open perspective that examines the influence of multidimensional factors that integrate culture, religious tradition, and lifestyle. The purpose of the current study is to 1) readily define the paradox and provide a thorough review of existing literature on the topic; 2) suggest a transition from exploring statistical explanations of the paradox …

Factors That Lead To The Immunotherapy Gap In Multiple Sclerosis Testing, Karthika Solai

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Multiple sclerosis is a disease that affects the central nervous system. Most doctors and scientists believe that it is an autoimmune disease. Simply put, the immune system attacks the nerves in a person’s body, thereby causing myelin damage, inflammation, and neurodegeneration. The plaque that then builds up on the nerves is scar tissue created when the wounds made by the immune system heal. It is this plaque that inhibits communication between the axons in the body and causes the symptoms of MS, which includes problems with movement, pain, vision problems, trouble swallowing, fatigue, and heat sensitivity (Baker et al., 2011, …

Personal Profile: Amanda Ndemo Archeological Accessibility Through 3-D Laser Scanning, Rebekah Rifareal

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

The familiar signs that chide visitors to refrain from touching historical artifacts in museums would have no place in Dr. Bernard Means’ Virtual Curation Laboratory. Thanks to the innovative, fast-paced world of 3-D scanning, senior Amanda Ndemo had an archeological site at her fingertips, all while staying in Richmond for the VCU Honors Summer Undergraduate Research Program (HSURP).

Scientific Argumentation As A Foundation For The Design Of Inquiry-Based Science Instruction, A. Falk, L. Brodsky

Journal of Mathematics and Science: Collaborative Explorations

Despite the attention that inquiry has received in science education research and policy, a coherent means for implementing inquiry in the classroom has been missing [1]. In recent research, scientific argumentation has received increasing attention for its role in science and in science education [2]. In this article, we propose that organizing a unit of instruction around building a scientific argument can bring inquiry practices together in the classroom in a coherent way. We outline a framework for argumentation, focusing on arguments that are central to science—arguments for the best explanation. We then use this framework as the basis for …

Distinctive G Protein-Dependent Signaling By Protease-Activated Receptor 2 (Par2) In Smooth Muscle: Feedback Inhibition Of Rhoa By Camp-Independent Pka, Wimolpak Sriwai, Sunila Mahavadi, Othman Al-Shboul, John R. Grider, Karnam S. Murthy

Physiology and Biophysics Publications and Presentations

We examined expression of protease-activated receptors 2 (PAR2) and characterized their signaling pathways in rabbit gastric muscle cells. The PAR2 activating peptide SLIGRL (PAR2-AP) stimulated Gq, G13, Gi1, PI hydrolysis, and Rho kinase activity, and inhibited cAMP formation. Stimulation of PI hydrolysis was partly inhibited in cells expressing PAR2 siRNA, Gaq or Gai minigene and in cells treated with pertussis toxin, and augmented by expression of dominant negative regulator of G protein signaling (RGS4(N88S)). Stimulation of Rho kinase activity was abolished by PAR-2 or Ga13 siRNA, and by Ga13 minigene. PAR2-AP induced a biphasic contraction; initial contraction was …

Building Kcnq1/Kcne1 Channel Models And Probing Their Interactions By Molecular-Dynamics Simulations, Yu Xu, Yuhong Wang, Xuan-Yu Meng, Mei Zhang, Min Jiang, Meng Cui, Gea-Ny Tseng

Physiology and Biophysics Publications and Presentations

The slow delayed rectifier (I_Ks) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits, and functions as a repolarization reserve in the human heart. Design of I_Ks-targeting anti-arrhythmic drugs requires detailed three-dimensional structures of the KCNQ1/KCNE1 complex, a task made possible by Kv channel crystal structures (templates for KCNQ1 homology-modeling) and KCNE1 NMR structures. Our goal was to build KCNQ1/KCNE1 models and extract mechanistic information about their interactions by molecular-dynamics simulations in an explicit lipid/solvent environment. We validated our models by confirming two sets of model-generated predictions that were independent from the spatial restraints used …

In Vivo Regulation Of Brain-Derived Neurotrophic Factor In Dorsal Root Ganglia Is Mediated By Nerve Growth Factor-Triggered Akt Activation During Cystitis, Li-Ya Qiao, Sharon Yu, Jarren C. Kay, Chun-Mei Xia

Physiology and Biophysics Publications and Presentations

Abstract

The role of brain-derived neurotrophic factor (BDNF) in sensory hypersensitivity has been suggested; however the molecular mechanisms and signal transduction that regulate BDNF expression in primary afferent neurons during visceral inflammation are not clear. Here we used a rat model of cystitis and found that the mRNA and protein levels of BDNF were increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. BDNF up-regulation in the L6 DRG was triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reduced BDNF levels during cystitis. The neutralizing NGF antibody also …

Challenging Pre-Service Students' Teaching Perspectives In An Inquiry-Focused Program, J. L. Pecore, A. Shelton

Journal of Mathematics and Science: Collaborative Explorations

Inquiry teaching based on constructivist learning theory has been an emphasis in pre-service education for over a decade. In general, a developmental teaching perspective supports inquiry-based instruction where teachers view learners as constructors of knowledge and teaching as providing questions, problems, and challenges that form a bridge from the learners' prior knowledge to a new, more sophisticated form of reasoning. Since teaching perspectives influence student learning, teacher effectiveness, and teacher attrition, challenging pre-service teachers to overcome experience-based convictions of a transmission perspective is necessary in teacher education. In this study, we examined the teaching perspectives of secondary, pre-service methods students …

Linear Perspective And Montage: Two Dominating Paradigms In Art Education, Charles R. Garoian

Journal of Social Theory in Art Education

As a former public high school art teacher, I was always puzzled by the common belief held by my students in what they referred to as the right way to represent images and ideas in their drawings and paintings. After years of producing art works during early childhood that appeared to be uninhibited in their expressive qualities, their world view in adolescence had shifted dramatically towards a preoccupation with photographic representation realism.

Amendment (2013)

Amendment, 2004-

Amendment is a VCU student-produced progressive literature and art journal that provides a platform for students to promote equality, tolerance, and social progression through artistic expression.

The Journal Of Social Theory In Art Education

Journal of Social Theory in Art Education

No abstract provided.

Craft As Activism, Elizabeth Garber

Journal of Social Theory in Art Education

Craft activists work outside the mainstream of consumer society, in grass-roots efforts, to create social change that positions individuals and groups of people as reflective contributors who occupy a participatory democracy. These activities connect to and draw from feminist and other civil rights movements, sustainability, and do-it-yourself [DIY] activities. They are forms of affective labor. The crafted products are considered in terms of whether they contribute (or do not) to the surplus economy, in terms of class taste, and vis-à-vis their ability to connect people and contribute to social change. Education of craft activists and audiences takes informal forms, such …

This Is What Democracy Looks Like: Art And The Wisconsin Uprising, Kim Cosier

Journal of Social Theory in Art Education

In February of 2011, an enormous popular political movement came to life in Wisconsin. For many people who were engaged in the month-long occupation of the Capitol in Madison, the Wisconsin Uprising was their first experience with direct political action. For the artists who are the focus of this article, taking part in the Wisconsin Uprising seemed like a natural outgrowth of their many years of socially engaged artmaking. In this article, I offer a brief overview of the Wisconsin Uprising followed by a discussion of the contributions of the artists in the protests in the context of their larger …

Exploring The Dynamics Of Identity Based Conflict And The Possibility For Its Sustainable Management: A Study Of The Persistent Ethno-Religious Conflict In Wukari Area Of Taraba State, Nigeria, Jude A. Momodu, G.I. Matudi, Abiodun L. Momodu

Ethnic Studies Review

This article explores the dynamics of identity-based conflict and the possibility for its management. The study in particular focuses on the persistent ethno-religious conflicts in the Wukari Area of Taraba State, Nigeria. The real issues precipitating the persistent ethno-religious conflicts and the costs of the conflicts were clearly brought to the fore. The study proposes a new paradigm for managing social conflicts at the community level through the 'use of community solutions for community problems' which will involve the constructive participation of all of the stakeholders in the community. This paper concludes by making a proposal for the establishment of …

Re:Creation, Heather Boone

Theses and Dissertations

This intent of this project is to explore the importance of handmade objects in the age of information.

The Role Of The Nucleosome Remodeling And Histone Deacetylase (Nurd) Complex In Fetal Γ-Globin Expression, Maria Amaya

Theses and Dissertations

An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell mouse model leads to a decrease in the number of sickled cells observed in the peripheral blood, and significantly increases survival in these mice. Although …

Hormone Epimers Regulate Er Stress And Core Regulatory Genes: Network Analysis With Applications To Glioma And Chronic Pressure Ulcers, Thomas L. Shaak

Theses and Dissertations

DHEA has been determined to have medically significant activity and is the parent compound to the more active metabolites; 17α-AED, 17β-AED and 17β-AET, which exhibit strong biological activity that has been attributed to androgenic, estrogenic or anti-glucocorticoid activity in vivo and in vitro. This study compared DHEA, 17α-AED, 17β-AED and 17β-AET for their ability to activate the human AR, ER and GR receptors and determine the relative androgenicity, estrogenicity and glucocorticoid activity. The results show that, at the receptor level, these androstene hormones are weak AR and even weaker ER activators. Direct androstene hormone activation of the human AR, ERα, …

Assessment Of The Feasibility Of Co-Administration Of Phenolic Dietary Compounds With Phenylephrine To Increase Its Bioavailability, Zhenxian Zhang

Theses and Dissertations

R-(-)-Phenylephrine (PE) is the most commonly used nonprescription oral nasal decongestant in the United States. It is a selective α1-adrenergic receptor agonist and has many years of safe usage. However, the efficacy of PE is controversial, due to its extensive pre-systemic metabolism, which leads to low and variable oral bioavailability (38 ± 9%, mean ± SD). Sulfation plays a very important role in pre-systemic metabolism of PE. The sulfation of PE occurs at its phenolic group, which is the preferred structural feature of many sulfotransferase (SULT) substrates. Compounds with phenolic groups have similar structures to PE, which may share the …

Thc-Mediated Induction Of Δfosb And Its Modulation Of Cb1r Signaling And Adaptation, Lazenka Matthew

Theses and Dissertations

The main psychoactive and therapeutic effects of Δ9-tetrahydrocannabinol (THC) are mediated through cannabinoid type 1 receptors (CB1Rs). The therapeutic uses of THC are mitigated by the development of tolerance to these therapeutic effects, whereas tolerance does not readily develop to some of the side-effects of THC, like motor impairment and reward. The development of tolerance occurs through adaptations at CB1Rs, which include desensitization (G-protein uncoupling) and downregulation (receptor degradation). Brain region-dependent differences in THC-mediated adaptations are proposed to explain the differences in tolerance to various THC-mediated effects. These studies focused on whether ΔFosB, a stable transcription factor, could regulate CB1R …

Experience As An Experiment, James Walker

Theses and Dissertations

My work is an exploration of new media that demonstrates the influence a community has on visual communication. The community reveals content as objects go unnoticed after they become a permanent part of the landscape and assumptions are made from cultural archetypes. Through exploration, immersion, and reflection, I am able to recognize the invisible and expected, establish a familiarity with a community, and design responses that communicate directly to it.

Transforming Narratives, Lucia Weilein

Theses and Dissertations

Narrative, often considered synonymous with “story,” can be viewed from a structuralist perspective and analyzed independent of any particular content. Breaking narrative into categories of story and discourse, this autonomous structure makes possible a translation of content from one form to another. The various media and form types common in graphic design can serve as both recipient and translator of narratives, converting content into a framework that includes the concept of craftsmanship, aesthetic components and specifications, legibility and composition, and the physical form of the designed object. To examine how this framework functions in practice, I have developed a series …

Cobblestone(S): A Chapbook Companion To Poictesme (2013)

Pwatem (Poictesme), 2006-

Poictesme (pwa-tem) (now Pwatem) is a student-run literary and art journal of Virginia Commonwealth University. Cobblestone(s) is the first ever chapbook companion to Poictesme.

Grappling With Issues Of Learning Science From Everyday Experiences: An Illustrative Case Study, A.-L. Tan, M. Kim, F. Talaue

Journal of Mathematics and Science: Collaborative Explorations

There are different perceptions among researchers with regard to the infusion of everyday experience in the teaching of science: 1) it hinders the learning of science concepts; or, 2) it increases the participation and motivation of students in science learning. This article attempts to contemplate those different perspectives of everyday knowledge in science classrooms by using everyday contexts to teach grade 3 science in Singapore. In this study, two groups of grade 3 students were presented with a scenario that required them to apply the concept of properties of materials to design a shoe. Subsequently, the transcripts of classroom discussions …