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Modulation Of Fast And Slow Inactivation In Two Cardiac Nav Channel Isoforms By Sdz 211-939, Tyce Jeffrey Kearl

Undergraduate Honors Capstone Projects

Here we report a hitherto unknown effect of a synthetic inactivation inhibitor on inactivation in cardiac sodium channels (Na_v1.5) from two different species: human and bovine. SDZ 211-93 9 stabilized the slow inactivated-state in both channels as seen by an increased steady-state probability of slow inactivation. SDZ also destabilized the fast-inactivated state and increased the amplitude of persistent currents. SDZ modulated conductance parameters, open-state fast inactivation time constants, and activation kinetics of hNa_v1.5, but not bNa_v1.5. These findings will aid future studies designed to elucidate the binding site and molecular mechanisms of inactivation inhibitors …

Oxidative Damage Caused By Iron Loading Into Ferritin, Talina Christensen Watts

Undergraduate Honors Capstone Projects

Ferritin is the iron storage protein found in humans, animals, plants, fungi and bacteria. We are interested in how iron is loaded and stored in mammalian ferritin. Ferrous iron must be oxidized to ferric iron in order to be stored in ferritin. It is generally believed that ferritin does the loading itself, dependant upon a "ferroxidase activity." Oxidation of iron can result in the production of the hydroxyl radical which can cause oxidative damage to surrounding proteins and other biomolecules. An indicator of oxidative damage to proteins is the formation of carbonyl groups. Using only the H subunit of human …

Influence Of Soil Compaction On Nitrogen Volatilization In A Management Intensive Grazing System: Estimation Of Gaseous N Losses Using Mass Balance In Intact Soil Cores, Luke Alan Petersen

Undergraduate Honors Capstone Projects

Increasing concern about the environmental impacts of greenhouse gases and PM 2.5 particulates has prompted many researchers to examine the processes of gaseous loss of nitrogen (N) from agricultural land. As agricultural production becomes more competitive and producers strive to become more efficient by reducing input costs, they will increasingly employ practices such as the rotational stocking, also called Management Intensive Grazing (MIG). MIG utilizes high animal stocking rates for short periods of time to efficiently harvest pasture crops. Unfortunately, MIG also produces relatively high concentrations of livestock excreta. This has caused intensive grazing practices to become a focal point …

Southern Hills, Pocatello, Idaho: Wildlife Conservation/Development Study, Justin Kmetzsch

Undergraduate Honors Capstone Projects

The sagebrush grassland landscape has shaped aspects of southeastern Idaho culture and enhanced its rural economy. Sharptail grouse, sage grouse and mule deer hunting are deeply rooted in family traditions. Each fall thousands of residents head out into the field to hunt, camp and enjoy the autumn outdoors. Deer hunting and associated activities generate an estimated 240 million dollars annually, in the Idaho economy. More recently, watching and photographing mule deer and other sagebrush grassland species is increasing in popularity and economic significance. But, trends in land conversion and development threaten sagebrush grassland landscapes, the wildlife they sustain, and cultural …

Emerging Physiological Significance Of R-Type Calcium Currents, Paul Jensen

Undergraduate Honors Capstone Projects

R-type channels are voltage dependent calcium channel subtypes. To date, the only variant of the R-type calcium channel that has been isolated and cloned is the Ca_v2.3 variant, encoded by the gene Cchral (Yamazaki et al., 1998). The channel was named "R-type" because it was initially characterized by its resistance to nifedipine (a blocker of L-type calcium channels), Ω-conotoxin GVIA (an N-type calcium channel blocker) and Ω -Aga IVA (a blocker of P/Q-type calcium channels) (Hille 2001). The Ca_v2.3 calcium channel is selectively inhibited by the peptide SNX-482, which was isolated from venom of the African …

The Fate Of Iron Released From Heme By Hemeoxygenase-1, Jonathan Mark Gardner

Undergraduate Honors Capstone Projects

A strain of Escherichia coli was genetically modified to co-express human heme oxygenase-1 and ferritin. The E. coli were then grown with varying amounts of hemin to see if the iron released upon degradation of the hemin by heme oxygenase-1 is loaded into ferritin. Following incubation, the ferritin was purified and the amount of iron loaded into ferritin determined. It was found that ferritin purifed from E. coli expressing human heme oxygenase-1 contained more iron than E. coli that did not contain human heme oxygenase-1. It was concluded that some of the iron released upon degradation of hemin by heme …

Regulation Of Cardiac Fibroblast Metalloprotease Secretion, Glen De Guzman

Undergraduate Honors Capstone Projects

Matrix metalloproteases (MMPs) are proteolytic enzymes secreted by cardiac fibroblasts. Altered expression of MMPs plays an important role in congestive heart failure and other cardiovascular diseases^1,2. Emerging evidence has led us to consider the role of phosphatidylinositol 4-kinase (PtdIns 4-kinase) in regulating MMP secretion in cardiac fibroblast cells^3-7. PtdIns 4-kinase is a lipid kinase involved in various cellular processes including protein secretion. This project was designed to test the hypothesis that PtdIns 4-kinase controls MMP secretion. Techniques such as cardiac cell culture, transfection, and in-gel zymography were used for this experiment. Results demonstrated that PtdIns 4-kinase …

History Of The Logan Bluff Landslide Zone, Seth P. Olsen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

On September 10, 2005, a landslide occurred to the south of Utah State University Campus and Highway 89. This landslide did considerable damage to the Logan and Northern canal, which is cut into the slope, and to a residence at the toe of the slope. This event brought many parties together to collaborate on possible solutions to the immediate fix of the slide as well slides that could occur in the future. The purpose of this report is to compile information useful to the study of the area and the possible solutions and/or risk assessment of the Logan Bluff Landslide …

Uncovering The Key Of Success In The Utah Medicaid Work Incentive Program: A Grounded Theory Study, Renee H. Nolan

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this grounded theory research was to determine what differentiates people with disabilities who leave Social Security Disability Insurance (SSDI) benefits due to increased income from those who cannot. Fifteen individuals, former and current participants in a Medicaid Buy-In program, were interviewed. Within the context of health and disability, four theoretical propositions were identified: education, opportunity to work, interpersonal support, and secure housing. Higher benefit levels were also found to be an effective barrier for many.

Predicting Child Outcomes From Parenting Styles Of Spanish-Speaking Families, Melissa Renee Donovick

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to evaluate observed parenting practices among first-generation Spanish-speaking Latinos living in Utah. Participants included 50 families with a child between the ages of 4 and 9. Parents and their child engaged in a behavioral observational task that was coded for parenting dimensions and styles to determine if they predict child outcomes among Latino families. Parents completed the Child Behavior Checklist to assess for behavioral problems. Observations were coded using the Parenting Scale, developed specifically for this study. In general, parents received high ratings on warmth and demandingness, and lower ratings on autonomy granting. Parenting …

Antimicrobial Properties Of Syringopeptin 25a And Rhamnolipids, Prerak T. Desai

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The increasing bacterial resistance to available antibiotics requires the search for new antibacterial compounds to be broadened. This study investigated the antimicrobial properties of two secondary metabolites from fluorescent pseudomonads -- syringopeptin 25A, a lipodepsipeptide produced by Pseudomonas syringae pv. syringae, and a rhamnolipid mixture produced by Pseudomonas aeruginosa. The rate of antimicrobial action was determined by monitoring the rate of uptake of propidium iodide during exposure to the compounds. Inhibition was also confirmed by the microbroth dilution method to determine the MI Cs. Both the compounds inhibited growth of Gram-positive organisms, including Mycobacterium smegmatis, staphylococci, and …

Use Of Natural Antioxidants To Control Oxidative Rancidity In Cooked Meats, Mihir Vasavada

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The research in this dissertation focused on determining antioxidant effects of various natural antioxidants in cooked meat systems. Milk mineral (MM), spices, and raisin paste were used in cooked meat systems to verify their potential antioxidant properties.

The MM study determined the antioxidant activity of 1.5% MM added to uncured cooked beef meatballs, and possible additive effects of MM in combination with 20-ppm or 40-ppm sodium nitrate in cooked beef sausages. There was no additive inhibition of lipid oxidation in samples containing 20-ppm or 40-ppm sodium nitrite plus 1.5% MM. Cooked meat yield was not different between control meatballs and …

Microbial Ecology Of An Animal Waste-Fueled Induced Blanket Reactor, Steven C. Curtis

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Use of an induced blanket reactor (IBR) to break down organic matter into methane is a financially attractive method to reduce the environmental impact of animal or industrial waste. In order to better understand the biological processes involved with the conversion of waste to biogas by an IBR, it is necessary to gain a better understanding of the microorganisms and their roles in the reactor. Molecular techniques based on the isolation of 16S rDNA were used in order to avoid the limitations posed by conventional culture-based techniques. Total DNA was extracted and amplified using universal primers specific to eubacteria and …

Addition Of Three Dietary Fibers In An Extruded Whey And Cornstarch Expanded Snack Food, Alisha M. Wood

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Different fiber types were incorporated in an extruded expanded high-protein snack food. Three dietary fibers (powdered cellulose, wheat fiber, and oat fiber) were selected based on ease of extrusion, percent total dietary fiber, visible expansion, and commercial availability. A high-fiber, high-protein snack food containing whey protein, normal cornstarch, and pregelatinized waxy cornstarch was extruded using the three selected fibers. The fibers replaced the normal cornstarch at 30, 60, and 80% yielding extrudates with three fiber levels (18, 36, and 48%). Each treatment or combination of fiber type and extrudate fiber level was extruded in triplicate. A control with no fiber …

Smoking, Anemia, And Risk Of Oral Clefts In Utah, Melinda Michelle Moss

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cigarette smoke contains sufficient carbon monoxide to induce maternal and fetal hypoxia. Hypoxia is a known teratogen, and consequently maternal smoking has been the focus of many studies on adverse birth outcomes, including cleft lip and palate. Current literature of epidemiological studies on smoking and clefts suggests a modest but statistically significant increase in risk of clefting associated with maternal smoking. A biological condition that may also contribute to hypoxia is anemia. Data from the Utah Child and Family Health Study was used to assess the effects of hypoxia-inducing conditions, maternal smoking, anemia, and their interaction, on the risk of …

Fathers' Perceptions Of Relationships With Young Adolescent Children: Implications For Family Therapy, Tyler D. Patrick

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study used family systems theory as a lens to examine fathers' relationships with young adolescent children as it relates to the areas of time spent together, communication between generations, and paternal satisfaction in raising an early adolescent child. Similarities and differences of scores on the Parent Success Indicator were examined for 191 Caucasian American (n=110) and African American (n=81) fathers of 10- to 14-year-old-children. Results showed that increased amounts of time that fathers report spending with children was significantly associated with paternal satisfaction, communication between generations, fathers' use of time, parental frustration, and parental teaching. …

Assessing The Cognitive Development Of A Sample Of Infants In Paraguay, Shannon Peairson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There is very little research to date on infant development in developing countries, including Paraguay. The present study aimed to determine the effects of Pastoral del Nino, an ECD program, in rural Paraguay by assessing two groups of infants. Group 1 (n = 50) was receiving no intervention and group 2 (n =58) was participating in Pastoral del Nino. Both groups were matched for SES and age of infant. Results indicate that group 2 performed better on the Bayley Scales of Infant Development Mental Development Index. Group 1 had a mean MDI score of 77.96 and group 2 …

Welfare Status, Gender, And The Utilization Of Marital Counseling Services, Courtney A. Wyatt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to examine how welfare status, gender, and the interaction between welfare status and gender relate to the utilization of counseling services related to marriage (i.e., "marital help-seeking"). This study was a secondary analysis of the Utah Marriage Survey data set from 2003. Two samples were utilized in this study, and generated a total sample of I ,316 participants. The first sample was made up of I, 173 randomly selected Utah households, identified through a random-digit dialing sampling technique. The second sample was obtained from a random selection of current Temporary Assistance for Needy Families …

Tapirs And Rhinoceroses In Captivity: An Examination Of The North American Captive Populations And Their Husbandry, Lisa A. Nordstrom

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

All species of Tapiridae and Rhinocerotidae are threatened or endangered in the wild. Captive populations have been established for most of these species, but successful management has proved challenging. Effective ex situ conservation strategies, however, rely on the ability of zoological institutions to maintain and breed these endangered species. In this study, I examined the captive environment to identify the factors associated with reproduction, mortality, and health of rhinos and tapirs. Zoological institutions in the North American region that currently housed rhinos and/or tapirs were surveyed in 2003. Attaining an approximately 90% response rate, I compiled information on the following …

Remapping The Cliff Chipmunk (Neotamias Dorsalis) Distribution And Creating A Habitat Association Model In Southern Idaho, Masako Niwa

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The distribution of the cliff chipmunk in Idaho was previously considered to include only the Raft River Valley and the Goose Creek Basin. A pilot study was conducted in 2003 and 2004. Thirty-five cliff chipmunk presence locations and 124 absence locations were recorded. Habitat variables of elevation, slope, deviation from south, distance to water, and vegetation type were extracted for all of the absence and presence points by means of GIS analysis. The data were analyzed by implementing a classification tree, and a "GIS habitat association model" was created. The model was tested in 2005, and the overall model accuracy …

Highway Effects On Small Mammal Communities And Effectiveness Of A Deer-Vehicle Collision Mitigation Strategy, Silvia A. S. Rosa

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

My work focused on the study of road effects and mitigation of negative impacts of roads on wildlife. Two different studies were conducted on Interstate 15, in southern Utah. My first study reported on road effects on small mammal communities. The results suggested that overall, there was no clear effect on small mammal populations relative to distance from the road. Most small mammal species did not appear to be negatively affected by the presence of the road. Instead, the road seemed to have either a neutral or a positive effect. The abundance and diversity of small mammals responded more markedly …

Environmental, Chemical, And Genetic Reduction Of Ethylene Sensitivity In Crop Plants, Timothy J. Hudelson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Ethylene is an endogenously synthesized plant hormone that dissipates quickly in field conditions and seldom exceeds five nmol mol^-1. Ethylene can accumulate to 1000 times this level in closed environments. The best-known effects of ethylene are its impacts on fruit ripening and senescence, yet ethylene influences growth and development throughout the plant life cycle. At low, continuous concentrations (20 to 50 nmol mol^-1), ethylene reduces yield of many plants. Clean-air treatment during critical stages of floral development, silver thiosulfate (STS), and 1-methylcyclopropene (1-MCP) may delay flower senescence and reduce the detrimental effects of ethylene on peas …

Vascular Plant Species Richness And Distribution In A Heterogeneous Landscape, Kelly J. Mccloskey

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The distribution of vascular plant species and species richness in a mid-elevation Rocky Mountain landscape can be attributed to a number of variables. The distribution of species with respect to physiognomic type, patch size, shape, and environmental heterogeneity was assessed for a mosaic landscape comprised of conifer forest, deciduous forest, and shrub-steppe physiognomic types in the southwest comer of Grand Teton National Park, Wyoming. This vegetation is representative of that found in other montane landscapes of the central Rocky Mountains. The vegetation was mapped to physiognomic type; distinct vegetation patches were sampled using one or more small (50 m^{2 …}

Movement Behavior And Habitat Selection Of The Endangered June Sucker (Chasmistes Liorus) In Utah Lake, Utah, Kris A. Buelow

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The June sucker (Chasmistes liorus) is a pelagic feeding sucker endemic to Utah Lake, Utah. It has been listed as an endangered species with the present population being estimated with as few as 300 individuals. Efforts to reinvigorate the population by placing breeding age individuals and augmenting the population with hatchery-reared fish have proved to have had limited success. At this stage there is an imperative to understand the behavioral traits and life history of June sucker to retrieve them from the brink. Previous efforts have been hampered by few individuals and a difficult habitat to study. Utah …

Therapeutic Processes In A Cognitive-Behavioral Treatment For Depressed Adolescents With Inflammatory Bowel Disease, Meredith Brent

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Youth with inflammatory bowel disease (IBD) have higher rates of depression than healthy youth. A cognitive-behavioral treatment, primary and secondary control enhancement training-physical illness (PASCET-PI), for depressed adolescents with IBD was associated with reductions in depressive symptoms. The purpose of this study was to examine the salience of nonspecific processes (factors inherent in any human relationship) and specific processes (factors related to therapy content) during PASCET-PI sessions and their association with improvements in psychological functioning.

Participants included 10 adolescent patients with IBD with mean illness duration of 31.9 months. At intake, eight participants qualified for a diagnosis of major depressive …

Identity Development, Identity Disclosure, And Identity Exploration Among Adolescent Sexual Minorities, Jenna A. Glover

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study investigated the utility of applying the social constructionist perspective to adolescent sexual minority identity development, disclosure, and identity explorations. Differences between middle and late adolescents and male and females were examined. No differences were found between middle and late adolescents on measures of identity development and identity exploration; however, differences in identity disclosure were found regarding history of accidental discovery of sexual orientation. Biological sex differences were found for identity development, disclosure, and exploration. Relationships between same- and opposite-sex attractions, behaviors, romantic experiences, and self-labels are presented. Trends in intentional disclosure patterns and unintentional discovery identify predicted reaction …

Age And Population Structure Of Joshua Trees (Yucca Brevifolia) In The Northwestern Mojave Desert, Kimberly D. Gilliland, Nancy J. Huntly, J. E. Anderson

Biology Faculty Publications

Many desert perennials are long-lived, but there are few data on ages or population structures of desert plants. We used 2 methods to estimate ages of a population of Yucca brevifolia (Joshua tree) in southwestern Utah from a 14-year census of plant sizes. Plant height at the 1st census ranged from 0.08 m to 6.0 m, and trees grew in height at a mean rate of 3.75 cm ⋅ yr^–1. Plants also increased slowly in basal diameter (0.142 cm ⋅ yr^–1) and branch length (0.024 m ⋅ yr^–1), but basal diameter varied greatly from …

The Water Vapor Permeability Of Polycrystalline Fat Barrier Films, Silvana Martini, D. A. Kim, M. Ollivon, A. G. Marangoni

Nutrition, Dietetics, and Food Sciences Faculty Publications

The water vapor permeability of fat barrier films has been associated with structural characteristics such as polymorphism, crystal size, and chemical composition, among others. However, no mechanistic models have been proposed to describe this relationship. In this study, we have determined the effects of processing conditions on the structure and physicochemical characteristics of four fats and their relationship to water vapor permeability. Results suggest that the solids' volume fraction and the domain size of the fat crystals seem to be the most important factors controlling water vapor migration. Moreover, materials with relatively large crystalline domains will yield malleable films with …

Queen Weights Of Polygyne Solenopsis Invicta And S. Xyloni Suggest Reduced Competitive Ability, Ricardo A. Ramirez, D C. Thompson

Biology Faculty Publications

Solenopsis invicta Buren populations were confirmed in southern New Mexico, resulting in a quarantine of Doña Ana County in 1998; however, Solenopsis xyloni McCook remains the dominant fire ant. This study compared the queen weights and egg production of polygyne colonies of both species. There was no difference in live weights of the major worker caste; however, queens were very different in weight. In this study, S. invicta queens weighed almost twice as much as S. xyloni (S. invicta = 11.32 ± 0.25mg vs. S. xyloni = 6.40 ± 0.30mg) and produced over 50% as many eggs as S. xyloni. …

Curriculum Subcommittee Minutes, February 2, 2006, Utah State University

Educational Policies Committee

Department of Nutrition and Food Sciences

• New Course

Department of Management and Human Resources

• Delete Course

Department of Health, Physical Education and Recreation

• Delete Course

Department of Psychology

• Credit Hour Change, Prerequisite Change

Department of Biological and Irrigation Engineering

• New Course
• Prerequisite Change

Department of Civil and Environmental Engineering

• Credit Hour Change, Course Description Change
• Prerequisite Change

Department of Engineering and Technology Education

• New Course

Department of Mechanical and Aerospace Engineering

• New Course

Department of English

• Change to Pass/Fail only

Department of History

• New Course

Department of Music

• Change to Pass/Fail only

Department of Political Science

• Change to Pass/Fail only …