Digital Commons Network^™

Ruminant Bloat, Austin Sears, Kerry A. Rood

All Current Publications

This fact sheet describes bloat, a non-infectious disease common among the ruminant species, including types and clinical signs, prevention, and treatment.

Scientific Twitter: The Flow Of Paleontological Communication Across A Topic Network, Richard T. Bex Ii, Lisa Lundgren, Kent J. Crippen

Instructional Technology and Learning Sciences Faculty Publications

The field of paleontology, which is based principally on observations of the natural world, includes an active community that is engaged across multiple social media platforms, consisting of museums, academic researchers, amateur fossil collectors, paleontological artists, and commercial fossil dealers. As such, it represents an ideal environment for examining the people, interactions, and flow of scientific information. Using interactions involving the four most popular Twitter hashtags for paleontology, this embedded mixed methods study defined the members of this social world and investigated how they influenced and controlled the flow of information, as well as how their expression of scientific practice …

Others’ Publications About Ehdi: October 2018 Through April 2019

Journal of Early Hearing Detection and Intervention

No abstract provided.

Foraging Economics Of The Hunt Bumble Bee, A Viable Pollinator For Commercial Agriculture, Abby Baur, James P. Strange, Jonathan B. Koch

All PIRU Publications

Globally, there are only five bumble bee (Hymenoptera: Apidae, Bombus) species that have been successfully commercialized for agriculture. The Hunt bumble bee, Bombus huntii Green, 1860, has been recognized as a suitable pollinator of crops and has a broad distribution in western North America, making it a viable candidate for commercialization. In this study, our goal was to characterize the foraging dynamics of B. huntii female workers under open field conditions. To accomplish this goal, we monitored three B. huntii colonies over an 8-wk period in the summer of 2012 in northern Utah. Using marked bees, we studied the …

Genome To Phenome: Improving Animal Health, Production, And Well-Being – A New Usda Blueprint For Animal Genome Research 2018–2027, Caird Rexroad, Jeffrey Vallet, Lakshmi Kumar Matukumalli, James Reecy, Derek Bickhart, Harvey Blackburn, Mark Boggess, Hans Cheng, Archie Clutter, Noelle Cockett, Catherine Ernst, Janet E. Fulton, John Liu, Joan Lunney, Holly Neibergs, Et Al.

Animal, Dairy, and Veterinary Science Faculty Publications

In 2008, a consortium led by the Agricultural Research Service (ARS) and the National Institute for Food and Agriculture (NIFA) published the “Blueprint for USDA Efforts in Agricultural Animal Genomics 2008–2017,” which served as a guiding document for research and funding in animal genomics. In the decade that followed, many of the goals set forth in the blueprint were accomplished. However, several other goals require further research. In addition, new topics not covered in the original blueprint, which are the result of emerging technologies, require exploration. To develop a new, updated blueprint, ARS and NIFA, along with scientists in the …

Young Germ Cell Depleted Ovaries In Post-Reproductive Mice And Its Effects On Immune Function, Mckenna Walters

Undergraduate Honors Capstone Projects

It has previously been shown that young, cycling ovarian transplantation in aged female mice increased the general health and life span in regard to their post-reproductive health. It has further been hypothesized that this enhancement of health is directly influenced by the ovarian somatic cells. To address this hypothesis, transplants of young germ cell depleted and germ cell containing ovaries were performed on female mice. The purpose of this study is to continue to discern the reproductive influence on aging health, specifically in the area of immunological well-being. Control group mice were separated by age and treatment mice were subsequently …

Development Of Mouse Models For Respiratory And Neurological Disease Caused By Enterovirus D68 And Evaluation Of Antiviral Therapies, Brett L. Hurst

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Enterovirus D68 (EV-D68) is a virus that normally causes disease in children. While this virus typically causes a respiratory infection, in 2014, a large outbreak of the virus was associated with patients that had paralysis of the arms or legs. Even though the virus was discovered in 1962, little was known about the life cycle of the virus or its ability to cause disease. An animal model of disease was needed to understand how the virus causes disease and to develop antiviral compounds to target the virus life cycle.

We adapted the virus by serial-passage in lung tissues from mice …

Male Reproductive Infection And Sexual Transmission Of Zika Virus In An Immunocompromised Mouse Model, Chad S. Clancy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Zika virus (ZIKV) is a sexually transmitted viral infection most frequently transmitted by mosquitoes. The source of infectious virions in the male reproductive tract has yet to be elucidated. The goals of the studies included developing and characterizing two mouse models for reproductive transmission studies and demonstration of sexual transmission of virus via artificial insemination. The mouse strains used in the study lacked receptors to interferon molecules, key signaling proteins of the host immune response. Inflammation severity was assessed during acute disease, 5-11 days after infection using a novel histopathology grading system. ZIKV proteins and genome were initially detected in …

Altered Gene Response To Aflatoxin B1 In The Spleens Of Susceptible And Resistant Turkeys, Kent M. Reed, Kristelle M. Mendoza, Roger A. Coulombe Jr.

Animal, Dairy, and Veterinary Science Faculty Publications

Susceptibility and/or resistance to aflatoxin B₁ (AFB₁) is a threshold trait governed principally by glutathione S transferase (GST)-mediated detoxification. In poultry, domesticated turkeys are highly sensitive to AFB₁, most likely due to dysfunction in hepatic GSTs. In contrast, wild turkeys are comparatively resistant to aflatoxicosis due to the presence of functional hepatic GSTAs and other possible physiological and immunological interactions. The underlying genetic basis for the disparate GST function in turkeys is unknown as are the broader molecular interactions that control the systemic response. This study quantifies the effects of dietary AFB₁ on gene …

Prediction Of Host-Pathogen Protein-Protein Interactions Using Machine-Learning, Cristian Loaiza

Student Research Symposium

Host-pathogen protein-protein interactions (HPIs) plays vital roles among several biological processes. Furthermore, there is an interest in those interactions that are related with infectious diseases, which seems crucial to understand the mechanism behind the infection process per se and therefore, unravel potential targets to develop therapeutic approaches. Recently, efforts have been made to collect most of the data present in the literature about HPIs and algorithms to transfer that knowledge into unknown systems has been implemented. Although, beyond intra-species PPIs there is not information about modeling those wide-range databases using machine learning techniques, which have been proved ideal to summarize …

Feral Swine Disease Surveillance – National Targets And Pilot Projects, Vienna R. Brown, Rachel M. Maison, Thomas Gidlewski

Wildlife Damage Management Conference

The National Feral Swine Damage Management Program (NFSP) in collaboration with the National Wildlife Disease Program (NWDP) and USDA APHIS Veterinary Services works to identify the diseases of national concern in feral swine. The current national disease surveillance program includes classical swine fever (CSF), swine brucellosis (SB), and pseudorabies (PRV). CSF is a foreign animal disease and feral swine samples collected and tested serve as part of Veterinary Services surveillance stream for this pathogen. Both SB and PRV have been eradicated from U.S. commercial swine operations; however, as they are endemic diseases in feral swine populations, monitoring of feral swine …

The Effect Of Phylogenetic Uncertainty And Imputation On Edge Scores, K. Bodie Weedop, Arne Ø. Mooers, Caroline M. Tucker, William D. Pearse

Biology Faculty Publications

Faced with the challenge of saving as much diversity as possible given financial and time constraints, conservation biologists are increasingly prioritizing species on the basis of their overall contribution to evolutionary diversity. Metrics such as EDGE (Evolutionary Distinct and Globally Endangered) have been used to set such evolutionarily based conservation priorities for a number of taxa, such as mammals, birds, corals, amphibians, and sharks. Each application of EDGE has required some form of correction to account for species whose positions within the tree of life are unknown. Perhaps the most advanced of these corrections is phylogenetic imputation, but to date …

The Plant Diversity Sampling Design For The National Ecological Observatory Network, David T. Barnett, Peter B. Adler, Benjamin R. Chemel, Paul A. Duffy, Brian J. Enquist, James B. Grace, Susan Harrison, Robert K. Peet, David S. Schimel, Thomas J. Stohlgren, Mark Velled

Ecology Center Publications

The National Ecological Observatory Network (NEON) is designed to facilitate an understanding of the impact of environmental change on ecological systems. Observations of plant diversity—responsive to changes in climate, disturbance, and land use, and ecologically linked to soil, biogeochemistry, and organisms—result in NEON data products that cross a range of organizational levels. Collections include samples of plant tissue to enable investigations of genetics, plot-based observations of incidence and cover of native and non-native species, observations of plant functional traits, archived vouchers of plants, and remote sensing airborne observations. Spatially integrating many ecological observations allows a description of the relationship of …

A Pilot Study Of The Effects Of Mycoplasma Ovipneumoniae Exposure On Domestic Lamb Growth And Performance, Thomas E. Besser, Jessica Levy, Melissa Ackerman, Danielle Nelson, Kezia R. Manlove, Kathleen A. Potter, Jan Busboom, Margaret Benson

Wildland Resources Faculty Publications

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. In order to assess the effects of M. ovipneumoniae on lamb performance, we generated a cohort of lambs free of M. ovipneumoniae by segregation of test negative ewes after lambing, then compared the growth and carcass quality traits of M. ovipneumoniae-free and -colonized lambs from weaning to harvest. Some signs of respiratory disease …

Faculty Senate Agenda, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 10, 2019
• Academic Freedom and Tenure Annual Report
• Council on Teacher Education Annual Report
• 405.7.2 – External Reviewers
• Greenhouse Gas Resolution
• 403.3.1 – Standards of Conduct – Faculty Responsibilities to Students
• 403.3.2 – Standards of Conduct – Professional Obligations
• 405.2.1 – 405.3.2 – 405.5.1 – 405.10.1 Community Engagement Inclusion
• 407.1.1 – Non Punitive Measure
• 407.8.5(3) – Sexual Harassment
• 407.11.2(2) - Notification of Faculty Member
• 407.11.3(2) – Protection of Complainant and Others

Faculty Senate Minutes, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Academic Freedom and Tenure
• Council on Teacher Education
• Greenhouse Gas Resolution

Exploring Mortality Rates For Major Causes Of Death In Korea, Hyo Jung Oh, Donng Min Yang, Chong Hyuck Kim, Jae Gyu Jeon, Nam Hyung Jung, Chan Young Kim, Jurgen Symanzik, Hyo Won Oh, Akugizibwe Edwin, Seong Ii Jo, Jeong Yong Ahn

Mathematics and Statistics Faculty Publications

Background: The trends and patterns of the mortality rates for causes of death are meaningful information. They can provide a basis for national demographic and health care policies by identifying the number, causes, and geographical distribution of deaths.

Objective: To explore and analyze the characteristics of the mortality rates for major causes of death in Korea.

Methods: Some common data analysis methods were used to describe the data. We also used some visualization techniques such as heat maps and line plots to present mortality rates by gender, age, and year.

Results: Our analysis shows the crude …

Faculty Senate Executive Committee Agenda, January 22, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 10, 2019
• Academic Freedom and Tenure Annual Report
• 405.7.2 – External Reviewers
• Greenhouse Gas Resolution
• 403.3.1 – Standards of Conduct – Faculty Responsibilities to Students
• 403.3.2 – Standards of Conduct – Professional Obligations
• 405.2.1 – 405.3.2 – 405.5.1 – 405.10.1 Community Engagement Inclusion
• 407.1.1 – Non Punitive Measure
• 407.11.2(2) - Notification of Faculty Member
• 407.11.3(2) – Protection of Complainant and Others

Faculty Senate Executive Committee Minutes, January 22, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Academic Freedom and Tenure
• Council on Teacher Education
• Greenhouse Gas Resolution
• USUSA Annual Report
• Professional Responsibilities and Procedures Committee
• Scholarship Advisory Board
• USUSA Recommendations

Human Polyclonal Antibodies Produced From Transchromosomal Bovine Provides Prophylactic And Therapeutic Protections Against Zika Virus Infection In Stat2 Ko Syrian Hamsters, Venkatraman Siddharthan, Jinxin Miao, Arnaud J. Van Wettere, Rong Li, Hua Wu, Eddie Sullivan, Jinan Jiao, Jay W. Hooper, David Safronetz, John D. Morrey, Justin G. Julander, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain–Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in STAT2 knockout (KO) golden Syrian hamsters both prophylactically and therapeutically. These antibodies also prevent testicular lesions in this hamster model. Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. Because suitable …

Utah State Magazine, Winter 2019, Utah State University

Utah State Magazine

The quarterly magazine for friends and alumni of Utah State University.

Control Efforts And Serologic Survey Of Pseudorabies And Brucellosis In Wild Pigs Of Tennessee, Lisa I. Muller, Neelam C. Poudyal, Roger Applegate, Chuck Yoest

Human–Wildlife Interactions

European wild pigs (Sus scrofa) are an introduced invasive species that now constitute a major threat to agriculture and the natural ecology of the environments they now inhabit. Wild pigs also carry many diseases known to infect wildlife, humans, and livestock. Two of these diseases, pseudorabies (PRV) and brucellosis, constitute major diseases in the United States. Better data are needed regarding the prevalence of these diseases in wild pigs to understand and manage the potential risks to wildlife, humans, and livestock. From July 1, 2011 to June 30, 2017, Tennessee Wildlife Resources Agency personnel trapped and euthanized 4,727 …

Carnivore-Livestock Conflicts In Chile: Evidence And Methods For Mitigation, Valeska Rodriguez, Daniela A. Poo-Muñoz, Luis E. Escobar, Francisca Astorga, Gonzalo Medina-Vogel

Human–Wildlife Interactions

Human population growth and habitat loss have exacerbated human–wildlife conflicts worldwide. We explored trends in human–wildlife conflicts (HWCs) in Chile using scientific and official reports to identify areas and species with higher risk of conflicts and tools available for their prevention and mitigation. The puma (Puma concolor) was considered the most frequent predator; however, fox (Lycalopex spp.) and free-ranging or feral dog (Canis lupus familiaris) attacks were also common. Our results suggest that the magnitude of puma conflicts may be overestimated. Domestic sheep (Ovis spp.) and poultry (Galliformes) were the most common species predated. …

Population Dynamics And Control Of Exotic South African Oryx In The Chihuahuan Desert, South-Central New Mexico, Louis Bender, Patrick Morrow, Mara Weisenberger, Bryce Krueger

Human–Wildlife Interactions

Introductions of exotic species can benefit certain publics but can also have many unanticipated consequences. South African oryx (Oryx gazella gazella) were introduced into the Chihuahuan Desert on White Sands Missile Range (WSMR), New Mexico, USA to alleviate a perceived lack of large mammal hunting opportunities. Because of conflicts with oryx as the population increased, we modeled population growth and determined survival of radio-collared oryx to identify rates of population increase, limiting factors to population growth, and levels of harvest necessary to control population growth. Following introductions in 1969–1977, oryx significantly increased their range and showed a rate …

A California Without Rodenticides: Challenges For Commensal Rodent Management In The Future, Niamh Quinn, Sylvia Kenmuir, Laura Krueger

Human–Wildlife Interactions

Rodenticides are an essential tool in the integrated pest management of infestations of commensal rodents (Rattus norvegicus, R. rattus, and Mus musculus). With the introduction of Assembly Bill 1788, the California Ecosystems Protection Act of 2019, California is potentially facing a future with new restrictions on the use of anticoagulant rodenticides to manage commensal rodents in urban areas. Assembly Bill 1788 has been proposed specifically to protect predators from anticoagulant rodenticide poisoning and seeks to restrict the application of second-generation anticoagulant rodenticides (SGARs) for use in many urban and non-urban areas of California, USA. Exclusion and cultural …

A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris N. Niebuhr, Susan I. Jarvi, Shane R. Siers

Human–Wildlife Interactions

Rat lungworm (Angiostrongylus cantonensis) is a zoonotic nematode that causes rat lungworm disease (angiostrongyliasis), a potentially debilitating form of meningitis, in humans worldwide. The definitive hosts for rat lungworm are primarily members of the genus Rattus, with gastropods as intermediate hosts. This parasite has emerged as an important public health concern in the United States, especially in Hawaii, where the number of human cases has increased in the last decade. Here we discuss the current knowledge of the rat lungworm, including information on the life cycle and host species, as well as updates on known infection levels. Three …

Harnessing Population Genetics For Pest Management: Theory And Application For Urban Rats, Matthew Combs, Kaylee Byers, Chelsea Himsworth, Jason Munshi-South

Human–Wildlife Interactions

Effective management of rodent pests requires an ecological understanding of how they move through their environment and how those movements influence the invasion, persistence, or reinvasion of problematic colonies. Traditional methodologies used to describe rodent movement patterns, such as mark-recapture, are hindered by their time-consuming nature and limited geographic scope. As such, our understanding of how rodents interact with urban environments remains limited. Population genetic principles and tools have the capacity to greatly increase our understanding of rodent population dynamics, ecological relationships, and movements across space, but this field is often unapproachable to non-scientist pest management professionals (PMPs). In this …

Numbers Of Human Fatalities, Injuries, And Illnesses In The United States Due To Wildlife, Michael R. Conover

Human–Wildlife Interactions

I reviewed published and unpublished papers, government reports, and websites to estimate how many people are injured or killed each year by wildlife or stricken by a zoonotic disease. Over 47,000 people annually in the United States sought medical attention after being attacked or bitten by wildlife, and approximately 8 people died annually. Most bites were by snakes, birds, rodents, and raccoons (Procyon lotor). Each year, wildlife–vehicle collisions resulted in >59,000 human injuries and >440 human fatalities, while wildlife–aircraft collisions added 16 more injuries and 10 fatalities. I also found that >68,000 people each year sought medical …

A Potent Lassa Virus Antiviral Targets An Arenavirus Virulence Determinant, Ikenna G. Madu, Megan Files, Dima N. Gharaibeh, Amy L. Moore, Kieh-Hoon Jung, Brian B. Gowen, Dongcheng Dai, Kevin F. Jones, Shanthakumar R. Tyavanagimatt, James R. Burgeson, Marcus J. Korth, Kristin M. Bedard, Shawn P. Iadonato, Sean M. Amberg

Animal, Dairy, and Veterinary Science Faculty Publications

Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a recent outbreak in Nigeria was larger and more geographically diverse than usual. We are developing LHF-535, a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, as a therapeutic candidate for Lassa fever and other hemorrhagic fevers of arenavirus origin. Using a lentiviral pseudotype infectivity assay, we determined that LHF-535 had sub-nanomolar potency against the viral envelope glycoproteins from all Lassa …

Development And Application Of A Reverse Genetics System For Zika Virus, Jordan C. Frank

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Zika virus (ZIKV) has emerged in many regions of the world, with infection outcomes spanning from no apparent illness to crippling nervous system disease. ZIKV and its close relatives, West Nile virus, Japanese encephalitis virus, dengue virus, and yellow fever virus are primarily transmitted by mosquitoes. Three ZIKVs were selected: MR-766 (Uganda, 1947), P6-740 (Malaysia, 1966), and PRVABC-59 (Puerto Rico, 2015), whose place of origin and time of isolation differ substantially. Stable, complementary DNA (cDNA) copies of the three ZIKV RNA genomes were cloned to examine the significance of viral and host genetic variations in directing ZIKV infection outcomes. Using …