Digital Commons Network^™

Mechanisms Of Induced Cell Death In Bluetongue Virus Challenged Human Cell Lines, Justin Darrel Hoopes

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Bluetongue virus (BTV) is a pathogenic member of the Reoviridae family. BTV does not cause disease in humans, but is capable of selectively infecting and killing certain transformed human cell lines. Understanding BTV's oncotrophism may lead to new therapeutics for treating cancer. This study focused on the underlying mechanisms of BTV-induced cell death in carcinoma cell lines. It was our hypothesis that BTV infects human carcinoma transformed cells, produces mRNA and protein, induces a strong inflammatory response, induces mitogen activated protein kinase (MAPK)-based pro-apoptotic signaling, inhibits PKB-based signaling, and eventually kills the cell by inducing apoptosis.

Three carcinoma cell lines …

The Correlation Between A Pre-Engineering Student's Spatial Ability And Achievement In An Electronics Fundamentals Course, Mark E. Smith

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Though there is ample evidence showing a positive relationship between a student's spatial ability and achievement in many fields of science, technology, and engineering, this study was seeking evidence that a relationship exists between a pre-engineering student's spatial ability and achievement in an electronics fundamentals course.

The importance of spatial ability to mentally design, develop, and manipulate images has been linked to measures of practical and mechanical abilities that are quite useful in technical occupations. Spatial abilities are frequently attributed to creative and higher order thinking skills in science and mathematics. Spatial imagery is tremendously important in art and creative …

Sonication Assisted Synthesis Of Oligomannosides, Christabel Tomla Tanifum

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Oligomannosides prevalently exist as cell surface antigens. They play important roles in diseases such as viral infection and cancer, and they have been shown to be useful as candidates for vaccines. HIV, one of the most devastating modern diseases, has a high content of mannose sugars on its envelope glycoprotein gp120. Oligomannosides of the HIV virus, also called Man9, which are found on the glycoprotein gp120, have been shown to play a protective role for the HIV virus, shielding highly conserved protein domains of gp120 from proteolytic attacks. Thus gp120 plays an important role in HIV infection of cells, being …

Assessing The Effects Of The Holidays On Body Composition And Weight Change Using Air Displacement Plethysmography, Jessyka Nicholle Larson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was conducted to determine the change in weight and body composition over a 6-week holiday period. Change in body composition was measured using air displacement plethysmography technology (Bod Pod^®). Thirteen men and 21 women ranging in age from 23-61 years were participants for this study. Baseline testing occurred the week of Thanksgiving Day (November 24 or 25), and the post-holiday assessment was the week after Utah State University's holiday break (January 5 or 6). Results from a nutrition and exercise questionnaire revealed a significant difference between pre-holiday and post-holiday consumption of vegetables (8.6 ± 8.3 vs. …

Taste Sensitivity To 6-N-Propylthiouracil (Prop) As A Biological Marker For Vulnerability To Stress In Mothers And Children, Deann Jones

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Some people are genetically more vulnerable to stress than others, leading them towards poorer outcomes following stressful events. Mothers' vulnerability to stress may, in turn, influence their children, leading their children towards poor outcomes as well. A biological marker of vulnerability to stress may indicate mothers who are at greater risk for experiencing parenting stress, depression, and less support of the infant's emotional development, and infants who are at greater risk for development of poor emotion regulation and behavior problems. Taste sensitivity to propylthiouracil (PROP) is proposed as a biological marker of stress vulnerability in mothers and children. This research …

New Beginnings: A Phenomenology Of The Lived Experiences Of Novice Secondary Teachers Who Have Completed The Induction And Mentorship Requirements Of Utah's Early Years Enhancement (Eye) Program, Philip D. Armstrong

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

It is estimated the national teacher shortage will be approximately two million by the year 2010. Thirty to 50% of new teachers leave the profession within the first 5 years. In an effort to improve teacher quality and retain teachers, many states and local school districts have instituted induction and mentoring programs. The state of Utah's Early Years Enhancement (EYE) induction and mentoring program went into effect January 1, 2003. This purpose of this study was to examine how secondary novice teachers experience the mentorship requirement of the EYE program. A phenomenological approach was used to illustrate the lived experience …

Development Of A Survey Measuring Visitor Satisfaction And Service Quality Of Cultural And Natural Sites In Belize, Dustin S. Wiberg

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The literature suggests that a correlation exists between visitor satisfaction and a visitor's choice to re-experience a product. The higher one's satisfaction level, the more likely he/she is to experience the product again and/or provide positive word-of-mouth advertising to friends and family. The Tian-Cole and Crompton model was chosen because of its acknowledgment and explanation of the differences between Visitor Satisfaction (VS) and Service Quality (SQ) and how their relationship influences satisfaction and contributes to Future Destination Selection.

In addition to identifying a theoretical framework that explains why visitors return, it was necessary to identify a survey methodology to be …

Nitrogen And Phosphorus Dynamics As Applied To Water Quality Under Management Intensive Grazing, Vaughn J. Thacker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Contamination of freshwater systems by nutrients has been studied extensively in the eastern U.S. Little research on the fate of nutrients in grazing conditions has been done in the western U.S. Western agriculture is often irrigated and research addressing the potential for leaching under these conditions is warranted. This study used Management Intensive Grazing (MIG) and eight grass-legume mixtures to evaluate the management and forage choice in relation to nitrogen and phosphorus leaching to ground water. Soil water samples were taken weekly through the growing season from 2001 through 2003. Water samples were analyzed for nitrate, ammonia, and phosphate. Soils …

Carbohydrate Derivatives In Antibiotics Research, Yi Liang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In this study, we investigated the potential applications of carbohydrates in the development of new antibiotics. To tackle the problem of multidrug-resistant variants of M. tuberculosis (MDR-TB), we investigated the biosynthesis pathways of trehalose, which has contributed to significant drug resistance. Some new methods were developed for the synthesis of potential inhibitors (6-azido-trehalose and 6,6'-diazido-trehalose) that have been designed to imitate the intermediate molecule (trehalose 6-phosphate, TPP) of OtsA-OtsB pathway. At the same time, some new antibacterial agents based on trehalose have been synthesized. Members of the 1,2,3-triazole family have shown interesting biological properties. Steroid derivatives have been developed in …

Gifted First Graders In A Multi-Ability Classroom: An Interpretive Case Study, Cari Buckner

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Young gifted students experience school in a variety of ways. They become bored in classrooms where they are not challenged. They can develop disruptive behaviors or underachieve in order to feel accepted by their classmates or teachers. Three gifted first graders in the teacher-researcher's classroom participated in this case study. A variety of assessment tools were used to identify the student participants. Data were collected through teacher observations, videotaped classroom activities, videotaped interviews with students, audiotaped interviews with parents, and portfolios.

Data are reported and discussed within the frame of five themes that emerged: high parent involvement, social relationships, characteristics …

Microbial Growth Inhibition And Decomposition Of Milk Mineral And Sodium Tripolyphosphate Added To Media Or Fresh Ground Beef, Rossarin Tansawat

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Milk mineral (MM) is a type II antioxidant (metal chelator) that can bind iron and prevent iron catalysis of lipid oxidation. Thus, MM might have microbial growth inhibition effects on iron-dependent bacteria. Objective 1 was to evaluate effects of MM on growth of non-pathogenic iron-dependent bacterial strains (Listeria innocua, Eschericia coli, Pseudomonas fluorescens). MM (1.5 % w/v) did not significantly inhibit growth of Listeria and E. coli. However, growth of Pseudomonas fluorescens was consistently and significantly reduced by ~1 log colony forming units per ml (CFU/ml) with all levels of MM (0.5, 0.75, 1.5 % …

Characterization Of The Substrate Specificity And Mechanism Of Protein Arginine Methyltransferase 1, Whitney Lyn Wooderchak

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Protein arginine methyltransferases (PRMTs) posttranslationally modify protein arginine residues. Type I PRMTs catalyze the formation of monomethylarginine (MMA) and asymmetric dimethylarginine (ADMA) via methyl group transfer from S-adenosyl methionine onto protein arginine residues. Type II PRMTs generate MMA and symmetric dimethylarginine. PRMT-methylation affects many biological processes. Although PRMTs are vital to normal development and function, PRMT-methylation is also linked to cardiovascular disease, stroke, multiple sclerosis, and cancer.

Thus far, nine human PRMT isoforms have been identified with orthologues present in yeast, plants, and fish. PRMT1 predominates, performing an estimated 85% of all protein arginine methylation in vivo. Yet, the substrate …

Grandparents As Adult Mentors On Reported Adolescent Risk-Taking Behaviors, Thane R. Goodrich

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Adolescent risk-taking behaviors, both negative and positive, continue to be a point of interest for researchers and of concern for society. Negative risk-taking behaviors threaten healthy adolescent development and may have deleterious effects on the remainder of the adolescent's life. Positive risk-taking behaviors promote healthy development and can aid in pro-social outcomes. Mentoring has been an established means of assisting adolescents through this sometimes difficult stage of life. Researchers have identified those elements which tend to make the greatest impact in mentoring programs. Among those known elements are adults who are found in "naturally" occurring settings. Teachers in schools, religious …

The Role Of Flavor-Flavor Conditioning And Sensory-Based, Vegetable-Themed Education In Increasing Vegetable Consumption In Elementary School-Aged Children, Meagan Roxanne Latimer

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study aimed to increase vegetable consumption and preference in elementary school-aged children using two interventions: 1) flavor-flavor conditioning; and 2) sensory-based, vegetable-themed education. In both interventions, increase in consumption was measured by visual observation of how many vegetables children took and consumed from a vegetable buffet. Preferences were measured with a self-administered survey.

In the flavor-flavor intervention, children ages 5 to 11 (n=59) were exposed to sweetened and nonsweetened vegetable purees. Preferences were assessed prior to intervention using a rating and ranking system. Nine paired tastings were presented. Children received a posttest immediately after the final conditioning (n=27) and …

Disordered: A Tale Of The Body, Elizabeth M. Benson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

While a body of creative nonfiction writing exists regarding experiences with various psychological disorders, few personal accounts have been written about the physical complications of Generalized Anxiety Disorder. Some memoirs tell a tale of serious illness in a straightforward narrative line. On the opposite end of this spectrum, other memoirs intentionally blur the lines of truth and heighten the confusion of a disorder. This thesis is as much a narrative of my experience with Generalized Anxiety Disorder as it is a response to the void in creative nonfiction surrounding this specific disorder and the narrative forms others have chosen to …

A Novel Role For Non-Heme Iron In Myoglobin Oxidation: An Examination Of The Antioxidant Effects Of Iron Chelating Compounds In Meat And Myoglobin Model Systems, Karin E. Allen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Myoglobin (Mb) oxidation, and the subsequent browning, is the primary basis for consumer rejection of fresh retail beef. Considerable effort has been directed by the industry towards the development of techniques that can enhance color stability. However, the underlying mechanism of Mb oxidation has been studied extensively, but is still not entirely understood. Current models focus on the role of lipid oxidation byproducts, pH, and anionic ligands as promoters of Mb oxidation. It is known that chelation of iron and copper delays Mb oxidation and browning, but a clear role for these metals has not been established in any current …

Design And Evaluation Of Oligonucleotide Microarrays For The Detection Of Bovine Pathogens, Ryan Weldon Black

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Two microarray designs were developed and produced to screen for multiple bovine pathogens commonly found in the cattle industry today. The first microarray was designed, built, and processed in-house using conventional material and equipment and targeted Pasteurella multocida, Manheimia haemolytica, Histophilus somni, and Arcanobacterium pyogenes. For each pathogen, 12 perfect-match oligonucleotide probes, which were also designed in-house, targeted different sections of the respective 16S ribosomal genes, and were coupled with 12 corresponding mismatched probes for background. These arrays were able to produce distinct hybridization patterns for each pathogen that were easily visible without the need for …

The Cult Of True Motherhood: A Narrative, Jacoba Lynne Mendelkow

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This thesis consists of five chapters including a traditional introduction and four chapters, which investigate cultural interpretations of motherhood within the genre of memoir and personal essay. In the introduction, I discuss my research as it relates to the larger collection and detail how this work is different from other works within the "mother memoir" genre. Chapters II thru V, then, are all essays which begin to explore the major themes of cultural motherhood: ambivalence, loss, legitimacy, morality, and sin. These chapters, especially chapter II, identify and detail the traits of true motherhood as patience, compassion, sacrifice, and strength.

Chapter …

Seasonal Outlook: An Examination Of How The Foundations Of Attachment To Community Differ Between Seasonal And Year-Round Residents In High Amenity Areas, Brain M. Jennings

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Utah is a popular second-home destination due to its unique landscapes that offer numerous natural amenities. Therefore, this research utilizes a mail survey of residents in six Utah counties to examine if seasonal residents become attached to their local communities in the same way as year-round residents. The objective of this research was two-fold: 1) to determine if the commonly cited dimensions of community attachment are an accurate representation of the concept itself; and 2) to determine if the foundations of community attachment, based on those conceptual dimensions, are different for year-round and seasonal homeowners.

Prior research has shown that …

An Assessment Of Utah Resident Incentives And Disincentives For Use Of Opencourseware (Ocw), Anne Arendt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation examines Utah resident views of incentives and disincentives for use of OpenCourseWare (OCW) and how they fit into the theoretical framework of perceived innovation attributes established by Rogers. Rogers identified five categories of perceived innovation attributes, which include relative advantage, compatibility, complexity, trialability, and observability.

A survey instrument was developed using attributes that emerged from a Delphi technique with input from experts in the OCW field. The survey instrument was sent to 753 (n = 753) random individuals between 18 and 64 years of age throughout Utah based on information obtained from Alseco Data Group, LLC.

Results …

Validation Of A Peer-Teaching-Peer Paraprofessional Model In Teen Parenting Nutrition Education, Sylvia D. Keller

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Each year, teen pregnancy occurs in 750,000 15-to-19 year-old women in the United States (U.S.). Utah has the youngest population and the lowest teen abortion rates in the U.S. Approximately 73% of teen pregnancies in Utah result in live births. The prevalence of teen pregnancy and the nutritional risk to mother and child result in a much greater need for social support, such as nutrition education. Current literature shows that the paraprofessional model is effective in increasing positive behavior change through nutrition education. Presently, there is a lack of evidence that paraprofessional teens are capable of accurately and effectively teaching …

Mycorrhizae In Sagebrush-Steppe Community Restoration: Mycorrhizal Dependency Of Invasive And Native Grasses With Intraspecific And Interspecific Competition, Dara S. Scherpenisse

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mycorrhizae have been used in restoration for decades. However, studies assessing the use of mycorrhizae in Bromus tectorum-invaded areas of the Great Basin are limited. Two greenhouse pot experiments were conducted to assess the role of mycorrhizae in sagebrush restoration.

The first objective (Chapter 2) was to determine the response of Pseudoroegneria spicatum, Elymus elymoides, and B. tectorum to mycorrhizal symbiosis by altering phosphorus, density, species, presence of mycorrhizae and water levels in a 5 factor design. To assess the mycorrhizal response, a variety of morphological and physiological traits were measured, such as tissue P concentration, specific …

The Effect Of Lipids On Recognition Thresholds And Intensity Ratings Of The Five Basic Tastes, Jennifer Ellen Thurgood

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In addition to the contribution of lipids to food texture and aroma, the effect of lipids on taste perception is now commonly studied. It has been found that lipids may affect taste perception through lipid composition (i.e., cis-polyunsaturated fatty acids).

This study assessed the effect of lipid composition on the recognition thresholds of the basic tastes (i.e., sour, umami, bitter, salty, sweet) in emulsion model systems as well as taste intensities perceived at low suprathreshold concentrations. Taste thresholds and intensities in corresponding aqueous systems were determined for comparison. To evaluate the effect of lipid chemical composition on tastant detection, …

Intuitive Eating And Its Relationship With Physical Activity Motivation, Amy Campbell Nielson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Research has shown that restrictive eating, or dieting, can be devastating to one's health. A new paradigm, intuitive eating, suggests that individuals eat based off of their physiological cues, and not for emotional or social ones. To date, restrictive eating has been extensively researched, but intuitive eating has not. The main purpose of this study was to examine the relationship between intuitive eating and its relationship between physical activity motivation and physical activity maintenance, using the self-determination theory.

Participants completed a survey to determine their intuitive eating level, their physical activity motivation, and their physical activity maintenance (n = …

A Case Study Of Learner Support Services In The Turkish Open Education System, Murat Ozoglu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study was to examine and identify support service needs and preferences of distance learners studying at the Turkish Open Education System (OES). In order to fulfill this purpose, views and perceptions of OES students on importance and accessibility of student support services at the OES were investigated through a mixed-method approach that uses both qualitative and quantitative data collection and analysis methods.

Data collection took place in three distinct phases. In the first phase, available learner support services were identified through review of the literature, investigation of institutional artifacts, and interviews with the institutional representatives. In …

An Epistemological Checkup: The Explication, Application, And Evolution Of An Integrated Theory Of Couples Therapy, Mckenzie Leigh Christensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

When clinicians practice therapy without a clear theoretical foundation, they lack direction and purpose. When training to be a marriage and family therapist, understanding and clarifying one's integrated theory and practice of therapy is essential. This mixed methods study was designed to elucidate and apply my theory of therapy in order to identify fidelity to my model as well as understand the effects it has on clients. This study also focused on how experiences in each session of therapy influenced the next session.

Three couples who presented for therapeutic services at the Utah State University Marriage and Family Therapy clinic …

"Real, Live Mormon Women": Understanding The Role Of Early Twentieth-Century Lds Lady Missionaries, Kelly Lelegren

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Missionary work has long been an important aspect of Christianity. At least as early as the 1870's, Protestant women began journeys to foreign lands to work as missionaries and teach people about Christianity, both the spiritual dimension and the lifestyle. These were primarily independent women who sought to enlarge the women's sphere from the confined, domestic life to which they were accustomed and because of its decline by the 1930's, historians have often labeled these missions as a "feminist movement."

Meanwhile, in 1898, their counterparts from The Church of Jesus Christ of Latter-day Saints also began filling missions, but with …

Punta Toro Virus Infection In Mice: Strain Differences In Pathogenesis And Regulation Of Interferon Response Pathways, Michelle Mendenhall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Adames strain of Punta Toro virus (PTV-A) causes acute hepatic disease in hamsters and mice similar to that seen in natural Rift Valley fever virus (RVFV) infection, while the Balliet strain (PTV-B) is apathogenic. The ability of PTV-A to suppress the interferon (IFN) response has been demonstrated in hamsters and is thought to be a contributing factor to PTV-A's pathogenicity in hamsters. PTV-B is not assumed to exhibit this IFN-antagonistic activity, as it stimulates production of significantly higher IFN-β levels. To elucidate the role of IFN in resistance of mice to PTV-B infection, we utilized mice deficient in a …

Empirically Examining Prostitution Through A Feminist Perspective, Shyann Child

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this thesis is to empirically explore prostitution through a feminist perspective. Several background factors are explored on a small sample of women in the northeastern United States. Some of these women have been involved in an act of prostitution in their lifetime; some have not. This research will add to the body of knowledge on prostitution, as well as highlight the unique experiences of women. The goal is to understand whether or not these life experiences have had a hand in women's choices to engage in prostitution.

Disparities In Birth Weight Between Non-Hispanic Blacks And Non-Hispanic Whites: The Effect Of Rural Residency, Theresa Marie Fedor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this study is to assess the prevalence of low birth weight among non-Hispanic Blacks and non-Hispanic Whites along the rural/urban continuum, as well as the combined effect of being both non-Hispanic Black and residing in a completely rural county. Degree of social isolation and lack of support are proposed mechanisms for explaining disparities in low birth weight for Blacks in rural counties.

Using data from the National Longitudinal Survey of Youth 1979 (NLSY79) and the National Longitudinal Survey of Youth 1979 Child (NLSY79-C) datasets, logistic regression models were used to estimate the odds of low birth weight. …