Digital Commons Network^™

Rna Therapeutics: Current Status And Future Directions, Barbara Yang, Melina J. Sedano, Karla Perez, Mahalakshmi Vijayaraghavan, Victoria Reid, Murali M. Yallapu Dr., Subhash Chauhan, Subramanian Dhandayuthapani, Enrique I. Ramos, Shrikanth S. Gadad

School of Medicine Publications

RNA-based therapeutics have enabled drug discovery and design by introducing a fundamentally different perspective from conventional therapeutics. RNAs are not only the upstream molecules of proteins (coding) but also functional components of an extensive and intricate regulatory network (noncoding) that helps govern biological processes and mechanisms. Recent advances in functional genomics have accelerated the identification of functional RNAs with well-defined roles and their use in diagnostic and therapeutic approaches, which was previously challenging. RNA molecules can dynamically regulate gene function through their sequence and/or structure. Thus, RNA therapeutics offer distinct strategies for both loss- and gain-of-function interventions. This review focuses …

The Rider (2026-09-21), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 5

Diabetes-Induced Organ Damage: Cellular Mechanisms And Therapeutic Opportunities, Mohammed S. Razzaque

School of Medicine Publications

No abstract provided.

Evaluation Of Spontaneous Pain In A Monosodium Iodoacetate-Induced Mouse Model Of Osteoarthritis Using The Mouse Grimace Scale, Mohammed Alnoud, Jose A. Rivera, Megan W. Szobody, Ayesha Usman, Alma Rodriguez, Thao-April Nguyen, Seryna Ayala, Massimo Salinas, Khalid Benamar

School of Medicine Publications

Animal models are critical for elucidating disease mechanisms and pathological outcomes, and for evaluating therapeutic interventions. Osteoarthritis (OA) is a leading cause of chronic pain and disability globally. Clinically, individuals with OA experience both sensory and ongoing pain. However, ongoing pain, as assessed by the Mouse Grimace Scale (MGS), has not yet been evaluated in animal models of OA. This study aims to address this significant knowledge gap. We induced OA by intra-articular injection of monosodium iodoacetate (MIA), while control mice received saline injections. We assessed pain behaviors using the MGS on days 1, 3, 7, and 14 after MIA …

Studying Peripheral Neuropathy And Associated Neuropathic Pain In Hiv-1 Transgenic Rats: Evaluation Of The Therapeutic Effect Of Cannabidiol And Beta-Caryophyllene, Mohammed Alnoud, Jose Rios, Salique Hassan Shaham, Manish K. Tripathi, Khalid Benamar

School of Medicine Publications

Background/Objectives: Peripheral neuropathy affects up to 50% of people living with HIV (PLWH). Currently, no small translational rodent model accurately replicates the peripheral neuropathy observed in PLWH. The primary objectives of this study are to assess whether HIV transgenic (HIV-tg) rats develop peripheral neuropathy with pathological and pain-like behaviors similar to those observed in PLWH and to evaluate the analgesic effects of the non-psychoactive cannabis compounds cannabidiol (CBD) and β-caryophyllene (BCP) in HIV-related neuropathic pain. Methods: We used a comprehensive set of behavioral, pharmacological, molecular, biochemical, and proteomic approaches. Results: Tissue analyses showed that HIV-tg rats had significantly reduced intra-epidermal …

White Shark Occurrence In Flower Garden Banks National Marine Sanctuary Revealed From Acoustic Telemetry In An Offshore Mpa, Michael A. Dance, Jay R. Rooker, R. J. David Wells, Megan V. Winton, Landes L. Randall, Marissa F. Nuttall, Brondum M. Krebs, Creed C. Branham, Brett B. Sweezey, Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

The outer continental shelf of the Gulf of Mexico (Gulf) is characterized by unique bathymetric features that provide critical habitat for marine fauna. Here, we demonstrate the utility of large-scale acoustic telemetry for monitoring an oceanic marine protected area (MPA) and document the first known occurrences of white sharks (Carcharodon carcharias) within Flower Garden Banks National Marine Sanctuary (FGBNMS). White sharks were tagged with acoustic transmitters in the western North Atlantic Ocean off the east coast of the United States and Canada. Nine white sharks were detected along the outer shelf ecosystem associated with FGBNMS over a three-year …

Automated And Quantitative Characterization Of Benthic Habitat And Associated Biological Communities Of An Unknown Southeast Pacific Seamount, Yakufu Niyazi, Denise J. B. Swanborn, Jan M. Tapia-Guerra, Javier Sellanes, Erin E. Easton, Germán Zapata-Hernández, Heather A. Stewart, Alan J. Jamieson

School of Earth, Environmental, & Marine Sciences Faculty Publications

Seamounts are prominent seafloor features that strongly influence geological processes, ocean circulation, and benthic biodiversity. Despite their importance, most seamounts remain unmapped and poorly characterized, particularly in the southeast Pacific Ocean, a region recognized for high marine endemism and ecological isolation. In this study, we present a quantitative habitat characterization of a previously undocumented seamount, informally named Solito Seamount, located between the Nazca–Desventuradas Marine Park and the Juan Fernández Archipelago, within Chile’s Exclusive Economic Zone. The seamount is a conical volcanic edifice approximately 37 km wide, rising >3,500 m above the surrounding abyssal plain. High-resolution multibeam bathymetry and backscatter intensity …

The Rider (2026-09-14), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 4

Antigen 85b Of Mycobacterium Tuberculosis: From Immunodominant Antigen To Vaccine Candidate, Vivek Chauhan, Gaytri Mahajan, Rakesh Kumar, Shrikanth S. Gadad, Subhash Chauhan, Chinnaswamy Jagannath, Subramanian Dhandayuthapani

School of Medicine Publications

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to pose a significant global health challenge despite the existence of effective treatments. The only licensed TB vaccine, Bacillus Calmette–Guérin (BCG), offers inconsistent and generally limited protection against adult pulmonary TB. As a result, the pursuit of more effective TB vaccines has intensified over the past two decades, prompting the evaluation of several immunodominant Mtb antigens as vaccines. Among these, antigen 85B (Ag85B) has emerged as a promising candidate due to its critical roles in mycobacterial cell wall biosynthesis, host cell adhesion, and the induction of immune responses. Ag85B has been incorporated …

Discovery Of Ro 41-0960, A Non-Steroidal Inhibitor Of The Na+/K+-Atpase, Carlos Cruz-Cortés, Jaroslava Šeflová, Guadalupe Guerrero-Serna, Eric N. Jimenez-Vazquez

Health & Biomedical Sciences Faculty Publications

The Na⁺/K⁺-ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure. Yet, cardiotonic steroids used in clinical practice are limited by a narrow therapeutic window and pro-arrhythmic effects. Here, we identify Ro 41-0960 as a non-steroidal inhibitor of NKA with a distinct mechanistic profile. The compound inhibits NKA activity with IC50 values of 17.9 ± 1.1 µM for purified enzyme and https://doi.org/10.3 ± 1.1 µM in microsomal preparations. ATP-dependent activity measurements revealed a non-monotonic response in which inhibition was most pronounced at ATP concentrations below 4 mM and diminished …

A New Bubblegum Coral From The Nazca Ridge Reveals Chitin As The Structural Scaffold Of Skeleton-Less Paragorgia Colonies, Juan Armando Sánchez, Erin E. Easton, Nayeli Elizavet Garcia, Yony Román-Ochoa, Julia Kaled Cáceres, Javier Sellanes

School of Earth, Environmental, & Marine Sciences Faculty Publications

Bubblegum corals (Paragorgia; Corallidae) form among the largest branching colonies in deep-sea environments despite lacking an axial skeleton. How these octocorals maintain structural cohesion using only sub-millimeter sclerites has remained unexplained. Here we describe Paragorgia quitinosa Sánchez & Easton n. sp., collected at 670 m depth on the Nazca Ridge (southeastern Pacific) during the Schmidt Ocean Institute RV Falkor (too) expedition FKt240708, and report the first evidence of visible chitin in octocoral tissues. The new species is diagnosed by autozoids and siphonozoids retracted on prominent, rounded mounds, large 8-derived radiate capstan sclerites (mean 0.095 mm), and canal walls …

The Rider (2026-09-08), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 3

Stress Conditioning Modulates Phenolic Antimicrobial Responses In Salmonella Typhimurium And Listeria Innocua, Titus Puorizaa, Veerachandra K. Yemmireddy

School of Integrative Biological & Chemical Sciences Faculty Publications

Environmental stress adaptation can alter bacterial responses to antimicrobial interventions used in food processing and preservation. This study evaluated how prior acid, osmotic, and cold conditioning affected the susceptibility and growth behavior of Salmonella enterica serovar Typhimurium and Listeria innocua during exposure to carvacrol and thymol. Cells were conditioned in acidic tryptic soy broth (TSB, pH 5.5), osmotic (TSB supplemented with 2.5% NaCl), or low temperature (4°C) before antimicrobial treatment. Susceptibility was assessed using modified broth microdilution and minimum bactericidal concentration assays, while recovery was evaluated using 24 h optical-density growth curves and primary growth modeling. Stress conditioning produced modest, …

Variability In Nutrient And Carbon Cycling Of Constructed Marshes, Alyssa Leclaire, Jenny Davis, Molly Bost, David De La Garza

School of Earth, Environmental, & Marine Sciences Faculty Publications

Salt marshes provide valuable ecosystem services, including filtering nutrients and trapping sediments from the water column, but are increasingly threatened by sea-level rise and coastal development. Constructed marshes offer a potential pathway to offsetting marsh loss, but the extent to which they can replace the ecosystem services provided by mature natural marshes is not well understood. Using a chronosequence of constructed marshes (1, 21, and 44 years old) and a natural reference marsh (>100y old) in Beaufort, NC, we assessed the development of plant communities, sediment characteristics, and nutrient and carbon cycling over time. We compared aboveground biomass, surface …

A Cell-Type-Resolved Meta-Analysis Reveals Glial Dna Methylation Changes Associated With Aging And Alzheimer's Disease, Uchit Bhaskar, Mark Z. Kos, Melanie A. Carless

Human Genetics Publications

INTRODUCTION: Epigenome-wide association studies implicate DNA methylation in Alzheimer's disease (AD) pathology. Although recent studies identified epigenetic signatures within non-neuronal cell types in disease risk, the role of the methylome in glial cell types (i.e., astrocytes, oligodendrocytes) in biological aging and AD pathogenesis is unclear.

METHODS: In this study, we examined archived DNA methylation data across 13 cohorts and performed cell type deconvolution in silico to identify novel epigenetic signatures associated with aging and AD in glial cells.

RESULTS: We observed pronounced age-associated methylation signatures in astrocytes within the prefrontal cortex (PFC) and AD-associated methylation signatures in oligodendrocytes of the …

Genomic Investigation Of Population Structure In A Secretive, Semi‐Fossorial Snake (Colubridae: Tropidoclonion Lineatum) Across The Great Plains, Taylor Probst, Cameron D. Siler, Drew R. Davis

School of Integrative Biological & Chemical Sciences Faculty Publications

With advances in genomic technologies, it has become increasingly feasible to generate large numbers of loci to address population genetic and phylogeographic questions. Nevertheless, many widespread and relatively abundant species remain unsampled using molecular approaches. The lined snake ( Tropidoclonion lineatum ), a semi‐fossorial snake distributed across the Great Plains, is one such example. Despite the historical recognition of multiple subspecies based on noted variation in morphological characters, no formal molecular investigation of population structure has been conducted to date due to a paucity of vouchered genetic samples. Here, we present the first genomic assessment of range‐wide population structure in …

Noncoding Rna Transcripts Based Molecular Phenotyping Of Masld And Mash Patients, Frida M. Delgadillo, Karla Perez, Barbara Yang, Subramanian Dhandayuthapani, Murali Yallapu, Subhash C. Chauhan, Enrique I. Ramos, Shrikanth S. Gadad

School of Medicine Publications

Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive hepatic metabolic disorder characterized by excessive fat accumulation in hepatocytes. MASLD can advance to metabolic dysfunction-associated steatohepatitis (MASH). These conditions often lead to hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC) if not timely diagnosed and managed; thus, molecular phenotyping of MASLD and MASH conditions is highly desirable. The analyses were performed to identify distinct, differentially expressed genes, particularly noncoding ones, in MASLD and MASH patient samples, thereby expanding diagnostic and therapeutic options.

Methods: We extracted the data from a recent transcriptomic study by Govaere et al. on MASLD …

Sedentary Behaviors And Functional Disability Among Chinese Older Adults (2008–2018): Evidence Including Mahjong, Yen-Han Lee, Yen-Chang Chang, Minzhi Ye, Cai Xu

School of Social Work Faculty Publications

Purpose: This study examined how different types of sedentary behavior relate to changes in functional disability, measured by activities of daily living (ADL) and instrumental activities of daily living (IADL), among Chinese older adults.

Major findings: Using data from 17,939 participants in four waves (2008–2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), sedentary behavior was categorized into four types: none, playing mahjong only, combining these with other sedentary activities, and other activities alone (e.g., reading and watching TV). Cox two-state regression models estimated the hazard of transitioning in ADL and IADL disability. Engaging in sedentary behaviors was generally …

Longitudinal Association Between Midlife Cardiovascular Health And Cognitive Change In A Bi-Ethnic Cohort, Janette Vazquez, Rebecca Bernal, Luis Aguirre, Jesus D. Melgarejo, Gladys Maestre, Sudha Seshadri, Helen P. Hazuda, Chen-Pin Wang, Claudia Satizabal

School of Medicine Publications

Introduction: Midlife cardiovascular burden contributes to cognitive decline and dementia. However, research in diverse populations remains scarce.

Methods: We included 402 San Antonio Heart Study participants (1979–1988; midlife mean age 57.9 ± 3.8, 58.5% women, 52% Mexican American) later enrolled in the San Antonio Longitudinal Study of Aging (1992–2004). Midlife cardiovascular health was assessed using Life's Simple 7. Cognition was measured up to four times with the Mini-Mental State Examination. Generalized estimating equation models adjusted for age, sex, income, and education were used to relate cardiovascular factors to cognitive change. Sensitivity analyses evaluated attrition bias.

Results: Physical activity was associated …

Vascular Burden Attenuates The Tdp-43-Tmem106b Pathological Relationship In Neurodegenerative Disease With And Without Alzheimer Disease Neuropathological Change, Matthew B. Dopler, Cole Corbett, Angelique D. Gonzalez, Ali Ghaseminejad-Bandpey, Mallory Keating, Kyra M. Clarke, Oluwaseun B. Ogunbona, Gladys Maestre, Sudha Seshadri, Shahroo Etemadmoghadam, Margaret E. Flanagan

School of Medicine Publications

TMEM106B, a lysosomal transmembrane protein, is a risk factor for neurodegenerative diseases, including Alzheimer disease (ad) and TDP-43 proteinopathies. TMEM106B pathology occurs in normal aging and is increased in TDP-43 proteinopathy but its role in dementia remains unclear. Cerebrovascular disease (CVD) is a driver and co-pathology of dementia, yet its contribution to TMEM106B accumulation in the context of TDP-43 and ad neuropathological changes (ADNC) has not been explored. We analyzed post-mortem human hippocampal sections spanning not-, low-, intermediate-, and high-ADNC. In secondary analyses, cases ≥65 years were stratified by TDP-43 immunopositivity and CVD severity; cases < 65 years were included to contextualize age-associated effects. TMEM106B immunoreactivity was quantified using digital pathology. Linear regression models demonstrated that age and sex (higher in females) were independent predictors of TMEM106B immunopositivity whereas Braak stage, CERAD-NP score, and Thal phase were not. The positive TDP-43-TMEM106B association was attenuated with increased CVD pathology severity, suggesting that vascular burden modifies this relationship. Sensitivity analyses restricted to LATE-NC attenuated several associations, indicating that pooled TDP-43 findings should be interpreted cautiously given possible disease heterogeneity. TMEM106B immunoreactivity was most strongly associated with age and sex, while vascular burden, rather than ADNC level, modified its relationship with TDP-43 proteinopathy.

Transcriptomic Architecture Of Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld) Risk In Mexican Americans, Satish Kumar, Miriam Aceves, Lorena Guerra, Jose C. Granados, Earl Novilla, Felicia Juarez, Tolulope Oluwadairo, Ana C. Leandro, Marcelo Leandro, Juan M. Peralta, Sarah Williams-Blangero, John Blangero, Joanne E. Curran

Human Genetics Publications

Hispanics of Mexican American descent in South Texas show a very high prevalence of MASLD, with some studies reporting rates as high as 50% in adults. However, assessment of genetic risk factors underlying this prevalence is complicated by a high co-occurrence of other metabolic disorders and variable endogenous and exogenous environmental risk factors. To map the transcriptomic architecture of MASLD hepatic steatosis risk, we conducted an epidemiological-scale investigation using human induced pluripotent stem cell (iPSC)-derived hepatocyte cultures from 193 participants in our longitudinal South Texas Family Study (STFS). iPSC-based models offer greater power to map genetic risk factors by experimentally …

Bridging The Lab-To-Clinic Gap In Intranasal Nanomaterial-Based Chemotherapy For Glioblastoma, Sophia Leslie, Stella Rios, Hana Elnahas, Megan E. Keniry

School of Integrative Biological & Chemical Sciences Faculty Publications

Clinical outcomes for brain cancer are often poor because the blood–brain/tumor barrier hinders effective drug delivery to malignant tissue. Glioblastoma, the most common primary brain malignancy in adults, has an average survival of approximately fourteen months. Here, we discuss novel strategies that our research group and others are developing to deliver chemotherapy to the brain via the nasal cavity. Although significant hurdles remain, intranasal delivery holds substantial promise for improving outcomes for patients with brain cancer. Intranasal delivery is noninvasive, permits repeated dosing, and has been shown to enable direct nose-to-brain transport that bypasses the blood–brain barrier. Challenges such as …

The Rider (2026-08-26), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 1

Studying What Matters: South Texas Community-Driven Dementia Research Priorities, Sara S. Masoud, Juana Escareño, Belinda Flores, Byeong Yeob Choi, Karla Daniela Lopez Lorenzo, Shanae L. Rhodes, Quetzaly Zenil, Carole L. White

School of Medicine Publications

South Texas has among the highest dementia prevalence rates in the United States, yet communities in the region remain consistently underrepresented in dementia research. Aligning research studies with what matters to communities most impacted by dementia is critical in addressing the crisis of research exclusion. This participatory study sought to identify community-driven dementia research priorities grounded in the experiences and needs of South Texas residents impacted by dementia. A two-year community-engaged study was conducted in partnership with a Community Council composed of individuals living with dementia, family caregivers, community health workers, and community-serving professionals. A plática program model was co-developed …

Interpretable Multimodal Learning For Integrating Neuroimaging And Genetic Data In Alzheimer’S Disease, Kun Zhao, Siyuan Dai, Yingying Zhang, Guodong Liu, Pengfei Gu, Chenghua Lin, Paul M. Thompson, Alex D. Leow, Heng Huang, Haoteng Tang

Computer Science Faculty Publications

Introduction: Early detection of Alzheimer's disease (AD) requires models that combine brain structure changes with genetic risk, but existing methods struggle to align these different data types.

Methods: We present R-GenIMA, an interpretable multimodal large language model that pairs a region-of-interest vision transformer with genetic prompting to jointly analyze structural MRI and single nucleotide polymorphisms (SNPs). Each brain region becomes a visual token and SNP profiles are encoded as structured text, letting the model link regional atrophy to genetic factors through cross-modal attention. Tested on the ADNI cohort, R-GenIMA performs well in classifying four groups: normal cognition, subjective memory concerns, …

South Texas Is Home To High Diversity Of Cytochrome Oxidase I Haplotypes Compared To Other Invasive Populations Of Aedes Aegypti, Rachel C. Malampy, Mariana Aguilar, Erin L. Schuenzel, Christopher J. Vitek

School of Integrative Biological & Chemical Sciences Faculty Publications

Simple Summary: The mosquito Aedes aegypti is capable of spreading a wide range of diseases that adversely affect human health. As the mosquito populations expand to new locations and increase in population, the risk to human health increases. To understand how the mosquito is spreading and the genetic composition of the current mosquito population in South Texas, partial DNA sequencing of the cytochrome oxidase I gene was completed for over 100 individuals. The large number of individuals sampled from a small geographic area resulted in new, unique sequences. These new sequences indicate the potential for new responses to pesticides and …

Feasibility And Patient-Reported Outcomes Of Full-Body Red And Near-Infrared Photobiomodulation For Musculoskeletal Pain In A Predominantly Hispanic/Latino Population: A Single-Arm Pilot Study, Robson Dias Scoz, Frida Garza, Ivana Burberg, Isabella Moreno, Melissa Espinosa Cantu, Mia Dominguez, Juan Gonzalez

Physical Therapy Faculty Publications

Objective: To characterize feasibility, tolerability, and patient-reported outcomes after a 10-session full-body red and near-infrared photobiomodulation (PBM) protocol for musculoskeletal pain in a predominantly Hispanic/ Latino community sample.

Background: PBM is a non-pharmacological intervention with potential analgesic and anti-inflammatory effects. Evidence from community-based and Hispanic/Latino populations remains limited, and full-body LED protocols are incompletely standardized.

Methods: This single-arm observational pilot study included 40 adults with self-reported acute or chronic musculoskeletal pain. Participants completed baseline and post-protocol Qualtrics surveys. The intervention used a full-body LED panel emitting 630, 660, 830, and 850 nm light in continuous-wave mode for 20 min per …

A Stochastic Nonlinear Dynamical System For Smoothing Noisy Eye Gaze Data, Thoa Thieu, Roderick Melnik

School of Mathematical & Statistical Sciences Faculty Publications

In this study, we address the challenges associated with accurately determining gaze location on a screen, which is often compromised by noise from factors such as eye tracker limitations, calibration drift, ambient lighting changes, and eye blinks. We propose the use of an extended Kalman filter (EKF) to smooth the gaze data collected during eye-tracking experiments and systematically explore the interaction of different system parameters. Our results demonstrate that the EKF significantly reduces noise, leading to a marked improvement in tracking accuracy. Furthermore, we show that our proposed stochastic nonlinear dynamical model aligns well with real experimental data and holds …

Land-Use Transitions And Carbon Emissions Of Aquaculture Expansion In The Brazilian Amazon, Felipe S. Pacheco, Sebastian A. Heilpern, Rafael M. Almeida, Suresh A. Sethi, Marcela Miranda, Nicholas Ray, Laura Greenstreet, Joshua Fan, Brendan H. Rappazzo, Marcelo Gomes Da Silva

School of Earth, Environmental, & Marine Sciences Faculty Publications

Accounting for land-use change underlying food sector expansion is critical for conserving ecosystem integrity. This challenge is particularly acute in the Amazon, where the conversion of forests for food production is pronounced and has broad implications for global biodiversity and the cycling of water and carbon. Here, we analyze land-use transitions associated with aquaculture development in the Brazilian Amazon. We found that a 450-fold increase in aquaculture pond area from 1985 to 2022 occurred primarily on pasturelands (87%) but also included wetland conversion (4%) and deforestation (5%). Notably, continued growth can be sustained within already altered landscapes: In Rondônia, the …

Frailty As A Framework To Understand Tuberculosis Severity, Recovery, And Sequelae, Yoscelina Estrella Martinez-Lopez, Benjamin W. Black, Jessica Lee, Brian J. Buta, Lisa Y. Armitige, William A. Fountain, Rafael Samper, Aanand D. Naik, Joanne Turner, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis (TB) causes profound systemic illness, and many survivors experience long-term sequelae associated with disability and premature mortality. Current TB severity indicators capture isolated aspects of disease and may not reflect the integrated physiological impact of infection on the host. Frailty, a multidimensional syndrome characterized by reduced physiological reserve and increased vulnerability to stressors, predicts adverse outcomes and guides clinical management in geriatrics. We propose frailty as an integrative framework for understanding the systemic effects of TB across the life course, encompassing disease severity, recovery, and long-term sequelae. We discuss biological mechanisms through which Mycobacterium tuberculosis infection may erode physiological …