Digital Commons Network^™

Alteration Of The Interferon Alpha Signaling Pathway Significantly Affects Alzheimer's Disease Pathology In App/Ps1 Mouse Model., Ranjit Kumar Das, Nirakar Sahoo, Chun Xu, Hansapani Rodrigo, Michael Paul Murphy, Upal Roy, Deepa Roy

Research Symposium

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 …

Adsorption Of Crystal Violet Dye From Synthetic Wastewater By Ball-Milled Royal Palm Leaf Sheath, Neloy Sen, Nawrin Rahman Shefa, Kismot Reza, Sk Md Ali Zaker Shawon, Md. Wasikur Rahman

Physics & Astronomy Faculty Publications

The current study shows that using a batch approach to remove crystal violet dye from synthetic wastewater is feasible when using royal palm leaf sheath powder as an adsorbent. In order to investigate the effects of many parameters, including starting concentration, pH effect, dye concentration, adsorbent dose, contact time, and temperature, experiments were carried out under various operating conditions. Maximum removal was obtained at pH 6 and at a concentration of 100 ppm, which are considered as ideal values. The influence of pH and dye concentration was shown to be substantial. Langmuir, Freundlich, and Temkin isotherm models were fitted to …

Gene Expression Networks Regulated By Human Personality, Coral Del Val, Elisa Díaz De La Guardia-Bolívar, Igor Zwir, Pashupati Mishra, Alberto Mesa, Ramiro Salas, Guillermo F. Poblete, Gabriel A. De Erausquin, Emma Raitoharju, Mika Kähönen

School of Medicine Publications

Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of expression and function in genes related to human personality. We devised an innovative multi-omic approach to network analysis to identify the key control elements and interactions in multi-modular networks. We identified sets of transcribed genes that were co-expressed in specific brain regions with genes known to be associated with personality. Then we identified the minimum networks for the co-localized genes using bioinformatic …

Applications Of Information Literacy To Teaching Independent Music Analysis, Katrina Roush

School of Music Faculty Publications

Undergraduate and graduate music students learn many tools beneficial for music analysis, and they practice applying these tools to music in their music theory classes. However, they often struggle to perform useful analysis on their own without the guidance of an instructor. They can have trouble understanding that analysis should communicate their personal interpretation of a work, and they may not realize that independent analysis usually requires some preparatory work (analytical research),such as discovering if others have analyzed the work and learning new analytical methods. This article shows that there is a strong connection between various steps in the music-analytical …

Exploitation Of Environmental Dna (Edna) For Ecotoxicological Research: A Critical Review On Edna Metabarcoding In Assessing Marine Pollution, Sakib Tahmid Rishan, Richard Kline, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Highlights

• eDNA describes the genetic material of organisms present in aquatic environments.

• eDNA metabarcoding characterizes DNA of various marine species from a single sample.

• eDNA has enormous promise for ecotoxicological research in marine environments.

Abstract

The rise in worldwide population has led to a noticeable spike in the production, consumption, and transportation of energy and food, contributing to elevated environmental pollution. Marine pollution is a significant global environmental issue with ongoing challenges, including plastic waste, oil spills, chemical pollutants, and nutrient runoff, threatening marine ecosystems, biodiversity, and human health. Pollution detection and assessment are crucial to understanding the state of …

Powerful Radio Sources In The Southern Sky. Iii. First Results Of The Optical Spectroscopic Campaign, A. García-Pérez, H. A. Peña-Herazo, A. Jimenez-Gallardo, V. Chavushyan, F. Massaro, S. V. White, A. Capetti, B. Balmaverde, W. R. Forman, Juan P. Madrid

Physics & Astronomy Faculty Publications

We recently built the G4Jy-3CRE catalog of extragalactic radio sources. This catalog lists 264 powerful radio sources selected with similar criteria to those of the revised Third Cambridge Catalog, but visible from the Southern Hemisphere. A literature search revealed that 119 sources in the G4Jy-3CRE catalog (i.e., 45%) lack a firm spectroscopic redshift measurement. Here, we present a campaign aimed at acquiring optical spectra of G4Jy-3CRE sources and measuring their redshifts. We used single-slit observations obtained with the Víctor Blanco Telescope, the New Technology Telescope, the Southern Astrophysical Research Telescope, and the 2.1 m telescope of the Observatorio Astronómico Nacional …

Comment On “Spectral Shifts In General Relativity,” [Am. J. Phys. 62(10), 903–907 (1994)], Joseph D. Romano, Teviet Creighton

Physics & Astronomy Faculty Publications

No abstract provided.

Nontrivial Invariant Subspaces Of Linear Operator Pencils, Jaewoong Kim, Jasang Yoon

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we introduce the spherical polar decomposition of the linear pencil of an ordered pair T=(T1,T2) and investigate nontrivial invariant subspaces between the generalized spherical Aluthge transform of the linear pencil of T and the linear pencil of the original pair T of bounded operators with dense ranges.

Community-Engaged Pedagogy For Equitable Hsi Teacher Preparation: Bridging Community, School, And University Cultures, Pauli Badenhorst, Sandra I. Musanti, Veronica L. Estrada, Patricia Robles, Amy Montoya

Teaching and Learning Faculty Publications

Drawing on interview data collected as part of a qualitative study among thirty-two local educators and community advocates in the borderlands context of the Lower Rio Grande Valley (RGV), we inquire about the fundamental characteristics of being a community-engaged teacher for sustainable and equitable Latinx student teaching and learning. The ultimate purpose is to collectively develop a model of community-engaged pedagogy that will bridge school and university cultures. Based on our findings, a community-engaged teacher preparation approach should prioritize that teacher candidates can establish rapport and relationship with students and their families; grapple with the contradictions entrenched in a prevalent …

Single Domain Soft Ferromagnetic Ferrofluid Suitable For Intratumoural Magnetic Hyperthermia, Karthickraja Duraisamy, Muthu Devaraj, Ajithkumar Gangadharan, Karen S. Martirosyan, Niroj Kumar Sahu, Prasath Manogaran, Girija Easwaradas Kreedapathy

Physics & Astronomy Faculty Publications

Magnetic hyperthermia is an effective modality for treating cancerous cells selectively at the intracellular level via proper administration, surface tagging and appropriate choice of magnetic nanoparticle. Also, achieving the therapeutic temperature with as much low concentration of nanoparticles, as possible, is desirable. Recently, ferromagnetic nanoparticles or ferrofluid are gaining attention as effective magnetic hyperthermia agents due to their enhanced heating potential under in vivo conditions. In the present work, we have fabricated citrate capped cobalt ferrite ferrofluid via a simple two-step process and investigated the physicochemical, magnetic and induction heating performance. The average size of the synthesized nanoparticle …

Extensions Of Polynomial Plank Covering Theorems, Alexey Glazyrin, Roman Karasev, Alexandr Polyanskii

School of Mathematical & Statistical Sciences Faculty Publications

We prove the complex polynomial plank covering theorem for not necessarily homogeneous polynomials. As the consequence of this result, we extend the complex plank theorem of Ball to the case of planks that are not necessarily centrally symmetric and not necessarily round. We also prove a weaker version of the spherical polynomial plank covering conjecture for planks of different widths.

Possible Role Of Correlation Coefficients And Network Analysis Of Multiple Intracellular Proteins In Blood Cells Of Patients With Bipolar Disorder In Studying The Mechanism Of Lithium Responsiveness: A Proof-Concept Study, Keming Gao, Marzieh Ayati, Nicholas M. Kaye, Mehmet Koyutürk, Joseph R. Calabrese, Eric Christian, Hillard M. Lazarus, David Kaplan

Computer Science Faculty Publications

Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD) remains unclear. The aim of this study was to explore the utility of correlation coefficients and protein-to-protein interaction (PPI) network analyses of intracellular proteins in monocytes and CD4+ lymphocytes of patients with BD in studying the potential mechanism of lithium treatment responsiveness. Methods: Patients with bipolar I or II disorder who were diagnosed with the MINI for DSM-5 and at any phase of the illness with at least mild symptom severity and received lithium (serum level ≥ 0.6 mEq/L) for 16 weeks were divided into two groups, responders (≥50% …

Improving Inpatient Hyperglycaemia In Non-Critically Ill Adults In Resident Wards Through Audit And Feedback, Chelsea H. Chang, Alcibiades Fleires, Alfarooq Alshaikhli, Hector Arredondo, Diana Gavilanes, Francisco J. Cabral-Amador, Jonathon Cantu, Daniela Bazan, Kathryn Oliveira Oliveira, Rene Verduzco, Lina Pedraza Sanchez

School of Medicine Publications

Inpatient hyperglycaemia is associated with an increase in morbidity and mortality, number of rehospitalisations and length of hospitalisation. Although the advantages of proper glycaemic control in hospitalised patients with diabetes are well established, a variety of barriers limit accomplishment of blood glucose targets. Our primary aim was to decrease the number of glucose values above 180 mg/dL in non-critical care hospitalised patients using an audit and feedback intervention with pharmacy and internal medicine residents. A resident-led multidisciplinary team implemented the quality improvement (QI) project including conception, literature review, educating residents, iterative development of audit and feedback tools and data analysis. …

Strongly Magnetized Accretion In Two Ultracompact Binary Systems, Thomas J. Maccarone, Thomas Kupfer, Edgar Najera Casarrubias, Liliana E. Rivera Sandoval, Aarran W. Shaw, Christoper T. Britt, Jan Van Roestel, David R. Zurek

Physics & Astronomy Faculty Publications

We present the discoveries of two of AM CVn systems, Gaia14aae and SDSS J080449.49+161624.8, which show X-ray pulsations at their orbital periods, indicative of magnetically collimated accretion. Both also show indications of higher rates of mass transfer relative to the expectations from binary evolution driven purely by gravitational radiation, based on existing optical data for Gaia14aae, which show a hotter white dwarf temperature than expected from standard evolutionary models, and X-ray data for SDSS J080449.49+161624.8 which show a luminosity 10−100 times higher than those for other AM CVn at similar orbital periods. The higher mass transfer rates could be driven …

An Independent Analysis Of A Retrospective Cohort Of 30,423 Covid-19 Patients Treated At Ihu-Mediterranean In Marseille, France: Part 1, Efficacy Of Early Treatment With Hydroxychloroquine And Azithromycin, Valere Lounnas, Eleftherios Gkioulekas, Marc Rendell, Alexis Lacout, Xavier Azalbert, Christian Perronne

School of Mathematical & Statistical Sciences Faculty Publications

A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple of months (56 days) from admission. Within limitations of the data and of the models, after adjustment for sampling biases, multivariate logistic regression analyses were performed to determine unadjusted and adjusted odds ratios (ORs) for the subset of patients having received the combined treatment hydroxychloroquine plus azithromycin (HCQ-AZ) …

An Independent Analysis Of A Retrospective Cohort Of 30,423 Covid-19 Patients Treated At Ihu-Mediterranean In Marseille, France: Part 2, A Real-Life Assessment Of Covid-19 Vaccination Efficacy, Valere Lounnas, Eleftherios Gkioulekas, Marc Rendell, Alexis Lacout, Xavier Azalbert, Christian Perronne

School of Mathematical & Statistical Sciences Faculty Publications

A cohort of 30,423 Covid-19 patients treated between March 2020 and December 2021 at the IHU-Méditerranée Infection in Marseille (France) was retrospectively analyzed in terms of treatment attempted and disease worsening factors to quantify vaccination efficacy with respect to the composite endpoint of transfer to intensive care unit or death, within a couple of months (56 days) from admission. Within limitations of the data and of the models, after adequate adjustment for sampling biases, multivariate logistic regression analyses were performed to determine unadjusted and adjusted odds ratios (ORs) for the subset of patients admitted after the Covid-19 vaccination program was …

Family-Centered Theory Of Change: A Conceptual Framework For Improving Teaching And Learning In Undergraduate Stem Courses, Juan Salinas, Parwinder Grewal, Jose J. Gutierrez, Nicolas A. Pereyra, Dagoberto Ramirez, Elizabeth Salinas, Griselda Salinas, Virginia Santanas, Can Saygin

School of Integrative Biological & Chemical Sciences Faculty Publications

Hispanic-Serving Institutions (HSIs) are often characterized as Hispanic enrolling (rather than serving) that practice deficit-based systems that continue to marginalize Latinx and other underrepresented students, especially in STEM fields. Extant research on HSIs stresses the importance of investigating the value of grassroots advocacy groups as external influencers of institutional servingness through deeper engagement with the Latinx community. Using a novel family-centered theory of change that addresses diversity, equity, and inclusion, we integrated intersectionality and servingness into a family-integrated education serving and transforming academic framework. We investigated the potential transformational impact of this framework on students, families, faculty, and administrators at …

Extrasynaptic Localization Is Essential For Α5gabaa Receptor Modulation Of Dopamine System Function, Alexandra M. Mccoy, Thomas D. Prevot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook, Etienne L. Sibille, Daniel J. Lodge

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Dopamine system dysfunction, observed in animal models with psychosis-like symptomatology, can be restored by targeting gamma-aminobutyric acid type A receptors (GABAARs) containing the α5, but not α1, subunit in the ventral hippocampus (vHipp). The reason for this discrepancy in efficacy remains elusive; however, one key difference is that gamma-aminobutyric acid type A receptors containing the α1 subunit (α1GABAARs) are primarily located in the synapse, whereas gamma-aminobutyric acid type A receptors containing the α5 subunit (α5GABAARs) are mostly extrasynaptic. To test whether receptor location is responsible for this difference in efficacy, we injected an siRNA into the vHipp to knock down …

Social, Cultural, And Psychological Obstacles To Advancing Stem Agendas In Rural Texas, Brandon Bretl

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Social-Emotional Learning (Sel) State Policy & Stem Education: Examining Equity & Investigating Implementation, E. Anthony Muhammad, Ashley Griffin-Gilchrist

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Food Security: At The Intersection Of Entrepreneurship, Engineering, And Agriculture, Noe Vargas Hernandez, Sylvia Robles, Joanne Rampersad-Ammons

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Mitosis Mystery!, Lluvia Garcia

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

The Rider (2024-02-26), Natalie Lapsley

The Rider Archives

Vol.9 No.21

Reimagining Teaching And Learning In Steam: Cultivating Sustainable Symbiotic Relationships Among Faculty And Students At An Hsi, Karin A. Lewis, Miryam Espinosa-Dulanto, Vejoya Viren, David Martinez-Prieto, Silvia P. Solis

Critical Proceedings of the STEM ED Conference (2023)

No abstract provided.

Sociocultural Factors That Influence Latinas’ Stem Trajectory, Kristen Hallas, Angela M. Chapman

Critical Proceedings of the STEM ED Conference (2023)

Females and people of color continue to be excluded from the STEM workforce, and those with identities intersecting those factors, like Latinas, experience exclusion at a greater scale. Though Western-focused scholars try to describe the experiences of historically excluded groups, their efforts have not significantly increased the inclusion in certain disciplines, especially for those with intersecting identities. This study explores what motivates Latinas to pursue a STEM degree at a Hispanic-Serving Institution (HSI) and analyzes these experiences with a LatCrit lens.

Roaring To Softly Whispering: X-Ray Emission After ∼3.7 Yr At The Location Of The Transient At2018cow And Implications For Accretion-Powered Scenarios, Giulia Migliori, R. Margutti, B. D. Metzger, R. Chornock, C. Vignali, D. Brethauer, Liliana E. Rivera Sandoval, J. S. Bright, T. Laskar, D. Milisavljevic

Physics & Astronomy Faculty Publications

We present the first deep X-ray observations of luminous fast blue optical transient (LFBOT) AT 2018cow at ∼3.7 yr since discovery, together with the reanalysis of the observation at δt ∼ 220 days. X-ray emission is significantly detected at a location consistent with AT 2018cow. The very soft X-ray spectrum and sustained luminosity are distinct from the spectral and temporal behavior of the LFBOT in the first ∼100 days and would possibly signal the emergence of a new emission component, although a robust association with AT 2018cow can only be claimed at δt ∼ 220 days, while at …

Finite Element Solution Of Crack-Tip Fields For An Elastic Porous Solid With Density-Dependent Material Moduli And Preferential Stiffness, Hyun C. Yoon, S. M. Mallikarjunaiah, Dambaru Bhatta

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, the finite element solutions of crack-tip fields for an elastic porous solid with density-dependent material moduli are presented. Unlike the classical linearized case in which material parameters are globally constant under a small strain regime, the stiffness of the model presented in this paper can depend upon the density with a modeling parameter. The proposed constitutive relationship appears linear in the Cauchy stress and linearized strain independently. From a subclass of the implicit constitutive relation, the governing equation is bestowed via the balance of linear momentum, resulting in a quasi-linear partial differential equation (PDE) system. Using the …

Research Experiences Via Integrating Simulations And Experiments (Revise): A Model Collaborative Research Project For Undergraduate Students In Co2 Sorbent Design, Anthony Griffin, Neziah Smith, Mark Robertson, Bianca Nunez, Jacob Mccraw, Haoyuan Chen, Zhe Qiang

Physics & Astronomy Faculty Publications

Undergraduate research experiences are an instrumental component of student development, increasing conceptual understanding, promoting inquiry-based learning, and guiding potential career aspirations. Moving one step further, as research continues to become more interdisciplinary, there exists potential to accelerate student growth by granting additional perspectives through collaborative research. This study demonstrates the utilization of a model collaborative research project, specifically investigating the development of sorbent technologies for efficient CO2 capture, which is an important research area for improving environmental sustainability. A model CO2 sorbent system of heteroatom-doped porous carbon is utilized to enable students to gain knowledge of adsorption processes, through combined …

Thermal Phonon Fluctuations And Stability Of The Magnetic Dual Chiral Density Wave Phase In Dense Qcd, Efrain J. Ferrer, William Gyory, Vivian De La Incera

Physics & Astronomy Faculty Publications

We study the stability against thermal phonon fluctuations of the magnetic dual chiral density wave (MDCDW) phase, an inhomogeneous phase arising in cold, dense QCD in a magnetic field. Following a recent study that demonstrated the absence of the Landau-Peierls (LP) instability from this phase, we calculate the (threshold) temperature at which the phonon fluctuations wash out the long-range order over a range of magnetic fields and densities relevant to astrophysical applications. Using a high-order Ginzburg-Landau expansion, we find that the threshold temperature is very near the critical temperature for fields of order 10 18     G and still a sizable …

Research Experiences Via Integrating Simulations And Experiments (Revise): A Model Collaborative Research Project For Undergraduate Students In Co2 Sorbent Design, Anthony Griffin, Neziah Smith, Mark Robertson, Bianca Nunez, Jacob Mccraw, Haoyuan Chen, Zhe Qiang

Physics & Astronomy Faculty Publications

Undergraduate research experiences are an instrumental component of student development, increasing conceptual understanding, promoting inquiry-based learning, and guiding potential career aspirations. Moving one step further, as research continues to become more interdisciplinary, there exists potential to accelerate student growth by granting additional perspectives through collaborative research. This study demonstrates the utilization of a model collaborative research project, specifically investigating the development of sorbent technologies for efficient CO2 capture, which is an important research area for improving environmental sustainability. A model CO2 sorbent system of heteroatom-doped porous carbon is utilized to enable students to gain knowledge of adsorption processes, through combined …