Digital Commons Network^™

Development Of Surface-Modified Liposomes For Drug Delivery Applications, Megan Louise Qualls

Doctoral Dissertations

Liposomes are spherical vesicles composed of a lipid bilayer membrane that assembles around an internal aqueous core. This duality gives liposomes the ability to encapsulate both hydrophobic cargo within the lipid bilayer and hydrophilic cargo in the aqueous core, making them versatile molecular carriers for drug delivery. Liposome platforms have many advantages and are promising drug delivery carriers, and research is ongoing to improve their designs for continued clinical applications. Many liposome types have been developed, but further work is needed to improve surface modification, site-specific targeting, and triggered cargo release in order to further the therapeutic applications of these …

Kinetics And Phase Stability Of Nano-Scale Precipitates In Fe-Based Binary Alloys During Ion Irradiations, Yajie Zhao

Doctoral Dissertations

Due to the high void-swelling resistance and good mechanical, thermal and chemical properties, FeCr based ferritic-martensitic steels are promising structural materials in future nuclear reactors. However, they suffer from the well-known “475 °C embrittlement” phenomenon due to formation of Cr-rich alpha prime (α’) precipitates. Despite the extensive observation of α’ after neutron irradiations, α’ formation was seldom reported after high dose rate ion irradiations.

In this study, high purity FeCr alloys with Cr concentrations of 5-18% were irradiated by 8 MeV Fe ions at -123 °C to 450 °C, 10^-5 – 10^-3 dpa/s to mid-range doses of 0.37-3.7 …

Purpose In Place: Discerning And Forefronting Forgotten Landscapes Using The Methodological Lens Of Augmented Reality, Lindy Westenhoff

Doctoral Dissertations

Augmented reality (AR) is an under-studied tool that deserves more academic attention and gaze. By using the built landscape as its point of orientation, but providing a virtual interface with which to engage, the augmented landscape serves as a departure of the traditional digital-physical divide. This realm raises questions regarding purpose and intention, but also has its own limitations and issues with dynamic, complex spaces that change frequently. Each chapter of this dissertation stands alone as a “part” – they connect, however, through the use of this technology to answer questions unique to their spaces.

Part 1 explores the relationship …

Development And Characterization Of Stable Low-Cost Salt Hydrate-Based Phase Change Materials For Thermal Energy Storage Applications, Damilola Olayinka Akamo

Doctoral Dissertations

Energy storage technologies are gaining attention due to rising utilization of renewable energy sources. One of the viable energy storage technologies is thermal energy storage (TES) in which system stores and releases thermal energy for various uses. Applications for TES systems include building systems, space heating and cooling, and refrigeration. Several TES systems use phase change materials (PCMs) to operate near-isothermally owing to phase change latent heat. Inorganic salt hydrate PCMs are popular because to their inexpensive cost, high energy density, and near ambient phase transition temperature. However, salt hydrate PCMs have phase separation, low thermal conductivity, and supercooling issues …

Understanding The Polymerization Of Ethyl Cyanoacrylate In The Superglue Fuming Of Latent Prints To Optimize Print Retrieval, Leondra Shawntae Lawson

Masters Theses

The cyanoacrylate fuming method (CFM) is a widespread process used in forensics to make latent prints visible for detection, acquisition, and analysis. CFM is governed by the reaction of ethyl cyanoacrylate (ECA) with biological components in fingerprints, which serve as initiators for this anionic polymerization. CFM is not a well-controlled polymerization and there are different outcomes that may result from lower temperature, one of which fits the generalization of creating more ion-pair initiators. Another effect could be minimizing termination through suppressing side reactions. Alternatively, when paired with humidity, lower temperatures may cause surface condensation, decreasing the quality of the print. …

Large Deviations For Self Intersection Local Times Of Ornstein-Uhlenbeck Processes, Apostolos Gournaris

Doctoral Dissertations

In the area of large deviations, people concern about the asymptotic computation of small probabilities on an exponential scale. The general form of large deviations can be roughly described as: P{Yn ∈ A} ≈ exp{−bnI(A)} (n → ∞), for a random sequence {Yn}, a positive sequence bn with bn → ∞, and a coefficient I(A) ≥ 0. In applications, we often concern about the probability that the random variables take large values, that is we concern about the P{Yn ≥ λ}, where λ > 0. Here, we consider the Ornstein-Uhlenbeck process, study the properties of the local times and self intersection …

Exploring Alternative Methodologies To Estimate By-Species Sawlog Volume In The Southeastern United States, Tara Skiba

Masters Theses

The Forest Inventory and Analysis (FIA) conducts Timber Products Output (TPO) studies to assess timber resource use across the United States. The TPO studies gather information through surveys of primary wood processing facilities to quantify the utilization of roundwood by geographic location, tree species, and timber product type. However, not all responding mills provide information on tree species utilized. As a result, a portion of the reported volume falls into the “unknown/unclassified” softwood or hardwood category, which account for up to 74% of total hardwood/softwood southern volumes in some cases. In addition, the detailed species in the TPO survey forms …

Tomato Flower Detection And Three-Dimensional Mapping For Precision Pollination, Kaitlyn Mckensie Nelms

Masters Theses

It is estimated that nearly 75% of major crops have some level of reliance on pollination. Humans are reliant on fruit and vegetable crops for many vital nutrients. With the intensification of agricultural production in response to human demand, native pollinator species are not able to provide sufficient pollination services, and managed bee colonies are in decline due to colony collapse disorder, among other issues. Previous work addresses a few of these issues by designing pollination systems for greenhouse operations or other controlled production systems but fails to address the larger need for development in other agricultural settings with less …

Use Of Automatic Metaheuristic Optimizations For Boron Neutron Capture Therapy, Christopher Busch

Masters Theses

Boron Neutron Capture therapy (BNCT) is a cancer treatment method investigated to reach malignant tumors that have added complications due to shape, size, or location. The unique property of BNCT is that it can deposit an immense dose gradient between the tumor cells and normal cells. This is done by selectively concentrating boron compounds in tumor cells and then irradiating the cells with an epithermal neutron beam. Due to complex nature of neutron interactions, a high fidelity neutronic model is needed to design and predict the outcomes of a BNCT experiment. This work aims to introduce a high level autonomous …

Survey Of Input Modalities In The Western World, John Ezat Sadik

Masters Theses

Having your account compromised can lead to serious complications in your life. One
way accounts become compromised is through the security risks associated with weak
passwords and reused passwords [22,23]. In this thesis, we seek to understand how
entering passwords on non-PC devices contributes to the problems of weak and reused
passwords. To do so, we conducted a survey that was distributed to people in the
the Western World. In our survey results, we found that users commented about
how the current password model was not created with a variety of device types in
mind, which created frustrations and complexity …

Consumer Perceptions Of Flatheaded Borer Control Methods, Samuel Gerloff

Masters Theses

Flatheaded borers are insect pests that cause damage to ornamental and fruit producing plants. This study examines consumers’ willingness to pay for four alternative flatheaded borer control methods across four products. The four products tested included two plants (maple trees, blueberry bushes) and two fruits (apples (3 pounds), blueberries (1 pint)) to ascertain if differences were observed between product categories (plant verses food) and potential product uses for the plant categories (aesthetic vs food producing). The four control methods included a chemical drench, spray, cultivar selection, and cover crop. A no control option was also included. Survey data were collected …

Stakeholders And Stakeseekers’ Perceptions Of Cultural Violations And International Crisis Communication, Najwa Nishaa Albaqami

Masters Theses

Applying the expectancy violation theory (EVT) to the crisis communication context, this research explores to what extent stakeholders and stakeseekers’ perceive violations in an international crisis context. Specifically, this study investigated to what extent organizations stakeholders and stakeseekers’ perceive cultural and expectancy violations in an international crisis. Through a case study that analyzed tweets, web blogs, and The New York Times articles, this study identified that the cultural violation theme has two components, including (1) perceived responsibility and harshness of the violation and (2) damage done by the company’s transgression. Whereas expectancy violation theme included (1) frequent use of verbal …

Sport Management Instructors’ Attitudes And Perceptions Of Students And Student-Athletes, Alaina Catherine Stem

Masters Theses

To investigate the attitudes that sport management instructors hold toward students and student-athletes, an adapted version of the Situational Analysis Scale (SAS) was completed by 247 faculty members across the United States at institutions of varying size, scale, and classification. The results indicated that sport management instructors held significantly different negative attitudes toward male revenue-generating student-athletes compared to female revenue-generating student-athletes and general population students. The findings hold implications for individuals working in sport management programs, academic services for athletics as well as general student affairs.

Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs

Masters Theses

After amputation, muscles in the residual limb are detached from their insertion points and no longer span the missing joints. Our objective was to quantify the effect of amputation-induced disuse on residual muscle structure, an indirect indicator of muscle force-generating capacity. One hind paw was surgically removed at the ankle joint of ten rabbits. At two weeks (n=5) and 4 weeks (n=5) post-amputation and for select muscles (gastrocnemius, soleus, tibialis cranialis, extensor digitorum, and flexor digitorum superficialis), we measured and computed several muscle structure properties. Additionally, we qualitatively assessed the muscle fiber appearance of histological samples at each timepoint. At …

Comparative Analysis On Low Cost Continuous Carbon Fiber Polypropylene Composite Using Compression Molding And Automated Tape Placement, Benjamin U. Schwartz

Masters Theses

Carbon fiber reinforced plastics (CFRP) are widely used throughout the aerospace industry where a weight reduction remains the highest priority with less emphasis on cost. Textile grade carbon fiber (TCF) and other low cost carbon fiber (LCCF) alternatives have recently emerged for use in the automotive market where emissions regulations have pushed automotive manufacturers and research institutions to look for cost effective light weight materials. Fiber reinforced thermoplastics provide an effective solution that align with automotive design including low cost, high processing rates, high impact toughness, unlimited shelf life, and recyclability.

TCF and Zoltek_PX35 fibers are two LCCF aimed at …

Characterization Of Key Odorants In Cumberland Rosemary, Conradina Verticillata, Claire Mackenzie Gorman

Masters Theses

Conradina verticillata Jennison, commonly known as Cumberland Rosemary, is a threatened plant from the mint family Lamiaceae. This species is a flowering, perennial shrub found in only a few counties of Kentucky and Tennessee. Cumberland Rosemary possesses a unique aroma profile; however, the odorants responsible for its aroma have not been previously identified. In this study, a total of 32 odorants were identified in Cumberland Rosemary using gas chromatography-olfactometry (GC-O) and gas chromatography-mass spectrometry (GC-MS). Odorant flavor dilution (FD) factors were determined through the application of aroma extract dilution analysis (AEDA). Seven odorants with FD factors ≥ [greater than or …

An Analysis Of Dairy Farm Financial Efficiency And Price Expectations In Seedstock Bull Markets, Seth H. Ingram

Masters Theses

The first thesis chapter employs two single-stage data envelopment analysis (DEA) models under varying returns to scale assumptions to provide technical efficiency estimates for 26 dairy farms in Tennessee, Kentucky, and North Carolina participating in the UT Dairy Gauge program. These analyses reveal how efficiently farms utilize inputs (cows, feed, labor, forage) to generate farm income relative to other sample farms. Under the assumption of constant returns to scale (CRS) 7 farms are estimated to be technically efficient, while 13 farms display comparative efficiency under an assumption of variable returns to scale (VRS). No …

Posttraumatic Stress, Depression, And Subjective Social Status: Potential Moderating Effects Of Optimism, Resilience, And Self-Efficacy, Caterina Obenauf

Masters Theses

The present study investigated the potential moderating effects of optimism, resilience, and self-efficacy on the relationships between subjective social status and both posttraumatic stress and depression symptom severity in a sample of undergraduate students (N = 382, M = 19.4, SD = 1.6, 81.5% White, 60.9% cisgender women) who reported experiencing one or more traumatic events. Many participants reported the highest education level attained by at least one parent being beyond a college degree (69%). Participants completed measures assessing trauma history, subjective social status, PTSD and depression symptoms, and potential psychological resources of optimism, resilience, and self-efficacy. In the …

Drought And Excess Moisture Crop Insurance Indemnities To Tennessee Corn Producers, Jordan Peterson

Masters Theses

The Federal Crop Insurance Program has grown to become the primary agricultural safety net for corn [Zea mays L.] producers. In 2020, insured liabilities totaled $43.98 billion in the United States (U.S.). Crop insurance provides corn producers in the U.S. with in-season protection against declines in revenue or production, below the revenue or production guarantee, due to an insured cause of loss. Crop insurance has evolved over time with significant changes occurring through Farm Bills and Ad Hoc legislation. This thesis is divided into two chapters. Chapter 1 discusses the legislative history of the crop insurance program, basics …

Examining Housing Experiences Among International Students At The University Of Tennessee, Knoxville (Utk), Rosemary Achentisa Ayelazuno

Masters Theses

As more students from across the world enrol in higher education to take advantage of the opportunities it offers, schools and universities are starting to address a problem that an increasing number of their students are experiencing, namely housing insecurity. With an increase in the number of students due to growing interest in higher education institutions, student housing has become a significant area of concern. More overseas graduate students are pursuing their degrees without regular access to their housing needs due to a lack of inexpensive and accessible housing, high tuition prices, and insufficient financial help. To better understand the …

Interactive Data Analysis Of Multi-Run Performance Data, Vanessa Lama

Masters Theses

Multi-dimensional performance data analysis presents challenges for programmers, and users. Developers have to choose library and compiler options for each platform, analyze raw performance data, and keep up with new technologies. Users run codes on different platforms, validate results with collaborators, and analyze performance data as applications scale up. Site operators use multiple profiling tools to optimize performance, requiring the analysis of multiple sources and data types. There is currently no comprehensive tool to support the structured analysis of unstructured data, when holistic performance data analysis can offer actionable insights and improve performance. In this work, we present thicket, a …

An Experimental Investigation Of The Effect Of Narrowband Freestream Noise On Fundamental Transitional Shockwave-Boundary Layer Interaction Mechanisms, Zane Matthew Shoppell

Masters Theses

Recent work at the University of Tennessee Space Institute has demonstrated that the resonant behavior observed in the spectra of cylinder- and blunt-fin-generated XSBLIs is connected to fundamental fluid mechanisms within the boundary layer. Therefore, a test campaign was conducted to characterize the fundamental mechanisms that drive the low-frequency unsteadiness in cylinder- and blunt-fin-generated shockwave-boundary layer interactions, specifically shockwave-boundary layer interactions in which the incoming boundary layer is undergoing a laminar-to-turbulent transition. This research aims to develop a deeper understanding of such interactions and characterize the resonant behavior observed in past work by varying the sweepback angle of a hemicylindrical …

Communication Distance Predicts Territory Size For An Urban Songbird, Ruth A. Simberloff

Masters Theses

Many studies demonstrate that urban noise interferes with animal communication by masking acoustic signals such as birdsong, but the functional consequences of impaired communication are still not well understood. Although many bird species sing at higher amplitude in noise pollution, communication distance is still reduced in noisy urban soundscapes. Song is a long-distance signal that functions to attract a mate and defend a territory, so a reduction in communication distance could negatively influence a male’s reproductive or competitive success. Reduced territorial success could manifest as more frequent territorial intrusions, reduced territory quality, or reduced territory size. We examined the relationship …

Can Packaging Impact Consumers Perceptions Of What Products Appear To Look Healthy Vs. If They Actually Are Healthy?, Allison Grace Bagwell

Masters Theses

Packaging is a crucial aspect in the marketing world. It can give implicit and explicit cues about the content within. Food packaging is especially crucial to examine when analyzing health perceptions about a product. Packaging is a communication vehicle for the consumer to perceive the quality of the food or beverage product and possibly infer if the product is healthy just by examining the exterior of the product. This research hopes to determine if consumers base perceived health notions on bottle shape and/or color. By manipulating the shape and color of the bottle, the study is looking to find any …

Characterization Of Arabidopsis Eukaryotic Translation Initiation Factor 2Α (Eif2Α) Mutants, Mark Edens

Masters Theses

Plants are stationary organisms that are charged with overcoming a multitude of biotic and abiotic stresses. The eukaryotic translation initiation factor 2 (eIF2) is responsible for charging the P-site of the forming 80S ribosome with the initiator methionyl-tRNA. Thus, eIF2 is a protein of utmost consequence in the growth and development of organisms. The eIF2 protein is also a mediator of global translational regulation in the eukaryotic integrated stress response (ISR), where the α-subunit is phosphorylated by protein kinases, such as the kinase GCN2. Here, five eIF2α allele mutants in Arabidopsis were found to be deleterious to plant growth, development, …

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Brown People, Green Spaces: Colonial Imaginaries And The Whiteness Of Nature, Jeffrey Michael Desalu

Masters Theses

For several years, conversations about the absence of racial and ethnic diversity in ecology and evolutionary biology (EEB) and the conservation movement have been growing in scope. Critics argue that the overwhelmingly white demography of EEB departments and conservation organizations deprive both of a necessary diversity of perspective and, more importantly, deprive people of color and other minoritized groups of a voice in the study of and advocacy for their lived environments. Here, I situate the current conversations in historical context, arguing that the current lack of diversity is in part a reflection of the material and ideological bases for …

Anthropology In A Rural Archive: A Study That Moves Along And Against The Archival Grain, Julian W. Mcdaniel

Masters Theses

Anthropologists have long engaged with archival materials in order to provide historically accurate information that might assist in the production of ethnographic projects. Archives are unique institutions where historical data can be found that contributes valuable information about particular groups of people; however, archives themselves are again and again being controlled by a higher power, particularly that of the State, and this act of ownership contributes to acts of omission that misconstrue historical narratives as well as descriptions of the people and places depicted within an archive. In this project, I engage with an archive located in a rural town …

Evaluating Bulk Carbon And Nitrogen Isotope Compositions Of Acidic Hydrothermal Sediments On Earth– Implications For Mars Astrobiology, Chance Sturrup

Masters Theses

Carbon isotopes have been widely used as unique biosignatures because biologic processes commonly result in distinctive negative delta ¹³C values (-35 to -10 ‰) within organic material on Earth. However, the bulk delta ¹³C analysis in Gale crater sediments on Mars revealed a wider range of values, from -25 to +56 ‰ (Franz et al., 2020), which suggests a more complex origin. To determine if bulk isotope analysis can be successfully used to detect a microbial signature in a martian analog environment, we analyzed concentrations and isotope compositions of C within hydrothermal sediments in Iceland (Námafjall, Krýsuvík, Hveragerdi) …

Covered Monuments And Black Erasure In Nashville, Tennessee, Kayla S. Roulhac

Masters Theses

Centennial Park is a staple of downtown Nashville, Tennessee because of its founding after the Tennessee Centennial and International Exposition in 1897, and also for the urban green space it provides for contemporary residents and visitors. A family-friendly space is presented to the visitors, yet there is a history of slavery within the park boundaries and Black removal. The lack of acknowledgement of the former plantation, the later removal of an African American university nearly adjacent to Vanderbilt University, and the modern presence of a Confederate monument in this space brings about questions regarding the memory of this particular landscape …