Digital Commons Network^™

The Aging Muscle Phenotype Of C57bl/6j Wild-Type Mice, Gaurav Shingote

OneUSF Undergraduate Research Conference

Aging causes a slow and progressive loss of muscle fiber number and size. Sarcopenia is termed as an age-related loss of muscle mass and function. Here, we characterized the aging skeletal muscle phenotype of C57Bl/6J wildtype mice. 30 weeks old (young) and 2 years old (aged) C57Bl/6J wildtype male mice were utilized in this study. The body weight and hind leg muscle weight were recorded during collection. The hind leg muscle Tibialis anterior (TA) was OCT embedded, cut at the mid- belly region, and stained with hematoxylin and eosin (H&E) stain as per our previously published protocol. The 20X images …

Leveraging Computer Vision-Based Hand Tracking In Smartphone Xr Exposure Scenarios To Enable Controller-Free Interaction, Alex C. Lim, Trang Nguyen

OneUSF Undergraduate Research Conference

Extended reality (XR) has emerged as an effective and convenient solution for broadening accessibility to exposure therapy. Smartphone-based XR, though cost-effective, is often constrained by limited interactivity, engendering a passive experience that can compromise the user-immersion and treatment efficacy. To address this limitation, this study presents a novel computer vision–based hand-tracking approach using Google MediaPipe, integrated within a stereoscopic smartphone-based XR system to enable real-time, controller-free interaction in a dog-fetch scenario. Hand landmark coordinates derived from MediaPipe are algorithmically adjusted based on changes in inter-knuckle distances during anterior/posterior movement to approximate depth, at which point interactive spheres are overlayed to …

Accelerating Protein Engineering: Using Computer Modeling To Identify Beneficial Interleukin-23 (Il-23) Mutations, Andrew S. Chadwell

OneUSF Undergraduate Research Conference

Interleukin-23 (IL-23) regulates inflammation, yet its overproduction, driven by genetics or overactive immune triggers, can lead to chronic inflammatory diseases like psoriasis. IL-23 consists of two subunits; an exclusive subunit, p19, and a second subunit, p40, that is shared with Interleukin-12. Driving selectivity of p19-p40 interactions promotes a shift in cytokine formation between IL-23 and IL-12. By integrating computational biology, protein engineering, and structural data from the RCSB Protein Data Bank (entry 4RGW), the research addressed structural challenges like unresolved regions in experimental structures and the difficulty of predicting beneficial mutations. Structural modeling using ColabFold, a prediction tool based on …

Impact Of Private Equity Investments Integration On U.S. And European Sports Industries, Evan Alexander

OneUSF Undergraduate Research Conference

Private equity investments in the sports industry have become increasingly prominent in both the United States and Europe, although the dynamics, regulations, and strategies differ between the two regions. In this thesis, I discuss the concept of private equity (PE) investments within the sports industry, evaluating it in the context of the United States of America and Europe.

I analyze the overall impact that the integration of private equity investments has had on several sports leagues, such as Major League Baseball (MLB), the National Football League (NFL), the National Basketball Association (NBA), and European Soccer Clubs, among other sports. I …

How The Erosion Of The German Drinking Culture Impacts Social Cohesion And The Economic Progression, Tran B. Duong, Monica Hennawy

OneUSF Undergraduate Research Conference

German drinking culture has begun to wane within the past decade. While this may be viewed as a public health success, it has multifaceted impacts. The lifestyle adjustment threatens the third space which has historically fostered social interaction, making their erosion significant not merely economically but also culturally. Substance use also has a multifaceted impact on mental health, whereas in regulation social drinking can promote bonding. This leads to the need for appropriate policy in alcohol consumption which should help the public draw a balance in sustainable drinking practices. Alternatively, Germany’s third places also serve as a significant source of …

Business Incubation And The Role That It Plays In The Future Economic And Financial Success Of Small Island Developing States, Warren Watkins

OneUSF Undergraduate Research Conference

Small Island Developing States (SIDS) face a unique blend of economic vulnerabilities and untapped potential, often stemming from their heavy reliance on tourism and limited diversification. This thesis explores how business incubation can serve as a strategic mechanism for fostering sustainable economic and financial growth within these nations. Through a comparative analysis of established models in countries such as Singapore, Japan, and Chile, alongside emerging initiatives in Caribbean SIDS, this research identifies the pathways through which foreign investment, education, and technology can jointly stimulate entrepreneurial development. Findings indicate that while foreign partnerships remain essential in the early stages of incubation, …

Pre-Existing Conditions And Their Effect On Neurological Prognosis And Rehabilitation In Older Cardiac Arrest Population - A Literature Review, Nadia A. Parsotan, Maya Awad, Greta Schmanke, Madeline Yee, Angelin Abraham

OneUSF Undergraduate Research Conference

The effectiveness of cardiac arrest rehabilitation can be influenced by pre-existing conditions, such as diabetes and hypertension particularly in the older population, where these comorbidities are more prevalent. This literature review aims to understand how these conditions affect the neurological prognosis and rehabilitation in cardiac arrest patients aged 60+. A systematic PubMed search was conducted for peer-reviewed studies published within the past 15 years using terms related to cardiac arrest, neurological outcomes, rehabilitation, and common chronic conditions. Studies were included if they focused on adults aged 60 and older, reported at least one pre-existing medical condition, and provided neurological rehabilitation …

The Power Of Physical Activity And Sleep: Sex-Specific Pathways To Cognitive Health In Older Adults, Gabriella K. Waldbauer

OneUSF Undergraduate Research Conference

Physical activity (PA) and sleep health are associated with cognition. However, limited research has examined the interactive effects of PA and sleep on domain-specific cognitive function in older adults. Although sex differences exist independently across all factors, sex-specific interactive investigations are limited. This study investigated whether the relationship between PA, sleep and cognition varies by sex in older adults. Older adults (N=119; Mage=68.3±5.6; 73 women) completed measures of insomnia severity (Insomnia Severity Index), physical activity (International Physical Activity Questionnaire) and cognition (NIH Toolbox-Cognitive Battery). Multiple regressions examined whether insomnia severity interacted with physical activity in associations with cognition and tested …

How Has Western Biomedical Framing Of Type 2 Diabetes Shaped Prevention And Treatment In South Asian Populations?, Amrita Nayak, Sreehitha Sajja

OneUSF Undergraduate Research Conference

This paper examines how Western biomedical framing of Type 2 diabetes (T2D) has shaped prevention and treatment strategies in South Asian populations, often with limited effectiveness. The dominant Western model emphasizes individual responsibility, standardized dietary guidelines, and generalized treatment protocols. While these approaches have proven useful in broader populations, they frequently fail to address the distinct biological, cultural, and structural realities that influence T2D risk among South Asians. A key limitation lies in the underrecognition of earlier metabolic risk. South Asian individuals tend to develop T2D at younger ages and lower body mass index (BMI) levels compared to European populations, …

Telemedicine Vs. In-Person Oncology Care During Covid-19, Sarah C. Widlak, Genelle Leo, Moksh Patel, Hailey Menias, Ariadna Coa, Serena Bhaskar

OneUSF Undergraduate Research Conference

Amidst the COVID-19 pandemic, healthcare rapidly shifted towards telemedicine, raising questions about its efficacy. Although there is limited research, it is critical to understand how telemedicine affected oncology patients during the pandemic to improve patient care and experiences post-pandemic. This review addresses this gap by evaluating how telemedicine use among adult oncology patients during the pandemic compares with in-person visits regarding quality of care and patient satisfaction. A comprehensive search was performed across multiple databases, mainly PubMed, using keywords related to telemedicine, cancer, and COVID-19. The search yielded 106 unique articles, of which 41 met the inclusion criteria. Two rounds …

The Effect Of Distraction On Emotion-Based Communication Behaviors, Twisha Nadella

OneUSF Undergraduate Research Conference

As technology becomes increasingly integrated in daily activities, there are growing concerns for the effects of multi-tasking within the workplace. It is important to consider how communication efficiency may be impacted by dual-task situations. Therefore, understanding the potential outcomes that distraction may have on language production is valuable in determining optimal working conditions for effective use of emotional communication. This dual-task study was designed to understand the effects of distraction on emotion-based communication behavior. A driving task was utilized as the means of distraction in this experiment, while the concurrent negotiation task was analyzed to understand how emotional language was …

Gender Differences In The Diagnosis Of Histrionic Personality, Monica Hennawy, Heidi Lieu, Dayanna Gonzalez, Devin Dombroski, Kaylie Jusino Ortiz, Genelle Leo

OneUSF Undergraduate Research Conference

Histrionic Personality Disorder (HPD) is characterized by attention-seeking, emotionality, and dramatic or seductive behaviors. Individuals with HPD often feel discomfort when not the center of attention and may use exaggerated affect to gain approval. While gender differences in diagnosis and presentation have been reported, the influence of trauma and comorbid conditions - such as alcohol use disorder (AUD) and eating disorders (EDs) - remains underexplored. A literature review was conducted using PubMed with search terms including HPD, trauma, substance use, and eating disorders. A total of 157 articles were identified. Studies not addressing at least two relevant domains were excluded. …

Cyclobenzaprine: Psychiatric Side Effects In Patients With Mood Disorders, Shelby R. Mcgrew, Michael Pestova-Habera

OneUSF Undergraduate Research Conference

Cyclobenzaprine, also known under the brand name Flexeril, is one of the most widely prescribed skeletal muscle relaxants globally. While treatment is typically limited to post-injury pain relief, long-term use has increased due to evidence of pain reduction in patients with chronic conditions such as fibromyalgia and temporomandibular joint disorder. Recently, cyclobenzaprine was found to be contraindicated for patients with bipolar disorder and other mood disorders. This is thought to result from its structural similarity to amitriptyline, a tricyclic antidepressant. As a result, some patients utilizing cyclobenzaprine for pain management may experience acute manic episodes following administration. This study reviews …

Reducing Expenses Through Digital Innovation Among Medicare Advantage Plans, Stanley Y. Huang, Jada N. Faircloth, Lauren R. Selent, Lauren R. Mcconnell

OneUSF Undergraduate Research Conference

The United States healthcare system is approaching unsustainable cost levels. Within the next ten years Medicare Advantage plans face potential insolvency. Medicare Advantage plans are expanding, and many receive priority over patient care and physician payments yet operating without meaningful accountability. Many of these rising costs affect quality and lead to increased overhead expenses. 1, 2 The purpose of this project was to examine whether replacing traditional methods with safe, timely, and HIPAA-compliant digital innovation would lower cost and maximize outcomes. A quantitative, causal- comparative design was used to identify differences across groups. The independent variable was fiscal year, and …

Investigation Of Antimicrobial Properties In Bacteria Of Loggerhead Turtle (Caretta Caretta) Nesting Beaches, Norah P. Nunez

OneUSF Undergraduate Research Conference

Loggerhead sea turtles (Caretta caretta) are considered threatened under the Endangered Species Act. Identifying bacteria of Loggerhead turtle nesting beaches can shed light on antimicrobial properties of agents that could impact turtle hatchling survival. Bacteria from beaches in Fort de Soto and Lido Key were isolated and analyzed for antimicrobial properties, as these beaches are commonly Loggerhead nesting sites. Isolates were chosen for apparent inhibition of bacterial growth then tested against medically significant bacteria in two rounds of modified Kirby-Bauer. The identities of the bacteria were investigated through a series of differential and selective tests and confirmed with …

Investigating The Role Of The Gut Microbiome In Modulating Immune Responses To Infections, Abhinav Muthiraparambath, Matthew Guzie, Matthew Lim, Aryan Sharma, Julia Mendez, Irelis Orlando, Archi Patel

OneUSF Undergraduate Research Conference

Increasing evidence links the gut microbiome to immune regulation, homeostasis, and infectious outcomes. Although gut dysbiosis is associated with impaired immune responses, the mechanisms linking microbial imbalance to immune dysfunction and diseases remain under-investigated. This study aims to investigate how changes in the gut microbiome contribute to immune dysfunction and disease progression, and whether biomarkers can improve the prediction of disease outcomes and therapeutic responses. A systematic literature review was conducted to identify peer-reviewed studies explaining the relationship between gut microbiome dysbiosis and immune dysfunction. This was conducted by searching select words such as ‘Gut microbiome’, ‘Gut dysbiosis’, and ‘microbial …

Benefits Of Art Therapy On Quality Of Life In Middle Aged Women With Gynecological And/Or Breast Cancer, Rylee N. Diehl, Iman Ahmed, Piper S. Bell, Lamya Moore, Giada Anastasi, Constanza Bravo Rodriguez, Taylor Edmondson

OneUSF Undergraduate Research Conference

Art therapy involves the use of art representations in clinical and mental health care. Art mediums such as painting, dance, and movement can be interventions for diagnoses such as gynecological or breast cancer (GBC). GBC incidence is highest among women 45-65, and art therapy has shown potential to improve their quality of life (QoL). Art therapy’s impact on QoL is often assessed by measuring physical and mental health, coping and adjustment capabilities, healthcare relationships, and social life. Using the PRISMA guidelines, a systematic review was conducted with an initial 181 articles extracted from multiple journals of psychology. A final selection …

Effectiveness Of Mindfulness-Based Interventions In Treating Behavioral Addictions, Arjun Tummala, Eshal Farhan, Tina Zhang, Ayesha Menon, Harshini Janapaty

OneUSF Undergraduate Research Conference

Behavioral addictions are non-substance compulsive disorders creating urges to engage with actions such as gambling and internet gaming disorder (IGD). Mindfulness-based interventions (MBIs) use conscious awareness of the present to improve both mental and physical health. However, their long-term effectiveness remains unclear compared to other therapies. This literature review explores how the use of MBIs, compared to other therapeutic techniques, help adults and adolescents struggling with behavioral addictions. A systematic screening of peer-reviewed articles was conducted using PubMed. Of 135 articles published from 2021-2026, “mindfulness”/“meditation”, “behavioral addiction”/”gambling”/“gaming disorder”/“internet”, and “long-term”/“relapse”, only studies that explored MBIs for behavioral addiction with experimental …

How Do Grandiose And Vulnerable Narcissism Differ In Their Expression Of Physical Aggression Within Intimate Partner Violence, Ryan Dumrauf, Kianna Romero, Adam Ghonimy, Vincent Yang

OneUSF Undergraduate Research Conference

Narcissistic Personality Disorder (NPD) involves the feeling of self-importance and apathy, divided into grandiose and vulnerable subtypes. Grandiose narcissism is characterized by dominance and confidence, while vulnerable narcissism reflects insecurity and sensitivity. However, patterns across these subtypes concerning physical aggression have minimal research. Thus, the study aims to identify differences between these subtypes with respect to physical aggression in intimate relationships. A comprehensive literature review was performed through reliable, academic engines with the following keywords: intimate partner violence, narcissism subtypes, physical aggression, and IPV narcissism, which yielded seventy-seven articles. These sources were screened for criteria constituting intimate partner violence, with …

Ai-Enabled Food As Medicine In Hospitality: Children’S Wellness Menus, Guest Perceptions, And Service Design, Isabella Fonte

OneUSF Undergraduate Research Conference

Dietary management plays a crucial role in alleviating symptoms of chronic health conditions, yet accessible, credible resources remain underutilized. This project focuses on collecting and standardizing online recipes designed to support individuals managing ailments through nutrition, emphasizing that these recipes provide foundational dietary guidance rather than curative solutions. For instance, recipes targeting heart disease consistently prioritize whole grains, low-fat proteins, and vegetables, offering structured starting points for those navigating dietary changes. Our methodology involves identifying credible sources that meet specific criteria: nutrition information, dietary tags, serving sizes, preparation and cooking times, and detailed instructions to name a few. Selected recipes …

Cardiometabolic Diseases And Immune-Responsive Metabolic Enzymes: Roles Of Lipoxygenases (5, 12, 15), Cyclooxygenases (1, 2), And Cytochrome P450, Shayla Pham

OneUSF Undergraduate Research Conference

Cardiometabolic diseases (CMD) encompass interrelated disorders involving cardiovascular dysfunction and metabolic dysregulation. Lipoxygenase (5-, 12/15-LOX), cyclooxygenase (COX-1/2), and cytochrome P450 (CYP450) enzymes regulate fatty acid metabolism and inflammatory signaling, significantly contributing to CMD pathogenesis. This review synthesizes recent evidence on LOX, COX, and CYP450 pathway crosstalk and evaluates their therapeutic and biomarker relevance in clinical cardiometabolic disease. A comprehensive PubMed literature search identified studies examining LOX, COX, and CYP450 enzymes inflammatory and metabolic pathways linked to CMD. Inclusion criteria were limited to human and animal studies published from 2010 to 2025, focusing on cardiac function, enzyme activity, or clinical outcome. …

The Mediterranean Diet And Lipid Profiles In Hyperlipidemia, Aarav Shah, Kartheek Malireddy, Advith Katta, Ishani Sunkara, Alyssa Resendez, Serena Bhaskar

OneUSF Undergraduate Research Conference

The Mediterranean Diet (MedDiet) reduces risk of hyperlipidemia by reducing LDL (Low-Density Lipoprotein) levels, which cause plaque buildup. However, the comparison of the MedDiet with other diets for improving lipid profiles in hyperlipidemic patients has not been thoroughly investigated. This study evaluates how MedDiet compares to diets such as the Vegan, Keto, and DASH diets on adults with hyperlipidemia concerning our primary outcome LDL-C levels and our secondary outcome HDL levels. A meta-analysis on 47 studies, 169 screened, from PubMed, Scopus, Web of Science, and ScienceDirect focused on comparing effects of DASH, vegan, low-fat, Western, and Keto diets against MedDiet. …

Resistance Is Futile: Using Star Trek Fanfiction To Reimagine Milton's Paradise Lost, Ezra J. Steffen

OneUSF Undergraduate Research Conference

“Resistance Is Futile: Using Star Trek Fanfiction to Reimagine Milton’s Paradise Lost” is a panel that discusses my reimagination of Milton’s epic for Dr. Emily Jones’ Selected British Authors class. There, I drew parallels between characters in P.L. and characters in Star Trek: The Original Series. Using a Gnostic lens, I reframed temptation as a positive and necessary action. I painted Sarek, Spock’s dad, as an imperfect god who stood in the way of Spock’s growth. Spock, acting as a hybrid of Adam and Eve, gets tempted to stray from his father by Leonard “Bones” McCoy. In my published fanfiction, …

Coaching Approach Behavior And Leading By Modeling (Calm) Program For Treating Early Childhood Anxiety: A Case Study, Dana G. John

OneUSF Undergraduate Research Conference

Anxiety disorders onset earlier than most mental health conditions, with preschool-age children showing prevalence rates comparable to children ages 5–17 years. Yet, there are limited treatment options suitable for preschool-age children that account for still-developing abstract thinking and metacognition. The Coaching Approach Behavior and Leading by Modeling (CALM) Protocol was adapted from Parent-Child Interaction Therapy (PCIT) to target a broad range of anxiety disorders in children ages 3-8 years. This case study outlines the implementation of a 10-session CALM treatment protocol for a 5-year- old female presenting with generalized anxiety disorder (GAD). Post-intervention assessments revealed significantly improved anxiety symptoms measured …

Evaluating The Effects Of Technology-Based Self-Monitoring And Contingency Mapping On The Disruptive Behavior Of Children With Autism Spectrum Disorder, Alexandra R. Pruitt

USF Tampa Graduate Theses and Dissertations

Self-monitoring (SM) is an evidence-based self-management procedure that can improve behavior and academic performance across diverse populations and settings. However, results of a meta-analysis of SM on strategy use and academic performance of K-12 and higher education students suggest that SM is more effective when it is embedded into a multi-component intervention. Contingency mapping (CM), a visual representation of contingencies in effect for desirable and undesirable behaviors, has been shown to improve behavior (e.g., increase social communication skills, increase on-task behavior) in the clinical and school settings. Previous research has not evaluated the effects of a treatment package consisting of …

Improving Cancer Diagnosis And Patient Outcomes With Deep Learning Models, Mariana Arriz-Jorquiera

USF Tampa Graduate Theses and Dissertations

Cancer care depends on timely and reliable decisions, from detection and diagnosis to treatment planning and patient monitoring. These decisions are often made under uncertainty because medical images and healthcare data may be noisy, incomplete, or difficult to interpret. In breast cancer imaging, ultrasound is widely used because it is safe, accessible, and complementary to other imaging modalities. However, variations in image quality, acquisition conditions, and noise can obscure lesion boundaries and texture, affecting human interpretation and artificial intelligence reliability. This dissertation develops deep learning, image-analysis, and optimization methods to improve healthcare decisions under imperfect information. Its primary focus is …

Gnsi Decision Brief: Is $1.7 Billion Enough? Breaking Down The Economic Effects Of Ukraine’S Cyber War, Tom Johansmeyer

GNSI Decision Briefs

Ukraine’s claims of causing Russia more than $1.72 billion in economic harm may have been intended to tout success, but the impact really reveals the limitations of offensive cyber operations outside a narrow collection of mission sets. By comparing that total to past cyber event economic losses, the shortcomings of cyber operations as a form of direct action become clear.

Engineering Fsh-Cer T Cells To Enhance Response To Epithelial Ovarian Cancer, Nolan J. Beatty

USF Tampa Graduate Theses and Dissertations

Ovarian cancer remains a significant cause of cancer-related mortality, with epithelial ovarian cancer (EOC) being the most common subtype. Despite advances in treatment, the 5-year survival rate for late-stage EOC remains low due to factors such as tumor heterogeneity and an immunosuppressive tumor microenvironment (TME). This study investigates the therapeutic potential of chimeric endocrine receptor (CER) T cells engineered to express follicle stimulating hormone (FSH) in a syngeneic mouse model of EOC expressing follicle stimulating hormone receptor (ID8-FSHR). We compared two different co-stimulatory domains—CD28ζ and 4-1BBζ—in FSH-CER T cells and found that FSH-CD28ζ CER T cells exhibited enhanced cytotoxicity, proliferation, …

From Shortage To Strategy: Optimizing Scarce Resource Allocation In Healthcare, Daniela Duran Cantarino

USF Tampa Graduate Theses and Dissertations

The allocation of scarce medical resources presents one of the most consequential challenges in health care, requiring decisions that balance equity and efficiency under pervasive uncertainty. This dissertation develops optimization-based frameworks for two critical domains, organ transplantation and emergency medical services, and demonstrates how operations research methods can improve upon current practice along both dimensions simultaneously.

In the domain of deceased-donor kidney allocation, two complementary frameworks are proposed. The first is a bi-objective stochastic optimization model that jointly maximizes post-transplant survival (efficiency) and prioritizes candidates with the highest pre-transplant mortality risk (equity), subject to regional chance constraints on graft failure …

Vertebrate Diversity In Cave Systems Of Colombia: An Approach Based On Environmental Dna Metabarcoding Analysis, Rita Daniela Martinelli Marín, Carlos Andres Lasso, Francesco Sauro, Susana Josefina Caballero

International Journal of Speleology

There is currently limited knowledge of the biological communities inhabiting cave ecosystems in South America. This study examines the vertebrate community composition of 21 caves across diverse subterranean ecosystems in Colombia using environmental DNA (eDNA) analysis. Water was collected from water bodies inside caves and subterranean systems in six of the eight speleological regions of Colombia in eight departments. Water was filtered manually through a 0.8 m pore size filter and preserved with Longmire solution. A 170-base pair (bp) fragment of the 12s mitochondrial gene specific for vertebrate identification was amplified by PCR and sequenced by Illumina (metabarcoding). Data corresponding …