Digital Commons Network^™

Using A Rapid Assessment Methodology To Identify And Address Immediate Needs Among Low-Income Households With Children During Covid-19, Shreela V. Sharma, Amier Haidar, Jacqueline Noyola, Jacqueline Tien, Melinda Rushing, Brittni M. Naylor, Ru-Jye Chuang, Christine Markham

All publications

Objective: Brighter Bites is a school-based health promotion program that delivers fresh produce and nutrition education to low-income children and families. Due to COVID-19-related school closures, states were under "shelter in place" orders, and Brighter Bites administered a rapid assessment survey to identify social needs among their families. The purpose of this study is to demonstrate the methodology used to identify those with greatest social needs during this time ("high risk"), and to describe the response of Brighter Bites to these "high risk" families.

Methods: The rapid assessment survey was collected in April 2020 across Houston, Dallas, Washington DC, and …

Implementation Of A Medical Student-Run Telemedicine Program For Medications For Opioid Use Disorder During The Covid-19 Pandemic, Marcus Castillo, Brianna Conte, Sam Hinkes, Megan Mathew, C J Na, Ainhoa Norindr, David P. Serota, David W. Forrest, Amar R. Deshpande, Tyler S. Bartholomew, Hansel E. Tookes

All publications

Objectives: The COVID-19 pandemic led to the closure of the IDEA syringe services program medical student-run free clinic in Miami, Florida. In an effort to continue to serve the community of people who inject drugs and practice compassionate and non-judgmental care, the students transitioned the clinic to a model of TeleMOUD (medications for opioid use disorder). We describe development and implementation of a medical student-run telemedicine clinic through an academic medical center-operated syringe services program.

Methods: Students advertised TeleMOUD services at the syringe service program on social media and created an online sign-up form. They coordinated appointments and interviewed patients …

The Impact Of Covid-19 On Hiv Treatment And Research: A Call To Action., Tiffany Chenneville, Kemesha Gabbidon, Patricia Hanson, Cashea Holyfield

All publications

The impact of the COVID-19 pandemic is far reaching, with devastating effects on individuals, communities, and societies across the world. People with chronic health conditions may be at greater risk of contracting or experiencing complications from COVID-19. In addition to illness or death for those who contract the virus, the physical distancing required to flatten the curve of new cases is having a negative impact on the economy, the effects of which intersect with mental health and other existing health concerns, thus affecting marginalized communities. Given that HIV also has a disproportionate impact on marginalized communities, COVID-19 is affecting people …

Social Media Engagement At Academic Conferences: Report Of The Association Of Pathology Chairs 2018 And 2019 Annual Meeting Social Media Committee, Yonah C. Ziemba, Dana Razzano, Timothy C. Allen, Adam L. Booth, Scott R. Anderson, Anne Champeaux, Michael D. Feldman, Valerie Fitzhugh, Simone Gittens, Marilea Grider, Mary Gupta, Christina Hanos, Karen Kelly, Tarush Kothari, Jennifer Laudadio, Amy Y. Lin, Kamran M. Mirza, Kathleen T. Montone, Priscilla S. Markwood

Pathology and Cell Biology Faculty Publications

The use of social media at academic conferences is expanding, and platforms such as Twitter are used to share meeting content with the world. Pathology conferences are no exception, and recently, pathology organizations have promoted social media as a way to enhance meeting exposure. A social media committee was formed ad hoc to implement strategies to enhance social media involvement and coverage at the 2018 and 2019 annual meetings of the Association of Pathology Chairs. This organized approach resulted in an 11-fold increase in social media engagement compared to the year prior to committee formation (2017). In this article, the …

Approach To High Volume Enrollment In Clinical Research: Experiences From An All Of Us Research Program Site, Titilayo O. Ilori, Emma Viera, Jillian Wilson, Francisco Moreno, Usha Menon, John Ehiri, Rachele Peterson, Tejo Vemulapalli, Sara C. Stimsonriahi, Cecilia Rosales, Elizabeth Calhoun, Amanda Sokan, Jason H. Karnes, Eric Reiman, Akinlolu Ojo, Andreas Theodorou, Tammy Ojo

Nursing Faculty Publications

Clinical trials and cohort studies are required to meet target recruitment of study participants within stipulated timelines, especially when the priority is to include populations traditionally unrepresented in biomedical research. By the third quarter of 2019, the University of Arizona-Banner Health Provider Organization (UA-Banner HPO) has enrolled > 30,000 core participants into the All of Us Research Program (AoURP), the research cohort of the Precision Medicine Initiative. The majority of enrolled participants meet the criteria for individuals under-represented in biomedical research. The enrollment goals were calculated based on a target of 20,000 as set by the National Institutes of …

An Evaluation Of Florida’S Zika Response Using The Who Health Systems Framework: Can We Apply These Lessons To Covid-19?, Jennifer Marshall, Blake Scott, Jennifer Delva, Cedrick Ade, Santiago Hernandez, Jaladhikumar Patel, Mantero Moreno-Cheek, Dogeli Rojas, Jean-Paul Tanner, Russell S. Kirby

All publications

Objectives: From 2016 to 2018 Florida documented 1471 cases of Zika virus, 299 of which were pregnant women (Florida Department of Health, https://www.floridahealth.gov/diseases-and-conditions/mosquito-bornediseases/surveillance.html , 2019a). Florida's response required unprecedented rapid and continuous cross-sector communication, adaptation, and coordination. Zika tested public health systems in new ways, particularly for maternal child health populations. The systems are now being challenged again, as the Coronavirus COVID-19 pandemic spreads throughout Florida. This qualitative journey mapping evaluation of Florida's response focused on care for pregnant women and families with infants exposed to Zika virus.

Methods: Fifteen focus groups and interviews were conducted with 33 public health …

The Aspet Mentoring Network: Enhancing Diversity And Inclusion Through Career Coaching Groups Within A Scientific Society, Veronica Y. Womack, Bhoomi K. Thakore, Christine V. Wood, David C. Jewett, Remi F. Jones, Susan L. Ingram, Janet A. Clark, Catherine L. Fry, Lynn Wecker, Richard Mcgee

Psychiatry & Behavioral Neurosciences Faculty Publications

Over the past decades, two persisting priorities in science, technology, engineering, and mathematics (STEM) training have been: 1) increasing the knowledge of and access to careers beyond academic scientist; and 2) increasing the diversity of the STEM workforce. Previous studies show that a uniquely constructed career coaching group provides strong support and progress for both priorities. This report extends this design into a more sustainable model that is positioned within the professional context of rising young scientists. This new model is based in the American Society for Pharmacology and Experimental Therapeutics (ASPET)—the ASPET Mentoring Network. Groups of PhD students and …

Utilizing Social Media To Spread Knowledge: The Association Of Pathology Chairs Experience At The 2018 Annual Meeting, Dana Razzano, Yonah C. Ziemba, Adam L. Booth, Priscilla Markwood, Christina T. Hanos, Nicole Riddle

Pathology and Cell Biology Faculty Publications

No abstract provided.

Symmetry Breaking Soliton, Breather, And Lump Solutions Of A Nonlocal Kadomtsev–Petviashvili System, Hong-Yu Wu, Jin-Xi Fei, Zheng-Yi Ma, Jun-Chao Chen, Wen-Xiu Ma

Mathematics and Statistics Faculty Publications

The Kadomtsev–Petviashvili equation is one of the well-studied models of nonlinear waves in dispersive media and in multicomponent plasmas. In this paper, the coupled Alice-Bob system of the Kadomtsev–Petviashvili equation is first constructed via the parity with a shift of the space variable x and time reversal with a delay. By introducing an extended Bäcklund transformation, symmetry breaking soliton, symmetry breaking breather, and symmetry breaking lump solutions for this system are presented through the established Hirota bilinear form. According to the corresponding constants in the involved ansatz function, a few fascinating symmetry breaking structures of the presented explicit solutions are …

Analytical Solutions For Nonlinear Dispersive Physical Model, Wen-Xiu Ma, Mohamed R. Ali, R. Sadat

Mathematics and Statistics Faculty Publications

Nonlinear evolution equations widely describe phenomena in various fields of science, such as plasma, nuclear physics, chemical reactions, optics, shallow water waves, fluid dynamics, signal processing, and image processing. In the present work, the derivation and analysis of Lie symmetries are presented for the time-fractional Benjamin–Bona–Mahony equation (FBBM) with the Riemann–Liouville derivatives. The time FBBM equation is reduced to a nonlinear fractional ordinary differential equation (NLFODE) using its Lie symmetries. These symmetries are derivations using the prolongation theorem. Applying the subequation method, we then use the integrating factor property to solve the NLFODE to obtain a few travelling wave solutions …

Literature-Guided Recommendations For Otolaryngologists During The Covid-19 Pandemic: A Contemporary Review, Mausumi Syamal

Otolaryngology Head & Neck Surgery Faculty Publications

Objective: The objective of this study was to review the current literature and guidelines on management of the novel coronavirus 2019 (COVID-19 or 2019nCoV) with respect to the field of Otolaryngology.

Design: Contemporary literature review.

Methods: Systematic literature review of global medical literature databases and communications were queried to find all available literature recommendations, research, and guidelines applicable to otolaryngologists in the COVID-19 pandemic.

Results: Guidance on personal protective equipment, office visits, and surgical scheduling, as well as recommendations for safe airway management and tracheotomy performance during the COVID-19 pandemic were compiled and interpreted.

Conclusion: Little guidance exists for otolaryngologists …

Advancing Stem Cell Therapy For Repair Of Damaged Lung Microvasculature In Amyotrophic Lateral Sclerosis, Svitlana Garbuzova-Davis, Robert Shell, Hilmi Mustafa, Surafuale Hailu, Alison E. Willing, Paul R. Sanberg, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration in the brain and spinal cord. Progressive paralysis of the diaphragm and other respiratory muscles leading to respiratory dysfunction and failure is the most common cause of death in ALS patients. Respiratory impairment has also been shown in animal models of ALS. Vascular pathology is another recently recognized hallmark of ALS pathogenesis. Central nervous system (CNS) capillary damage is a shared disease element in ALS rodent models and ALS patients. Microvascular impairment outside of the CNS, such as in the lungs, may occur in ALS, triggering lung damage …

Translating Intracarotid Artery Transplantation Of Bone Marrow-Derived Ncs-01 Cells For Ischemic Stroke: Behavioral And Histological Readouts And Mechanistic Insights Into Stem Cell Therapy, Yuji Kaneko, Jea-Young Lee, Naoki Tajiri, Julian P. Tuazon, Trenton Lippert, Eleonora Russo, Seong-Jin Yu, Brooke Bonsack, Sydney Corey, Alexandreya B. Coats, Chase Kingsbury, Thomas N. Chase, Minako Koga, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow-derived NCS-01 cells. Coculture with NCS-01 cells protected primary rat cortical cells or human neural progenitor cells from oxygen glucose deprivation. Adult rats that were subjected to middle cerebral artery occlusion, transiently or permanently, and subsequently received intracarotid artery or intravenous transplants of NCS-01 cells displayed dose-dependent improvements in motor and neurological behaviors, and reductions in infarct area and peri-infarct cell loss, much better than intravenous administration. The optimal dose was 7.5 × 106 cells/mL when …

Annual Report, Collection Development & Technical Services, 2019 - 2020, Christine Dunleavy

Library Department and Committee Reports

2019-2020 annual report for the Collection Development and Technical Services Department at Nelson Poynter Memorial Library at the University of South Florida St. Petersburg.

Resolvin E1 Derived From Eicosapentaenoic Acid Prevents Hyperinsulinemia And Hyperglycemia In A Host Genetic Manner, Anandita Pal, Abrar E. Al-Shaer, William Guesdon, Maria J. Torres, Michael Armstrong, Kevin Quinn, Traci Davis, Nichole Reisdorph, P. Darrell Neufer, Espen E. Spangenburg, Ian Carroll, Richard P. Bazinet, Ganesh V. Halade, Joan Clària, Saame Raza Shaikh

Internal Medicine Faculty Publications

The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia. EPA ethyl esters prevented obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia in C57BL/6J mice. Supporting NHANES analyses showed that fasting glucose levels of obese adults were inversely related to EPA intake. We next investigated how EPA improved murine hyperinsulinemia and hyperglycemia. EPA overturned the obesity-driven decrement in the concentration …

Race-Based And Sex-Based Differences In Bioactive Lipid Mediators After Myocardial Infarction, Ganesh V. Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A. Limdi

Internal Medicine Faculty Publications

Aims: Leucocyte-directed specialized pro-resolving mediators (SPMs) are essential for cardiac repair, and their biosynthesis coincides with the expression of pro-inflammatory mediators; however, the precise quantitation during an acute myocardial infarction (MI) event is poorly understood in race-specific and sex-specific manner. Coronary heart disease is the leading cause of death and disability in the USA. Although the prevalence of coronary heart disease is similar between Black and White patients, cardiovascular events (including MI), rehospitalization, and mortality are disproportionately higher in Black patients. Therefore, understanding differences in inflammation and resolution can enable the development of predictive, personalized, and precise treatment and attenuate …

“Why The H**L Is There A White House Correspondents’ Dinner?” Boundary Work In Political Journalism, Gregory P. Perreault, Kellie Stanfield, Shelby Luttmann

School of Advertising & Mass Communications Faculty Publications

Political journalism is a pertinent part of newsrooms across theworld. This study aimed to analyze the shifting role conceptionsof U.S. political journalists, primarily in reference to the WhiteHouse Correspondents’Dinner. Researchers conducted 32 long-form phone interviews with political journalists from news outletsranging from theLos Angeles Timesto VICE. The study found mostjournalists uncomfortable with the White House Correspondents’Dinner, especially after the response to Michelle Wolf’s speech atthe 2018 event. This particular event helped journalists identifyhow the event works in opposition to their role conception.Through the lens of boundary work, this study argues the comedyformat of the dinner, which ceased following 2018, pushedoutside …

Metal–Organic Frameworks For Enzyme Immobilization: Beyond Host Matrix Materials, Xiaoliang Wang, Pui Ching Lan, Shengqian Ma

Chemistry Faculty Publications

Enzyme immobilization in metal–organic frameworks (MOFs) as a promising strategy is attracting the interest of scientists from different disciplines with the expansion of MOFs’ development. Different from other traditional host materials, their unique strengths of high surface areas, large yet adjustable pore sizes, functionalizable pore walls, and diverse architectures make MOFs an ideal platform to investigate hosted enzymes, which is critical to the industrial and commercial process. In addition to the protective function of MOFs, the extensive roles of MOFs in the enzyme immobilization are being well-explored by making full use of their remarkable properties like well-defined structure, high porosity, …

C‑Jun And Foxo1 Mediate The Expression Of Oncogenic Pkc‑Ι In Human Prostate Cancer Cells With An Interplay Between Nf‑Κb, Il‑8 And Icam‑1, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Sloan Breedy, Mildred Acevedo-Duncan

Chemistry Faculty Publications

Aggressive and metastatic prostate cancers are among the leading causes of fatality in men. Prior observations by the authors regarding atypical protein kinase C isoforms (aPKCs) in relation to prostate cancers demonstrated elevated levels of PKC‑iota (PKC‑ι) in patient samples compared to non‑malignant prostate tissues. This indicates that PKC‑ι is a potential biomarker for initiating and maintaining prostate carcinogenesis. In addition, PKC‑ι is an oncogene that encourages the activation of the nuclear factor (NF)‑κB, assisting carcinogenesis. The specific inhibition of PKC‑ι de‑regulated the expression of both PKC‑ι and its phosphorylation; thus, PKC‑ι functionally controls its own expression in prostate carcinoma. …

Beyond Confined Catalysis In Porous Materials, Xiaoliang Wang, Pui Ching Lan, Sai Wang, Shengqian Ma

Chemistry Faculty Publications

No abstract provided.

Highly Efficient Electrocatalytic Hydrogen Evolution Promoted By O–Mo–C Interfaces Of Ultrafine Β-Mo2C Nanostructures, Hui Yang, Xing Chen, Guoxiang Hu, Wan-Ting Chen, Siobhan J. Bradley, Weijie Zhang, Gaurav Verma, Thomas Nann, De-En Jiang, Paul E. Kruger, Xiangke Wang, He Tian, Geoffrey I. N. Waterhouse, Shane G. Telfer, Shengqian Ma

Chemistry Faculty Publications

Optimizing interfacial contacts and thus electron transfer phenomena in heterogeneous electrocatalysts is an effective approach for enhancing electrocatalytic performance. Herein, we successfully synthesized ultrafine β-Mo2C nanoparticles confined within hollow capsules of nitrogen-doped porous carbon (β-Mo2C@NPCC) and found that the surface layer of molybdenum atoms was further oxidized to a single Mo–O surface layer, thus producing intimate O–Mo–C interfaces. An arsenal of complementary technologies, including XPS, atomic-resolution HAADF-STEM, and XAS analysis clearly reveals the existence of O–Mo–C interfaces for these surface-engineered ultrafine nanostructures. The β-Mo2C@NPCC electrocatalyst exhibited excellent electrocatalytic activity for the hydrogen evolution reaction (HER) in water. Theoretical studies indicate …

Adaptive Learning In A Numerical Methods Course For Engineers: Evaluation In Blended And Flipped Classrooms, Renee M. Clark, Autar Kaw

Mechanical Engineering Faculty Publications

As use of adaptive learning technology in STEM courses gains traction, studies evaluating its impacts are important to undertake. Adaptive e‐learning platforms provide personalized, flexible learning via monitoring of student progress and performance and subsequent provision of an individualized learning path containing various resources. In this study, adaptive technology was utilized in blended and flipped versions of a numerical methods course. A particular challenge with flipped instruction is preclass preparation, in which videos with the same instruction for all students are often assigned. Therefore, to diversify preclass learning, the instructor developed adaptive lessons via an NSF grant and rigorously assessed …

Collagen Production And Niche Engineering: A Novel Strategy For Cancer Cells To Survive Acidosis In Dcis And Evolve, Mehdi Damaghi, Hidetoshi Mori, Samantha Byrne, Liping Xu, Tingan Chen, Joseph Johnson, Nathan D. Gallant, Andriy Marusyk, Alexander D. Borowsky, Robert J. Gillies

Mechanical Engineering Faculty Publications

Growing tumors are dynamic and nonlinear ecosystems, wherein cancer cells adapt to their local microenvironment, and these adaptations further modify the environment, inducing more changes. From nascent intraductal neoplasms to disseminated metastatic disease, several levels of evolutionary adaptations and selections occur. Here, we focus on one example of such an adaptation mechanism, namely, “niche construction” promoted by adaptation to acidosis, which is a metabolic adaptation to the early harsh environment in intraductal neoplasms. The avascular characteristics of ductal carcinoma in situ (DCIS) make the periluminal volume profoundly acidic, and cancer cells must adapt to this to survive. Based on discovery …

Examining Older Adults’ Perspectives On The Built Environment And Correlates Of Healthy Aging In An American Age-Friendly Community, Kathy Black, Dylan J. Jester

Aging Studies Sarasota Manatee Campus Faculty Publications

Population aging has led to an increased focus on the environmental context in which we age. While researchers have identified significant health benefits associated with built community features such as housing, transportation and outdoor spaces and buildings, less attention has focused on the correlates of healthy aging and other characteristics via the perspective of community-dwelling older adults. This study utilized cluster analysis to examine health-related subgroups of older adults (n = 598) in an age-friendly community located in the United States, of which nearly half of its residents are age 60 and older. Linear regression was used to associate the …

What Is Digital Journalism? Defining The Practice And Role Of The Digital Journalist, Gregory P. Perreault, Patrick Ferrucci

School of Advertising & Mass Communications Faculty Publications

Through the lens of theories of field and normalization process, this research seeks to understand technology’s current role in how self-identifying digital journalists define the field. The definitions of digital journalism/journalists and what constitutes digital journalism practices are essential–they shape a range of crucial activities including how journalists prioritize sources to how journalists shape their content for audience consumption. Built on long-form interviews with 68 U.S.-based self-identifying digital journalists, this article argues that the digital turn in the industry has emboldened new entrants to the field and required dominantly placed legacy media journalists to reconsider their definition of journalism as …

Metajournalistic Discourse On The Rise Of Gaming Journalism, Gregory P. Perreault, Tim P. Vos

School of Advertising & Mass Communications Faculty Publications

Gaming journalism, which finds its origins in public relations-oriented gaming magazines, discursively attached itself to traditional journalism in the wake of the 2014 GamerGate controversy. Yet it had remained unclear where gaming journalism fits within the ecology of journalism. This study examines metajournalistic discourse regarding gaming journalism from 2010 to 2018 and analyzes 53 articles about gaming journalism from that period in order to understand how the broader journalistic field conceptualized gaming journalism’s place within it. This study argues that gaming journalism is discursively marked as a lower, marginal form of journalism based on perceived differences in professional values and …

The Discursive Construction Of The Gamification Of Journalism, Tim P. Voss, Gregory P. Perreault

School of Advertising & Mass Communications Faculty Publications

This study explores the discursive, normative construction of gamification within journalism. Rooted in a theory of discursive institutionalism and by analyzing a significant corpus of metajournalistic discourse from 2006 to 2019, the study demonstrates how journalists have negotiated gamification’s place within journalism’s boundaries. The discourse addresses criticism that gamified news is a move toward infotainment and makes the case for gamification as serious journalism anchored in norms of audience engagement. Thus, gamification does not constitute institutional change since it is construed as an extension of existing institutional norms and beliefs.

Making Disciplinary Research Audible, Andrew Smith, Meghan L. Cook, Matt Torrence

Tampa Library Faculty and Staff Publications

Academic libraries have long consulted with faculty and graduate students on ways to measure the impact of their published research, which now include altmetrics. Podcasting is becoming a more viable method of publicizing academic research to a broad audience. Because individual academic departments may lack the ability to produce podcasts, the library can serve as the most appropriate academic unit to undertake podcast production on behalf of researchers. The article identifies what library staff and equipment are required, describes the process needed to produce and market the published episodes, and offers preliminary assessments of the podcast impact.

Interferon Beta Activity Is Modulated Via Binding Of Specific S100 Proteins, Alexei S. Kazakov, Alexander D. Sofin, Nadezhda V. Avkhacheva, Alexander I. Denesyuk, Eugenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Molecular Medicine Faculty Publications

Interferon-β (IFN-β) is a pleiotropic cytokine used for therapy of multiple sclerosis, which is also effective in suppression of viral and bacterial infections and cancer. Recently, we reported a highly specific interaction between IFN-β and S100P lowering IFN-β cytotoxicity to cancer cells (Int J Biol Macromol. 2020; 143: 633–639). S100P is a member of large family of multifunctional Ca2+-binding proteins with cytokine-like activities. To probe selectivity of IFN-β—S100 interaction with respect to S100 proteins, we used surface plasmon resonance spectroscopy, chemical crosslinking, and crystal violet assay. Among the thirteen S100 proteins studied S100A1, S100A4, and S100A6 proteins exhibit strictly Ca2+-dependent …

Hsp22 With An N-Terminal Domain Truncation Mediates A Reduction In Tau Protein Levels, Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad Anthony Dickey, Laura J. Blair

Molecular Medicine Faculty Publications

Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these insults. Small heat shock proteins (sHsps) engage proteins early in the process of misfolding and can facilitate their proper folding or refolding, sequestration, or clearance. Here, we evaluate the effects of the sHsp Hsp22, as well as a pseudophosphorylated mutant and an N-terminal domain deletion (NTDΔ) variant on tau aggregation in vitro and tau accumulation and aggregation in cultured cells. Hsp22 wild-type (WT) protein had a significant inhibitory effect on …