Digital Commons Network^™

Targeting Cancer With T Cells: Preclinical And In Silico Insights To Improve Immunotherapies, Nina Obertopp

USF Tampa Graduate Theses and Dissertations

T-cell–based immunotherapies are often constrained by limited trafficking and persistence in tumors and by functional exhaustion under chronic antigen exposure. This dissertation addresses these barriers through two distinct strategies: (i) preclinical studies testing how radiation therapy modulates tumor-infiltrating lymphocytes (TIL) therapy, and (ii) agent based modeling (ABM) to optimize treatment day treatment-free intervals (TFI) in T-cell engager (TCE) therapy. (i) In a human papillomavirus–positive (HPV⁺) head-and-neck cancer (HNC) model, a single local-dose of RT (8 Gy) delivered five days before tumor harvest increased the success and functional quality of ex vivo TIL outgrowth from tumor fragments, enriching polyfunctional CD8⁺ subsets. …

Effects Of Peer-Assisted Reading To Enhance Reading Proficiency For Learners With Mild Hearing Impairment Included In A South African Mainstream Classroom, Gaone Molapisi, Nareadi Phasha

Journal of Global Education and Research

This paper reports on the findings of a case study investigating the effects of peer-assisted reading in relation to learners identified with mild hearing impairment included in South African general education settings. These learners are often confronted with considerable challenges in developing proficient reading skills, which are crucial for curriculum access. In this study, peers with no hearing loss assisted learners with hearing impairment in reading activities to enhance their reading proficiency. The study involved two female educators and 15 learners in Grade 8 presenting with hearing impairment. The study employed a case study design, with data gathered through direct …

Impact Of Femalized Kinesthetic Learning Model On African American Middle School Girls’ Career Interest, Mercy F. Fash, Andrea Ofori-Boadu

Journal of Global Education and Research

Engaging African American middle school girls in out-of-school-time (OST) Architecture, Engineering, and Construction (AEC) programs can boost interest in male-dominated AEC careers. This study adopts Lent’s Social Cognitive Career Theory to evaluate the impact of an OST feminized AEC kinesthetic learning model (fAEC-KLM) on the career interests of this demographic. Through a qualitative research approach, fourteen (14) African American middle school girls from Guilford County, NC, completed pre- and post-interviews on how fAEC-KLM interactions influenced their AEC career interests. Inductive thematic analysis was carried out on transcribed interviews. Results show that effective components, such as lectures on AEC, bridge construction …

Advances In Culture, Tourism, And Hospitality Research: Volume 1, Cihan Cobanoglu, Hanqin Qiu, Jiaying Lyu, James H. W. Shen

University of South Florida (USF) M3 Publishing

This is the first volume of the Advances in Culture, Tourism, and Hospitality Research Book Series.

Sensi-Train: Context-Aware Sensitive Content Detection Using Transformers And Large Language Models, Nazeefa Muzammil

USF Tampa Graduate Theses and Dissertations

The detection of sensitive content has become a critical task in natural language processing due to the widespread use of online platforms and the social harm caused by it. Even though current methods have advanced significantly, many of them mainly rely on surface-level text and neglect to take into consideration contextual and cultural elements that are crucial for correctly assessing sensitivity of any content to a particular individual. Due to this, implicit offense, sarcasm, and culturally grounded expressions frequently cause problems for such systems. To enable culturally grounded sensitive content detection, this thesis presents Sensi-Train, a context-rich dataset and modeling …

Geochemistry Of Crusts In Palaeontological Deposits, Taphonomic Settings In An Upper Pleistocene Cave Site (San Teodoro, Sicily), Gerlando Vita, Luca Sineo, Francesco Armetta, Maria Luisa Saladino

International Journal of Speleology

The mineralogical and geochemical composition of cave sediments provides crucial insights into past climatic and biological dynamics. This study investigates the authigenic crusts of San Teodoro Cave (Sicily), a key Upper Pleistocene palaeontological site, through a multi-analytical approach.The cave hosts two superimposed phosphatic crusts, separated by sterile sediment, reflecting shifts in depositional and post-depositional conditions. Our analyses reveal a complex mineral assemblage consisting of calcite, aragonite, and various phosphate phases. Calcite is the dominant phase in the older crust, whereas the presence of aragonite in the younger brown crust likely indicates periods of increased aridity, potentially corresponding to conditions during …

Inside The System, Outside The Circle: A Parent-Educator’S Journey Of Navigating Through Systemic Oppression While Advocating For Her Son With A Learning Disability, Sanora L. White

USF Tampa Graduate Theses and Dissertations

This autoethnographic study examines how I, as a Black parent-educator, navigated racialized and ableist educational systems while advocating for my child with a learning disability. Grounded in Disability Studies in Education, DisCrit, Critical Pedagogy, Universal Design for Learning, and Black Feminist Thought, the study explores how systemic inequities shape parent–teacher collaboration and how advocacy functions as relational care and resistance. The guiding research question asked how I experienced and navigated collaboration within racialized and ableist special education systems. Data sources included reflective journals, IEP documents, personal narratives, and dialogic conversations with critical friends. Using composite narratives and thematic analysis, the …

From The Tropics To The Poles: Chemical Investigation Of Marine Invertebrates Through Elucidation And Synthesis, Benjamin Reed Smith

USF Tampa Graduate Theses and Dissertations

Society’s perpetual need for new disease treatments continuously leans on the shouldersof willing researchers. Even in modern day, many described diseases lack a cure or a symptomatic treatment; worse yet, the necessity for new drugs is amplified with rises in drug- resistant microbial infections, such as methicillin-resistant Staphylococcus aureus (MRSA). Historically, remedies and disease treatments have been rooted in the medicinal properties of plants and animals; naturally derived analgesics, like milk of the poppy or willow bark tea, date back thousands of years. With the developments of modern medicine, drug discovery, and natural product researchers found a wealth of potential …

The Role Of Campus Symbols In College Student Belonging: A Photo-Elicitation And Photovoice Qualitative Study, Abigail W. Bradley-Tyler

USF Tampa Graduate Theses and Dissertations

This qualitative study examines the impact of campus symbols on the sense of belonging among second-year students at a public, four-year institution in Florida. This topic is relevant as there is a lack of research about positive or neutral campus symbols. Using sense of belonging and symbolic interactionism as theoretical frameworks, this study investigates how students interpret and emotionally connect with university symbols, including campus mascots, monuments, personnel, and campus traditions and rituals. Using photo-elicitation and photovoice interviews, participants engaged with photographs of official university symbols and captured images representing their campus experience. Using Braun and Clarke’s thematic analysis, the …

Monitoring Strategies In Cave Microclimate Studies, Nenad Buzjak, Dalibor Paar, Aurel Persoiu, Christos Pennos, Franci Gabrovšek, Valerija Rossi

International Journal of Speleology

Cave atmospheres are spatially confined but dynamical systems that influence subterranean ecosystems, geomorphological processes, registration and preservation of climatic signals in sedimentary archives, cultural heritage, and conservation management. Despite major advances in cave climatology, methodological approaches to microclimate monitoring remain fragmented and are in some cases still shaped by the long-standing assumption that cave air temperature simply reflects the mean annual surface temperature. This paper revisits that assumption and develops an experience- and literature-based methodological framework for cave microclimate research. Key terminology is addressed by distinguishing between cave climate, cave microclimate, and cave meteorology, and by situating microclimatic variability within …

Improving Quantitative Support Across An Institution Using An Ecosystem Framework, Laura Muller, Melissa Eblen-Zayas

Numeracy

In our keynote address at the 2025 National Numeracy Network Annual Meeting, we introduced the framework we developed for considering four domains of an institution’s quantitative skills/reasoning support ecosystem that includes bridge programs with a quantitative component, approaches to assessing readiness, curricular on-ramps, and supplementary support. We believe this ecosystem framework has the potential to help campus leaders coordinate institutional efforts around student success in areas connected to students’ quantitative preparation. This keynote highlighted the idea that coordination of stakeholders and their engagement with domains of the ecosystem fall along a spectrum. We provide approaches for using this framework to …

Exceptional Variety Of Baryte-Celestine-Series Speleothems In Lechuguilla Cave (New Mexico, Usa), Max Wisshak, Johannes Birkenstock, Andrea Schröder-Ritzrau, Norbert Frank, Hazel A. Barton, Harvey R. Duchene

International Journal of Speleology

An inventory of speleothems primarily composed of the closely related sulfate minerals baryte (BaSO₄) and celestine (SrSO₄) in Lechuguilla Cave (New Mexico, USA) has revealed an extraordinary variety. This includes subaerial stalactites, stalagmites, flowstone, coralloids, wall crusts, floor crystals, snow, frostwork, and subaqueous pool crystals. Large baryte and celestine crystals have also been documented in hydrothermal veins in the host rock, predating the cave and truncated when intersected by it. The respective carbonate mineral phases witherite (BaCO₃) and strontianite (SrCO₃), in contrast, were found to be rare in the studied speleothem samples, …

Exploring Enacted Active Learning Practices In Postsecondary Chemistry Lecture And Laboratory Courses, Kendall M. Zammit

USF Tampa Graduate Theses and Dissertations

The work in this thesis begins to explore the enacted active learning practices in postsecondary chemistry lecture and laboratory courses. Chapter 1 explores the level of inquiry in postsecondary laboratories. Chapter 2 explores instructional and assessment practices at two-year institutions.

Chemistry postsecondary laboratories offer a unique opportunity to engage students in inquiry-based instruction. Inquiry-based instruction was categorized by the asking faculty members at four-institutions about six characteristics of laboratory design: choosing a problem, background research, designing procedures, analyzing data, communicating results, and interpreting results. As students have the freedom to make decisions on more characteristics of inquiry learning, the closer …

Adaptive Multi-Agent Intelligence: A Dynamic Data Management System For Enhanced Data Quality And Reconciliation, Anthony Taeyang Vigil

USF Tampa Graduate Theses and Dissertations

Organizations struggle with data quality problems that cost them millions of dollars annually. Manual data cleanup and standardizing, also known as reconciliation, can take skilled analysts days to complete and can still contain human errors. This dissertation addresses this challenge by developing and validating the Origin Data Management System, which automates processes that traditionally require days of manual work. The system achieved up to 100% accuracy in standardizing vendor names and identifying CEO information across real-world test datasets from Jefferson County Public Schools, Forbes, and Fortune Magazines. Processing time dropped from days to minutes—a 96-fold improvement over manual methods. These …

Pitfalls Of Multiplied 3d Landforms Projection: Mapping Deep Multilevel Cave Systems In The Alps (Gamssteig Cave System, Göll Massif), Mateusz Golicz, Jacek Szczygieł

International Journal of Speleology

Cave mapping represents one of the most complex challenges in geomorphological cartography, as it must convey the true three-dimensional geometry of subterranean spaces such as overlapping passages, irregular cross-sections, and variable ceiling and floor morphologies, within a two-dimensional framework. This study examines the methodological and interpretive challenges of cave mapping, utilizing the Gamssteighöhle cave in the Austrian Alps as a case study. During the 11 years of exploration, over 10 km of passages were surveyed using the DistoX vector survey method. Yet, the complex morphological forms necessitated deviations from the standard symbology recommended by the International Union of Speleology. Several …

Correlation Analysis Of Factors Associated With Students’ Numeracy Skills Using Decision Tree Algorithms, Yenita Roza, Arisman Adnan, Zul Indra, Tuti Alawiyah

Numeracy

Numeracy is a critical competency for academic and everyday functioning. This study investigates the key factors associated with students’ numeracy skills by employing decision tree algorithms as a data mining technique. The dataset used in this study is educational assessment data from Indonesia. Utilizing a dataset comprising 6,953 entries and 60 variables from Education Report, the research adopts an exploratory approach involving data preprocessing, exploratory data analysis, and decision tree model construction. The findings reveal that students’ literacy skills serve as the most dominant predictor of numeracy proficiency, emerging as the root node in the decision tree structure. Additional associated …

Considering Context In Latent Models Of Externalizing: Measurement Invariance By Environmental And Systemic Disadvantage In System-Involved Youth, Kendall D. Smith

USF Tampa Graduate Theses and Dissertations

Externalizing forms of psychopathology are said to result from a general liability towards impulsive and disruptive behaviors, including substance use, conduct problems, aggression, and antisocial behavior (Krueger et al., 2021). While the field often focuses on dispositional explanations of externalizing behaviors, there is a notable lack of attention to the contextual factors that contribute to these behaviors, beyond immediate environmental influences. This study uses Ecological Systems Theory (Bronfenbrenner, 2005) as a framework to address such gaps in the context of behavioral indicators of the latent externalizing (EXT) construct, an analysis with implications for understanding racial/ethnic and socioeconomic disparities. The present …

Assessing The Impact Of Visitors On Airborne Particle Deposition In The Giant Gypsum Geode Of Pulpí (Se Spain), Ana Camila Mendoza, Ángel Fernández-Cortés, Fernando Gázquez, Jesús Morilla, Milagros Carretero, Jose Maria Calaforra, David Benavente

International Journal of Speleology

The Giant Geode of Pulpí is a unique mineralogical phenomenon worldwide, remarkable for its large selenite gypsum crystals. Its recent development as a tourist site and inclusion on UNESCO’s Tentative World Heritage List, highlight the need to assess the impact of visits on its conservation. This study investigates airborne particle dynamics inside the Geode, focusing on tourist activity and natural ventilation. We measured deposition rates and composition of airborne particles using passive traps and a continuous laser-optical particle counter. Microenvironmental variables linked to ventilation, such as temperature and radon gas concentration (²²²Rn), were simultaneously monitored. Results show a predominance of …

Teaching Numeracy For Social Justice: Educational Equity, Esther Isabelle Wilder, Crystal C. Rodriguez, Caterina Shost, Eduardo Vianna, Frank Wang

Numeracy

The special collection, “Teaching Numeracy for Social Justice: Educational Equity,” focuses on how quantitative reasoning (QR) can function as a vehicle for equity, empowerment, and democratic participation. Building on a longstanding tradition that treats numeracy as inseparable from social justice, these contributions highlight how progressive pedagogies (e.g., active learning, authentic research, and equity-oriented assessment) have the potential to broaden access for students historically excluded from quantitative fields. The studies span a variety of conceptual frameworks, introductory and advanced quantitative instruction, and interdisciplinary applications, showcasing how inclusive QR practices can build confidence, agency, and real-world understanding. These articles demonstrate that when …

A Study Of The Impacts Of Infusing Data Analysis And Research In An Interdisciplinary Environmental Economics Course, Sean P. Macdonald

Numeracy

This paper explores the impacts of introducing quantitative literacy skills in an interdisciplinary Environmental Economics course typically taught as an issues and policy course without a quantitative component. The study examines the effects of infusing an engaging, student-selected data collection and analysis assignment on students' quantitative reasoning skills, as well as their interest in and attitudes about data analysis and quantitative information. Using data gathered from a set of pre- and post-assessment questions designed to measure changes in quantitative reasoning skills and attitudes, the findings point to significant attitudinal impacts, gains, but smaller, insignificant gains in quantitative reasoning skills.

Quantitative Reasoning In Calculus Iii: Advancing Student Engagement, Confidence, And Aspirations At An Hsi, Tanvir Prince

Numeracy

This study examines the impact of integrating Quantitative Reasoning (QR) into a Calculus III course at a Hispanic-Serving Institution (HSI) on student engagement, confidence, and aspirations. The course is offered at Hostos Community College in the South Bronx. It incorporated QR-focused projects on economic inequality, environmental pollution, and access to healthcare. These projects allowed students to apply advanced calculus concepts to real-world social issues. A pre- and post-survey design was employed to assess changes in students’ mathematical confidence, perceptions of relevance, and career and educational goals. Results showed statistically significant gains in confidence and in the belief that advanced math …

A Comparison Of First- And Continuing-Generation Students Completing A Project-Based Introductory Statistics Course, Susan A. Dumais, Naomi J. Spence, Lisa Dierker

Numeracy

Traditional introductory statistics courses that focus on techniques are not engaging for many college students; this may be especially true for first-generation college students, who generally have more difficulty engaging in the college environment than continuing-generation students. We study first-generation college students’ experiences in a course-based undergraduate research experience called Passion-Driven Statistics. Passion-Driven Statistics is a multidisciplinary, project-based introductory statistics course where students develop their own research topics, analyze publicly available quantitative data, and focus on conceptual understanding of statistics rather than hand calculations. Using pre-course and post-course surveys from students taking Passion-Driven Statistics in colleges throughout the United States, …

Toward Fairer And More Equitable Numeracy Measurement: Improvements To The Quantitative Reasoning For College Science Assessment, Vonna L. Hemmler, Isaac Rosenthal, Kate Follette, Catherine Sarosi, Erin Galyen, Sanlyn Buxner, Jackson Carter, Samantha Maynard, Sarah Bunnell

Numeracy

Numeracy has become an increasingly important 21st-century skill that, due to the relationship between math and science, is often formally developed at the college level in general education science courses. These courses serve a diverse group of students, many of whom have historically experienced science teaching, curriculum, and assessment on the margins. The well-documented biases of assessments in particular against Individuals of Color (IoC) have inspired us to approach numeracy for social justice in our work from this angle, and in this paper, we detail our efforts to revise our validated numeracy assessment to ensure it more fairly and equitably …

The Roles Of Mathematics In Teaching For Social Justice: A Framework For The College Classroom, Vivian Lim, Daniel Libertz

Numeracy

In this paper, we present a framework for understanding the multiple roles that mathematics can serve in the classroom towards social justice goals, developed through an analysis of 36 social justice mathematics curricular modules in college settings. The framework is grounded in Patricia Hill Collins's matrix of domination and consists of seven themes that represent the different roles mathematics can play: measuring inequality, illuminating conditions resulting in inequality, understanding the mechanisms of phenomena, challenging stereotypes and misconceptions, generating and evaluating solutions, communication and action, and criticizing quantification. Our framework supports the perspective that mathematics can serve important and distinct roles …

Bridging Functions And Values: Advancing Wetland Ecosystem Service Assessment Through Use Of A Service Capacity Index, William J. Kleindl, Sarah P. Church, Kai C. Rains, Mark C. Rains, Eric D. Stein, Morgan K. Suddreth

School of Geosciences Faculty and Staff Publications

Wetland service or values are often assumed to occur at a comparable level to wetland function (i.e., higher functioning wetlands provide more services). However, services are seldom directly evaluated because of the lack of structured assessment approaches. For wetland ecosystem service to be effectively incorporated in regulatory and monitoring programs, there needs to be parsimonious assessment tools that can be applied systematically, repeatably, and rapidly. This approach begins by disentangling existing terminology and clearly defining all the terms necessary to support the assessment of ecosystem services (ES). We provide context to illustrate how these terms have been variously employed in …

Implications Of Quantum Computing For Enterprise Cybersecurity And Data Integrity, Manikantha Varaprasad Inakollu

Computer Science and Engineering Faculty Publications

Quantum computing represents a paradigm shift in computational capabilities that poses both unprecedented threats and opportunities for enterprise cybersecurity. This research examines the implications of quantum computing advancement on current cryptographic systems, data protection mechanisms, and organizational security frameworks. Through analysis of quantum computing developments from 2019-2024 and surveys of 280 cybersecurity professionals across various industries, this study identifies critical vulnerabilities in existing encryption standards and explores emerging quantum-resistant solutions. The findings reveal that approximately 78% of enterprises remain unprepared for quantum threats, with current RSA and ECC encryption systems facing potential compromise within the next 10-15 years. The research …

No Groundwater, No Fish: The Critical Role Of Groundwater In Supporting Non-Glacial, Salmon-Bearing Rivers In South-Central Alaska, Tyelyn Brigino, Kai Rains, Edgar Guerron-Orejuela, Jacob Argueta, Syverine Bentz, Coowe Walker, Mark Rains

School of Geosciences Faculty and Staff Publications

Groundwater discharge plays an important role in the hydrologic and ecologic functioning of rivers including sustaining streamflow and related habitat year-round. Simultaneously, groundwater supports the increasing demands of people as the global population continues to grow. Balancing the needs of users becomes increasingly important as climate change introduces greater uncertainty in water resources and fisheries, especially for economically important anadromous species that depend on freshwater resources. We investigated the seasonal and regional variability of groundwater contributions to six non-glacial mainstem salmon-bearing rivers in south-central Alaska. We hypothesized that groundwater contributes more than half of the annual streamflow, and nearly all …

Non-Destructive Characterization Of Variously Colored Gypsum And Aragonite/Calcite Speleothems From The Cigalère Cave (Ariège, France), Martin Vlieghe, Johan Wouters, Gérald Fanuel, Jean-François Drion Du Chapois, Anne Gallez, Stéphane Pire-Stevenne, Gaëtan Rochez, Johan Yans

International Journal of Speleology

The Cigalère Cave is a 21 km-long karstic cave located in the Ariège Department, in the French Pyrenees, and underlies directly the Bentaillou Pb-Zn-Fe sulfide ores. The cave hosts abundant gypsum mineralizations, some of them exhibiting various colorations including blue, yellow, purple, orange and black. Due to strict preservation policies, these colored mineralizations have not been studied much. Here we propose a non-destructive characterization of five distinct gypsum or carbonate speleothem structures from the Cigalère, exhibiting different colorations. To comply with the preservation policies, no sample was taken from the cave, and all speleothems were analyzed in situ using portable …

Hydrothermal Vents In Sulfuric Acid Speleogenesis Karst: Isolated Feeders With Pristine Hypogenic Water Or Interconnected Conduits With Rapid Flow And Recycled Water?, Jakub Mareš, Marek Audy, Serban M. Sarbu, Jan Kukačka, Romeo Eftimi, Jiří Bruthans

International Journal of Speleology

Underwater connectivity and flow paths in the saturated zone of hypogenic sulfuric acid speleogenesis (SAS) karst remain unclear, despite sustained research over the past 30 years. Being regarded as sources of pristine H₂S-charged water, narrow inflow conduits called "feeders" are typically considered primary sources of water and hotspots of speleogenesis. In southeastern Albania, there is a newly discovered active SAS karst system comprising numerous caves and springs. Tracer tests were conducted to investigate the connection of these caves to the surrounding springs and to characterize the flow paths. The results show that water flows from cave lakes to …

A Cave In Miocene Conglomerate: The Törökpince-Abaliget Cave System, Hungary, Krisztina Sebe, Piroska Pazonyi, Márton Bauer, Bálint Szappanos, Márton Szabó, Zoltán Szentesi, Mihály Gasparik, Ákos Juhász, Luca Pandolfi, Máté Gregorits, József Haász, Ágnes Novothny, Zsófia Ruszkiczay-Rüdiger

International Journal of Speleology

Conglomerate caves are rare, and only a few have been described in the scientific literature. Here, we present a newly discovered and significant cave system in SW Hungary, comprising over 500 m of upper passages and a shorter, lower section of a through-cave developed in Lower–Middle Miocene conglomerates. The formation of these cave passages was controlled chiefly by bedding and fractures. Dissolution has produced typical karstification morphologies, whereas corrasion, granular disintegration, and rock collapse have also played a role in shaping the cave. The cave is dominated by vadose-zone morphologies, but sediment infills indicating upward water flow, along with ceiling …