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Innate Immune Responses To Respiratory Syncytial Virus: Age-Associated Changes, Terianne Maiko Wong

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) infection causes ~64 million cases of respiratory disease and 200,000 deaths annually worldwide, yet there is no broadly effective prophylactic or treatment regimen. RSV can produce acute respiratory illness in patients of all ages but strikes the age extremes, infants and the elderly, with highest frequency presumably due to innate immune deficiencies. A higher morbidity and mortality has been reported for the elderly above 65 years of age, which has been attributed to immune senescence. Efforts to generate an effective vaccine have thus far been unsuccessful.

The innate immune system provides the first line of defense …

Histone Deacetylases As Targets For Melanoma Immunotherapy, David Michael Woods

USF Tampa Graduate Theses and Dissertations

Cancer represents the second leading cause of death in the United States. For many malignancies, currently available treatment options offer little long-lasting survival benefits to patients. However, recent studies have shown immunotherapeutic approaches to be an attractive strategy to cancer treatment. While many current immunotherapeutic strategies convey durable responses, such responses are only seen in a minority of patients. An increased understanding of the mechanisms governing tumor immunogenicity and the biology of immune responses is crucial to improving upon the efficacy of current and future cancer immunotherapies. Histone deacetylases (HDACs), enzymes classically associated with regulation of gene expression, have been …

Effects Of Speech Production Ability On A Measure Of Speech Perception Capacity In Young Children With Cochlear Implants And Their Articulation-Matched Peers, Victoria Beatriz Gonzalez

USF Tampa Graduate Theses and Dissertations

With reductions in the age criterion for cochlear implantation, the need for age-appropriate measures of speech perception skills has increased. One recently developed tool that shows great promise for the clinical assessment of auditory speech perception capacity in young children with cochlear implants is the On-Line Imitative Test of Speech-Pattern Contrast Perception (OlimSpac). The OlimSpac requires a child to imitate nonword utterances by providing a verbal response. The child's perceptual abilities are inferred from the child's productions through having a listener, who is masked to the stimulus select the utterance produced by the child in an eight-alternative force-choice task. Although …

Social Determinants Of Racial And Ethnic Disparities In Perinatal Morbidity: Social Origins Of Perinatal Health Study, Abraham A. Salinas-Miranda

USF Tampa Graduate Theses and Dissertations

BACKGROUND: The social causation of preterm birth remains elusive, without an adequate explanatory framework. Thus, this study proposed and evaluated a conceptual model of the social determinants of perinatal health for the understanding of perinatal health disparities.

METHODS: A prospective cohort study was conducted with pregnant women between 20 and 35 weeks gestation who were participating in two Healthy Start programs in Central Florida, from July 2011-August 2013. Perinatal health was operationalized based on gestational age, birth weight, and healthy start infant risk screen score. The predictors were: early life adversity, social position, maternal health-related quality of life, maternal stress, …

Development Of A Confirmatory Pcr Assay To Detect Onchocerca Volvulus In Pools Of Vector Black Flies, Alex Jeanne Talsma

USF Tampa Graduate Theses and Dissertations

Onchocerciasis, or river blindness, has historically represented one of the significant neglected tropical diseases on the planet in terms of socio-economic impact. The discovery that ivermectin was a safe and effective treatment for onchocerciasis, together with the decision of the manufacturer to donate the drug for the treatment of this disease became the basis for several large international programs to control and eventually eliminate the infection. These programs have managed to virtually eliminate transmission of the parasite causing Onchocerca volvulus from many foci in Africa and the Americas. Verifying that transmission has been halted requires sensitive and specific assays to …

Associations Of Perceived Stress, Sleep, And Human Papillomavirus In A Prospective Cohort Of Men, Stephanie Kay Kolar

USF Tampa Graduate Theses and Dissertations

Introduction: Mucosal human papillomavirus (HPV) infection is the most common sexually transmitted infection (STI) and is associated with genitals warts, anogenital cancers, and oropharyngeal cancers. Most sexually active persons will become infected with HPV at some point in their lives, however few will develop HPV-related diseases such as warts, lesions, or cancer as a result of the infection. It is unclear why a minority of individuals fail to clear HPV infection and develop clinical disease. Due to initial associations with cervical lesions, much research has focused on women. Th1 type immune responses have been associated with successful response to HPV …

Practices And Factors Influencing Sharps Use And Safety In A Suburban Fire Department And Among Emergency Medical Services Personnel, Christine Michelle Mcguire-Wolfe

USF Tampa Graduate Theses and Dissertations

Needlestick injuries (NSIs) are a recognized risk for occupationally-related transmission of bloodborne pathogens (BBP). The occurrence of NSIs and BBP exposures among firefighters (FFs) and emergency medical services (EMS) personnel has been documented.

The purposes of this study were: 1) to define the problem of NSI among FFs and EMS personnel in a suburban fire department (FD) and identify practices and factors that influence sharps use and safety; 2) design and implement and intervention to promote safer sharps device usage; and 3) to measure the effectiveness of the intervention among FFs and EMS personnel.

A multi-phase, mixed methods approach was …

Commencement Convocation Program, Usf, Graduate, December 15, 2012, University Of South Florida

USF Graduation and Convocation Programs

Honorary Doctor of Science - Joseph S. Francisco

Antiviral Activity Of Cyclopentene Nitro-Ester And Derivatives, Kirpal S. Bisht, Alberto Van Olphen, Pasha M. Khan, Cynthia Bucher

USF Patents

Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new field for application of these compounds. Starting from a meso-diol, optically pure compounds were prepared without utilizing chiral ligands at any stage of the synthesis. The stereochemical outcome of the product (>99% ee) was influenced by desymmetrization catalyzed by Pseudomonas cepacia lipase and the stereo selective nature of the palladium catalyzed transformations.

Pathology In Euthermic Bats With White Nose Syndrome Suggests A Natural Manifestation Of Immune Reconstitution Inflammatory Syndrome, Carol U. Meteyer, Daniel Barber, Judith N. Mandl

KIP Articles

No abstract provided.

Materials And Methods For Prevention And Treatment Of Rna Viral Diseases, Shyam S. Mohapatra, Aruna K. Behera

USF Patents

The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleotide encoding 2-5 AS, or at least one catalytically active fragment thereof, such as the p40, p69, p100 subunits, to a patient in need thereof. The present inventors have determined that overexpression of 2-5AS causes a reduction in epithelial cell damage, reduction in infiltration of mononuclear cells in the peribronchiolar and perivascular regions, and reduction in thickening of …

Genetic Relatedness Of The Novel Human Group C Betacoronavirus To Tylonycteris Bat Coronavirus Hku4 And Pipistrellus Bat Coronavirus Hku5, Patrick Cy Woo, Susanna Kp Lau, Kenneth Sm Li, Alan Kl Tsang, Kwok-Yung Yuen

KIP Articles

No abstract provided.

Toxicity Reporting System, Andrea Trotti, Iii

USF Patents

The present invention is a method for communicating and forecasting the extent of toxicity of a given treatment program by deploying a uniform multi-modality grading system, and capturing significant high-grade events within defined risk periods to create a treatment-specific summary rating or classification of the toxicity experience.

Present And Potential Future Distribution Of Common Vampire Bats In The Americas And The Associated Risk To Cattle, Dana N. Lee, Monica Papeş, Ronald A. Van Den Bessche

KIP Articles

Success of the cattle industry in Latin America is impeded by the common vampire bat, Desmodus rotundus, through decreases in milk production and mass gain and increased risk of secondary infection and rabies. We used ecological niche modeling to predict the current potential distribution of D. rotundus and the future distribution of the species for the years 2030, 2050, and 2080 based on the A2, A1B, and B1 climate scenarios from the Intergovernmental Panel on Climate Change. We then combined the present day potential distribution with cattle density estimates to identify areas where cattle are at higher risk for the …

Speleo Spiel, No. 391, July-August 2012, Alan Jackson

Speleo Spiel

Contents: Regular Bits -- Trip Reports -- Other Exciting Stuff -- Surveys

Thy Brother’S Keeper? The Relationship Between Social Distance And Intensity Of Dehumanization During Genocide, Lisa Haagensen, Marnix Croes

Genocide Studies and Prevention: An International Journal

This paper puts forth the hypothesis that the degree of social distance between perpetrator and vic- tim groups prior to the outbreak of genocide is inversely related to the degree of severity of dehu- manization employed by the perpetrator group during genocide. Derived from psychological theory, this hypothesis is illustrated by using a primarily literature-based method of analysis combined with a vignette-designed severity of dehumanization scale. Three genocides are compared: the Rwandan Genocide, the Holocaust as it occurred in Western Europe, and the Holocaust as it occurred in East- ern Europe. The findings for Rwanda and the Holocaust in Eastern …

Usf Women's Club Yearbook, 2012–2013, Usf Women's Club

USF Women’s Club Collection

Yearbook of the USF Women's Club. Inside is a list of past presidents, officers, committee chairmen, and members for 2012–2013. The booklet also includes a tribute to Grace Allen, interest groups, calendar of events, and a copy of the constitution and by-laws from the handbook.

Fungal Disease And The Developing Story Of Bat White-Nose Syndrome, David S. Blehert

KIP Articles

No abstract provided.

Analysis Of Variable Effects On Presence Of Cryptosporidium Oocysts And Giardia Cysts In Effluent Water From Wastewater Treatment Utilities In Florida From 1998 To 2010, Katherine Jane Barkan

USF Tampa Graduate Theses and Dissertations

The concern of a Cryptosporidium or Giardia waterborne outbreak due to treated wastewater has had water treatment utilities using some of the highest water cleansing technologies available. Cryptosporidiosis and Giardiasis are severe diarrheal diseases which can lead to death, thus it is important that appropriate steps are taken to assure these parasites are not present in the effluent of treated wastewater. This study examined the results of 863 assays for Giardia and Cryptosporidium on the effluent of wastewater treatment facilities and found that county of collection, watershed of collection, and laboratory analyzing the sample have the most significant impact on …

Responsiveness Of The Federal Health System To The Needs Of 18-45 Year Old Adults With Physical Disabilities In Islamabad, Pakistan, Shaista Habibullah

USF Tampa Graduate Theses and Dissertations

Abstract

The health system has been defined as all people, institutions and resources that undertake actions with the primary intent of improving health, while responsiveness of the health system refers to its objective of responding to the legitimate expectations of the population it serves. Although responsiveness is a non-health objective of the health system, it affects the health status of the population by influencing treatment compliance, patient-provider communication and health services utilization. Furthermore, responsiveness has a fundamental value as it concerns basic human rights of the individuals being served by the health system.

This study was undertaken to determine how …

Frequent Arousal From Hibernation Linked To Severity Of Infection And Mortality In Bats With White-Nose Syndrome, Deeann M. Reeder, Craig L. Frank, Gregory G. Turner

KIP Articles

White-nose syndrome (WNS), an emerging infectious disease that has killed over 5.5 million hibernating bats, is named for the causative agent, a white fungus (Geomyces destructans (Gd)) that invades the skin of torpid bats. During hibernation, arousals to warm (euthermic) body temperatures are normal but deplete fat stores. Temperature-sensitive dataloggers were attached to the backs of 504 free-ranging little brown bats (Myotis lucifugus) in hibernacula located throughout the northeastern USA. Dataloggers were retrieved at the end of the hibernation season and complete profiles of skin temperature data were available from 83 bats, which were categorized as: (1) unaffected, (2) WNS-affected …

Frequent Arousal From Hibernation Linked To Severity Of Infection And Mortality In Bats With White-Nose Syndrome, Deeann M. Reeder, Craig L. Frank, Gregory G. Turner, Carol U. Meteyer, Allen Kurta, Eric R. Britzke, Megan E. Vodzak, Scott R. Darling, Craig W. Stihler, Alan C. Hicks, Roymon Jacob, Laura E. Grieneisen, Sarah A. Brownlee, Laura K. Muller, David S. Blehert

KIP Articles

No abstract provided.

A Cross-National Analysis Of The Human Papillomavirus, Sexually Transmitted Infections, And Sexual Behavior Among Men, Euna Marie August

USF Tampa Graduate Theses and Dissertations

There is a paucity of research on the risk for sexually transmitted infections (STIs) and sexual behavior among general populations of men. Research with male populations predominantly has focused on those subgroups considered to be at high risk of disease transmission, such as gay and bisexual men, injection drug users, and adolescents/young adults. Considerably fewer studies have examined factors among men, in general, and heterosexual men, specifically. Therefore, I conducted analyses with a cross-national sample of adult, sexually active men in Brazil, Mexico, and the United States to investigate sexual behaviors and risk factors associated with the human papillomavirus (HPV) …

Impact Of Life History Theory On Host Compentence Through The Selection Of Divergent Immunological Strategies, Alessandra Araujo

Honors Thesis and Capstone Projects

No abstract provided.

Inoculation Of Bats With European Geomyces Destructans Supports The Novel Pathogen Hypothesis For The Origin Of White-Nose Syndrome, Lisa L. Warnecke, James M. Turner, Trent K. Bollinger

KIP Articles

No abstract provided.

Determination Of Anti-Malarial Properties Of Delta Lactam Derivatives From Mycosynthetix Sample 232697, Alexander Gonzalez-Jacobo

Honors Thesis and Capstone Projects

No abstract provided.

Enhancing The Immune Response Through Ikkbeta-Induced Activation Of Nf-Kappab, Emily Hopewell

USF Tampa Graduate Theses and Dissertations

Nuclear factor-κB (NF-κB) is one of the main regulators of inflammatory and immune responses. It is a family of transcription factors composed of five members: RelA, RelB, cRel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Homo- and hetero-dimers of family members are inhibited by inhibitor of &klappaB (IκB) family members and activated by IκB kinase (IKK) family members. The IKK family is comprised of IKKα, IKKΒ, and IKKγ. The focus of my dissertation delves into the role of NF-κB activation by IKKΒ in both an immunotherapy setting and its role in T cell mediated anti-tumor immune responses.

A central focus of immunotherapy …

Regulation Of Natural Killer Cells: Ship-1, 2b4, And Immunomodulation By Lenalidomide, Nicole Renee Fortenbery

USF Tampa Graduate Theses and Dissertations

Natural Killer cells (NK) are critical components of the innate immune system. Often referred to by their morphology, these large granular lymphocytes (LGLs) are bone marrow-derived lymphocytes and can be found throughout the body. NK cells reside in the liver, lymph nodes, spleen, thymus, and mucosal-associated lymphoid tissues (MALT). Importantly, NK cells also circulate throughout the blood where they function as surveyors of the body and are armed to eliminate malignant, infected, damaged, or foreign cells.

NK cells function by a dual receptor system. That is, NK receptors are broadly categorized as inhibitory or activating. It is a fine balance, …

Activity Of New N-Acylated Ciprofloxacin Derivatives Against Faculative Intracellular Bacteria, Edward Turos, Burt E. Anderson, Ryan Scott Cormier, John C. Thomas, Rebecca J. Kapolka, Glenn Roma

USF Patents

Bartonella species are facultative intracellular pathogens responsible for a range of diseases in animals and in humans. A selection of N-acyl ciprofloxacin analogues, chemically synthesized from ciprofloxacin, have been tested in vitro for activity against Bartonella species as models for therapeutic development. Nine Bartonella strains, including five of B. henselae, two of B. quintana, and one each of B. elizabethae and B. vinsonii, have been tested for susceptibility to different N-acyl ciprofloxacin derivatives. Several techniques have been used to test the in vitro antibacterial activity of the derivatives. Seven of them, labeled RC4-125, RC4-143, RC4-147, RC5-28, RC5-29, RC5-32 and RC5-69 …

Investigation And Synthesis Of Novel Graphene-Based Nanocomposites For Hydrogen Storage, Anthony Joseph D'Angelo

USF Tampa Graduate Theses and Dissertations

It is of great interest to develop and utilize a high surface area material with optimized hydrogen sorption properties. The need for a renewable energy source to replace automobile gasoline has become more critical in the past decade. Hydrogen is a viable fuel source for automobile usage; however, the question of how hydrogen will be safely and efficiently stored still remains. Critical factors for optimum hydrogen storage include ambient conditions and low activation temperature for adsorption and desorption phenomena. In order for optimum hydrogen adsorption to be achieved, the properties of (1) high surface area, (2) optimum hydrogen adsorption energy, …