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Using A Novel Partitivirus In Pseudogymnoascus Destructan, Vaskar Thapa, Gregory G. Turner, Susan Hafenstein, Barrie E. Overton, Karen J. Vanderwolf, Marilyn J. Roossinck Dec 2016

Using A Novel Partitivirus In Pseudogymnoascus Destructan, Vaskar Thapa, Gregory G. Turner, Susan Hafenstein, Barrie E. Overton, Karen J. Vanderwolf, Marilyn J. Roossinck

KIP Articles

No abstract provided.

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Effective Treatment Of Tumors And Cancer With Triciribine And Related Compounds, Jin Q. Cheng, Said M. Sebti Dec 2016

Effective Treatment Of Tumors And Cancer With Triciribine And Related Compounds, Jin Q. Cheng, Said M. Sebti

USF Patents

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

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Commencement Convocation Program, Usf, Graduate, December 10, 2016, University Of South Florida Dec 2016

Commencement Convocation Program, Usf, Graduate, December 10, 2016, University Of South Florida

USF Graduation and Convocation Programs

Honorary Doctor of Business - Retired Vice Admiral Mike McConnell

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Unlocking Bat Immunology: Establishment Of Pteropus Alecto Bone Marrow-Derived Dendritic Cells And Macrophages, Peng Zhou, Yok Teng Chionh, Sergio Erdal Irac, Matae Ahn, Justin Han Jia Ng, Even Fossum, Bjarne Bogen, Florent Ginhoux, Aaron T. Irving, Charles-Antoine Dutertre, Lin-Fa Wang Dec 2016

Unlocking Bat Immunology: Establishment Of Pteropus Alecto Bone Marrow-Derived Dendritic Cells And Macrophages, Peng Zhou, Yok Teng Chionh, Sergio Erdal Irac, Matae Ahn, Justin Han Jia Ng, Even Fossum, Bjarne Bogen, Florent Ginhoux, Aaron T. Irving, Charles-Antoine Dutertre, Lin-Fa Wang

KIP Articles

Bats carry and shed many emerging infectious disease agents including Ebola virus and SARS-like Coronaviruses, yet they rarely display clinical symptoms of infection. Bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. However, the lack of professional immune cells such as dendritic cells (DC) and macrophages has greatly limited the significance of current investigations. Using Pteropus alecto (P. alecto ) GM-CSF plus IL4, FLT3L and CSF-1, we successfully generated bat bone marrow-derived DC and macrophages. Cells with the phenotype, morphology and functional features of monocyte-derived DC, bona fide DC or macrophages …

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Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju Dec 2016

Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju

USF Patents

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

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White-Nosed Coatis (Nasua Narica) As Hosts For The Endoparasite, Giardia Lamblia, December 2016, Megan Sha Dec 2016

White-Nosed Coatis (Nasua Narica) As Hosts For The Endoparasite, Giardia Lamblia, December 2016, Megan Sha

Monteverde Institute: Tropical Ecology and Conservation

Giardiasis, the disease caused by the protozoan endoparasite, Giardia lamblia, has become an increasingly concerning threat to both animals and humans, especially for travelers in the form of “travelers’ diarrhea” and in developing countries such as Costa Rica. Parasitic infections are an omnipresent problem that are often a result of zoonotic diseases, or diseases that are transmitted from animal to human. This study strove to determine if white-nosed coatis (Nasua narica) could potentially be hosts to Giardia lamblia in Monteverde, similar to how they are capable of acting as hosts for other zoonoses. I collected 28 coati fecal samples at …

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Ectoparasite Abundance And Diversity On Farm Animals In Monteverde And San Luis Along An Elevation Gradient, December 2016, Sarah Callahan Dec 2016

Ectoparasite Abundance And Diversity On Farm Animals In Monteverde And San Luis Along An Elevation Gradient, December 2016, Sarah Callahan

Monteverde Institute: Tropical Ecology and Conservation

Abundance and diversity of arthropods are largely dependent on climate. Elevation gradients provide different microclimates that can support a unique number and variety of species. In order to test the effect of elevation on abundance and diversity of arthropod ectoparasites, I collected samples on four different farms: Life Monteverde and Benito Guindon’s farm in Monteverde at about 1,800 m, and Lelo Mata’s farm and Tim Sayles’ farm in San Luis around 700 m. At each elevation, I compared abundance and diversity of ectoparasites on dogs and cattle. I found a presence of Ctenocephalides and Pulex fleas on dogs, and 22 …

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Immune Dimorphism In Wild Mice Of Monteverde, Costa Rica, December 2016, Danielle M. Thoene Dec 2016

Immune Dimorphism In Wild Mice Of Monteverde, Costa Rica, December 2016, Danielle M. Thoene

Monteverde Institute: Tropical Ecology and Conservation

Rodents are at risk as climate change and human interference promote the spread of infectious disease. As a result, understanding the relationship between disease and population characteristics is important in developing conservation and management strategies. I investigated the existence of immune dimorphism, which is the variation in immune response and function between sexes, in mice of the Monteverde region. I captured a total of 33 mice and 1 rat: Heteromys nubicolens (n=18), Peromyscus nudipes (n=13), Scotinomys teguina (n=1), and Oligoryzomys fulvescens (n=1). For each captured individual, I collected all visible ectoparasites and took a blood sample for further laboratory analysis. …

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The Effects Of Phytohormones And Isoprenoids In Dihydroartemisinin-Induced Dormancy In The Erythrocytic Stages Of Plasmodium Falciparum, Marvin Duvalsaint Duvalsaint Nov 2016

The Effects Of Phytohormones And Isoprenoids In Dihydroartemisinin-Induced Dormancy In The Erythrocytic Stages Of Plasmodium Falciparum, Marvin Duvalsaint Duvalsaint

USF Tampa Graduate Theses and Dissertations

Our ability to control malaria has been challenged by increasing antimalarial resistance. Plasmodium falciparum undergoes dormancy in the blood stages which is hypothesized to be a means by which they are able to survive under drug pressure. This helps select for resistant parasites which grow following removal of drug. The mechanisms behind dormancy and the subsequent recrudescence are not fully understood but translating knowledge from related organisms which undergo a similar phenomenon might shed some light. Higher plants utilize dormancy during the early development stages to survive under unfavorable conditions, increasing fitness of the seedling and ensuring viability when this …

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Mitochondrial Heteroplasmy Contributes To The Dynamic Atovaquone Resistance Response In Plasmodium Falciparum, Sasha Victoria Siegel Nov 2016

Mitochondrial Heteroplasmy Contributes To The Dynamic Atovaquone Resistance Response In Plasmodium Falciparum, Sasha Victoria Siegel

USF Tampa Graduate Theses and Dissertations

Of the considerable challenges researchers face in the control and elimination of malaria, the development of antimalarial drug resistance in parasite populations remains a significant hurdle to progress worldwide. Atovaquone is used in combination with proguanil (Malarone) as an antimalarial treatment in uncomplicated malaria, but is rendered ineffective by the rapid development of atovaquone resistance during treatment. Previous studies have established that de novo mutant parasites confer resistance to atovaquone with a substitution in amino acid 268 in the cytochrome b gene encoded by the parasite mitochondrial genome, yet much is still unknown about how this resistance develops, and whether …

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Gamma-Aapeptides With Potent And Broad-Spectrum Antimicrobial Activity, Shruti Padhee, Haifan Wu, Youhong Niu, Jianfeng Cai Nov 2016

Gamma-Aapeptides With Potent And Broad-Spectrum Antimicrobial Activity, Shruti Padhee, Haifan Wu, Youhong Niu, Jianfeng Cai

USF Patents

The present invention is directed to a novel class of antimicrobial agents called .gamma.-AApeptides. The current invention provides various categories of .gamma.-AApeptides, for example, linear .gamma.-AApeptides, cyclic .gamma.-AApeptides, and lipidated .gamma.-AApeptides. .gamma.-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. .gamma.-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed .gamma.-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

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Pseudogymnoascus Destructans Transcriptome Changes During White-Nose Syndrome Infections, Sophia M. Reeder, Jonathan M. Palmer, Jenni M. Prokkola Nov 2016

Pseudogymnoascus Destructans Transcriptome Changes During White-Nose Syndrome Infections, Sophia M. Reeder, Jonathan M. Palmer, Jenni M. Prokkola

KIP Articles

White nose syndrome (WNS) is caused by the psychrophilic fungus Pseudogymnoascus destructans that can grow in the environment saprotrophically or parasitically by infecting hibernating bats. Infections are pathological in many species of North American bats, disrupting hibernation and causing mortality. To determine what fungal pathways are involved in infection of living tissue, we examined fungal gene expression using RNA-Seq. We compared P. destructans gene expression when grown in culture to that during infection of a North American bat species, Myotis lucifugus, that shows high WNS mortality. Cultured P. destructans was grown at 10 to 14 C and P. destructans growing …

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Climate Change Drives Outbreaks Of Emerging Infectious Disease And Phenological Shifts, Jeremy Cohen Nov 2016

Climate Change Drives Outbreaks Of Emerging Infectious Disease And Phenological Shifts, Jeremy Cohen

USF Tampa Graduate Theses and Dissertations

Climate change is expected to impact species by altering infectious disease outcomes, modifying community composition, and causing species to shift their phenology, body sizes and range distributions. However, the outcomes of these impacts are often controversial; for example, scientists have debated whether climate change will exacerbate emerging infectious disease and which species are at greatest risk to advance their phenology. There reason for these controversies may be that climate change is impacting diverse processes across a wide range of ecological scales, as the interplay between fine-scale processes and broad-scale dynamics can often cause unpredictable changes to the biosphere. Therefore, it …

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Compositions Including Triciribine And One Or More Platinum Compounds And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti Nov 2016

Compositions Including Triciribine And One Or More Platinum Compounds And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

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Pepper Mild Mottle Virus As A Surrogate For Enteric Viruses: Implications For Assessing Water Quality, Erin Michelle Symonds Nov 2016

Pepper Mild Mottle Virus As A Surrogate For Enteric Viruses: Implications For Assessing Water Quality, Erin Michelle Symonds

USF Tampa Graduate Theses and Dissertations

Less than 10% of the world’s domestic wastewater is disinfected prior to discharge into surface waters; therefore, human exposure to diverse wastewater-related pathogens results in millions of cases of illness each year. Among the enteric pathogens, viruses represent an important group of emerging pathogens and are frequently the cause of food- and water-borne outbreaks of illness. Although the World Health Organization and many government agencies mandate the use of bacterial indicators to identify poor microbial water quality, it is well known that these indicators poorly correlate with fecal pollution contamination events and risk of disease. The field of public health-related …

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Predictive Mapping Of Mycobacterium Tuberculosis At The County Level In The State Of Florida, Ali Moradi Nov 2016

Predictive Mapping Of Mycobacterium Tuberculosis At The County Level In The State Of Florida, Ali Moradi

USF Tampa Graduate Theses and Dissertations

Introduction: One of the major barriers to developing an accurate tuberculosis (TB) surveillance program for Florida is the design and implementation of a sampling system that will adequately monitor and predict varying sizes and characteristics of county-level vulnerable endemic sub-populations and their explanatory covariates (e.g., living or working in a residential care facility). The aim of this research study is to envision an endemic, tuberculosis-related web-based interface for use by public health officials in the State of Florida which includes generating essential information such as a real-time syndrome-based reporting to regulate automated and immediate 'Alerts' to public health officials, doctors, …

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Broad And Temperature Independent Replication Potential Of Filoviruses On Cells Derived From Old And New World Bat Species, Megan R. Miller, Rebekah J. Mcminn, Vikram Misra, Tony Schountz, Marcel A. Müller, Andreas Kurth, Vincent J. Munster Oct 2016

Broad And Temperature Independent Replication Potential Of Filoviruses On Cells Derived From Old And New World Bat Species, Megan R. Miller, Rebekah J. Mcminn, Vikram Misra, Tony Schountz, Marcel A. Müller, Andreas Kurth, Vincent J. Munster

KIP Articles

No abstract provided.

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Methods Of Treating Disease-Induced Ataxia And Non-Ataxic Imbalance, Theresa A. Zesiewicz, Kelly L. Sullivan Oct 2016

Methods Of Treating Disease-Induced Ataxia And Non-Ataxic Imbalance, Theresa A. Zesiewicz, Kelly L. Sullivan

USF Patents

Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.

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A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu, Tao Jin, Yingze Zhao, Jingdong Song, Yi Shi, Wei Ji, Hao Jia, Yongming Zhou, Honghua Wen, Honglan Zhao, Huaxing Liu, Hong Li, Qihui Wang, Ying Wu, Liang Wang, Di Liu, Guang Liu, Hongjie Yu, Edward C. Holmes, Lin Lu, George F. Gao Sep 2016

A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu, Tao Jin, Yingze Zhao, Jingdong Song, Yi Shi, Wei Ji, Hao Jia, Yongming Zhou, Honghua Wen, Honglan Zhao, Huaxing Liu, Hong Li, Qihui Wang, Ying Wu, Liang Wang, Di Liu, Guang Liu, Hongjie Yu, Edward C. Holmes, Lin Lu, George F. Gao

KIP Articles

No abstract provided.

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A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu Sep 2016

A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu

KIP Articles

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has generated enormous interest in the biodiversity, genomics and cross-species transmission potential of coronaviruses, especially those from bats, the second most speciose order of mammals. Herein, we identified a novel coronavirus, provisionally designated Rousettus bat coronavirus GCCDC1 (Ro-BatCoV GCCDC1), in the rectal swab samples of Rousettus leschenaulti bats by using pan-coronavirus RT-PCR and next-generation sequencing. Although the virus is similar to Rousettus bat coronavirus HKU9 (Ro-BatCoV HKU9) in genome characteristics, it is sufficiently distinct to be classified as a new …

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Howard N. Jacobson Oral History Interview, Howard N. Jacobson Sep 2016

Howard N. Jacobson Oral History Interview, Howard N. Jacobson

Florida Public Health Oral History Project

Charles Mahan records an oral history on Howard N. Jacobson, M.D. from notes taken on weekly visits to him at his home in Plant City in the first five months of the year 2015. Mahan speaks on Jacobson’s education in Minnesota and his subsequent service in the Navy, as well as many of Jacobson’s accomplishments and life history. Particular notes of interest are Jacobson’s fondest memories in the Chicago Maternity Center, his time spent at Harvard, and Jacobson’s observations on many medical approaches to various conditions from cancer prevention to autism.

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The Cost Of Inter-Ethnic Conflicts In Ghana’S Northern Region: The Case Of The Nawuri-Gonja Conflicts, Emmanuel Debrah, Seidu Alidu, Isaac Owusu-Mensah Sep 2016

The Cost Of Inter-Ethnic Conflicts In Ghana’S Northern Region: The Case Of The Nawuri-Gonja Conflicts, Emmanuel Debrah, Seidu Alidu, Isaac Owusu-Mensah

Journal of African Conflicts and Peace Studies

The article assesses the socio-economic and human repercussions of one of the fiercest ethnic conflicts in Ghana’s Northern Region on people and society. While Ghana remains a stable democracy, sporadic ethnic and chieftaincy conflicts have been a recurrent feature of the political process. Analyzing data from survey opinions and interviews from wide spectrum of respondents, the study noted that the Nawuri-Gonja conflicts have destroyed the fabric of the society leaving behind squalor, breakdown of healthcare, education and psychological trauma. Women and children have suffered rape assaults and unprecedented high rate of mortality due to malnourishments respectively. The plights of these …

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Crow's Nest, August 29, 2016, Crow's Nest Staff Aug 2016

Crow's Nest, August 29, 2016, Crow's Nest Staff

Crow's Nest

The August 29, 2016, issue of the Crow's Nest.

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First Detection Of Bat White-Nose Syndrome In Western North America, Jeffrey M. Lorch, Jonathan M. Palmer, Daniel L. Lindner Aug 2016

First Detection Of Bat White-Nose Syndrome In Western North America, Jeffrey M. Lorch, Jonathan M. Palmer, Daniel L. Lindner

KIP Articles

White-nose syndrome (WNS) is an emerging fungal disease of bats caused by Pseudogymnoascus destructans. Since it was first detected near Albany, NY, in 2006, the fungus has spread across eastern North America, killing unprecedented numbers of hibernating bats. The devastating impacts of WNS on Nearctic bat species are attributed to the likely introduction of P. destructans from Eurasia to naive host populations in eastern North America. Since 2006, the disease has spread in a gradual wavelike pattern consistent with introduction of the pathogen at a single location. Here, we describe the first detection of P. destructans in western North America …

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The Weekly Challenger, July 28, 2016, The Weekly Challenger, Et Al Jul 2016

The Weekly Challenger, July 28, 2016, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The July 28, 2016, issue of The Weekly Challenger.

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Antimalarial Exoerythrocytic Stage Drug Discovery And Resistance Studies, Lynn Dong Blake Jul 2016

Antimalarial Exoerythrocytic Stage Drug Discovery And Resistance Studies, Lynn Dong Blake

USF Tampa Graduate Theses and Dissertations

Malaria is a devastating global health issue that affects approximately 200 million people yearly and over half a million deaths are caused by this parasitic protozoan disease. Most commercially available drugs only target the blood stage form of the parasite, but the only way to ensure proper elimination is to treat the exoerythrocytic stages of the parasite development cycle. There is a demand for the discovery of new liver stage antimalarial compounds as there are only two current FDA approved drugs for the treatment of liver stage parasites, one of which fails to eliminate dormant forms and the other inducing …

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Reclaiming The Activity Of Lost Therapeutics, Rallya Telussa Jul 2016

Reclaiming The Activity Of Lost Therapeutics, Rallya Telussa

USF Tampa Graduate Theses and Dissertations

ESKAPE pathogens are notorious in causing nosocomial infections and escaping current antibiotic treatments. There has been a dramatic increase in nosocomial infections accompanied with a decrease in the number of antibiotics developed, leading to significant increase in morbidity and mortality among patients. In an attempt to combat this problem, derivatives of ciprofloxacin, rifabutin and beta-lactam antibiotics were synthesized and tested against the ESKAPE pathogens. From minimum inhibitory concentration assays, 4 ciprofloxacin analogs and 8 beta-lactam analogs were found to be effective against multiple bacterial species. Additionally, 12 rifabutin analogs and 23 beta-lactam analogs were potent against single bacterial species, primarily …

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Development Of A Rt-Pcr-Elisa Wuchereria Bancrofti Detection Assay For The Monitoring Of Mosquito Vector Infection And Infectivity, Nompumelelo Mzizi Mzizi Jul 2016

Development Of A Rt-Pcr-Elisa Wuchereria Bancrofti Detection Assay For The Monitoring Of Mosquito Vector Infection And Infectivity, Nompumelelo Mzizi Mzizi

USF Tampa Graduate Theses and Dissertations

Lymphatic filariasis (LF) is an incapacitating disease caused by three filarial nematodes belonging to the family Onchocercidae, namely Brugia timori, Wuchereria bancrofti and Brugia timori. An estimated 90% of lymphatic filariasis cases globally are caused by Wuchereria bancrofti. To evaluate the success of the Global Program to eliminate Lymphatic Filariasis it is essential to monitor the frequency of larval infection in the mosquito vector. Molecular methods to detect Wuchereria bancrofti DNA in mosquitoes have been in existence since 1996. However these methods have not been widely adopted due to the high cost associated with them and the inability …

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Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar Jul 2016

Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar

USF Tampa Graduate Theses and Dissertations

Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV3 integrin which ultimately helps in clot formation.

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Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity Via Interferon-Beta And Indoleamine-2,3-Dioxygenase, Michael B. Cheung Jun 2016

Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity Via Interferon-Beta And Indoleamine-2,3-Dioxygenase, Michael B. Cheung

USF Tampa Graduate Theses and Dissertations

Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in young children worldwide, accounting for an estimated 33.8 million cases of respiratory disease, over 3 million of which require hospitalization, and between 66,000 and 199,000 deaths in this susceptible population. Additionally, severe RSV infection early in life is associated with an increased risk of wheeze and other airway disorders later in life. Despite this, there is currently no vaccine or economically reasonable prophylactic regimen to prevent infection. While disease is typically more severe in infancy RSV can infect throughout the lifespan repeatedly as the …

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