Digital Commons Network^™

A Novel Magnetic Respiratory Sensor For Human Healthcare, Kee Young Hwang

USF Tampa Graduate Theses and Dissertations

Breathing is vital to life. Therefore, the real-time monitoring of a patient’s breathing pattern is crucial to respiratory rehabilitation therapies such as magnetic resonance exams for respiratory-triggered imaging, chronic pulmonary disease treatment, and synchronized functional electrical stimulation. While numerous respiratory devices have been developed, they are often in direct contact with a patient, which can yield inaccurate or limited data. In this study, we developed a novel, non-invasive, and contactless magnetic sensing platform that can precisely monitor a patient’s breathing, movement, or sleep patterns, thus providing efficient monitoring at a clinic or home. A magneto-LC resonance (MLCR) sensor converts the …

Two Clinical Prediction Tools To Improve Tuberculosis Contact Investigation, Ruoran Li, Francesco Nordio, Chuan-Chin Huang, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Zibiao Zhang, Mercedes C. Becerra, Leonid Lecca, Megan B. Murray

Social Work Faculty Publications

Background: Efficient contact investigation strategies are needed for the early diagnosis of TB disease and treatment of latent TB infections.

Methods: Between September 2009 and August 2012, we conducted a prospective cohort study in Lima, Peru in which we enrolled and followed 14,044 household contacts of adult pulmonary TB patients. We used information from a subset of this cohort to derive two clinical prediction tools that identify contacts of TB patients at elevated risk of progressing to active disease by training multivariable models that predict (1) co-prevalent TB among all household contacts and (2) one-year incident TB among adult contacts. …

Crow's Nest, September 21, 2020, Crow's Nest Staff

Crow's Nest

The September 21, 2020, issue of the Crow's Nest.

Did You Wash Your Caving Suit? Cavers’ Role In The Potential Spread Of Pseudogymnoascus Destructans, The Causative Agent Of White-Nose Disease, Violeta Zhelyazkova, Antonia Hubancheva, Georgi Radoslavov, Nia Toshkova, Sebastien J. Puechmaille

International Journal of Speleology

White-Nose Disease (WND) has killed millions of hibernating bats in the US and Canada. Its causative agent, the fungus Pseudogymnoascus destructans was introduced to North America, but is native to Europe and Asia, where it is not associated with mass mortality. Although it is nearly impossible to eradicate an emerging wildlife disease, research on P. destructans spread mechanisms can aid in prevention of new introductions and development of better environmental management strategies. It is of particular importance to quantify the potential role of people visiting caves (cavers, tourists, bat researchers, etc.) whom inadvertently move P. destructans spores between sites, and …

Re-Assessing The Genocide Of Kurdish Alevis In Dersim, 1937-38, Dilşa Deniz

Genocide Studies and Prevention: An International Journal

This article discusses a century-long denial of historic genocide targeting Kurdish Alevis in Turkey. Firstly, I argue that the state-sponsored killings and forced displacements that occurred in Dersim in 1937-38 constitute genocide. Secondly, I use census numbers and other available documentation to suggest a possible figure for the causalities, while pointing out the methods by which the state has tried to cover up these numbers, indicating state planning and preparation. Finally, I show that as a part of the continued denial of such genocide, Turkish leftist organizations have been manipulated by the state, and thus have ended up supporting much …

Possibility For Reverse Zoonotic Transmission Of Sars-Cov-2 To Free-Ranging Wildlife: A Case Study Of Bats, Kevin J. Olival, Paul M. Cryan, Brian R. Amman, Ralph S. Baric, David S. Blehert, Cara E. Brook, Charles H. Calisher, Kevin T. Castle, Jeremy T. H. Coleman, Peter Daszak, Jonathan H. Epstein, Hume Field, Winifred F. Frick, Amy T. Gilbert, David T. S. Hayman, Hon S. Ip, William B. Karesh, Christine K. Johnson, Rebekah C. Kading, Tigga Kingston, Jeffrey M. Lorch, Ian H. Mendenhall, Alison J. Peel, Kendra L. Phelps, Raina K. Plowright, Deeann M. Reeder, Jonathan D. Reichard, Jonathan M. Sleeman, Daniel G. Streicker, Jonathan S. Towner, Lin-Fa Wang

KIP Articles

No abstract provided.

Population-Level Covid-19 Mortality Risk For Non-Elderly Individuals Overall And For Non-Elderly Individuals Without Underlying Diseases In Pandemic Epicenters, John P.A. Ioannidis, Cathrine Axfors, Despina G. Contopoulos-Ioannidis

All publications

Objective: To provide estimates of the relative rate of COVID-19 death in people < 65 years old versus older individuals in the general population, the absolute risk of COVID-19 death at the population level during the first epidemic wave, and the proportion of COVID-19 deaths in non-elderly people without underlying diseases in epicenters of the pandemic.

Eligible data: Cross-sectional survey of countries and US states with at least 800 COVID-19 deaths as of April 24, 2020 and with information on the number of deaths in people with age < 65. Data were available for 14 countries (Belgium, Canada, France, Germany, India, Ireland, Italy, Mexico, Netherlands, Portugal, Spain, Sweden, Switzerland, UK) and 13 US states (California, Connecticut, Florida, Georgia, Illinois, Indiana, Louisiana, Maryland, Massachusetts, Michigan, New Jersey, New York, Pennsylvania). We also examined available data on COVID-19 deaths in people with age

Main outcome measures: Proportion of COVID-19 deaths in people < 65 years old; relative mortality rate of COVID-19 death in people < 65 versus ≥ 65 years old; absolute risk of COVID-19 death in people < 65 and in those ≥ 80 years old in the general population as of June 17, 2020; absolute COVID-19 mortality rate expressed as equivalent of mortality rate from driving a motor vehicle.

Results: Individuals with age < 65 account for 4.5–11.2% of all COVID-19 deaths in European countries and Canada, 8.3–22.7% in the US locations, and were the majority in India and Mexico. People < 65 years old had 30- to 100-fold lower risk of COVID-19 death than those ≥ 65 years old in 11 European countries and Canada, 16- to 52-fold lower risk in US locations, and less than 10-fold in India and Mexico. The absolute risk of COVID-19 death as of June 17, 2020 for people < 65 years old in high-income countries ranged from 10 (Germany) to 349 per million (New Jersey) and it was 5 per million in India and 96 per million in Mexico. The absolute risk of COVID-19 death for people ≥ 80 years old ranged from 0.6 (Florida) to 17.5 per thousand (Connecticut). The COVID-19 mortality rate in people < 65 years old during the period of fatalities from the epidemic was equivalent to the mortality rate from driving between 4 and 82 miles per day for 13 countries and 5 states, and was higher (equivalent to the mortality rate from driving 106–483 miles per day) for 8 other states and the UK. People < 65 years old without underlying predisposing conditions accounted for only 0.7–3.6% of all COVID-19 deaths in France, Italy, Netherlands, Sweden, Georgia, and New York City and 17.7% in Mexico.

Conclusions: People < 65 years old have very small risks of COVID-19 death even in pandemic epicenters and deaths for people < 65 years without underlying predisposing conditions are remarkably uncommon. Strategies focusing specifically on protecting high-risk elderly individuals should be considered in managing the pandemic.

Zoonotic Diseases: Etiology, Impact, And Control., Md. Tanvir Rahman, Md. Abdus Sobur, Md. Saiful Islam, Samina Ievy, Md. Jannat Hossain, Mohamed E El Zowalaty, Amm Taufiquer Rahman, Hossam M Ashour

All publications

Most humans are in contact with animals in a way or another. A zoonotic disease is a disease or infection that can be transmitted naturally from vertebrate animals to humans or from humans to vertebrate animals. More than 60% of human pathogens are zoonotic in origin. This includes a wide variety of bacteria, viruses, fungi, protozoa, parasites, and other pathogens. Factors such as climate change, urbanization, animal migration and trade, travel and tourism, vector biology, anthropogenic factors, and natural factors have greatly influenced the emergence, re-emergence, distribution, and patterns of zoonoses. As time goes on, there are more emerging and …

Personality Affects Dynamics Of An Experimental Pathogen In Little Brown Bats, Quinn M.R. Webber, Craig K.R. Willis

KIP Articles

Host behaviour can affect host–pathogen dynamics and theory predicts that certain individuals disproportionately infect conspecifics during an epidemic. Consistent individual differences in behaviour, or personality, could influence this variation with the most exploratory or sociable individuals most likely to spread pathogens. We quantified exploration and sociability in little brown bats ( Myotis lucifugus ) and then experimentally manipulated exposure to a proxy pathogen (i.e. ultraviolet (UV) fluorescent powder) to test two related hypotheses: (i) more sociable and more exploratory individuals would be more likely to transmit infections to other individuals, and (ii) more sociable and more exploratory individuals uninfected with …

The Impact Of Myeloid-Mediated Co-Stimulation And Immunosuppression On The Anti-Tumor Efficacy Of Adoptive T Cell Therapy, Pasquale Patrick Innamarato

USF Tampa Graduate Theses and Dissertations

Adoptive T cell therapy (ACT) in combination with lymphodepleting chemotherapy is an effective strategy to induce the eradication of tumors, providing long-term regression in cancer patients. However, only a minority of patients that receive ACT with tumor infiltrating lymphocytes (TILs) exhibit durable benefit. Thus, there is an urgent need to define strategies that potentiate anti-tumor activity conducted by adoptively transferred T cells. In these studies, we aimed to identify novel strategies to enhance the therapeutic efficacy of ACT. Accordingly, we describe the disparate roles of myeloid cells in the context of ACT characterized by the augmentation of TIL proliferation in …

Soil Characteristics Associated With Horse Cases Of Eastern Equine Encephalitis Virus In Florida, Fulya Guzelkucuk

USF Tampa Graduate Theses and Dissertations

Eastern Equine Encephalitis virus (EEEV) is a mosquito-borne virus found in Florida that affects humans and horses. Also, EEEV is an agricultural land management issue in Florida, as it causes mortality in large numbers of horses each year and sometimes humans. This study investigates the characteristics of soils associated with horse cases of EEEV in the State of Florida, focusing on differences in soil characteristics between summer and winter cases. This study analyzed a total of 676 EEEV cases during 2005-2018, including 611 summer cases and 65 winter cases. Soil characteristics that were examined include: soil texture, drainage class, hydrology …

Chemical Investigation Of Floridian Mangrove Endophytes And Antarctic Marine Organisms, Bingjie Yang

USF Tampa Graduate Theses and Dissertations

Nature creates diseases and illnesses for mankind, however, nature also provides therapeutics by making biological systems produce secondary metabolites. Although the secondary metabolites originally play roles in chemical defense or evolution, researchers have been working on them for drug discovery. Plants, fungi and marine organisms have been mostly explored by natural products chemists over the century and contributed most drugs to the market. With the increasing need of new drugs resulting from drug resistance and pathogen evolution, the natural products area has been focused on developing innovative methodologies to achieve higher efficiency of isolating new bioactive compounds.

This dissertation herein …

From R0 To The Herd: A Review Of The Rules Of Contagion, By Adam Kucharski, Nathan D. Grawe

Numeracy

Adam Kucharski. 2020. The Rules of Contagion: Why Things Spread--and Why They Stop; (London: Profile Books, Ltd.). Hardback ISBN 978-17-88-16019-3. E-book ISBN 978-17-82-83430-4.

Kucharski's well-timed Rules of Contagion provides an introduction to the mathematical and epidemiological principles behind contagious phenomenon. While the author's primary expertise stems from work on biological epidemics, the book points to examples from a wide range of fields including finance, psychology, computer science, and criminology. As such, selections of the book could be used by faculty in a wide range of classes to show how our recent experience with a viral epidemic might add to …

Developing A Taxonomic Framework Of Security Methods For Security Management And Information Resource Management, Yejun Wu

Journal of Strategic Security

People who are concerned with security (such as security professionals) are naturally interested in methods of achieving security. This paper proposes an approach to creating a taxonomic framework of security methods. The taxonomic framework is developed using facet analysis based on a tetra-facet model of security, which identifies four facets of security: subject/scope of security, object of protection, source of insecurity, and method of protection. The taxonomic framework of security methods is created by combining two of the facets: source of insecurity and method of protection. The taxonomic framework of security methods can be integrated with the taxonomic framework of …

Treating And/Or Preventing Insulin-Resistance Related Weight Gain, Robert Vito Farese, Mini Paliyath Sajan

USF Patents

Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).

The Role Of Threat And Efficacy In Anti-Vaping Ads: A Test Of The Extended Parallel Process Model, Ryan Noone

USF Tampa Graduate Theses and Dissertations

Often thought of as a safer alternative to traditional cigarettes, electronic cigarette use among youth and young adults has steadily increased over the past 10 years. With over 34 percent of high school students and over 7.8 percent of young adults using electronic cigarettes, organizations like the CDC and the FDA have created campaigns and advertisements to combat the epidemic (Truth Initiative). This study uses a 2x2 between subject factoral experiment to gain insights into how varying levels of anti-vaping advertisements’ threat and efficacy elements effect college age students’ perceptions and behaviors towards e-cigarettes. While several of the study’s hypotheses …

Non-Invasive Sex Determination And Genotyping Of Transgenic Brugia Malayi Larvae, Santiago E. Hernandez Bojorge

USF Tampa Graduate Theses and Dissertations

Lymphatic filariasis is a very painful and disfiguring helminth disease caused by the tissue nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. This parasitosis is considered a Neglected Tropical Disease and it is a major public health burden for 72 tropical countries of Africa, Southeast Asia, the Caribbean, and South America. Despite the effectiveness of many control programs, there remains the need to develop new pharmacological agents to treat lymphatic filariasis, as most programs rely on a limited variety of drugs that are expensive, logistically difficult to obtain, and can lead to drug resistance. The Clustered Regularly Interspaced Short Palindromic …

Safe And Effective Disinfection Of Show Cave Infrastructure In A Time Of Covid-19, Hazel A. Barton

International Journal of Speleology

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has been responsible for over 650,000 deaths worldwide. Transmission of SARS-CoV-2 occurs primarily through airborne transmission or direct human contact, demonstrating the importance of social distancing measures and the use of face masks to prevent infection. Nonetheless, the persistence of coronavirus on surfaces means that disinfection is important to limit the possibility of contact transmission. In this paper, the potential for various surfaces in show caves to serve as sources for SARS-CoV-2 infection is examined. Given the isoelectric potential (pI) of SARS and SARS-like coronaviruses, it is likely that they are …

‘It’S Been A Huge Stress’: An In-Depth, Exploratory Study Of Vaccine Hesitant Parents In Southern California, Mika Kadono

USF Tampa Graduate Theses and Dissertations

In 2015, the US experienced a widespread measles outbreak that originated at Disneyland, California and spread to six other states, Mexico, and Canada. That year, California passed Senate Bill 277 (SB 277), which eliminated the personal belief exemption for vaccinations required for school entry; California became the third state in the country to eliminate nonmedical exemptions. In 2019, Washington, Maine, and New York followed suit eliminating all nonmedical exemptions amid the largest measles outbreak in the US in 25 years. Many countries, including the US, are experiencing a rise in vaccine preventable diseases due, in part, to increasing vaccine hesitancy, …

The Weekly Challenger, April 16, 2020, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The April 16, 2020, issue of The Weekly Challenger.

Full Issue 49(1)

International Journal of Speleology

No abstract provided.

Socially Aware Network User Mobility Analysis And Novel Approaches On Aerial Mobile Wireless Network Deployment, Ismail Uluturk

USF Tampa Graduate Theses and Dissertations

Service demand patterns for wireless networks are evolving with the technological developments in areas such as personal computing, unmanned vehicles, and internet-of-things, where increasing mobile service demand is one of the significant challenges introduced. In addition to these new intrinsic dynamics, natural disasters and societal upheaval are also disrupting the conventional patterns of network demand. Situations like damaged infrastructure due to a natural disaster or large numbers of displaced people caused by political strife and social upheaval demand flexible, rapidly deployable network architectures. The increasing demands of next-generation communication services are straining the capabilities of the traditional approach of the …

Hiding Under The Sun: Health, Access, And Discourses Of Representation In Undocumented Communities, Jaime Shamado Robb

USF Tampa Graduate Theses and Dissertations

This project examines how undocumented immigrants in the United States communicate health and illness, specifically focusing on health narratives of undocumented immigrants in the South Florida region. In order to do this, I conducted 27 field interviews with undocumented immigrants living in South Florida to gain understanding of how this group meets health and wellness needs. Conversations revolved around prominent themes that highlighted the role of communication that produce stigma towards this group; the complexity of a costly bureaucratic health system, and the fears participants experience that stems from the possibility of deportation. Additionally, participants detailed the role of their …

Differences In Knowledge Acquisition, Perceived Engagement And Self-Efficacy In Latino Promotores Delivering The Heart Disease Prevention Program Su Corazόn, Su Vida, Samuel Matos-Bastidas

USF Tampa Graduate Theses and Dissertations

Su Corazόn, Su Vida (Your Heart, Your Life) is a community-based, small-group health intervention designed to empower Latinos to enhance cardiovascular disease awareness and initiate enduring lifestyle changes to improve health outcomes and quality of life. Originally developed to be delivered in weekly sessions in Spanish or English language, it addresses several heart disease risk factors including unhealthy eating habits, poor physical activity, high cholesterol, overweight, metabolic syndrome, diabetes and tobacco smoking, among others. Instructors use diverse learning and support strategies such as group discussion, role modeling, problem-solving, health action planning, and self-monitoring. Participants help each other to stay on …

Novel De Novo Genome Of Cynopterus Brachyotis Reveals Evolutionarily Abrupt Shifts In Gene Family Composition Across Fruit Bats, Balaji Chattopadhyay, Kritika M. Garg, Rajasri Ray, Ian H. Mendenhall, Frank E. Rheindt

KIP Articles

Major novel physiological or phenotypic adaptations often require accompanying modifications at the genic level. Conversely, the detection of considerable contractions and/or expansions of gene families can be an indicator of fundamental but unrecognized physiological change. We sequenced a novel fruit bat genome (Cynopterus brachyotis) and adopted a comparative approach to reconstruct the evolution of fruit bats, mapping contractions and expansions of gene families along their evolutionary history. Despite a radical change in life history as compared with other bats (e.g., loss of echolocation, large size, and frugivory), fruit bats have undergone surprisingly limited change in their genic composition, perhaps apart …

Developing Agent-Based Models To Study Financial Markets, Saurav Chakraborty

USF Tampa Graduate Theses and Dissertations

This dissertation presents research that employs agent-based modelling to provide a framework to support simulation as a complement to traditional economic models for policy evaluation. It consists of three studies. The first study employs cluster analysis to capture the different types of banks and the associated business models that define their decision-making. The results from study one will help us get an understanding of how different banks behave and provide an insight into their lending practices. Hence, it would be very helpful in evaluating and analyzing the impact of future policies. Study two develops a fine-grained interbank lending model based …

Understanding The Role Of Cereblon In Hematopoiesis Through Structural And Functional Analyses, Afua Adutwumwa Akuffo

USF Tampa Graduate Theses and Dissertations

The discovery and implementation of immunomodulatory drugs (IMiD®s) has revolutionized the treatment of many hematological malignancies due to the plethora of IMiD®-induced clinical responses that include anti-angiogenesis, anti-inflammation, and anti-tumor effects, as well as enhanced erythropoiesis, immune modulation and improved metabolism. More ground-breaking was the identification of cereblon as the target of IMiD®s. Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction of neo-substrates by engaging the DDB1-CUL4A-Roc1-RBX1 E3-ubiquitin ligase in human cells but not in mouse cells suggesting that sequence variations in CRBN may cause its inactivation. Therapeutically, CRBN engagers …

Investigating Mechanisms Of Immune Suppression Secondary To An Inflammatory Microenvironment, Wendy Michelle Kandell

USF Tampa Graduate Theses and Dissertations

The immune system plays a dynamic role in cancer progression. The theory of immunoediting suggests that the relationship between the tumor cell and the immune cell is one that is in flux: initially highly active and responsive to tumor antigen to one that has escaped immune responsiveness. Once the tumor has formed and effectively “escaped”, there are multiple mechanisms that work against a conventional immune response. The tumor cell clones that have escaped the elimination phase are those that are less immunogenic. These clones downregulate MHC, have increased apoptosis through DAMP-driven mechanisms, and suppressive cell phenotypes are driven through cytokine-driven …

Identification Of Snps Associated With Multiple Antibiotic Resistance Genes In Eight Clinical Variants Of Enterococcus Faecium., Krishna S. Karia

USF Tampa Graduate Theses and Dissertations

The evolution of multi drug resistant (MDR) bacteria has been well documented these last decade, suggesting that resistance to antibiotics is most commonly associated to single nucleotide polymorphism (SNPs) mutation. To this aim, several molecular methods have been performed to elucidate SNPs in the increasing number of resistant microorganisms. Early detection of MDR bacteria has become of prime necessity in order to combat the disease and ensure public health. Therefore, this research was conducted to screen for SNP mutations correlated to drug resistance in some nosocomial MDR bacteria strains donated from Moffitt Cancer Center (MCC) hospital. Blood, stool, urine, and …

Targeting The Eskape Pathogens By Botanical And Microbial Approaches, Emily Dilandro

USF Tampa Graduate Theses and Dissertations

There is a vital need to find new clinical treatment options to combat ESKAPE pathogen infections. Nature has thus far been the most fruitful at providing antimicrobial compounds, which have been derived from a plethora of sources. Ranging from plants to microbial communities, these organisms create chemical compounds that are used as defense mechanisms against invasive or encroaching organisms and confer the producers with competitive advantages. In this study, cinnamaldehyde was investigated as a botanical approach to finding active antimicrobial compounds that inhibit the ESKAPE pathogens. Here, we show that all the ESKAPE pathogens are inhibited by cinnamaldehyde concentrations between …