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A Mathematical Model For The Upper Limits Of Thyroid Volume In Adolescents, Jacob Treanor Jan 2019

A Mathematical Model For The Upper Limits Of Thyroid Volume In Adolescents, Jacob Treanor

Undergraduate Journal of Mathematical Modeling: One + Two

This paper describes a mathematical model that relates age to the volume of the thyroid gland, given in milliliters, of adolescents based on data from a 1997 study by the World Health Organization (W.H.O.) (World Health Organization, 1997). Using the upper limit per age group provided by the data, a model was constructed through integration of the second derivative of the data for males and females, ages 6-15. It was concluded that the upper limit for the thyroid volume could be expressed by one of two second order polynomial equations, depending on gender, with any values significantly larger than those …

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The Present State Of Things: Class Struggle In The 21st Century, Lukas M. Desjardins Jan 2019

The Present State Of Things: Class Struggle In The 21st Century, Lukas M. Desjardins

USF St. Petersburg campus Honors Program Theses (Undergraduate)

No abstract provided.

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My Experiences With Body Image And Eating Disorders In Figure Skating, Emma M. Chinault Jan 2019

My Experiences With Body Image And Eating Disorders In Figure Skating, Emma M. Chinault

USF St. Petersburg campus Honors Program Theses (Undergraduate)

This is a personal reflection of my experiences with an eating disorder and body image issues that I have dealt with throughout my figure skating career. I reflect on body dysmorphia issues, my obsession with the scale, the realization that I had an eating disorder, and my journey to heal. These experiences, stories, pictures, and journal entries are used to show how relevant these issues are in the figure skating world and give hope and inspiration to other athletes that have gone through similar struggle. I discuss how these issues are prevalent throughout the sport of figure skating and discuss …

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Factors Associated With Patient Trust In Primary Care Physicians In The United States, Emily Grace Lind Jan 2019

Factors Associated With Patient Trust In Primary Care Physicians In The United States, Emily Grace Lind

USF St. Petersburg campus Honors Program Theses (Undergraduate)

For a patient to efficiently communicate medical history and sensitive medical information, and to properly adhere to treatment plans put forward by his or her physician, a relationship of trust must be established. Data suggests that compassion and empathy shown by doctors, along with the encouragement they give their patients to play an active role in their treatment, contributes to the trust they earn. Outside the scope of the patient-physician interaction, multiple extrinsic factors play a role in the patients’ social trust of the physician and the institution of healthcare. This study aimed to gain a better understanding of areas …

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“But In A Story, I Can Steal [Its] Soul”: Vietnam War Veterans And The Literature Of Catharsis, Gina P. E. Marks Jan 2019

“But In A Story, I Can Steal [Its] Soul”: Vietnam War Veterans And The Literature Of Catharsis, Gina P. E. Marks

USF St. Petersburg campus Honors Program Theses (Undergraduate)

How does a returning veteran cope with the consequences of their experiences in a war they were drafted to fight? How do they face a society that sees that war only in statistics, only in the clips seen on the nightly news across the dinner table, only from what seems like another world? How do they explain how it felt to watch his friends get shot down with a sudden pop or step on a grenade and explode in the sky? How do they explain how it felt to kill someone, to take the life of a stranger because they …

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The Rise Of The Md/Mba Dual Degree: Revitalizing Healthcare Through Physician Leadership, Nicholas D'Souza Jan 2019

The Rise Of The Md/Mba Dual Degree: Revitalizing Healthcare Through Physician Leadership, Nicholas D'Souza

USF St. Petersburg campus Honors Program Theses (Undergraduate)

Shortcomings of healthcare are evident on multiple fronts: the monstrosity of costs for patients, the complex relationship between physician and patient, and the controlling atmosphere created by hospital administrators, to name a few. Often, doctors run into a myriad of problems while caring for patients and think, “Why does this system not work better? Why has it not been fixed yet? If I were in charge...” In recent years, more physicians are indulging in the mindset of leading by making decisions and appropriately assuming roles as hospital administrators and executives. Thanks to the growing number of medical schools offering the …

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Usft Collection Assessment Dss Annual Report Digital Collections 2018-2019fy, Usf Libraries Jan 2019

Usft Collection Assessment Dss Annual Report Digital Collections 2018-2019fy, Usf Libraries

All Assessment Data

No abstract provided.

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State Emotion Regulation As A Mediator Of The Relationship Between State Attachment Security And State Mindfulness, Jamie Onufrak Jan 2019

State Emotion Regulation As A Mediator Of The Relationship Between State Attachment Security And State Mindfulness, Jamie Onufrak

USF St. Petersburg campus Master's Theses (Graduate)

Recent research has found associations between attachment security and mindfulness, such that individuals who are more secure in their relationships are more mindful, while those less secure in their relationships are less mindful. However, not much is known about the directionality and underlying mechanisms of this relationship. Recent research has suggested that emotion regulation is a mediator of this relationship. The present study tests if priming attachment security leads to an increase in state mindfulness, and if this relationship is mediated by state emotion regulation. Participants recruited using Amazon’s Mechanical Turk (N = 205) were randomly assigned to complete one …

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Effects Of In Situ Incubation Temperatures On Hatchling Loggerhead Sea Turtle (Caretta Caretta) Morphology, Health Indices, And Locomotor Performance, Kelsey Alexandra Fleming Jan 2019

Effects Of In Situ Incubation Temperatures On Hatchling Loggerhead Sea Turtle (Caretta Caretta) Morphology, Health Indices, And Locomotor Performance, Kelsey Alexandra Fleming

USF St. Petersburg campus Master's Theses (Graduate)

Incubation temperatures, in addition to an embryo’s genetic makeup, play crucial roles in development and alter a variety of characteristics in sea turtle embryos. Atmospheric temperatures are currently predicted to rise at least 1.5°C above preindustrial levels by 2052, potentially impacting embryonic development. Most sea turtle temperature studies document the effects of “high” and “low” incubation temperatures in laboratory-reared nests. This study’s objective was to examine impacts of varying in situ incubation temperatures on loggerhead sea turtle (Caretta caretta) hatchling morphology, health, and locomotor performance. Temperature data loggers were deployed in 15 individual loggerhead nests on Juno Beach, Florida between …

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Comparing The Fertility Of Florida’S Eastern Mosquitofish, Gambusia Holbrooki, Based On Differences In Female Traits, Water Quality, And Habitat Type, Jordan David Miller Jan 2019

Comparing The Fertility Of Florida’S Eastern Mosquitofish, Gambusia Holbrooki, Based On Differences In Female Traits, Water Quality, And Habitat Type, Jordan David Miller

USF St. Petersburg campus Master's Theses (Graduate)

The eastern mosquitofish, Gambusia holbrooki, is a surface-dwelling guppy native to the southeastern United States. While resilient to poor water quality, the fish is a voracious predator of the epilimnion, with established populations in most subtropical/tropical regions with surficial freshwater. Eastern mosquitofish are farmed and collected for use as biocontrol agents against the spread of many infectious, often life-threatening, mosquito-borne illnesses. I compared the reproductive success (fertility) of 370 gravid mosquitofish among 32 sites across central Florida to test the hypothesis that fertility is influenced by maternal, ecological, and environmental factors. I found that fish fertility (clutch size) differed significantly …

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A Comparative Behavioral Analysis Of Time Budgets Of Sea Turtles At The Florida Aquarium Through The Application Of An Ethogram, Kate Rae Lowry Jan 2019

A Comparative Behavioral Analysis Of Time Budgets Of Sea Turtles At The Florida Aquarium Through The Application Of An Ethogram, Kate Rae Lowry

USF St. Petersburg campus Master's Theses (Graduate)

Sea turtles are a crucial component of many coastline habitats due to their roles as ecosystem engineers and their ability to raise awareness for conservation efforts. Despite the extensive amount of research conducted on nesting behaviors of wild sea turtles, there are few behavioral studies of turtles in managed care. Sea turtles were observed at The Florida Aquarium from February 2018 to May 2019 to examine possible variations among behavior for five Loggerhead (Caretta caretta), Green (Chelonia mydas), and Kemp’s Ridley turtles (Lepidochelys kempii). The first part of this study includes a baseline time budget for the five turtles using …

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Pah Exposure In Red Snapper (Lutjanus Campechanus) Collected At Natural And Artificial Reef Systems In The Northwestern Gulf Of Mexico, Tiffany Jane Nicholson Jan 2019

Pah Exposure In Red Snapper (Lutjanus Campechanus) Collected At Natural And Artificial Reef Systems In The Northwestern Gulf Of Mexico, Tiffany Jane Nicholson

USF St. Petersburg campus Master's Theses (Graduate)

Red Snapper are commonly recognized as an important fishery across the bordering states of the Gulf of Mexico (GoM) and are found in abundance around oil and gas platforms. A small, yet toxic and environmentally persistent component, of crude oil known as polycyclic aromatic hydrocarbons (PAHs), are released into Gulf waters through both anthropogenic (e.g., oil and gas activities) and natural (e.g., hydrocarbon seeps) sources. These pollutants are associated with a variety of negative health effects in fish including cardio-toxicity, reproductive and developmental impairment, and external skin lesions. The objectives of this study were to measure and to compare PAH …

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A Survey And Comparison Of Plant Communities In Crescent Lake Park, An Urban Lake In St. Petersburg, Florida, Hunter Hajaistron Jan 2019

A Survey And Comparison Of Plant Communities In Crescent Lake Park, An Urban Lake In St. Petersburg, Florida, Hunter Hajaistron

USF St. Petersburg campus Master's Theses (Graduate)

In Florida, urban lakes are challenged. Pollution from surrounding urban ecosystems is detrimental to the ecological health of these lakes. Planting and restoring native wetlands along the littoral zone of these lakes will reduce the effects of pollution. Crescent Lake is an urban lake in Pinellas County, Florida, USA, that has recently begun to restore its wetlands system. This study surveys and evaluates the plant species in the wetland, shoreline, and parkland habitats of Crescent Lake to determine the effectiveness of management. Transects and quadrats were used to determine the diversity and structure of native and non-native plant species. 58 …

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Psychological Factors Related To Resilience And Vulnerability Among Youth With Hiv In An Integrated Care Setting., Tiffany Chenneville, Kemesha Gabbidon, Courtney Lynn, Carina Rodriguez Jan 2019

Psychological Factors Related To Resilience And Vulnerability Among Youth With Hiv In An Integrated Care Setting., Tiffany Chenneville, Kemesha Gabbidon, Courtney Lynn, Carina Rodriguez

USF St. Petersburg Campus Faculty Publications

Approximately 22% of HIV diagnoses in 2015 occurred among youth aged 13–24. Much is known about the risk factors and psychopathology present in youth living with HIV (YLWH), however, relatively little is known about resiliency in this population. The current study sought to assess factors related to resilience and vulnerability among YLWH as well as the impact of psychosocial factors on these constructs using existing clinical data from an integrated care clinic serving YLWH in the southeastern United States. Data included findings from mental health screeners administered as part of the standard protocol of care for youth aged 13–24 including …

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Florida Newspaper History Chronology, 1783-2001, David Shedden Jan 2019

Florida Newspaper History Chronology, 1783-2001, David Shedden

USF St. Petersburg Campus Faculty Publications

This resource guide about the history of Florida newspapers begins in 1783 during the last days of British rule and ends with the first generation of news websites.

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Climate Policy Implications Of Nonlinear Decline Of Arctic Land Permafrost And Other Cryosphere Elements, Dmitry Yumashev, Chris Hope, Kevin Schaefer, Kathrin Riemann-Campe, Fernando Iglesias-Suarez, Elchin Jafarov, Eleanor J. Burke, Paul J. Young, Yasin Elshorbany, Gail Whiteman Jan 2019

Climate Policy Implications Of Nonlinear Decline Of Arctic Land Permafrost And Other Cryosphere Elements, Dmitry Yumashev, Chris Hope, Kevin Schaefer, Kathrin Riemann-Campe, Fernando Iglesias-Suarez, Elchin Jafarov, Eleanor J. Burke, Paul J. Young, Yasin Elshorbany, Gail Whiteman

USF St. Petersburg Campus Faculty Publications

Arctic feedbacks accelerate climate change through carbon releases from thawing permafrost and higher solar absorption from reductions in the surface albedo, following loss of sea ice and land snow. Here, we include dynamic emulators of complex physical models in the integrated assessment model PAGE-ICE to explore nonlinear transitions in the Arctic feedbacks and their subsequent impacts on the global climate and economy under the Paris Agreement scenarios. The permafrost feedback is increasingly positive in warmer climates, while the albedo feedback weakens as the ice and snow melt. Combined, these two factors lead to significant increases in the mean discounted economic …

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From Journal Selection To Open Access: Practices Among Academic Librarian Scholars, Tina Neville, Camielle Crampsie Jan 2019

From Journal Selection To Open Access: Practices Among Academic Librarian Scholars, Tina Neville, Camielle Crampsie

USF St. Petersburg Campus Faculty Publications

In this study, researchers surveyed academic librarians about their open access publishing practices. This analysis explores approaches to journal selection, awareness of open access options, and self-archiving practices. Fifty percent of the librarians in this study considered free open access when selecting a potential journal for publication, but a journal's fit to the topic and peer review were higher priorities. Findings indicate that, although many librarians publish in open access journals or take advantage of institutional repositories, there are still barriers to publishing in open access journals, including article processing charges, the tenure and promotion culture, and uncertainty around intellectual …

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When It Comes To Moocs, Where You Are From Makes A Difference, Bahaa Gameel, Karin Gwinn Wilkins Jan 2019

When It Comes To Moocs, Where You Are From Makes A Difference, Bahaa Gameel, Karin Gwinn Wilkins

USF St. Petersburg Campus Faculty Publications

Millions of learners have enrolled in MOOCs in the last few years. However, little is known about the essential skills students need to succeed in MOOCs. Even less is known about how country of origin or other aspects such as gender might affect these skills. By integrating the resources and appropriation scholarship with second-level digital divide research, this study considers skills used to engage ICTs with self-efficacy and locus of control among MOOC learners from five regions. Results from surveying 2882 learners who enrolled in five English and Arabic MOOCs reveal significant differences among learners from various regions. Based on …

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Usft Services Assessment Dss Annual Report 2018-2019fy, Usf Libraries Jan 2019

Usft Services Assessment Dss Annual Report 2018-2019fy, Usf Libraries

All Assessment Data

No abstract provided.

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Carbon Cycling In The North American Coastal Ocean: A Synthesis, Katja Fennel, Simone Alin, Leticia Barbero, Wiley Evans, Timothée Bourgeois, Sarah Cooley, Frank E. Muller-Karger, Lisa Robbins Jan 2019

Carbon Cycling In The North American Coastal Ocean: A Synthesis, Katja Fennel, Simone Alin, Leticia Barbero, Wiley Evans, Timothée Bourgeois, Sarah Cooley, Frank E. Muller-Karger, Lisa Robbins

Marine Science Faculty Publications

A quantification of carbon fluxes in the coastal ocean and across its boundaries with the atmosphere, land, and the open ocean is important for assessing the current state and projecting future trends in ocean carbon uptake and coastal ocean acidification, but this is currently a missing component of global carbon budgeting. This synthesis reviews recent progress in characterizing these carbon fluxes for the North American coastal ocean. Several observing networks and high-resolution regional models are now available. Recent efforts have focused primarily on quantifying the net air–sea exchange of carbon dioxide (CO2). Some studies have estimated other key …

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Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien Adriaenssens, Bas Dutilh, Eugene Koonin, Andrew Kropinski, Mart Krupovic, Mya Breitbart, Karyna Rosario Jan 2019

Minimum Information About An Uncultivated Virus Genome (Miuvig), Simon Roux, Evelien Adriaenssens, Bas Dutilh, Eugene Koonin, Andrew Kropinski, Mart Krupovic, Mya Breitbart, Karyna Rosario

Marine Science Faculty Publications

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. In turn, this should enable more robust comparative …

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Pepper Mild Mottle Virus: Agricultural Menace Turned Effective Tool For Microbial Water Quality Monitoring And Assessing (Waste)Water Treatment Technologies, Erin Symonds, Karyna Rosario, Mya Breitbart Jan 2019

Pepper Mild Mottle Virus: Agricultural Menace Turned Effective Tool For Microbial Water Quality Monitoring And Assessing (Waste)Water Treatment Technologies, Erin Symonds, Karyna Rosario, Mya Breitbart

Marine Science Faculty Publications

No abstract provided.

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Developing High Resolution Baseline Coast Resource Maps Using World View 2 Imagery For A Coastal Village In Fiji, Ashneel Ajay Singh, Anish Maharaj, Michelle Kumar, Priyatma Singh, Sanjay Singh, Frank Muller-Karger, Matthew James Mccarthy, Lionel Joseph, Herve Damlamian, Zulfikar Begg Jan 2019

Developing High Resolution Baseline Coast Resource Maps Using World View 2 Imagery For A Coastal Village In Fiji, Ashneel Ajay Singh, Anish Maharaj, Michelle Kumar, Priyatma Singh, Sanjay Singh, Frank Muller-Karger, Matthew James Mccarthy, Lionel Joseph, Herve Damlamian, Zulfikar Begg

Marine Science Faculty Publications

In Fiji, like most Pacific Island countries, there have been numerous reports of degradation of coastal resources, including adverse changes in abundance and stock distribution of numerous aquatic species associated with the coastal habitat. To develop effective management plans, assessment of existing coastal resources is pertinent. High spatial resolution satellite imagery, combined with geographic information systems allow for efficient and synoptic mapping of coastal resources to provide a baseline for developing effective and improved management plans. The purpose of this study was to develop a baseline habitat map of the intertidal benthic cover in Komave Village, Coral Coast, Sigatoka, Fiji. …

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Bioinformatics Haracterisation Of The (Mutated) Proteins Related To Andersen–Tawil Syndrome, Carlos Polanco, Vladimir N. Uversky, Manlio F. Márquez, Thomas Buhse, Miguel Arias Estrada, Alberto Huberman Jan 2019

Bioinformatics Haracterisation Of The (Mutated) Proteins Related To Andersen–Tawil Syndrome, Carlos Polanco, Vladimir N. Uversky, Manlio F. Márquez, Thomas Buhse, Miguel Arias Estrada, Alberto Huberman

Molecular Medicine Faculty Publications

In the last two decades, a group of proteins whose mutations are associated with a disease manifested by episodes of muscle weakness (periodic paralysis), changes in heart rhythm (arrhythmia), and developmental abnormalities has been under constant study. This malady is known as Andersen–Tawil syndrome, with ~60% of cases of this syndrome being caused by 16 mutations in the KCNJ2 gene [UniProt ID: P63252-01—P63252-17]. In this work, we present a computational study designed to obtain a fingerprint of Andersen–Tawil mutated proteins and differentiate them from mutated proteins associated with Brugada syndrome and from functional groups of proteins belonging to APD3, UniProt, …

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On The Need To Develop Guidelines For Characterizing And Reporting Intrinsic Disorder In Proteins, Michael Vincent, Vladimir N. Uversky, Santiago Schnell Jan 2019

On The Need To Develop Guidelines For Characterizing And Reporting Intrinsic Disorder In Proteins, Michael Vincent, Vladimir N. Uversky, Santiago Schnell

Molecular Medicine Faculty Publications

Since the early 2000s, numerous computational tools have been created and used to predict intrinsic disorder in proteins. At present, the output from these algorithms is difficult to interpret in the absence of standards or references for comparison. There are many reasons to establish a set of standard-based guidelines to evaluate computational protein disorder predictions. This viewpoint explores a handful of these reasons, including standardizing nomenclature to improve communication, rigor and reproducibility, and making it easier for newcomers to enter the field. An approach for reporting predicted disorder in single proteins with respect to whole proteomes is discussed. The suggestions …

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Cyclized Ndga Modifies Dynamic Α-Synuclein Monomers Preventing Aggregation And Toxicity, Malcolm J. Daniels, J. Brucker Nourse, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J. Ferrie, Conor M. Haney, Rani Moons, Neal S. Gould, Antonino Natalello, Rita Grandori, Frank Sobott, E. James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vladimir N. Uversky, Kim A. Caldwell, Guy A. Caldwell, Edward S. Krol, Harry Ischiropoulos Jan 2019

Cyclized Ndga Modifies Dynamic Α-Synuclein Monomers Preventing Aggregation And Toxicity, Malcolm J. Daniels, J. Brucker Nourse, Hanna Kim, Valerio Sainati, Marco Schiavina, Maria Grazia Murrali, Buyan Pan, John J. Ferrie, Conor M. Haney, Rani Moons, Neal S. Gould, Antonino Natalello, Rita Grandori, Frank Sobott, E. James Petersson, Elizabeth Rhoades, Roberta Pierattelli, Isabella Felli, Vladimir N. Uversky, Kim A. Caldwell, Guy A. Caldwell, Edward S. Krol, Harry Ischiropoulos

Molecular Medicine Faculty Publications

Growing evidence implicates α-synuclein aggregation as a key driver of neurodegeneration in Parkinson’s disease (PD) and other neurodegenerative disorders. Herein, the molecular and structural mechanisms of inhibiting α-synuclein aggregation by novel analogs of nordihydroguaiaretic acid (NDGA), a phenolic dibenzenediol lignan, were explored using an array of biochemical and biophysical methodologies. NDGA analogs induced modest, progressive compaction of monomeric α-synuclein, preventing aggregation into amyloid-like fibrils. This conformational remodeling preserved the dynamic adoption of α-helical conformations, which are essential for physiological membrane interactions. Oxidation-dependent NDGA cyclization was required for the interaction with monomeric α-synuclein. NDGA analog-pretreated α-synuclein did not aggregate even without …

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Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair Jan 2019

Small Heat Shock Proteins, Big Impact On Protein Aggregation In Neurodegenerative Disease, Jack M. Webster, April L. Darling, Vladimir N. Uversky, Laura J. Blair

Molecular Medicine Faculty Publications

Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein-induced neurotoxicity and disease progression. Molecular chaperones have a wide range of functions from facilitating proper nascent folding and refolding to degradation or sequestration of misfolded substrates. In disease states, molecular chaperones can display protective or aberrant effects, including the promotion and stabilization of toxic protein aggregates. This seems to be dependent on the aggregating protein and discrete chaperone interaction. Small heat shock proteins (sHsps) are a class of molecular chaperones …

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Intrinsically Disordered Proteins And Their “Mysterious” (Meta)Physics, Vladimir N. Uversky Jan 2019

Intrinsically Disordered Proteins And Their “Mysterious” (Meta)Physics, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Recognition of the natural abundance and functional importance of intrinsically disordered proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions (IDPRs) and ordered regions, is changing protein science. IDPs and IDPRs, i.e., functional proteins and protein regions without unique structures, can often be found in all organisms, and typically play vital roles in various biological processes. Disorder-based functionality complements the functions of ordered proteins and domains. However, by virtue of their existence, IDPs/IDPRs, which are characterized by remarkable conformational flexibility and structural plasticity, break multiple rules established over the years to explain structure, folding, and functionality of …

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Rational Discovery Of Antimetastatic Agents Targeting The Intrinsically Disordered Region Of Mbd2, Min Young Kim, Insung Na, Ji Sook Kim, Seung Han Son, Sungwoo Choi, Seol Eui Lee, Ji-Hun Kim, Kiseok Jang, Gil Alterovitz, Yu Chen, Arjant Van Der Vaar, Hyung-Sik Won, Vladimir N. Uversky, Chul Geun Kim Jan 2019

Rational Discovery Of Antimetastatic Agents Targeting The Intrinsically Disordered Region Of Mbd2, Min Young Kim, Insung Na, Ji Sook Kim, Seung Han Son, Sungwoo Choi, Seol Eui Lee, Ji-Hun Kim, Kiseok Jang, Gil Alterovitz, Yu Chen, Arjant Van Der Vaar, Hyung-Sik Won, Vladimir N. Uversky, Chul Geun Kim

Molecular Medicine Faculty Publications

Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging due to their extreme structural flexibility. We report a rational discovery of inhibitors targeting an IDPR of MBD2 that undergoes disorder-to-order transition upon PPI and is critical for the regulation of the Mi-2/NuRD chromatin remodeling complex (CRC). Computational biology was essential for identifying target site, searching for promising leads, and assessing their binding feasibility and off-target probability. Molecular action of selected leads inhibiting the targeted PPI of MBD2 was validated in vitro and in cell, followed by confirming their …

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Intrinsic Disorder-Based Emergence In Cellular Biology: Physiological And Pathological Liquid-Liquid Phase Transitions In Cells, April L. Darling, Boris Zaslavsky, Vladimir N. Uversky Jan 2019

Intrinsic Disorder-Based Emergence In Cellular Biology: Physiological And Pathological Liquid-Liquid Phase Transitions In Cells, April L. Darling, Boris Zaslavsky, Vladimir N. Uversky

Molecular Medicine Faculty Publications

The visible outcome of liquid-liquid phase transitions (LLPTs) in cells is the formation and disintegration of various proteinaceous membrane-less organelles (PMLOs). Although LLPTs and related PMLOs have been observed in living cells for over 200 years, the physiological functions of these transitions (also known as liquid-liquid phase separation, LLPS) are just starting to be understood. While unveiling the functionality of these transitions is important, they have come into light more recently due to the association of abnormal LLPTs with various pathological conditions. In fact, several maladies, such as various cancers, different neurodegenerative diseases, and cardiovascular diseases, are known to be …

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