Digital Commons Network^™

Literature-Guided Recommendations For Otolaryngologists During The Covid-19 Pandemic: A Contemporary Review, Mausumi Syamal

Otolaryngology Head & Neck Surgery Faculty Publications

Objective: The objective of this study was to review the current literature and guidelines on management of the novel coronavirus 2019 (COVID-19 or 2019nCoV) with respect to the field of Otolaryngology.

Design: Contemporary literature review.

Methods: Systematic literature review of global medical literature databases and communications were queried to find all available literature recommendations, research, and guidelines applicable to otolaryngologists in the COVID-19 pandemic.

Results: Guidance on personal protective equipment, office visits, and surgical scheduling, as well as recommendations for safe airway management and tracheotomy performance during the COVID-19 pandemic were compiled and interpreted.

Conclusion: Little guidance exists for otolaryngologists …

Novel Titanium Cages For Minimally Invasive Lateral Lumbar Interbody Fusion: First Assessment Of Subsidence, Paul R. Krafft, Brooks Osburn, Andrew C. Vivas, Gautam Rao, Puya Alikhani

Neurosurgery and Brain Repair Faculty Publications

Introduction: Implant subsidence is a potential complication of spinal interbody fusion and may negatively affect patients subjected to procedures relying on indirect decompression such as minimally invasive transpsoas lateral lumbar interbody fusion (LLIF). The porous architecture of a recently developed titanium intervertebral cage maximizes bone-to-implant contact and minimizes stress shielding in laboratory experiments; however, its subsidence rate in patients has not yet been evaluated. The goal of this current study was to evaluate implant subsidence in patients subjected to LLIF.

Methods: Our institutional review board-approved single-center experience included 29 patients who underwent 30 minimally invasive LLIF from July 2017 to …

Mesenchymal Stem Cell Therapy Alleviates The Neuroinflammation Associated With Acquired Brain Injury, Brooke Bonsack, Sydney Corey, Alex Shear, Matt Heyck, Blaise Cozene, Nadia Sadanandan, Henry Zhang, Bella Gonzales-Portillo, Michael Sheyner, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death and secondary cell death closely model disease progression and worsen outcomes. Mounting evidence indicates that long-term neuroinflammation extensively exacerbates the secondary deterioration of brain structure and function. Due to their immunomodulatory and regenerative properties, mesenchymal stem cell transplants have emerged as a promising approach to treating this facet of stroke and TBI pathology. In this review, we summarize the classification of cell death in ABI and discuss the prominent role of inflammation. We then …

Advancing Stem Cell Therapy For Repair Of Damaged Lung Microvasculature In Amyotrophic Lateral Sclerosis, Svitlana Garbuzova-Davis, Robert Shell, Hilmi Mustafa, Surafuale Hailu, Alison E. Willing, Paul R. Sanberg, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration in the brain and spinal cord. Progressive paralysis of the diaphragm and other respiratory muscles leading to respiratory dysfunction and failure is the most common cause of death in ALS patients. Respiratory impairment has also been shown in animal models of ALS. Vascular pathology is another recently recognized hallmark of ALS pathogenesis. Central nervous system (CNS) capillary damage is a shared disease element in ALS rodent models and ALS patients. Microvascular impairment outside of the CNS, such as in the lungs, may occur in ALS, triggering lung damage …

Foraminal Ligaments Tether Upper Cervical Nerve Roots: A Potential Cause Of Postoperative C5 Palsy, Andrew S. Jack, Brooks R. Osburn, Zane A. Tymchak, Wyatt L. Ramey, Rod J. Oskouian, Robert A. Hart, Jens R. Chapman, Line G. Jacques, R. Shane Tubbs

Neurosurgery and Brain Repair Faculty Publications

Background: Nerve root tethering upon dorsal spinal cord (SC) migration has been proposed as a potential mechanism for postoperative C5 palsy (C5P). To our knowledge, this is the first study to investigate this relationship by anatomically comparing C5–C6 nerve root translation before and after root untethering by cutting the cervical foraminal ligaments (FL).

Objective: The aim of this study is to determine if C5 root untethering through FL cutting results in increased root translation.

Methods: Six cadaveric dissections were performed. Nerve roots were exposed via C4–C6 corpectomies and supraclavicular brachial plexus exposure. Pins were inserted into the C5–C6 roots and …

Cell Therapy For Central Nervous System Disorders: Current Obstacles To Progress, Takao Yasuhara, Satoshi Kawauchi, Kyohei Kin, Jun Morimoto, Masahiro Kameda, Tatsuya Sasaki, Brooke Bonsack, Chase Kingsbury, Naoki Tajiri, Cesar V. Borlongan, Isao Date

Neurosurgery and Brain Repair Faculty Publications

Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS cells has provided a robust stem cell donor source for neurorestoration via transplantation. Additionally, iPS cells have served as a platform for the discovery of therapeutics drugs, allowing breakthroughs in our understanding of the pathology and treatment of neurological diseases. Despite these recent …

Translating Intracarotid Artery Transplantation Of Bone Marrow-Derived Ncs-01 Cells For Ischemic Stroke: Behavioral And Histological Readouts And Mechanistic Insights Into Stem Cell Therapy, Yuji Kaneko, Jea-Young Lee, Naoki Tajiri, Julian P. Tuazon, Trenton Lippert, Eleonora Russo, Seong-Jin Yu, Brooke Bonsack, Sydney Corey, Alexandreya B. Coats, Chase Kingsbury, Thomas N. Chase, Minako Koga, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

The present study used in vitro and in vivo stroke models to demonstrate the safety, efficacy, and mechanism of action of adult human bone marrow-derived NCS-01 cells. Coculture with NCS-01 cells protected primary rat cortical cells or human neural progenitor cells from oxygen glucose deprivation. Adult rats that were subjected to middle cerebral artery occlusion, transiently or permanently, and subsequently received intracarotid artery or intravenous transplants of NCS-01 cells displayed dose-dependent improvements in motor and neurological behaviors, and reductions in infarct area and peri-infarct cell loss, much better than intravenous administration. The optimal dose was 7.5 × 106 cells/mL when …

A Qualitative Exploration Of Racial And Ethnic Differences In Cost Of Care Conversations Among Older Adults, Kyaien Oquinn Conner, Jaqueline Wiltshire, Edlin Colato Garcia, Barbara Langland-Orban, Erica Anderson, Iraida Carrion, Amber Goodman, Ashley Goodman

Sociology Faculty and Staff Publications

Background: The rapidly growing racially diverse, aging population in the United States is presenting unique challenges for our social, economic, and healthcare systems. Rising health care costs, increased patient cost-sharing, and limited financial resources make this generation of older Americans susceptible to large medical bills or debt which disproportionally impacts older racial/ethnic minorities. Cost-of-care (CoC) conversations between patients and doctors is one recommended approach to containing health care costs and alleviating patients’ financial burden of care.

Methods: The current study used focus group methodology to qualitatively explore the contextual factors that influence CoC conversations in a diverse sample of older …

Impact Of Excess Weight Gain On Risk Of Postpartum Infection In Class Iii Obesity, Courtney J. Mitchell, Lamani Adkins, Ann Tucker, Haywood Brown, Anne Siegel, Sarah Dotter-Katz

Obstetrics & Gynecology Faculty Publications

Objective: To assess the impact of gestational weight gain >20 pounds (more than Institute of Medicine [IOM] recommendations) on postpartum infectious morbidity in women with class III obesity.

Methods: This is a retrospective cohort of term, nonanomalous singleton pregnancies with body mass index ≥40 at a single institution from 2013 to 2017. Pregnancies with multiple gestation, late entry to care, and missing weight gain data are excluded. Primary outcome is a composite of postpartum infection (endometritis, urinary tract, respiratory, and wound infection). Secondary outcomes include components of composite, wound complication, readmission, and blood transfusion. Bivariate statistics compared demographics, pregnancy complications, …

Observational Study Of Talimogene Laherparepvec Use In The Anti-Pd-1 Era For Melanoma In The Us (Cosmus-2), James Sun, Brian R. Gastman, Lucy Mccahon, Elizabeth I. Buchbinder, Igor Puzanov, Michele Nanni, James M. Lewis, Richard D. Carvajal, Shahnaz Singh-Kandah, Anupam M. Desai, Leon Raskin, Carrie M. Nielson, Rubina Ismail, Jonathan S. Zager

Oncologic Sciences Faculty Publications

Aim: Talimogene laherparepvec (T-VEC) is an intralesional therapy for unresectable, metastatic melanoma. T-VEC real-world use in the context of anti-PD1-based therapy requires further characterization.

Materials & methods: A retrospective review of T-VEC use from 1 January 2017 and 31 March 2018 for melanoma patients was conducted at seven US institutions.

Results: Among 83 patients, three categories of T-VEC and anti-PD-1 therapy were identified: T-VEC used without anti-PD-1 (n = 29, 35%), T-VEC after anti-PD-1-based therapy (n = 22, 27%) and concurrent T-VEC and anti-PD-1-based therapy (n = 32, 39%). 25% of patients discontinued T-VEC therapy due to no remaining injectable …

Diffuse Intrasinusoidal Hepatic Metastasis From Breast Cancer Presenting As Liver Failure: Effective And Rapid Treatment With Weekly Low-Dose Adriamycin, Thanh-Phuong N. Afiat, Timothy N. Hembree, Erin A. Dean, Cyrillo Araujo, Luis R. Pena, Marilin Rosa, Hyo S. Han, Kaitlin Hendrix, Asha Ramsakal

Oncologic Sciences Faculty Publications

Background: Hepatic metastasis is well known in breast cancer. Approximately 12–20% of breast cancer patients will develop liver metastasis, which usually presents as discrete mass lesions. Rarely, metastatic spread can be so diffuse that it is unidentifiable on imaging but can progress to fulminant hepatic failure. Our case report suggests that clinicians need to have a high index of suspicion when patients present with rapidly decompensating liver failure in the absence of discrete radiologic hepatic lesions, and that weekly Adriamycin should be considered as a first-line therapeutic option.

Case Report: A 28-year-old African American woman with a history of locally …

Resolvin E1 Derived From Eicosapentaenoic Acid Prevents Hyperinsulinemia And Hyperglycemia In A Host Genetic Manner, Anandita Pal, Abrar E. Al-Shaer, William Guesdon, Maria J. Torres, Michael Armstrong, Kevin Quinn, Traci Davis, Nichole Reisdorph, P. Darrell Neufer, Espen E. Spangenburg, Ian Carroll, Richard P. Bazinet, Ganesh V. Halade, Joan Clària, Saame Raza Shaikh

Internal Medicine Faculty Publications

The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia. EPA ethyl esters prevented obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia in C57BL/6J mice. Supporting NHANES analyses showed that fasting glucose levels of obese adults were inversely related to EPA intake. We next investigated how EPA improved murine hyperinsulinemia and hyperglycemia. EPA overturned the obesity-driven decrement in the concentration …

Race-Based And Sex-Based Differences In Bioactive Lipid Mediators After Myocardial Infarction, Ganesh V. Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A. Limdi

Internal Medicine Faculty Publications

Aims: Leucocyte-directed specialized pro-resolving mediators (SPMs) are essential for cardiac repair, and their biosynthesis coincides with the expression of pro-inflammatory mediators; however, the precise quantitation during an acute myocardial infarction (MI) event is poorly understood in race-specific and sex-specific manner. Coronary heart disease is the leading cause of death and disability in the USA. Although the prevalence of coronary heart disease is similar between Black and White patients, cardiovascular events (including MI), rehospitalization, and mortality are disproportionately higher in Black patients. Therefore, understanding differences in inflammation and resolution can enable the development of predictive, personalized, and precise treatment and attenuate …

Aspirin Use For Cardiovascular Disease Prevention In The Uninsured Population, Nina Liu, Adithya Mathews, Justin Swanson, Rahul Mhaskar, Akshay Mathews, Noura Ayoubi, Abu-Sayeef Mirza

Internal Medicine Faculty Publications

Introduction: Aspirin is an effective anti-inflammatory and antiplatelet agent as an irreversible inhibitor of cyclooxygenase. In 2016, the U.S. Preventive Services Task Force recommended aspirin for primary prevention of cardiovascular disease in patients aged 50–69 years with a 10% or greater 10-year cardiovascular disease risk. Current guidelines for patients with prior myocardial infarction or coronary artery disease recommend aspirin use for the secondary prevention of cardiovascular disease. Due to the lack of literature describing adherence to these recommendations in the uninsured patient population, we studied aspirin use for cardiovascular disease prevention in free medical clinics.

Methods: We conducted a cross …

Electrocardiographic Changes Associated With Ibrutinib Exposure, Michael G. Fradley, Allan Welter-Frost, Matthew Gliksman, Josephine Emole, Federico Viganego, Dae Hyun Lee, Bijal Shah, Julio C. Chavez, Javier Pinilla-Ibarz, Matthew B. Schabath

Internal Medicine Faculty Publications

Although ibrutinib-associated atrial and ventricular arrhythmias have been well described, there is little information about ibrutinib’s effects on other electrocardiographic parameters, particularly the QT interval. Using our database of 137 patients treated with ibrutinib, we retrospectively identified 21 patients in whom an electrocardiogram (ECG) was obtained both prior to and after ibrutinib exposure. All traditional ECG parameters as well as QT dispersion were manually measured by an electrophysiologist. Compared to baseline ECGs, post ibrutinib ECGs demonstrated QT interval shortening from 386 ms to 356 ms (P = .007), corrected QT interval shortening using Bazett’s formula from 446 ms to …

Factors Associated With Current And Severe Pain Among People Living With Hiv: Results From A Statewide Sample, Verlin Joseph, Abenaa Jones, Shantrel Canidate, Zachary Mannes, Huiyin Lu, Nicole Ennis, Gladys Ibanez, Charurut Somboonwit, Robert Cook

Internal Medicine Faculty Publications

Background: People living with HIV (PLHIV) are more likely to suffer from pain compared to the general public. Pain often clusters with mental health symptoms and substance use. This study sought to evaluate mental health and substance use factors associated with any pain and severe pain intensities among PLHIV.

Methods: Data were derived from HIV+ adults (N=733) recruited from community health centers across Florida who completed questionnaires regarding demographics, chronic pain, HIV clinical outcomes, mental health symptoms, and substance use information. Pain was assessed using the Brief Pain Inventory (BPI) short form. Multivariate logistic regression analysis was utilized to assess …

Physician-Directed Smoking Cessation Using Patient “Opt-Out” Approach In The Emergency Department: A Pilot Program, Marna Rayl Greenberg, Natalie M. Greco, Timothy J. Batchelor, Andrew H.F. Miller, Theodore Doherty, Ali S. Aziz, Stephanie Z. Yee, Faiza Arif, Lauren M. Crowley, Edward W. Casey, Robert J. Kruklitis

Internal Medicine Faculty Publications

Objective: Using a physician-directed, patient “opt-out” approach to prescriptive smoking cessation in the emergency department (ED) setting, we set out to describe patient actions as they related to smoking cessation behaviors.

Methods: A convenience sample of smokers at 2 Pennsylvania hospital EDs who met inclusion/exclusion criteria were approached to participate in a brief intervention known as screening, treatment initiation, and referral (STIR) counseling that included phone follow-up. Demographic information, current smoking status, and specific physician prescription and follow-up recommendations were collected. Approximately 3 months later, patients were contacted to determine current smoking status and actions taken since their ED visit. …

Computed Tomography And Point-Of-Care Ultrasound Findings In 2 Covid-19 Patients, Kevin R. Roth, Joseph B. Zackary, Lauren M. Crowley, Marna Rayl Greenberg

Internal Medicine Faculty Publications

No abstract provided.

Decimated Little Brown Bats Show Potential For Adaptive Change, Giorgia G. Auteri, L. L. Knowles

KIP Articles

The degree to which species can rapidly adapt is key to survival in the face of climatic and other anthropogenic changes. For little brown bats (Myotis lucifugus), whose populations have experienced declines of over 90% because of the introduced fungal pathogen that causes white-nose syndrome (WNS), survival of the species may ultimately depend upon its capacity for adaptive change. Here, we present evidence of selectively driven change (adaptation), despite dramatic nonadaptive genomic shifts (genetic drift) associated with population declines. We compared the genetic makeups of wild survivors versus non-survivors of WNS, and found significant shifts in allele frequencies of genes …

Direct Oral Anticoagulant Failure In Stroke/Transient Ischaemic Attack: Neurologic And Pharmacokinetic Considerations, David Z. Rose, W. Scott Burgin

Neurology Faculty Publications

No abstract provided.

Untreated Stroke As Collateral Damage Of Covid-19: “Time Is Brain” Versus “Stay At Home, David Z. Rose, W. Scott Burgin, Swetha Renati

Neurology Faculty Publications

For decades, neurologists have been advocating that anyone with acute focal deficits report immediately to the closest hospital’s emergency room. Major advancements in the hyperacute diagnosis and treatment of stroke have justified our call-to-action slogan of “Time is Brain”—faster therapy leads to superior outcomes. However, this mantra has been recently usurped by the catchphrase “Stay at Home” during the coronavirus disease 2019 (COVID-19) pandemic. Fewer patients are presenting to hospitals with acute stroke; our census is down. Presumably the etiology of this phenomenon is either strict “social distancing” that some people may misperceive to exclude even emergent situations, or fears …

“Why The H**L Is There A White House Correspondents’ Dinner?” Boundary Work In Political Journalism, Gregory P. Perreault, Kellie Stanfield, Shelby Luttmann

School of Advertising & Mass Communications Faculty Publications

Political journalism is a pertinent part of newsrooms across theworld. This study aimed to analyze the shifting role conceptionsof U.S. political journalists, primarily in reference to the WhiteHouse Correspondents’Dinner. Researchers conducted 32 long-form phone interviews with political journalists from news outletsranging from theLos Angeles Timesto VICE. The study found mostjournalists uncomfortable with the White House Correspondents’Dinner, especially after the response to Michelle Wolf’s speech atthe 2018 event. This particular event helped journalists identifyhow the event works in opposition to their role conception.Through the lens of boundary work, this study argues the comedyformat of the dinner, which ceased following 2018, pushedoutside …

Synthesis, Characterization, And Investigation Of The Antimicrobial Activity Of Cetylpyridinium Tetrachlorozincate, Viktor Dubovoy, Shiri Nawrocki, Gaurav Verma, Lukasz Wojtas, Primit Desai, Hassan Al-Tameemi, Tatiana V. Brinzari, Michael Stranick, Dailin Chen, Shaopeng Xu, Shengqian Ma, Jeffrey M. Boyd, Tewodros Asefa, Long Pan

Chemistry Faculty Publications

Cetylpyridinium tetrachlorozincate (referred to herein as (CP)₂ZnCl₄) was synthesized and its solid-state structure was elucidated via single-crystal X-ray diffraction (SC-XRD), revealing a stoichiometry of C₄₂H₇₆Cl₄N₂Zn with two cetylpyridinium (CP) cations per [ZnCl₄]^2– tetrahedra. Crystal structures at 100 and 298 K exhibited a zig-zag pattern with alternating alkyl chains and zinc units. The material showed potential for application as a broad-spectrum antimicrobial agent, to reduce volatile sulfur compounds (VSCs) generated by bacteria, and in the fabrication of advanced functional materials. Minimum inhibitory concentration (MIC) of (CP) …

Water Fountain Decal, Usf

USF COVID-19 Public Health Signage

No abstract provided.

A Revised Diet Matrix To Improve The Parameterization Of A West Florida Shelf Ecopath Model For Understanding Harmful Algal Bloom Impacts, Holly A. Perryman, Joseph H. Tarnecki, Arnaud Grüss, Elizabeth A. Babcock, Skyler R. Sagarese, Cameron H. Ainsworth, Alisha M. Gray Dileone

Marine Science Faculty Publications

Harmful algal blooms (HABs) are a growing concern in the West Florida Shelf (WFS) region. An Ecopath with Ecosim (EwE) model of the WFS explicitly simulating HABs was previously developed to illuminate the potential impacts of blooms of the dinoflagellate Karenia brevis (colloquially referred to as “red tides”) on the WFS ecosystem. However, the diet matrix of the Ecopath component of this EwE model (referred to as “WFS-HAB Ecopath”) was based largely on sparse, cursory information and not on local survey data. Here, we revise the diet matrix of the WFS-HAB Ecopath model using predictions of a robust statistical model …

A Synthesis Of Deep Benthic Faunal Impacts And Resilience Following The Deepwater Horizon Oil Spill, Patrick T. Schwing, Paul A. Montagna, Samantha B. Joye, Claire B. Paris, Erik E. Cordes, Craig R. Mcclain, Joshua P. Kilborn, Steven A. Murawski

Marine Science Faculty Publications

The Deepwater Horizon (DWH) oil spill significantly impacted the northern Gulf of Mexico (nGoM) deep benthos (>125 m water depth) at different spatial scales and across all community size and taxa groups including microbes, foraminifera, meiofauna, macrofauna, megafauna, corals, and demersal fishes. The resilience across these communities was heterogeneous, with some requiring years if not decades to fully recover. To synthesize ecosystem impacts and recovery following DWH, the Gulf of Mexico Research Initiative (GOMRI) Core 3 synthesis group subdivided the nGoM into four ecotypes: coastal, continental shelf, open-ocean, and deep benthic. Here we present a synopsis of the deep …

Baseline And Stress-Induced Corticosterone Levels Across Birds And Reptiles Do Not Reflect Urbanization Levels, Allison S. Injaian, Clinton D. Francis, Jenny Q. Ouyang, Davide M. Dominoni, Jeremy W. Donald, Matthew J. Fuxjager, Wolfgang Goymann, Michaela Hau, Jerry F. Husak, Michele A. Johnson, Bonnie K. Kircher, Rosemary Knapp, Lynn B. Martin, Eliot T. Miller, Laura A. Schoenle, Tony D. Williams, Maren N. Vitousek

Global Health Faculty Publications

Rates of human-induced environmental change continue increasing with human population size, potentially altering animal physiology and negatively affecting wildlife. Researchers often use glucocorticoid concentrations (hormones that can be associated with stressors) to gauge the impact of anthropogenic factors (e.g. urbanization, noise and light pollution). Yet, no general relationships between human-induced environmental change and glucocorticoids have emerged. Given the number of recent studies reporting baseline and stress-induced corticosterone (the primary glucocorticoid in birds and reptiles) concentrations worldwide, it is now possible to conduct large-scale comparative analyses to test for general associations between disturbance and baseline and stress-induced corticosterone across species. Additionally, …

Examining Older Adults’ Perspectives On The Built Environment And Correlates Of Healthy Aging In An American Age-Friendly Community, Kathy Black, Dylan J. Jester

Aging Studies Sarasota Manatee Campus Faculty Publications

Population aging has led to an increased focus on the environmental context in which we age. While researchers have identified significant health benefits associated with built community features such as housing, transportation and outdoor spaces and buildings, less attention has focused on the correlates of healthy aging and other characteristics via the perspective of community-dwelling older adults. This study utilized cluster analysis to examine health-related subgroups of older adults (n = 598) in an age-friendly community located in the United States, of which nearly half of its residents are age 60 and older. Linear regression was used to associate the …

Relationship Between Obesity-Induced Metabolic Abnormalities And Nutrient Intake: Sex Differences In Japanese University Students, Mayumi Yamamoto, Mausam Mehta, Akihiro Nishio, Ryo Horita, Ricardo Izurieta

Global Health Faculty Publications

Background: Preventive measures and interventions for obesity in young adults are urgently needed. However, evidence-based guidelines for interventional programs in this generation have not been established worldwide because of limited access to data on this group. To establish effective methods of obesity prevention in young adults, we analyzed the relationship between nutrient intake and obesity-related metabolic factors in each body mass index (BMI) group among Japanese university students. Methods: A cross-sectional analysis was performed using annual health checkup data, which is conducted mandatory for all students according to the School Health and Safety Act in Japan, from Gifu University’s incoming …

Prediction Of Chronic Disease-Related Inpatient Prolonged Length Of Stay Using Machine Learning Algorithms, Hasan Symum, José Zayas-Castro

Industrial and Management Systems Engineering Faculty Publications

Objectives: The study aimed to develop and compare predictive models based on supervised machine learning algorithms for predicting the prolonged length of stay (LOS) of hospitalized patients diagnosed with five different chronic conditions. Methods: An administrative claim dataset (2008–2012) of a regional network of nine hospitals in the Tampa Bay area, Florida, USA, was used to develop the prediction models. Features were extracted from the dataset using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes. Five learning algorithms, namely, decision tree C5.0, linear support vector machine (LSVM), k-nearest neighbors, random forest, and multi-layered artificial neural networks, were …