Digital Commons Network^™

Paving The Way For Synthetic Intrinsically Disordered Polymers For Soft Robotics, Orkid Coskuner-Weber, Elif Yuce-Erarslan, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Nature is full of examples of processes that, through evolution, have been perfected over the ages to effectively use matter and sustain life. Here, we present our strategies for designing intrinsically disordered smart polymers for soft robotics applications that are bio-inspired by intrinsically disordered proteins. Bio-inspired intrinsically disordered smart and soft polymers designed using our deep understanding of intrinsically disordered proteins have the potential to open new avenues in soft robotics. Together with other desirable traits, such as robustness, dynamic self-organization, and self-healing abilities, these systems possess ideal characteristics that human-made formations strive for but often fail to achieve. Our …

Limosilactobacillus Fermentum 3872 That Produces Class Iii Bacteriocin Forms Co-Aggregates With The Antibiotic-Resistant Staphylococcus Aureus Strains And Induces Their Lethal Damage, Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Tatiana V. Priputnevich, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Irina O. Chikileva, Tatiana N. Abashina, Alexander N. Panin, Vyacheslav G. Melnikov, Natalia E. Suzina, Ilya N. Nikonov, Marina V. Selina, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev

Molecular Medicine Faculty Publications

LF3872 was isolated from the milk of a healthy lactating and breastfeeding woman. Earlier, the genome of LF3872 was sequenced, and a gene encoding unique bacteriocin was discovered. We have shown here that the LF3872 strain produces a novel thermolabile class III bacteriolysin (BLF3872), exhibiting antimicrobial activity against antibiotic-resistant Staphylococcus aureus strains. Sequence analysis revealed the two-domain structural (lysozyme-like domain and peptidase M23 domain) organization of BLF3872. At least 25% residues of this protein are expected to be intrinsically disordered. Furthermore, BLF3872 is predicted to have a very high liquid-liquid phase separation. According to the electron microscopy data, the bacterial …

Pre-Molten, Wet, And Dry Molten Globules En Route To The Functional State Of Proteins, Munishwar Nath Gupta, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed.

Liaisons Dangereuses: Intrinsic Disorder In Cellular Proteins Recruited To Viral Infection-Related Biocondensates, Greta Bianchi, Stefania Brocca, Sonia Longhi, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Liquid–liquid phase separation (LLPS) is responsible for the formation of so-called membrane-less organelles (MLOs) that are essential for the spatio-temporal organization of the cell. Intrinsically disordered proteins (IDPs) or regions (IDRs), either alone or in conjunction with nucleic acids, are involved in the formation of these intracellular condensates. Notably, viruses exploit LLPS at their own benefit to form viral replication compartments. Beyond giving rise to biomolecular condensates, viral proteins are also known to partition into cellular MLOs, thus raising the question as to whether these cellular phase-separating proteins are drivers of LLPS or behave as clients/regulators. Here, we focus on …

Can Covid-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading To?, Altijana Hromić-Jahjefendić, Debmalya Barh, Vladimir N. Uversky, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Fuad M. Alzahrani, Saleh Alshammeri, Kenneth Lundstrom

Molecular Medicine Faculty Publications

According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced …

Yield And Composition Variations Of The Milk From Different Camel Breeds In Saudi Arabia, Amr A. El-Hanafy, Yasser M. Saad, Saleh A. Alkarim, Hussein A. Almehdar, Fuad M. Alzahrani, Mohammed A. Almatry, Vladimir N. Uversky, Elrashdy M. Redwan

Molecular Medicine Faculty Publications

With the increasing interest in the identification of differences between camel breeds over the last decade, this study was conducted to estimate the variability of milk production and composition of four Saudi camel breeds during different seasons. Milk records were taken two days per week from females of Majahem, Safra, Wadha, and Hamra breeds distributed over Saudi Arabia. The milk yield during winter indicated that the weekly average of the Wadha breed was significantly lower (27.13 kg/week) than Majahem and Hamra breeds. The Safra breed had the lowest milk yield (30.7 kg/week) during summer. During winter, the Hamra breed had …

From The Hydrophobic Core To The Globular-Disorder Interface: New Challenges And Insights Into Protein Design, Sankar Basu, Devlina Chakravarty, Qingzhen Hou, Vladimir N. Uversky

Molecular Medicine Faculty Publications

No abstract provided.

Advanced Phytochemical-Based Nanocarrier Systems For The Treatment Of Breast Cancer, Vivek P. Chavda, Lakshmi Vineela Nalla, Pankti Balar, Rajashri Bezbaruah, Vasso Apostolopoulos, Rajeev K. Singla, Avinash Khadela, Lalitkumar K. Vora, Vladimir N. Uversky

Molecular Medicine Faculty Publications

As the world’s most prevalent cancer, breast cancer imposes a significant societal health burden and is among the leading causes of cancer death in women worldwide. Despite the notable improvements in survival in countries with early detection programs, combined with different modes of treatment to eradicate invasive disease, the current chemotherapy regimen faces significant challenges associated with chemotherapy-induced side effects and the development of drug resistance. Therefore, serious concerns regarding current chemotherapeutics are pressuring researchers to develop alternative therapeutics with better efficacy and safety. Due to their extremely biocompatible nature and efficient destruction of cancer cells via numerous mechanisms, phytochemicals …

Chapter 03 Careers In Information Technology, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

Information technology now offers a range of attractive career options for workers with a wide variety of interests, skill levels, and career ambitions. See Figure 6. Some of these roles are highlighted in this chapter.

Chapter 05 Microcomputers, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

In the previous chapter, we saw how computers are used in organizations. In this chapter, we will introduce the common types of computers and provide an overview of the parts of a typical computer. This will allow you to compare computers with different specifications and make the right choices when selecting a computer for a specific task.

Chapter 04 Researching And Using The Web, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

Never in history have we had so much knowledge stored, organized, and ready to be consumed with the click of a mouse or the tap of a button. If we step back for a moment and think about what is available on the web, we will be amazed by the information close at hand, all thanks to computers and the Internet. You can find the score of any weekend football game, price of grain in Nebraska, weather in Antarctica, tide schedules in South Australia, and the outcome of an election in Britain by typing your question in any search engine. …

Capítulo 03 Carreras En La Tecnología De La Información, Shambhavi Roy, Clinton Daniel, Manish Agrawal, Pablo Brescia, Clara Olivia Ocampo, Sonia Labrador

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – Spanish

La tecnología de la información actualmente ofrece una gama de opciones profesionales atractivas con una amplia variedad de intereses, niveles de habilidad y ambiciones laborales. En esta sección explicaremos algunas de estas profesiones.

Chapter 09 Introduction To Spreadsheets, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

Spreadsheets are electronic documents that help users to manipulate data. While word processors and email are probably the most used productivity applications, much of the world’s business runs on spreadsheets. This is because spreadsheets are the productivity applications designed to store numbers. Spreadsheets make it easy to visualize data and identify trends in that data. Any teacher tracking student grades will find it easiest to do so using spreadsheets. Student clubs will find it easiest to track contributions and expenses if they use spreadsheets. You may not use spreadsheets every day of your life, but your most valuable information is …

Chapter 13 Computer Languages, Applications, And Emerging Technologies, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

Computer languages are the rules for writing computer programs. Just as we need languages such as English to communicate ideas and information with each other, we need computer languages to tell computers what to do. Computer languages are popularly called programming languages. The important difference between human languages and computer languages originates from the human ability to handle ambiguity and fill context. For example, in most contexts people would understand the phrase “let’s meet tomorrow.” But computers would not be able to figure out who is meeting, the place of the meeting, the time of the meeting, any prior preparation …

Chapter 18 Social Media, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

At the turn of the century, we were still at the beginning of our journey into this always-on, always-connected world. We still wrote physical letters and sent birthday cards by mail. Phone calls were expensive and video calling was like science fiction. Google and Facebook didn’t exist. You couldn’t download video games on your mobile phone because you didn’t have access to an app store that sold software.

In contrast, just today you might have viewed TikTok videos, checked Instagram, sent a WhatsApp message, liked an author’s tweet, and chatted with your friends on Discord. All before starting your school …

Chapter 16 Cybersecurity, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

The National Institute of Standards and Technology (NIST), founded in 1901, is part of the U.S. Department of Commerce and supports the U.S. mission to promote today’s innovations and industrial competitiveness. This mission is accomplished by advancing measurements and standards in science and technologies that enhance economic security and quality of life. NIST, defines cybersecurity as:

Prevention of damage to, protection of, and restoration of computers, electronic communicationssystems,electroniccommunicationsservices,wirecommunication, and electronic communication, including information contained therein, to ensure its availability, integrity, authentication, confidentiality, and nonrepudiation.

At the core of cybersecurity is the motivation to protect information and the systems that manage …

Chapter 17 Ethical Issues In Information Technology, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

Ethics are a community’s shared beliefs about what is good for the individual and for society and the duties that people owe themselves and one another. The word “ethics” traces to the Greek word ήθος (ethos), which describes the guiding ideals of a community. Though some ethical principles may be codified as law, ethics are more commonly enforced by disapproval among members of the community. For example, not breaking a promise to a friend is a common ethical principle. It is not prohibited by the law; however, strong disapprovals ensure that friends do not break promises among each other.

Today, …

Capítulo 16 Ciberseguridad, Shambhavi Roy, Clinton Daniel, Manish Agrawal, Pablo Brescia, Clara Olivia Ocampo, Sonia Labrador

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – Spanish

El Instituto Nacional de Estándares y Tecnología (NIST, siglas en inglés de National Institute of Standards and Technology), fundado en 1901, forma parte del Departamento de Comercio de EE. UU. y apoya la misión estadounidense de promover las innovaciones y la competitividad industrial actuales. Esta misión se logra mediante el avance de mediciones y estándares en ciencia y tecnologías que mejoran la seguridad económica y la calidad de vida. NIST define la ciberseguridad como:

Prevención de daños, protección y restauración de computadoras, sistemas de comunicaciones electrónicas, servicios de comunicaciones electrónicas, comunicaciones por cable y comunicaciones electrónicas, incluida la información contenida …

Chapter 12 Introduction To Html And Website Development, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

The Internet has been around since the early 1970s. In the early years, the Internet only supported plain text and using the Internet required users to learn the precise syntax of several computer commands. For example, to send an email to user [email protected] required users to type the command: mail -s “mail subject” [email protected] <<< “Mail body.” Most users found this too challenging and the only users on the early Internet were computer science researchers at universities.

This changed in 1989 when Sir Tim Berners Lee proposed and demonstrated an information management system in 1989 based on hyperlinks. Users could click on links to navigate to other pages. By 1993, Tim Berners Lee had specified the first version of HTML, which made information …

Capítulo 17 Cuestiones Éticas En La Información Tecnología, Shambhavi Roy, Clinton Daniel, Manish Agrawal, Pablo Brescia, Clara Olivia Ocampo, Sonia Labrador

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – Spanish

La ética incluye las creencias compartidas de una comunidad sobre lo que es bueno para el individuo y para la sociedad, y los deberes de las personas con ellos mismos y con los demás. La palabra “ética” se remonta a la palabra griega ήθος (ethos), que describe los ideales rectores de una comunidad. Aunque algunos principios éticos pueden codificarse como leyes, la ética es más comúnmente impuesta por lo que la comunidad desaprueba. Por ejemplo, romper una promesa a un amigo va en contra de un principio ético común. No está prohibido por la ley; sin embargo, las fuertes desaprobaciones …

Capítulo 18 Redes Sociales, Shambhavi Roy, Clinton Daniel, Manish Agrawal, Pablo Brescia, Clara Olivia Ocampo, Sonia Labrador

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – Spanish

En el cambio de siglo, todavía estábamos al comienzo de un viaje hacia este mundo siempre activo y siempre conectado. Todavía escribíamos y enviábamos cartas y tarjetas de cumpleaños por correo. Las llamadas eran costosas y las videollamadas parecían ciencia ficción. Google y Facebook no existían. No se podía descargar videojuegos en el teléfono móvil porque no había acceso a una tienda de aplicaciones que vendiera software.

En la actualidad, en cambio, todo es diferente. Es posible que hoy mismo hayas visto vídeos de TikTok, o mirado tu cuenta de Instagram; quizás hayas enviado un mensaje por WhatsApp, o te …

Fundamentals Of Information Technology, Shambhavi Roy, Clinton Daniel, Manish Agrawal

FUNDAMENTALS OF INFORMATION TECHNOLOGY: Textbook – English

No abstract provided.

Microalgal Cultivation Characteristics Using Commercially Available Air-Cushion Packaging Material As A Photobioreactor, Clifford R. Merz, Neha Arora, Michael Welch, Enlin Lo, George P. Philippidis

Marine Science Faculty Publications

Air-cushion (AC) packaging has become widely used worldwide. ACs are air-filled, dual plastic packaging solutions commonly found surrounding and protecting items of value within shipping enclosures during transit. Herein, we report on a laboratory assessment employing ACs as a microalgal photobioreactor (PBR). Such a PBR inherently addresses many of the operational issues typically encountered with open raceway ponds and closed photobioreactors, such as evaporative water loss, external contamination, and predation. Using half-filled ACs, the performance of microalgal species Chlorella vulgaris, Nannochloropsis oculata, and Cyclotella cryptica (diatom) was examined and the ash-free dry cell weight and overall biomass productivity determined …

Diagnosis Disclosure And Peer-To-Peer Information Seeking Among Covid-19–Infected Social Media Users: Survey Of Us-Based Adults, Stephen Neely, Feng Hao

Sociology Sarasota Manatee Campus Faculty Publications

Background: Research examining online health communities suggests that individuals affected by chronic health conditions can obtain valuable information and social support through participation in peer-to-peer web-based information exchanges, including information sharing and seeking behaviors. The risks and rewards of these same behaviors in the case of acute illnesses, such as COVID-19, are less well understood, though there is reason to believe that individuals with COVID-19 and other acute illnesses may accrue similar benefits.

Objective: This study examines the propensity of American adults to disclose and discuss their COVID-19 diagnosis and symptoms on social media while actively infected with the SARS-CoV-2 …

Gender, Generations, And Guilt: Defendant Gender And Age Affect Jurors’ Decisions And Perceptions In An Intimate Partner Homicide Trial, Christine L. Ruva, Kendall D. Smith, Elizabeth C. Sykes

Psychology Sarasota Manatee Campus Faculty Publications

Using the context of an intimate partner homicide trial, the study explored the effects of defendant gender and age on mock-jurors’ verdicts, sentences, and culpability ratings—and whether defendant credibility and juror anger mediate these effects. The study used a 2 (Defendant Gender: male vs. female) × 3 (Defendant Age: 25, 45, or 65 years) between-subjects design. Participants (N = 513 community members) completed the experiment online. Participants were randomly assigned to one of the six Defendant Gender × Age Conditions. Participants read the trial transcripts that included the age and gender manipulations, provided verdicts and sentences, and completed the …

Section Ii: Administration, Coordination, And Staffing (Evidence), Usf Libraries

SACSCOC 2025

No abstract provided.

Section Vi: Subject Area Report Cards (Evidence), Usf Libraries

SACSCOC 2025

No abstract provided.

Section Xvi: Usf Health Libraries (Evidence), Usf Libraries

SACSCOC 2025

No abstract provided.

Sacs 2025 Table Of Contents, Usf Libraries

SACSCOC 2025

No abstract provided.

On The Potential Therapeutic Roles Of Taurine In Autism Spectrum Disorder, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Contemporary research has found that people with autism spectrum disorder (ASD) exhibit aberrant immunological function, with a shift toward increased cytokine production and unusual cell function. Microglia and astroglia were found to be significantly activated in immuno-cytochemical studies, and cytokine analysis revealed that the macrophage chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and transforming growth factor β-1 (TGFB-1), all generated in the neuroglia, constituted the most predominant cytokines in the brain. Taurine (2-aminoethanesulfonic acid) is a promising therapeutic molecule able to increase the activity of antioxidant enzymes and ATPase, which may be protective against aluminum-induced neurotoxicity. …