Digital Commons Network^™

Synthetic Studies Of Potential New Ketogenic Molecules, Mohammad Nazmus Sakib

USF Tampa Graduate Theses and Dissertations

The ketogenic diet has gained popularity in the past few decades among people and physicians due to its various health benefits. A significant amount of research has been done for the modification of the original ketogenic diet and investigation of its potential health benefits. However, synthesis of novel ketogenic compounds as a dietary supplement has not received the same level of attention. That is the primary objective of this research project. The first chapter of this manuscript describes the synthesis of various short and medium chain esters of different polyols that have been done so far, and areas of their …

Psychological Distress, Resilience, And The Impact On Quality Of Life In Breast Cancer Survivors With Taxane-Induced Peripheral Neuropathy, Lauren Schwab

USF Tampa Graduate Theses and Dissertations

The purpose of this dissertation study was to longitudinally examine psychological distress (depressive symptoms and anxiety symptoms), resilience, and the impact on quality of life (QOL) in breast cancer survivors (BCS) with taxane-induced peripheral neuropathy (TIPN). The specific aims were 1) to describe psychological distress (depressive and anxiety symptoms) in BCS with TIPN and the impact on QOL using a scoping review; 2) to determine the relationship between psychological distress, QOL, and resilience in BCS with TIPN over time in a 16-week randomized controlled trial (RCT); and 3) to determine if resilience moderates psychological distress and QOL in BCS with …

The Great Resignation: An Exploration Of Strategies To Combat School Bus Driver Shortages In The Post-Covid-19 Era, James E. Cole Jr.

USF Tampa Graduate Theses and Dissertations

Leading school transportation providers have been turning toward data-driven incentive programs to engage, motivate, and get the best out of their school bus drivers, but the nationwide school bus driver shortage has emerged as a pressing issue of critical importance affecting the education system, transportation infrastructure, and safety of students across the United States. School bus driving is one of the most challenging driving jobs, and low wages, demanding schedules, stringent licensing requirements, and the COVID-19 pandemic have exacerbated the shortage of drivers. Identification of strategies to improve school bus driver retention was the objective of this qualitative phenomenological study. …

Student Perceptions Of The Nonmedical Use Of Prescription Stimulants And Preferences For Health Education, Ana Gutierrez

USF Tampa Graduate Theses and Dissertations

Nonmedical use of prescription stimulants (NMUPS) for the purpose of improving academic performance is a growing concern among the college population. According to the Substance Abuse and Mental Health Services Administration in 2020, rates of NMUPS were highest among 18–25-year-olds attending college. There are several adverse health outcomes associated with NMUPS, including cardiovascular damage, seizures, psychosis, and dependence. Given the rising rates of NMUPS in this group, and the negative health outcomes associated with NMUPS, it is vital to employ health education that allows students to make informed decisions about behaviors that impact their health. The purpose of this study …

All Quiet On The Digital Front: The Unseen Psychological Impacts On Cybersecurity First Responders, Tammie R. Hollis

USF Tampa Graduate Theses and Dissertations

Driven by the increasing frequency of cyberattacks and the existing talent gap between industry needs and skilled professionals, this research study focused on the crucial human element in the domain of cybersecurity incident response. The objective of this dissertation was to offer a meaningful exploration of the lived experiences encountered by cybersecurity incident responders and an assessment of the subsequent impacts on their well-being. Additionally, this study sought to draw comparisons between the experiences of cybersecurity incident responders and their counterparts in traditional emergency response roles. Semi-structured interviews were conducted with a cohort of 22 individuals with first-hand experience working …

Saudi Mothers’ Perspectives And Experiences About Family-School Partnership In Early Childhood: A Qualitative Study, Mona Mohsen Alzahrani

USF Tampa Graduate Theses and Dissertations

In this study, I explored Saudi mothers’ perspectives on family-school partnerships, besides understanding the challenges they had faced. I used the ecological theoretical framework, to understand the complexity of the relationships between family and school and the impact of the environment on children's development. The ecological theory allowed me to simplify these relationships and recognize the effect on the children's development by examining Saudi mothers' perspectives. I selected qualitative research to gain a better thoughtful of the complex phenomena. I conducted semi-structured interviews to gain a deeper understanding of mothers’ perspectives. I applied a thematic analysis by Clark and Braun …

Learning After Retirement: The Stories Of Three Chinese Senior Citizens, Yanan Li

USF Tampa Graduate Theses and Dissertations

China, with its vast population, has qualified as an aging society. As a response to this, education and learning have become an important means of improving the quality of life for older people in China. The primary objective of this study is to uncover what stimulates three older Chinese individuals to engage in learning activities by exploring their personal stories. The two research questions guiding the study are: (a) How do three senior Chinese citizens describe their life and learning experiences? and, (b) What factors motivate and influence these three senior Chinese citizens to participate in learning activities? In this …

The Influence Of Psychosocial Factors On Opioid Decision-Making For Cancer-Related Pain Among Breast Cancer Survivors: A Mixed Method Study, Melody Nichole Chavez

USF Tampa Graduate Theses and Dissertations

Introduction: Breast cancer is the most frequently reported malignancy among women in the United States. Cancer-related pain is highly prevalent occurrence and is often the most fearful side effect following curative intent treatment. Opioid pain management is considered a standard of care and can be of great benefit to treat moderate to severe pain. However, undertreatment of pain remains a significant issue affecting the patient’s physical function, psychological well-being, and overall quality of life. Barriers to adequate pain management are multifactorial and often attributed to patients’ beliefs and attitudes revolving around opioid pain management. In addition, the opioid epidemic has …

Lgbtq+ Inclusivity In The Implicit And Explicit Social Studies Curriculum: A Descriptive Exploratory Study In Teacher Self-Efficacy, K. B.F. Francis

USF Tampa Graduate Theses and Dissertations

This descriptive exploratory study describes teacher self-efficacy in providing LGBTQ+ support in the implicit and explicit social studies curriculum in the wake of numerous anti-LGBTQ+ legislation in education in Florida. Four high school social studies teachers from three different Florida public school districts were interviewed to answer three main questions. All participating teachers expressed broad knowledge of their subject matter but could not identify LGBTQ+ inclusivity in their state and district-mandated curriculum. All participants had a great sense of self-efficacy in supporting their LGBTQ+ students but low self-efficacy in educating their colleagues about these issues. All participating teachers expressed a …

The Contextualization Of Socioscientific Issues In An Age Of Accountability, Karrie A. Wikman

USF Tampa Graduate Theses and Dissertations

The overarching aim of this research was to ultimately support global resiliency through science education, preparing citizens to laudably negotiate the contentious socio-cultural science- and technology-based issues of modern times. Correspondingly, this mixed methods study aimed to move a large, diverse school district toward school environments conducive to contextualized socioscientific issues (SSI)-based learning. Of interest to teachers, administrators, and policymakers, the research investigated the effects of subsuming standards-based objectives within the SSI instructional framework on science achievement. Analysis of variance of multilevel assessment and classroom observation protocol data revealed that students experiencing the SSI intervention showed statistically significant gains in …

Becoming What One Is: Nietzsche And Buddhism - A Transcultural Perspective, Sarah Linda Jacob

USF Tampa Graduate Theses and Dissertations

Friedrich Nietzsche (1844-1900) prophetically called himself an untimely philosopher. But what inspired this untimely genius? In what follows, I argue that Nietzsche’s philosophical departure from the Western metaphysical and epistemological tradition marks a paradigm shift enabled by the European encounter with the East. My thought is that the “untimely” philosopher was very timely—timelier than his educators and philosophical compadres—because he recognized that the Western religious and philosophical system would be, and had to be, forever altered due to the confrontation with new ontological horizons enabled by new, wholly foreign, perspectives. My argument is founded upon the historical significance of India …

Elucidation Of Molecular Mechanisms Underlying Novel Multi-Targeted Therapy Strategies For, Qianqian Hu

USF Tampa Graduate Theses and Dissertations

EML4-ALK fusion non-small cell lung cancer (NSCLC) represents a distinct subset of lung cancers that possesses unique molecular and clinical features, paving the way for targeted therapeutic interventions. Despite the promise of ALK-directed therapies, challenges such as metastasis at the time of diagnosis and treatment resistance persist, necessitating deeper research into the underlying mechanisms and potential solutions. In the context of these challenges, our study embarked on two specific objectives. The first goal, elucidated in Chapter 2, revolved around brain metastasis, an event critically facilitated by cell migration. Here, we assessed the anti-migratory activities of several clinical ALK inhibitors in …

Big Data Analytics For Healthcare Social Media: New Algorithms And Insights, Negar Maleki

USF Tampa Graduate Theses and Dissertations

Over the last two decades, there has been a rapid evolution in information and communication technology, including the emergence of social media. Social media has a significant impact on various fields such as politics, business, culture, education, careers, innovation, and especially healthcare. This influence is not a new phenomenon since a survey from ten years ago showed that up to 78\% of American adults used the internet to look for health-related information for themselves or someone else. With the shift towards on-demand services in society, healthcare is also affected by this trend. Instead of waiting for weeks or months to …

Motivations For Planning: Uncovering The Inhibitors To The Adoption Of Comprehensive Financial Planning For Business Owners, Daniel R. Gilham

USF Tampa Graduate Theses and Dissertations

Though comprehensive financial planning is well-known terminology, it is not a well-known or adopted concept. Broadly, financial planning is associated with investment management, but this approach is changing. Most research on financial planning is confined to the benefits, or process, behind planning. For business owners, coordinated, comprehensive financial planning should include the founder’s largest, most concentrated financial asset, the business they are running. The underlying motivations and bias that inhibit business owners from engaging in a comprehensive financial planning relationship has not been heavily researched. In this dissertation, I studied business owner inhibitors to the adoption of comprehensive financial planning …

Compositions And Uses Thereof For Treatment Of Idiopathic Preterm Birth, Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Ali Kayisli, Frederick Schatz

USF Patents

Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.

Representation And Visualization Of Multivariate Sensory Time Series Data, Ismail Uysal, Alla Abdella

USF Patents

In accordance with some embodiments, systems, methods, and media for processing and representing multivariate sensor information gathered from multiple sources are provided. In some embodiments, the method comprises: receiving a data sequences from respective sources; identifying a shortest data sequence that corresponds to a first interval; calculating, for pairs of data sequences, a similarity value over the first interval; forming a first segment of a representative data sequence that is a weighted combination of the data sequences over the first interval based on similarity values associated with the data sequences; truncating at least a subset of data sequences to exclude …

System Of Language Learning With Augmented Reality, Sara Ashley Smith, Maria Soledad Carlo, Sanghoon Park, Howard Kaplan

USF Patents

Education curricula materials include encoded indicia such as a QR code that contains information related to identifying requested augmented reality image data from a server over a network. By scanning the QR code, a computer uses its decoding software to create a data set for transmitting to the server. The data set may include an identifier for selected augmented reality image data associated with the user's curriculum, information about the curriculum at issue, the academic level of the user, and any other data necessary to ensure that the most appropriate augmented reality image data is transmitted back to the computer. …

Metabolic Therapy For Wound Healing, Dominic Paul D'Agostino, Shannon Kesl

USF Patents

Ketone supplementation, such as through use of precursors of beta-hydroxybutyrate (BHB) and acetoacetate (AcAc), increased blood levels of ketone bodies, increases blood flow and wound closure in ischemic young and aged fisher rats significantly earlier compared to standard diet in aged rats. In vitro experiments with ketone bodies demonstrate decreased mitochondrial and cytosolic ROS in young and aged primary human dermal fibroblasts (PHDF). Ketone bodies increased migration in young and aged PHDFs.

Utilizing Binding-Based Proteomic Profiling And Mass Spectrometry Imaging As Innovative Tools For Lipid Research, Suzeeta Bhandari

USF Tampa Graduate Theses and Dissertations

Mass spectrometry-based omics research involves global identification and quantification of molecules in the biological system, which can form the basis of the multi-omics approach integrating multiple layers of information to provide a comprehensive overview of systems biology. The investigation of fatty acid amides (FAA) is one such research avenue that benefits significantly from the high-throughput, multi-level, and interdisciplinary approach of integrative omics. Currently, FAA research is dominated by lipidomic-based studies that have successfully identified and quantified >100 different FAAs in different model systems. Few studies are credited with exploring the biological function and evolution of FAA-dependent signaling pathways. Previous literature …

The Functions Of Oligodendrocyte Lineage-Derived Laminins Under Homeostatic And Intracerebral Hemorrhagic Stroke Conditions, Minkyung Kang

USF Tampa Graduate Theses and Dissertations

Oligodendrocyte lineage is a glial cell population in the central nervous system. The lineage starts with oligodendrocyte precursor cells, which differentiate and mature into mature oligodendrocytes. Myelination, the major function of mature oligodendrocytes, plays a significant role for normal function of the central nervous system, and its dysfunction leads to many demyelinating diseases, such as multiple sclerosis. During the lineage progression, an extracellular matrix protein, laminin, actively regulates the cells' biology, including cell proliferation, differentiation, and myelination. However, the cellular sources of the laminin that controls oligodendrocyte lineage cells remain largely unknown. Interestingly, previous studies have shown that oligodendrocyte lineage …

Restorative Practices Interrupted, Celeste Kellar

USF Tampa Graduate Theses and Dissertations

The initial critical event precipitating the problem of practice at my school was the repercussions of the mass shooting at Marjorie Stoneman Douglas High School, Parkland, Florida on February 14, 2018. This shooting and the resulting legislative mandates of Florida Senate Bill 7026, led to my administrative decision to adopt Restorative Practices at my school, a school for students with disabilities. Restorative Practices purport to encourage the development of positive relationships, repair and restore existing relationships thereby decreasing the chance of a repeated offense and improving school climate (Zehr, 2015). Additional rationale for the adoption was to address the disproportionality …

Crossing Schools, Language, And Migration Borders: The Experiences Of Latinx And Caribbean Emergent Multilingual Mothers In K-12 Public Schools, Michelle Angelo-Rocha

USF Tampa Graduate Theses and Dissertations

Anti-immigrant sentiment and "English-only" ideologies have a significant impact on educational policies, practices, and processes. This includes parental engagement, the quality of education and life opportunities offered to immigrant children, and families’ well-being. The purpose of this study was to examine how Latinx and Caribbean mothers in Florida with various immigration statuses (i.e., undocumented, asylum seekers, refugees, international students, and mixed-status) and often with limited financial resources attempt to steward their children through the U.S. educational system. The research question was: How did emergent multilingual immigrant mothers experience the K-12 education system in Florida? The sub-question was: How did schools …

Deciphering Trends And Tactics: Data-Driven Techniques For Forecasting Information Spread And Detecting Coordinated Campaigns In Social Media, Kin Wai Ng Lugo

USF Tampa Graduate Theses and Dissertations

The main objective of this dissertation is to develop models that predict and investigate the spread of information in social media over time. In this context, we consider topics of discussions as the information that spreads. Thus, we are interested in forecasting the number of messages per day in a future interval of time. We take a data-driven approach, in which we compare our results with real datasets from a multitude of socio-political contexts and from multiple social media platforms, specifically, Twitter and YouTube.

We identified a number of challenges related to forecasting social media time series per topic. First, …

Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson

USF Tampa Graduate Theses and Dissertations

Chronic Myelomonocytic Leukemia (CMML) is a rare myeloid malignancy with a dismal prognosis and no therapeutic options which are capable of altering the natural course of the disease. There remains a significant need for novel therapies that are able to meaningfully improve patient outcomes. In this study we explore the effectiveness of Bromodomain and Extra-Terminal domain protein inhibitor (BETi) combinations in CMML. Preclinical studies in myeloid neoplasms have demonstrated efficacy of BETi. However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combinations with other anti-cancer inhibitors may enhance the efficacy of BETi. To nominate BETi …

Coupling Chemical And Genomic Data Of Marine Sediment-Associated Bacteria For Metabolite Profiling, Stephanie P. Suarez

USF Tampa Graduate Theses and Dissertations

Marine sediment-associated bacteria house many new and exciting novel secondary metabolites. These metabolites can be tested for bioactivity against various types of cancer and fungal, bacterial, and viral infections. In this thesis, we investigated the combination of biosynthetic gene cluster information with mass spectra to perform a chemical profiling of sediment- associated bacteria. Furthermore, we utilized a scoring technique to provide an identification and confidence score to each annotated compound. The sediment was collected from east Arthur Harbor, Palmer Station, Antarctica, at depths of 20 ft and 60 ft. After plating on agar, 52 unique bacterial strains were isolated, with …

Integrated Periphyton Biofilters In Marine Recirculating Aquaculture Systems, Adam N. Bell

USF Tampa Graduate Theses and Dissertations

Marine aquaculture is a growing industry that has the potential to reduce eutrophication, overfishing, and loss of biodiversity. Recirculating aquaculture systems (RAS) are a type of aquaculture system that decreases discharge, raises biological control, and conserves water; however, RAS are challenged due to high energy cost, low biodiversity, water quality control, and waste nutrients. Periphyton biofilters are a new technology that allows for feed production, water quality control, microbial diversity, and resource recovery in marine aquaculture systems. The overarching question that this dissertation investigates is, how can periphyton biofilters be integrated into RAS to address the challenges of modern sustainable …

Procedures For Assessment Of The Marine Carbon System And Evaluation Of Access And Ocean Acidification Literacy In The Deaf Community, Loraine Martell-Bonet

USF Tampa Graduate Theses and Dissertations

One major goal of this dissertation addresses the need for improved laboratory procedures to measure chemical changes in seawater caused by the uptake of atmospheric CO2, especially in coastal environments. Due to the proximity of anthropogenic stressors in the coastal zone, the biogeochemical complexity of the CO2 system is more dynamic than the open ocean. My principal research objectives were addressed by developing methods for (1) improving the accuracy of pH measurements over a wide range of salinities and (2) investigating the acid-base properties of natural organics in the coastal ocean.

The accuracy of pH electrode calibrations is affected when …

Context Matters: Profiles Of Emotion Regulation At Work And Home, Roxanne C. Lawrence

USF Tampa Graduate Theses and Dissertations

Previous research has often examined emotion regulation strategies in isolation, without considering how they may combine to form distinct profiles of emotion regulation. This study aimed to address this limitation by identifying profiles of emotion regulation strategies in the work and home contexts, and by examining their associations with individual differences and outcomes. Latent profile analyses (LPA) with expression of naturally felt emotions and the three emotion regulation strategies suppression, avoidance, and reappraisal as indicators revealed three profiles at work (i.e., low regulators, high regulators, and drain regulators) and three profiles at home (i.e., low regulators, gain regulators, and drain …

Advancing Equity And Congestion Relief: An Investigation Of On-Demand Shared Rides For Underserved Populations, Ipek Nese Sener, Austin Sibu, Audrey Cabay

Research Reports

Transportation network companies (TNCs) and microtransit are changing the way people travel by providing dynamic, on-demand mobility that can supplement public transit and personal vehicle use. However, heavy use of such motorized vehicles among all sociodemographic populations could contribute to increased vehicle miles traveled, congestion, and/or greenhouse gas emissions. To balance the objectives of increasing mobility and access for underserved communities while simultaneously mitigating the potential adverse impacts of increased motor vehicle use, well-designed policy strategies, such as pooling and first-mile/last-mile linkages, are needed. In this study, we applied a mixed-method approach to examine on-demand transportation services for underserved populations …

Effectiveness Of Virtual Onboarding, Shanker Menon

USF Tampa Graduate Theses and Dissertations

During the COVID pandemic that began in 2020, interest in onboarding efficacy increased with going virtual. This survey research study focused on the effectiveness of virtual onboarding by comparing it with face-to-face (traditional) and hybrid onboarding. It spanned 12 different business sectors and involved 730 respondents, including executives, managers, technical personnel, and non-managerial staff. This exploratory study investigated the influence of the onboarding process on important organizational variables, including turnover intention and perception of self-performance. In addition, the study investigated the perception of success of the onboarding process. Results indicated that hybrid onboarding was the most effective followed by virtual …