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Covalent Organic Frameworks: Opportunities Of Covalent Organic Frameworks For Advanced Applications, Yanpei Song, Qi Sun, Briana Aguila, Shengqian Ma
Covalent Organic Frameworks: Opportunities Of Covalent Organic Frameworks For Advanced Applications, Yanpei Song, Qi Sun, Briana Aguila, Shengqian Ma
Chemistry Faculty Publications
Covalent organic frameworks (COFs) are an emerging class of functional nanostructures with intriguing properties, due to their unprecedented combination of high crystallinity, tunable pore size, large surface area, and unique molecular architecture. The enormous possible design space available within COFs provides virtually unlimited room for imagination, allowing designed incorporation of different functionalities. In article number 1801410, Qi Sun, Shengqian Ma, and co-workers review the recent advancements of COFs for numerous applications.
Construction Of A Cross-Layer Linked G-Octamer Via Conformational Control: A Stable G-Quadruplex In H-Bond Competitive Solvents, Ying He, Yanbin Zhang, Lukasz Wojtas, Novruz G. Akhmedov, David Thai, Heng Wang, Xiaopeng Li, Hao Guo, Xiaodong Shi
Construction Of A Cross-Layer Linked G-Octamer Via Conformational Control: A Stable G-Quadruplex In H-Bond Competitive Solvents, Ying He, Yanbin Zhang, Lukasz Wojtas, Novruz G. Akhmedov, David Thai, Heng Wang, Xiaopeng Li, Hao Guo, Xiaodong Shi
Chemistry Faculty Publications
Methanol soluble and stable guanosine octamers were successfully achieved via H-bond self-assembly. Through structural conformational design, we developed a new class of guanosine derivatives with modification on guanine (8-aryl) and ribose (2′,3′-isopropylidene). This unique design led to the formation of the first discrete G8-octamer with its structure characterized by single crystal X-ray diffraction, MS and NMR spectroscopy. The G8-octamer showed unique cation recognition properties, including the formation of a stable Rb+ templated G-quadruplex. Based on this observation, further modification on the 8-aryl moiety was performed to incorporate a cross-layer H-bond or covalent linkage. Similar G-octamers …
Iridium Complex Immobilization On Covalent Organic Framework For Effective C—H Borylation, Harsh Vardhan, Yanxiong Pan, Zhongyu Yang, Gaurav Verma, Ayman Nafady, Abdullah M. Al-Enizi, Tawfiq M. Alotaibi, Omar A. Almaghrabi, Shengqian Ma
Iridium Complex Immobilization On Covalent Organic Framework For Effective C—H Borylation, Harsh Vardhan, Yanxiong Pan, Zhongyu Yang, Gaurav Verma, Ayman Nafady, Abdullah M. Al-Enizi, Tawfiq M. Alotaibi, Omar A. Almaghrabi, Shengqian Ma
Chemistry Faculty Publications
The strong coordination between metal ions and binding moieties in functional porous materials is central to the design and advancement of heterogeneous catalysis. In this study, we have successfully immobilized catalytically active iridium ions on a two-dimensional covalent organic framework (COF) having bipyridine moieties using a programmed synthetic procedure. The iridium immobilized framework, Ircod(I)@Py-2,2′-BPyPh COF, had high porosity, good stability, and exhibited excellent catalytic activity for C—H borylation, as compared with the pristine framework. Additionally, Ircod(I)@Py-2,2′-BPyPh COF was found to be an efficient catalyst for a series of electronically and sterically substituted substrates. The immobilized COF …
The Modulation Of Actin Dynamics Via Atypical Protein Kinase-C Activated Cofilin Regulates Metastasis Of Colorectal Cancer Cells, S. M. Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
The Modulation Of Actin Dynamics Via Atypical Protein Kinase-C Activated Cofilin Regulates Metastasis Of Colorectal Cancer Cells, S. M. Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
Chemistry Faculty Publications
Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study …
Analysis Of Pkc‑Ζ Protein Levels In Normal And Malignant Breast Tissue Subtypes, Tracess Smalley, S. M. Anisul Islam, Christopher Apostolatos, André Apostolatos, Mildred Acevedo-Duncan
Analysis Of Pkc‑Ζ Protein Levels In Normal And Malignant Breast Tissue Subtypes, Tracess Smalley, S. M. Anisul Islam, Christopher Apostolatos, André Apostolatos, Mildred Acevedo-Duncan
Chemistry Faculty Publications
It is estimated that breast cancer will be the second leading cause of cancer‑associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C‑ζ (PKC‑ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cycle upregulation. The present study investigated the PKC‑ζ protein in breast tissue to evaluate its potential as a biomarker for breast cancer invasion, and demonstrated that an overexpression of PKC‑ζ protein can be indicative of carcinogenesis. The present study analyzed the expression of PKC‑ζ in individuals with no tumor complications and malignant female human …
Polycofs: A New Class Of Freestanding Responsive Covalent Organic Framework Membranes With High Mechanical Performance, Zhifang Wang, Qi Yu, Yubo Huang, Hongde An, Yu Zhao, Yifan Feng, Xia Li, Xinlei Shi, Jiajie Liang, Fusheng Pan, Peng Cheng, Yao Chen, Shengqian Ma, Zhenjie Zhang
Polycofs: A New Class Of Freestanding Responsive Covalent Organic Framework Membranes With High Mechanical Performance, Zhifang Wang, Qi Yu, Yubo Huang, Hongde An, Yu Zhao, Yifan Feng, Xia Li, Xinlei Shi, Jiajie Liang, Fusheng Pan, Peng Cheng, Yao Chen, Shengqian Ma, Zhenjie Zhang
Chemistry Faculty Publications
Traditional covalent organic frameworks (COFs) are prepared via polymerization based on small molecular monomers. However, the employment of polymers as building blocks to construct COFs has not been reported yet. Herein, we create a new concept of polymer covalent organic frameworks (polyCOFs) formed by linear polymers as structural building blocks, which inherit the merits from both COFs and linear polymers. PolyCOFs represent a new category of porous COF materials that demonstrate good crystallinity and high stability. More importantly, benefiting from the flexibility and processability of a linear polymer, polyCOFs can spontaneously form defect-free, flexible, and freestanding membranes that exhibit excellent …
Construction And Interconversion Of Anion-Coordination-Based (‘Aniono’) Grids And Double Helicates Modulated By Counter-Cations, Xiaoxia Fan, Dan Zhang, Shiyu Jiang, Heng Wang, Lin-Ting Lin, Bo Zheng, Wen-Hua Xu, Yanxia Zhao, Benjamin P. Hay, Yi-Tsu Chan, Xiao-Juan Yang, Xiaopeng Li, Biao Wu
Construction And Interconversion Of Anion-Coordination-Based (‘Aniono’) Grids And Double Helicates Modulated By Counter-Cations, Xiaoxia Fan, Dan Zhang, Shiyu Jiang, Heng Wang, Lin-Ting Lin, Bo Zheng, Wen-Hua Xu, Yanxia Zhao, Benjamin P. Hay, Yi-Tsu Chan, Xiao-Juan Yang, Xiaopeng Li, Biao Wu
Chemistry Faculty Publications
Supramolecular assembly of well-defined discrete architectures has been of great interest due to the tunable properties of these structures in functional materials and bio-mimicking. While metal-coordination-driven assembly has been extensively studied, anion-coordination-driven assembly (ACDA) is just emerging for constructing complex supramolecular structures. Herein two A2nL2n (A = anion, L = ligand; n = 1 or 2) ‘aniono’-supramolecular assemblies, i.e. double helicates and the first anion grid, have been constructed based on the coordination between phosphate (PO43−) anion and a bis–tris(urea) ligand. Moreover, the aniono-grid and double helicate motifs can be readily interconverted …
Opportunities Of Covalent Organic Frameworks For Advanced Applications, Yanpei Song, Qi Sun, Briana Aguila, Shengqian Ma
Opportunities Of Covalent Organic Frameworks For Advanced Applications, Yanpei Song, Qi Sun, Briana Aguila, Shengqian Ma
Chemistry Faculty Publications
Covalent organic frameworks (COFs) are an emerging class of functional nanostructures with intriguing properties, due to their unprecedented combination of high crystallinity, tunable pore size, large surface area, and unique molecular architecture. The range of properties characterized in COFs has rapidly expanded to include those of interest for numerous applications ranging from energy to environment. Here, a background overview is provided, consisting of a brief introduction of porous materials and the design feature of COFs. Then, recent advancements of COFs as a designer platform for a plethora of applications are emphasized together with discussions about the strategies and principles involved. …
Solvent-Assisted Coordination Driven Assembly Of A Supramolecular Architecture Featuring Two Types Of Connectivity From Discrete Nanocages, Zheng Niu, Lei Wang, Sheng Fang, Pui Ching Lan, Briana Aguila, Jason Perman, Jian-Gong Ma, Peng Cheng, Xiaopeng Li, Shengqian Ma
Solvent-Assisted Coordination Driven Assembly Of A Supramolecular Architecture Featuring Two Types Of Connectivity From Discrete Nanocages, Zheng Niu, Lei Wang, Sheng Fang, Pui Ching Lan, Briana Aguila, Jason Perman, Jian-Gong Ma, Peng Cheng, Xiaopeng Li, Shengqian Ma
Chemistry Faculty Publications
The rapid development of supramolecular chemistry provides a powerful bottom-up approach to construct various well-defined nano-architectures with increasing complexity and functionality. Compared to that of small and simple nanometric objects, the self-assembly of larger and more complex nanometric objects, such as nanocages, remains a significant challenge. Herein, we used a discrete nanocage as the monomer to successfully construct a novel three-dimensional (3D) supramolecular architecture, which comprises two types of nanocage building units with different connectivity, using the solvent-assisted coordination-driven assembly approach. The mechanism of this supramolecular assembly process was investigated by electrospray ionization mass spectrometry (ESI-MS) studies, which identified for …