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The Modulation Of Actin Dynamics Via Atypical Protein Kinase-C Activated Cofilin Regulates Metastasis Of Colorectal Cancer Cells, S. M. Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
The Modulation Of Actin Dynamics Via Atypical Protein Kinase-C Activated Cofilin Regulates Metastasis Of Colorectal Cancer Cells, S. M. Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
Chemistry Faculty Publications
Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study …