Digital Commons Network^™

Comparing The Health Information Practices Of Sapphic People By Age Group And Generation, Vanessa Lynn Kitzie

Faculty Publications

This qualitative research examines how sapphic people (i.e., umbrella term inclusive of lesbian, bisexual, and pansexual trans femmes, mascs, nonbinary people, and ciswomen) in South Carolina navigate informational barriers within healthcare systems. An information practices lens that examines how sapphic people create, seek, use, and share information to achieve desired healthcare outcomes describes such navigation. The research focuses on how intersectional identities, with a particular emphasis on age and considerations of race/ethnicity, geography, and gender, mediate these practices and their outcomes. The research uses participant data from semi-structured interviews and focus groups with 34 sapphic people about their health information …

A Comparative Analysis Of Chemotherapeutic Administrations In Inhibiting Glioblastoma Multiforme Cellular Growth Utilizing An Integration Of Differentiation-Based Growth Models And Pharmacokinetic Equations, Anagha Chethan Gowda

Journal of the South Carolina Academy of Science

Glioblastoma multiforme, a disease of grade IV astrocytoma, accounts for 60-70% of malignant brain tumors.¹ Despite its low survival rate, little is known about GBM and its treatment. The purpose of this study was to assess the comparative effectiveness of the most common drugs (temozolomide, carmustine, bevacizumab) in reducing tumor growth within GBM chemotherapy. It was hypothesized that due to their properties as alkylating agents inhibiting growth genes within GBM, temozolomide and carmustine would provide the most reduction in cellular growth mathematically.² VisualPDE simulations were used to model administration of temozolomide, carmustine, bevacizumab, and none in chemotherapy and provide the …

Investigating The Synergistic Antibacterial Effects Of Ulva Lactuca And Fucus Vesiculosus Extracts On The Growth Of Staphylococcus Epidermidis, Bryan Lee

Journal of the South Carolina Academy of Science

This study investigates the antibacterial properties of extracts from marine macroalgae, Ulva lactuca (green algae) and Fucus vesiculosus (brown algae), individually and in combination, with a focus on combating antibiotic-resistant pathogens. The escalating challenge of antibiotic resistance requires the exploration of alternative antimicrobial agents derived from natural sources. Utilizing the agar well diffusion method, the study evaluates the inhibitory effects of the algae extracts on Staphylococcus epidermidis. Chloramphenicol serves as the positive control, while 5% dimethyl sulfoxide acts as the negative control. The combination of Ulva lactuca and Fucus vesiculosus extracts did not exhibit a significantly greater antibacterial effect than …

Cortisol And Alpha-Synuclein Stability In Saliva Under Varying Storage And Handling Conditions, Mo Zheng, Sujata Srikanth, Jeremiah Carpenter, Delphine Dean

Journal of the South Carolina Academy of Science

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments and non-motor symptoms, significantly impacting patients' quality of life. Currently, cerebrospinal fluid (CSF) is the primary biofluid used for PD biomarker studies, notably α-synuclein, despite the invasive nature of lumbar puncture procedures. Recent work has shown that some of these PD biomarkers have been measured in saliva. As an alternative to CSF, saliva can be non-invasively self-collected by patients repeatedly over time to monitor biomarker levels. However, the stability of these biomarkers in saliva needs to be evaluated before saliva can be considered for patient self-collection studies. Therefore, …

Neurosymbolic Cognitive Methods For Enhancing Foundation Model-Based Reasoning, Kaushik Roy, Siyu Wu, Alessandro Oltramari

Faculty Publications

Foundation models have emerged as powerful tools, exhibiting extraordinary performance across various tasks, such as language processing, visual recognition, code generation, and human-centered engagement. However, recent studies have highlighted their limitations when grounded, abstract, and generalized reasoning capabilities are required. Complex tasks often involve multiple hierarchical reasoning steps, which are typical features of human thinking processes. In fact, in this chapter we claim that cognitively-inspired computational models, such as the so-called Common Model of Cognition, are key to enable complex reasoning within foundation model-based artificial intelligence (AI) systems. We investigate neurosymbolic approaches for mapping AI system components to those of …

September 11, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

September 4, 2024 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

First-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations: Mathematical Framework And Illustrative Application To The Nordheim–Fuchs Reactor Safety Model, Dan Gabriel Cacuci

Faculty Publications

This work introduces the mathematical framework of the novel “First-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations” (1st-CASAM-NODE) which yields exact expressions for the first-order sensitivities of NODE decoder responses to the NODE parameters, including encoder initial conditions, while enabling the most efficient computation of these sensitivities. The application of the 1st-CASAM-NODE is illustrated by using the Nordheim–Fuchs reactor dynamics/safety phenomenological model, which is representative of physical systems that would be modeled by NODE while admitting exact analytical solutions for all quantities of interest (hidden states, decoder outputs, sensitivities with respect to all parameters and initial conditions, …

Tranisitioning From Film To Stage: Three Years Of Growth And Reflections, Ruihan Liu

Theses and Dissertations

This thesis delves into my journey as a Master of Fine Arts candidate specializing in Scenic Design within the Theatre program at the University of South Carolina.

Comprising seven chapters, this thesis provides a comprehensive exploration of my academic and professional trajectory. The introductory chapter offers insights into my transition from a background in Film Production to the realm of Theatre Arts, reflecting on the challenges and revelations encountered along the way.

Chapters 2 through 5 offer in-depth analyses of five stage productions wherein I served as a scenic designer during my graduate tenure. Each chapter delves into the creative …

Advances In Chalcogenide Crystal Growth, Anna Berseneva

Theses and Dissertations

Chalcogenides are the cornerstone of the semiconductor and thermoelectric industries and are up-and-coming materials for superconductors, catalysis, and battery applications. Challenges in the synthesis of those materials emerge from the chalcogen’s volatility and the tendencies of chalcogenide to react with even trace quantities of oxygen. Nonetheless, many techniques have been applied to the growth of chalcogenide single crystals, which are convenient for structure determinations and intrinsic property measurements. This dissertation will detail synthetic strategies applied to the crystal growth of novel chalcogenide materials via molten flux preparation (Chapters 2, 4, and 5), hydrothermal synthesis (Chapter 1 and 3), and single-crystal-to-single …

The Crucial Role Of The Ahr-Ilc3-Il22 Pathway In I3c-Mediated Protection Against Colitis And Associated Microbial Dysbiosis, Chandani Mitchell

Theses and Dissertations

Colitis is an inflammatory bowel disease characterized by dysregulation of the immune system that results in chronic inflammation and dysbiosis. Previously we showed that a naturally sourced aryl hydrocarbon receptor (AhR) ligand, indole-3-carbinol (I3C), was effective in the reduction of colitis-associated disease severity through innate lymphoid type 3 cells (ILC3s) in an interleukin-22 (IL-22) dependent manner. In one of our studies, we used single cell RNA sequencing (scRNAseq) analysis of colonic lamina propria cells from colitis models treated with I3C. Our results indicated that there were changes in the expressions of genes integral to IL-22 signaling when I3C was used …

Deconvolving Provenance Signatures Of Pliocene-Pleistocene Coastal Loess Deposits Along The Atlantic Margin Of Argentina, Will Robert Quanrud

Theses and Dissertations

Dust derived from southern South America provides critical nutrients for autotropic marine biota in the South Atlantic Ocean, such that fluxes of wind-blown sediment may ultimately affect the concentration of atmospheric CO2. Expansive sand, silt, and loess deposits are exposed in Central Argentina, recording millions of years of eolian processes; however, the provenance and transport pathways of this dust remains unclear. Coastal loess deposits ranging in age from Pliocene to upper Pleistocene are present along the Atlantic margin of Argentina and provide information on sediment transport pathways for the last 4 million years. Nine samples of loess were collected and …

Selected Commissioned Works For Solo Piano By National Artists For Music In The Philippines' National Competitions For Young Artists (Namcya) In The Philippines, Almond See Ponge

Theses and Dissertations

This document examines the importance of the role of the National Competitions for Young Artists (NAMCYA) in the Philippines and its commissioned competition pieces for solo piano by Philippine National Artists for Music. It underscores the significance of NAMCYA’s contribution to nurturing young talents and enriching Philippine piano literature that helps strengthen its national identity. An analysis of selected commissioned works by Col. Antonino Buenaventura, Lucrecia Kasilag, and Ramon Santos, shows the integration of Western and Filipino musical idioms with neo-classical, neo-romantic, and contemporary composition techniques. Performance notes are also provided to assist future pedagogues and performers of these works.

Examining The Impact Of A Professional Learning Community On Teachers' Awareness Of Neurodiversity In The Classroom, Taylor Diane Williams

Theses and Dissertations

In this action research study, the researcher sought to explore the influence of Professional Learning Community (PLC) participation on the recognition and awareness of general education teachers on neurodiversity in their classrooms. Additionally, the study aimed to investigate the effects of the teachers’ awareness on their instructional approaches. The participants of this study hail from a variety of cultures and languages from around the world. Conducted over a six-week period in an international school in southern Germany, the participants demonstrated an enhanced understandings of neurodiversity through their engagement in the PLC sessions. The data collection tools used in the study …

“That Desolate Section Of Dixiecrats And Hookworms”: The Rise And Fall Of The Cio In Sumter, South Carolina, 1927-1950, Stephen Malenowski

Theses and Dissertations

In March of 1942, the Williams Furniture Company of Sumter, South Carolina signed the first union contract in Sumter County history, the Congress of Industrial Organization’s (CIO) United Furniture Workers of America Local 273. This contract provided the CIO with one of their largest victories in all of South Carolina and helped create a sense of hope that the CIO could win organizing battles in South Carolina. Despite the optimism, unionization failed to spread across Sumter County during the postwar Operation Dixie organizing campaign. This thesis looks to answer why the Southern drive failed in Sumter. Local 273 did not …

Modeling, Analysis, Approximation, And Application Of Viscoelastic Structures And Anomalous Transport, Yiqun Li

Theses and Dissertations

(Variable-order) fractional partial differential equations are emerging as a competitive means to integer-order PDEs in characterizing the memory and hereditary properties of physical processes, e.g., anomalously diffusive transport, viscoelastic mechanics and financial mathematics, and thus have attracted widespread attention. In particular, optimal control problems governed by fractional partial differential equations are attracting increasing attentions since they are shown to provide competitive descriptions of challenging physical phenomena. Nevertheless, variable-order fractional models exhibit salient features compared with their constant-order analogues and introduce mathematical difficulties that are not typical encountered in the context of integer-order and constant-order fractional partial differential equations.

This dissertation …

Uav-Based Tracking And Following Of Railroad Lines, Keith Michael Lewandowski

Theses and Dissertations

Given the pivotal role of the railroad industry in modern transportation and the potential risks associated with track malfunctions, the inspection and maintenance of railroad tracks emerges as a critical concern. While existing solutions excel in performing accurate measurements and detection, they often rely on large, expensive, and time-consuming platforms for inspections. This project, however, seeks to solve the same problem with the use of an unmanned aerial vehicle (UAV), significantly reducing time and cost while maintaining detection capabilities. In particular, this solution is ideal for large-scale, high-level inspections following major events such as floods [6], hurricanes [7] or earthquakes …

Macro–Micro-Coupled Simulations Of Bead–Spring Breaking-Reforming Networks, Andrei Medved

Theses and Dissertations

In this work we investigate the dynamic behavior of bead-spring polymer solutions in viscoelastic fluids, which are essential in industries like materials science, biotechnology, and pharmaceuticals. The study leverages GPU-accelerated simulations and detailed modeling of polymer chain dynamics at the mesoscale, which enables efficient analysis of intricate fluid behaviors and the microscale dynamics of polymer chains. Additionally, the research examines the breaking-reforming dynamics of polymer chains, crucial for understanding phenomena such as shear thinning and thickening. The findings have broad applications, from improving inkjet printing and 3D printing technologies to developing new drug delivery systems and biocompatible materials. This work …

Businesses Or Beneficiaries: The Submerged Consequences Of Workfare Policy Design, Morgan Alexander Lowder

Theses and Dissertations

This dissertation critically analyzes the policy association between the Supplemental Nutrition Assistance Program (SNAP) and the Work Opportunity Tax Credit (WOTC), and in doing so, sheds light on the employer-uplifting design of the U.S. welfare state. I examine this association in three stand-alone Chapters with the intent of answering the following questions: 1) Is the SNAP-WOTC association mutually beneficial to SNAP recipients and the employers that access the WOTC; 2) Is the SNAP-WOTC association truly intended to be mutually beneficial; and 3) What are the perceptive consequences of revealing how SNAP benefits employers through the WOTC. Using both quantitative and …

Thermodynamic Modeling Of Uranium Nitride With Select Actinides And Fission Products, Eric Reece Mcmanus

Theses and Dissertations

Uranium mononitride fuel is being investigated as a potential nuclear fuel for a Westinghouse lead-cooled fast reactor due to factors such as its high uranium density, high melting point, and favorable thermal conductivity. To obtain an understanding of the thermochemical behavior of UN fission products and minor actinides, thermodynamic data was obtained from various resources to create a database to represent the behavior of the fuel. This database was used to generate an Ellingham diagram to represent the relative thermodynamic stability of the phases over the reactor temperature range. A simulation was run computing the equilibrium state of the fuel, …

(Re)Imagining Decolonial Cookbooks After Deforestation, Kamran Shams

Theses and Dissertations

Food, like most else, is fundamentally changed by colonization. It is not just the aftermath of colonization, the settlement, that changes food—it is the act of colonial infiltrating itself. Such is the case made by Fernando Ismael Quiñones Valdivia in “Colonial Imaginations: Solitude in the Cartas y Relaciones of Hernán Cortés”—though not for food but for colonized societies broadly. More specifically, he contends that a new epistemological possibility arises when colonizer regards land as an object to be conquered, which precedes the epistemological articulation of subject/object divide. His article supplies a framework for thinking about coloniality so that a close …

Erodibility Of Sand-Silt-Xanthan Gum Mixtures, Edwin Kotey

Theses and Dissertations

The high frequency of earthen embankment failure recorded during floods has led to the general rule that embankments should not be overtopped. This notwithstanding, overtopping cannot be entirely avoided particularly during extreme events, such as winter storms and hurricanes. Reducing soil erodibility is thus fundamental to prevent and control disasters caused by embankment failure. Recent studies have explored the use of environmentally friendly additives, such as biopolymers, to improve soil properties. Geotechnical tests have shown that biopolymers can effectively increase soil strength, but little is known about biopolymer-treated soil resistance to erosion by flowing water. Results of flume experiments to …

A Formative Process Evaluation Of Social Care Programming In A Health Care System Serving A Predominantly Rural State, Samuel Bethel

Theses and Dissertations

Health and social care continue to integrate, but relatively little is known about how social care is designed, implemented, and maintained across the health care continuum. This is especially true for health systems serving rural and under-resourced communities. To fill these gaps, this dissertation project applied formative process evaluation methods to a single case study of the largest health care system serving a predominantly rural state and its integrated social care programming. Data were collected from in-depth, semi-structured interviews following a purposeful and snowball sampling method among key informants for the design, implementation, and maintenance of social care programming as …

Quantification Of Immunometabolite Derived Protein Modifications During Mitochondrial Metabolic Stress, Justin Hunter Cox

Theses and Dissertations

The immunometabolite itaconate accumulates during lipopolysaccharide (LPS) stimulation of macrophages and microglia. Itaconate non-enzymatically reacts with cysteine residues to generate 2,3-dicarboxypropylcysteine (2,3-DCP), referred to as protein dicarboxypropylation. The tricarboxylic acid (TCA) cycle metabolite fumarate non-enzymatically reacts with the amino acid cysteine to form S-(2-succino)-cysteine (2SC), resulting in irreversible protein succination. Since fumarate and itaconate levels dynamically change in activated immune cells, the levels of both 2SC and 2,3-DCP reflect the abundance of these metabolites and their capacity to modify protein structure and function. I generated esters of 2SC and 2,3-DCP from protein hydrolysates and used stable isotope dilution liquid chromatography-tandem …

Unpacking The Relationship Between Legitimacy, Procedural Justice, Identity, And Desistance, Qassim Bolaji

Theses and Dissertations

Knowing why people stop offending over time and the criminal justice agencies' role in this process is essential for designing effective crime control interventions. Legal authorities have the core function of ensuring that social norms and laws are obeyed. However, the coercive and punitive tactics that police, judicial, and penal authorities typically resort to have been shown to have only limited impact on controlling and preventing crime while having the unintended consequence of worsening the public's perception of their institutional legitimacy. Specific to policing, the use of coercive policing tactics and their perceived ineffectiveness has, in recent decades, led to …

Simultaneous Crack & Wave Propagation And Acoustic Emission Signal Modelling Using Peri-Elastodynamic, Md Mushfiqur Rahman Fahim

Theses and Dissertations

This work presents the use of Peri-Elastodynamic, a guided wave simulation method based on meshfree non-local Peridynamics theory. To model simultaneous crack and wave propagation simulation and its application on Acoustic Emission (AE) signal modelling, a new formulation is presented. The field of nondestructive evaluation (NDE) and structural health monitoring (SHM) is slowly embracing the advancement in Machine Learning (ML) / Artificial Intelligence (AI) for better and cost-effective assessment of structures and damage prediction. AI/ML can revolutionize the NDE/SHM field by automating the data collection and analyzing processes. However, the big challenge is that the model needs a sheer amount …

Perspectives From Caregivers For Children With Retinoblastoma: Psychosocial Concerns And Genetic Counseling, Kayla Marie Lashinger

Theses and Dissertations

Caregivers play a vital role in the care of children affected with retinoblastoma as most cases are diagnosed before the age of five years old. While previous studies have explored the psychosocial needs of caregivers of children with pediatric cancer, these have not specifically focused on retinoblastoma in the United States (US). Prior research identified the profound emotional burden in terms of depression, anxiety, guilt, isolation, and loneliness experienced by caregivers. Given previous findings and the National Cancer Institute’s recommendation for genetic counseling and testing for all individuals affected with retinoblastoma, this study aimed to assess psychosocial concerns in relation …

Cell Based Sodium Alginate Microcapsules Within Ocular Disease: A Proof Of Concept, Chelsea Marie Zizzi

Theses and Dissertations

Sodium alginate is a natural polymer that has been widely used as a drug delivery system due to its controlled-release qualities and low cellular toxicity. These capsules are effective at transporting therapeutics in various diseased animal models. Retinitis Pigmentosa is an incurable genetic disease affecting the retina, which causes gradual blindness as the disease progresses. In our study, we injected cell-based sodium alginate capsules into the vitreous cavity of C57BL/6 and Pde6b^rd10/J mice to observe the migration of these capsules in both wildtype and diseased mouse models over a course of 2 weeks. Our intention was …

Beyond The Plastic Facade: Unveiling The Multifaceted Discourse And Impact Of Barbie In Film, Sarah Johnson

Theses and Dissertations

This paper presents an exploration into the multifaceted dimensions of public discourse surrounding Barbie, the film released in 2023 directed by Greta Gerwig, by leveraging advanced natural language processing techniques. Employing BERTopic for topic modeling, I analyzed conversations embedded in YouTube comments from Warner Bros.'s own promotional content as well as third-party YouTube content pre- and post- the film’s release to unearth the themes and sentiments associated with the iconic character. Our primary objective was to look beyond the stereotypical perception of Barbie as a two-dimensional figure and shed light on the diverse and complex discussions surrounding her cinematic representation. …

Stem Identity In African American Middle School Students: A Phenomenological Study, Amara L. Alexander

Theses and Dissertations

Using a phenomenological approach, this action research study explored the influence of culturally sustaining teaching practices (Ladson-Billings, 2014; Paris 2012, 2021) to impact African American students STEM identity (Collins & Roberson, 2020). Qualitative data were generated through interviews with students, practitioner reflective notes, and classroom observations during the intervention. Analysis and interpretation of the data indicated student- participants had positive experiences during the intervention and the culturally sustaining STEM lessons positively impacted African American middle school students STEM identity. The implications of these findings for STEM curriculum writers, STEM education and STEM educators, particularly those in K-12 education.