Digital Commons Network^™

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

A Math Teacher’S Reflexive Journey Into The Opportunity Gap, Richard A. Ball Iii

Theses and Dissertations

This multiple case study sought to determine what educational factors, if any, impacted Black students in a public school located in the South-eastern United States, to enroll in a lower-level math course. The study also aimed to view the mathematical identities of these students and have myself reflect on my practice both locally and globally. This, however, is a result of the Problem of Practice, the opportunity gap. H. Richard Milner’s (2012) opportunity gap framework served as the theoretical framework for this study and for which all findings were situated. The data was analyzed using deductive coding, with the elements …

The Dark Side Of The Internet: The Facilitation Of Csam By Social Media Companies And What Should Be Done About It, Megan Holderness

South Carolina Journal of International Law and Business

No abstract provided.

Table Of Contents, Administration, Faculty, Submission Information

South Carolina Journal of International Law and Business

No abstract provided.

Navigating The Seas Of History In International Law, Valentina Vadi

South Carolina Journal of International Law and Business

Inquiries into questions of time, history, and international law have recently come to the fore. So far, however, many studies have only examined developments in international law from a temporally and thematically fragmented, brief, and narrow perspective. Due to international law’s growing normative and institutional fragmentation and emphasis on specific crises, episodes, and events, many analyses focus on transient trends and particular facets of international law. This study suggests an alternative to these constrained viewpoints: a thorough, multilayered, and broad perspective to questions of international law, drawing on Fernand Braudel’s tripartite theory of time.

Braudel’s theory of time provides valuable …

Evolutive Regime Assertion For The International Military Laws Of Outer Space: U.S. Legal Problems And Solutions Relating To The International Law Of Space Warfare, Matthew Lively

South Carolina Journal of International Law and Business

This article has three interrelated purposes. It 1) makes several novel contributions to and unite problematically disparate pieces of space law scholarship, 2) illustrates a disconnection between U.S. strategic space policies and the U.S. practice of military operations in outer space, 3) offers a new framework for international military space law, Evolutive Regime Assertion, that could remedy that connection and advance U.S. strategic interests while enhancing the safety of space operations for all the world. Evolutive Regime Assertion is mostly a prescriptive framework, but some of its elements are descriptive as well. In advancing the utility of the framework, this …

Lambat Asal Selamat: The Slow But Safe Twenty-Five Year Recalibration Of Personal Bankruptcy In Malaysia, Jason J. Kilborn

South Carolina Journal of International Law and Business

A popular Malay proverb advises, “[L]et it be slow, as long as it is safe” (biar lambat asal[kan] selamat),1 combining the sentiments of two similar English proverbs: “haste makes waste,” and “slow and steady wins the race.” These principles certainly seem to have guided Malaysian lawmakers in the quarter-century, multistage development of the most important element of modern bankruptcy law: the discharge. Adopted in 1967,2 Malaysian bankruptcy law has long included a very limited debt discharge, but as it left more and more economically debilitated debtors in perpetual bankruptcy limbo, policymakers became dissatisfied with leaving a huge and growing mass …

The Federal Trade Commission, Germany, And Non-Compete Agreements: An Analysis Of The Federal Trade Commission's Proposed Ban On Non-Compete Agreements And A Comparison To German Non-Compete Law, Madison Nicole Whiting

South Carolina Journal of International Law and Business

No abstract provided.

College Student-Athlete Perceptions Of Characterizations And Interpersonal Trust In Their Athletic Trainer: A Point-Of-Care Research Study, Ryan N. Moran, Deidre Leaver-Dunn, Jeff Allen, Jessica Wallace

Clinical Practice in Athletic Training

Patient-centered care is essential in athletic training with limited research examining the relationship between patient and clinician. Previous theory has identified constructs of quality athletic trainers (ATs); however, it remains unknown how current athletes perceive these theorized constructs in the ATs providing them medical care. The purpose of this study was to determine the perceptions of characterizations of a quality athletic trainer and interpersonal trust between the student-athlete and AT in the collegiate setting and establish reliability of these surveys. A second aim was to explore differences between sex, previous exposure to an AT, and having had access to an …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Workforce Profile Of Alternatively Certified Teachers In South Carolina For 2022–23, Brian Cartiff, Svetlana Dmitrieva, Angela Starrett

Reports

Alternatively certified teachers constitute a growing portion of public school educators in the US. This is a trend that is expected to continue, due to the declining enrollment in traditional teacher preparation programs across recent years.

As such, this report examines the profiles of alternatively certified teachers working in South Carolina public schools (those currently enrolled in alternative certification programs and those who have completed them). The analysis delves into the demographics and placements of these teachers and explores how their employment correlates with teacher attrition rates. Altogether, it offers preliminary insights into the roles of alternatively certified educators in …

Progerin Can Induce Dna Damage In The Absence Of Global Changes In Replication Or Cell Proliferation, Liza A. Joudeh, P. Logan Schuck, Nina M. Van, Alannah J. Dicintio, Jason A. Stewart, Alan S. Waldman

Faculty Publications

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, and individuals with HGPS seldom live beyond their mid-teens. The syndrome is commonly caused by a point mutation in the LMNA gene which codes for lamin A and its splice variant lamin C, components of the nuclear lamina. The mutation causing HGPS leads to production of a truncated, farnesylated form of lamin A referred to as "progerin." Progerin is also expressed at low levels in healthy individuals and appears to play a role in normal aging. HGPS is associated with an accumulation of genomic DNA …

Strategic (Non)Disclosure: Activation And Avoidance Of Social Ties Among Women Seeking Abortion, Kathleen Broussard

Faculty Publications

The increased politicization of sexual and reproductive health has created barriers to medically necessary care. In absence of formal health care, social ties become critical sources of information and resources, yet the disclosure of stigmatized health needs carries significant risk. How do people navigate the risks and benefits of disclosure when seeking care for stigmatized needs? Drawing on original survey data (N = 153) and in-depth interviews (N = 55) with women who attempted a self-managed abortion, I first describe the distinct roles of weak and strong ties in women’s health-seeking experiences. I then demonstrate how both partial disclosure and …

Beyond Amateurism: Examining The Potential Labor Expenses Of Ncaa Student-Athlete Employment, Alayna K. Falak, Tyler L. Custis

Journal of Issues in Intercollegiate Athletics

In light of recent administrative developments urging the classification of student-athletes as employees, litigation challenging the current employment status of student-athletes, and the Supreme Court’s willingness to tackle National Collegiate Athletic Association (NCAA) issues, many questions surrounding the future of college sports under an employment model have emerged. The authors analyzed key litigation, recent developments from administrative agencies, and academic literature. The authors used publicly available data from the NCAA, the United States Department of Labor (DOL), and other sources to construct two estimates of what it would cost NCAA member institutions to provide baseline compensation to their Division I …

A Theory-Guided Qualitative Exploration Of Occupational Influences On Firefighters’ Dietary Behaviors, Cynthia Horton Dias, Courtney Catledge Dnp, Msn, Aprn, Fnp-Bc, Robin M. Dawson Phd, Rn, Cpnp-Pc

Publications

Background: Firefighters face many inherent occupational health hazards and increased risk for several cancers, making peak health essential. However, cardiac events and stroke continue as leading causes of on-duty deaths. Healthy diets promote prevention of cardiovascular disease and cancers. While some dietary interventions have been undertaken, sustained improvements have not been observed. Understanding firefighters’ occupational influences on dietary behavior is vital for implementation of effective interventions to improve nutrition. Methods: The Theoretical Domains Framework (TDF) guided this qualitative study. Nine focus groups of firefighters who work 24-hour shifts and one interview with a fire administrator (N = 34) were conducted …

Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—I: Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work introduces the mathematical framework of the novel “First-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations” (1st-FASAM-NODE). The 1st-FASAM-NODE methodology produces and computes most efficiently the exact expressions of all of the first-order sensitivities of NODE-decoder responses with respect to the parameters underlying the NODE’s decoder, hidden layers, and encoder, after having optimized the NODE-net to represent the physical system under consideration. Building on the 1st-FASAM-NODE, this work subsequently introduces the mathematical framework of the novel “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE)”. The 2nd-FASAM-NODE methodology efficiently computes the exact expressions …

Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—Ii: Illustrative Application To Heat And Energy Transfer In The Nordheim–Fuchs Phenomenological Model For Reactor Safety, Dan Gabriel Cacuci

Faculty Publications

This work presents an illustrative application of the newly developed “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE)” methodology to determine most efficiently the exact expressions of the first- and second-order sensitivities of NODE decoder responses to the neural net’s underlying parameters (weights and initial conditions). The application of the 2nd-FASAM-NODE methodology will be illustrated using the Nordheim–Fuchs phenomenological model for reactor safety, which describes a short-time self-limiting power transient in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted. The representative model responses that will …

Motivational Dysregulation With Melanocortin 4 Receptor Haploinsufficiency, Alex M. Steiner, Robert F. Roscoe, Rosemarie M. Booze, Charles F. Mactutus

Faculty Publications

Obesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a range of dietary fat (0–12 %) in a longitudinal design. Physiological and motivational assessments were performed using a locomotor task, a 5-choice sucrose preference task, an operant task with fixed and progressive ratios, as well as a distraction operant task. Dendritic spine morphology of medium spiny neurons (MSNs) of the nucleus …

Characterization Of Health And Safety Resources For Athletes With Sickle Cell Trait At Ncaa Institutions, Susan W. Yeargin Ph.D., Atc, Lat, Courtney M. Meyer Ph.D., Rebecca M. Hirschhorn, Abbi D. Lane, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Clint R. Haggard

Faculty Publications

Yeargin, SW, Meyer, CM, Hirschhorn, RM, Lane, AD, Arent, SM, and Haggard, CR. Characterization of health and safety resources for athletes with sickle cell trait at NCAA institutions. J Strength Cond Res 38(11): 1967-1973, 2024 - The purpose of this study was to report the prevalence of student-athletes with sickle cell trait (SCT), determine which screening practices are most commonly used, describe the health and human performance services provided to athletes, and ascertain if differences between National Collegiate Athletic Association (NCAA) designations or divisions exist. A cross-sectional survey design was used to query healthcare administrators regarding SCT resources at their …

How Do Scholars Conceptualize And Conduct Health And Digital Health Literacy Research? Survey Of Federally Funded Scholars, Mayank Sakhuja, Brooks Yelton Ma, Lmsw, Simone Kabarana, Lauren Schaurer, Jancham Rachel Rumthao, Samuel Noblet, Michelle Angelique Arent, Mark M. Macauda Phd, Mph, Lorie Donelle Phd, Rn, Fcan, Daniela B. Friedman Ph.D.

Faculty Publications

Background: The concept of health literacy (HL) is constantly evolving, and social determinants of health (SDoH) have been receiving considerable attention in public health scholarship. Since a 1-size-fits-all approach for HL fails to account for multiple contextual factors and as a result poses challenges in improving literacy levels, there is a need to develop a deeper understanding of the current state of HL and digital health literacy (DHL) research. Objective: This study examined scholars’ conceptualization and scope of work focused on HL and DHL. Methods: Using a search string, investigators (N=2042) focusing on HL, DHL, or both were identified from …

How Do Scholars Conceptualize And Conduct Health And Digital Health Literacy Research? A Survey Of Federally Funded Scholars, Mayank Sakhuja, Brooks Yelton, Simon Kavarana, Lauren Schaurer, Jancham Rachel Rumthao, Samuel Noblet, Michelle Angelique Arent Rd, Mph, Cscs, Cissn, Mark M. Macauda Phd, Mph, Lorie Donelle Phd, Rn, Fcan, Daniela B. Friedman Ph.D.

Publications

Background: The concept of health literacy (HL) is constantly evolving, and social determinants of health (SDoH) have been receiving considerable attention in public health scholarship. Since a 1-size-fits-all approach for HL fails to account for multiple contextual factors and as a result poses challenges in improving literacy levels, there is a need to develop a deeper understanding of the current state of HL and digital health literacy (DHL) research.

Objective: This study examined scholars’ conceptualization and scope of work focused on HL and DHL.

Methods: Using a search string, investigators (N=2042) focusing on HL, DHL, or both were identified from …

Mutation In Prkra Results In Cerebellar Abnormality And Reduced Elf2Α Phosphorylation In A Model Of Dyt-Prkra, Samuel B. Burnett, Allison M. Culver, Tricia A. Simon, Taylor Rowson, Kenneth Frederick, Kristina Palmer, Stephen A. Murray, Shannon W. Davis

Faculty Publications

Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkra^lear-5J, exhibit progressive dystonia. In the present study, we investigated the biochemical and developmental consequences of the Prkra^lear-5J mutation. Our results indicated that the …

October 9, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

You're Not The Only One Who Can Teach Us: Teacher Facilitation In Three Secondary School Music Contexts, David Dwight Bowman

Theses and Dissertations

Over the last half-century, school music reforms have focused more on content than process, and the directive teaching that serves as the dominant method used by secondary school music teachers is not adequately meeting the needs of the students who currently occupy American high schools. To improve teaching practice in one such high school, an action research study was conducted to investigate the use of facilitative teaching strategies, how those teaching strategies impact students’ learning experience, and what the perceived impacts of those strategies are. A qualitative case study methodology was employed to determine how an intervention period of facilitative …

Protecting Coastal Communities And Marine Biodiversity Under The Coastal Zone Management Act, Eric V. Hull

South Carolina Law Review

No abstract provided.

Juries And Tax: The Effect Of Income Taxation On Tort Damages, Jeffrey H. Kahn, John E. Lopatka

South Carolina Law Review

No abstract provided.

Infringing Uses, Not Works, Timothy J. Mcfarlin

South Carolina Law Review

No abstract provided.

Identification Of Obstructive Sleep Apnea Symptoms Among Veterans In The Primary Care Setting, John Dominic Rosella Iv

Doctor of Nursing Practice Scholarly Projects

Untreated obstructive sleep apnea (OSA) has long-term cardiovascular and metabolic health implications, impacting quality of life and increasing health expenditures. Veterans have a higher prevalence rate of OSA attributed to an aging population and higher rates of comorbid conditions. The problem of under recognition of OSA symptoms partly relates to clinicians needing to elicit relevant symptoms routinely. At the same time, the lack of primary-care-based screening protocols contributes to the percentage of undiagnosed OSA. The purpose of this evidence-based project was to implement routine screening to identify OSA risk among veterans in primary care settings in South Carolina. The method …

Caroliniana Columns - Fall 2024, University Libraries--University Of South Carolina

University South Caroliniana Society Newsletter - Columns

The 87th Annual Meeting of the University South Caroliniana Society May 11, 2024 (Business Session) / Nathan Saunders… p.2

Taste the State: Program of the 87th Annual Meeting of the University South Caroliniana Society … p.3

Rowe address: An important new acquisition … p.8

Reunited: SCL, SCPC, and the DOH … p.8

Personal Reflections on the South Caroliniana Library / Jay White … p.9

Renovations recognized: Work on Caroliniana Wins Preservation Award … p.16

Thank you, Graham Duncan / Craig M. Keeney … p.17

Proslavery Malthusianism at South Carolina College / K. Howell Keiser, Jr. … p.18

Primary Sources: Authors …