Digital Commons Network^™

Vaccinia Virus And Measles Virus As Oncolytic Vaccines: The Modulation Of The Viral Infectivity Via Surface Conjugations, Monchupa Kingsak

Theses and Dissertations

Oncolytic virus (OV) therapy has been shown to be an effective targeted cancer therapy treatment in recent years, providing an avenue of treatment that poses no damage to surrounding healthy tissues. Not only do OVs cause direct oncolysis, but they also amplify both innate and adaptive immune responses generating long-term antitumor immunity. However, a key challenge facing oncolytic virotherapy is neutralizing antibodies in vaccinated patients, leading to the viral clearance after systemic administration and failure in the treatment. The encapsulation of OVs using biocompatible polymers is one of the promising methods to prevent the viral clearance from antiviral immune responses. …

Is There A Relationship Between Direct Patient Care Registered Nurses Emotional Intelligence And Patient Satisfaction?, James J. Leach

Theses and Dissertations

Many studies have examined Emotional Intelligence (EI) ’s role in various groups of people. However, to date, there have not been any studies examining the role of EI in direct patient care given by ICU nurses and the relationship between the nurses’ EI and patient satisfaction. With the importance of patient satisfaction tied to hospital reimbursement and the many approaches that have been made to improve patient satisfaction, studying the people (nurses) who spend the most time with the patient seems right. The data used for this study was obtained from an EI inventory for the nurses and an ICU-specific …

Nature As Culture: Ecofeminist Narratives Of Environmental And Colonial History, Sydney Leimbach

Theses and Dissertations

“Nature as Culture: Ecofeminist Narratives of Environmental and Colonial History” is a cross-cultural, comparative, feminist investigation of two films, The Nightingale and Wolfwalkers, and two books, The Giving Tree and The Overstory. The narratives are analyzed through a combination of ecofeminism and decolonial feminism, revealing the four narratives’ investment in the effects of colonization on the environment. The two chapters explore the association of women with nature, traditionally used as a subordinating position, instead as a condition of empathetic understanding with both the colonized and the environment. Further, these narratives use the association of women with nature as …

A Cross-Sectional Analysis Of Infectious Causes Of Congenital Morbidity And Mortality In Central America: Torch, El Salvador, Mary Katherine Lynn

Theses and Dissertations

The primary goal of this dissertation was to understand the prevalence of the most regionally salient TORCH pathogens among a group of perinatal women from a highly vulnerable region of El Salvador at the time of parturition. TORCH pathogens, that cause TORCH congenital syndromes, are classically defined as Toxoplasma gondii, other infectious causes of concern (Zika virus, malaria, human immunodeficiency virus, etc), Rubella virus, Cytomegalovirus(CMV), and Herpes Simplex Viruses. These infections can be passed from mother to fetus through the placenta or other perinatal routes and cause severe maternal and neonatal morbidity and mortality. This dissertation sought to understand perinatal …

Leptin, Serotonin, And The Control Of Food Intake, Nicholas David Maxwell

Theses and Dissertations

Obesity has created a devastating public health crisis that severely affects both quality of life and exacerbates serious health conditions such as heart disease and diabetes. For this reason, better treatments are critical, yet there are very few. The systems that regulate our metabolism and food consumption are intricate, complex, and still poorly understood, as the brain integrates peripheral signals with central neural networks to control our energy balance. One of these peripheral signals, leptin, holds great promise as a way to treat obesity but has been ineffective in patients with obesity. Therefore, our goal is to better understand the …

“We Are Created Inferior To Men”: Leveraging Horsemanship To Reinforce Gender Expectations, 1830-1861, Gabrielle Marie Mccoy

Theses and Dissertations

Horses have played a central role in human society since 3500 BCE when humans began domesticating and riding horses in large numbers. Horses continued to be important to human society during the nineteenth century as people used horses to drive industrialization, manage plantations, and transport goods, among other uses. Although historians and anthropologists have long extolled the horse’s laboring value, this paper views the horse and horsemanship (i.e., horseback riding, horse training) in a social context. Through the examination of newspapers, fictional literature, and manuals, this paper argues that Americans used horses and horsemanship to reinforce antebellum gender expectations. Reinforcing …

Targeting Macrophages In Cancer Models Using Natural Compounds, Sierra Jordan Mcdonald

Theses and Dissertations

Cancer remains a leading cause of death worldwide. More specifically, breast cancer (BrCa) and colorectal cancer (CRC) continue to be the most diagnosed cancers and leading causes of cancer-related death worldwide. Given that surgery followed by adjuvant chemotherapy is only effective in 20% of CRC patients, and that there are no preventive agents for BrCa metastasis for hormone receptor negative patients, more effective agents and strategies are needed in both the prevention and treatment of these cancers. As one of the most abundant immune cells in the tumor microenvironment, macrophages help regulate primary tumor growth, angiogenesis, and metastasis in many …

Kurt Vonnegut, A Difficult Feminist: Investigating Female Characters In Bluebeard, Matthew Steven Medl

Theses and Dissertations

After a brief contextualization of Vonnegut’s work, this essay close-reads his 1987 novel, Bluebeard, and locates the feminism within. I argue that Vonnegut establishes women as agents of generative change, breakers of marital conventions, artistic sages, authors, expressionists, interlopers, and nonviolent activists. I primarily examine Circe Berman and Marilee Kemp, supplementing with evidence from Edith Taft and Dorothy, as well as wider scholarship.

The Widened Hearthstone Urban Playgrounds As The Infrastructure Of Public Mothering, 1900-1930, Alexandra Miller

Theses and Dissertations

Despite the limitations on their formal political involvement, women across the United States took control of the Progressive Era playground movement, and playground advocates nationwide argued that urban play spaces constructed motherhood into the city. While many mothers used playgrounds for child care, playground directors used the maternal authority constructed into playgrounds to promote their ideas about ideal citizenship. One playground director, Mabel E. Macomber, called this aspect of playground work the “'mother' element,” believing, as did other workers and advocates, that playgrounds were part of the apparatus of urban mothering, and in the case of many poor working women, …

Female Infertility And Maternal And Infant Outcomes In South Carolina – The Role Of Insurance Type, Chelsea Mencio Norregaard

Theses and Dissertations

The overall objective of this research study was to examine the association between fertility treatments and maternal and infant birth outcomes, and to understand what role insurance type plays in these associations.

This retrospective statewide cohort study utilized population-based birth certificate data from January 2018 – December 2021in South Carolina, linked to all-payer claims data for outpatient services, inpatient admissions/discharges, and emergency department visits. Key exposure variables included insurance type and fertility treatment, depending on Aim. Key outcomes of interest included fertility treatment (Aim 1); maternal outcomes (Aim 2) including severe maternal morbidity, cesarean delivery without medical indication, elective labor …

Learning To Spell, Alana Ines Perez

Theses and Dissertations

This thesis explores homonymic variations of the word “spell,” sewing together the framework for the ways my poems think about bilingualism, magic, Caribbean poetics, migration between northern and southern terrain, the body and personal spirituality. This thesis also experiments with forms old and new, such as the sonnet, and what I am naming “little altar poems” and “fragmented episodes.” These three forms attempt to do the work of recuperating Caribbean narratives and epistemologies. The “estrella sonnet” sequence uses the premise of an abortion as a way to initiate a nuanced discussion around how white patriarchy defines choice, consequently disregarding the …

Queer Mary: Queer Temporalities In Late Medieval And Early Modern Drama, Bradley James Peppers

Theses and Dissertations

This dissertation explores how the Virgin Mary’s presence in late medieval and early modern drama stages biblical events that distort temporal strictures, disrupting how a viewer would experience the past, present, and future. In this way, past events occur nonlinearly, foreign concepts become implicit, and eternal life no longer exists outside of time. Using queer theories of temporality and history, I explore how the Virgin Mary represents a figure of change, ambivalence, and ambiguity—an evolving symbol and image having no clearly defined referent—one who, at once, inhabits a queer temporality, history, subjectivity, and sexuality. I chart these ideas by closely …

Tragic Relief!, Katherine Shanks

Theses and Dissertations

This poetry manuscript explores loneliness, sexuality, violence, gender/fluidity, the self, the idea of the self, and American capitalism with an irreverent and dry humor. Tragicomic in tone, the poems balance a sense of dire exuberance with personal history and anecdote ranging from sentimental to sarcastic to withering. Located in New Jersey, the manuscript engages with local history, lore, and culture. A wide range of references bridge various ends of the literary canon, while the poems likewise reach for referents from fine art, music, TV, and film. Characters recur as figures of patriarchy, capitalistic work ethic, and gender trouble in various …

Piratical Transportation: Highlighting Silences In Carolina’S Enslavement And Exportation Of Native Americans, Jordan Stenger

Theses and Dissertations

When Carolina colony was established, its early financial success was inherently bound to its enslavement and exportation of countless Indigenous people in the colonial pursuit of Native land, wealth, and enslaved labor. However, given the Indian slave trade was largely illegal in Carolina, how did colonists export Indigenous people? This study seeks to expand the land-locked historiography and explore how enslaved Indigenous people appear in the historical record across the Atlantic world. Utilizing term proximity as a methodological approach in reading historical records, and privileging Carolina’s black-market trade with pirates, I propose that the trade with pirates also included enslaved …

Ciento Ochenta Grados: South Carolina Promotores De Salud And The Covid-19 Pandemic, Richard Lyle Strater

Theses and Dissertations

This research engages with promotores de salud in South Carolina to examine sustainability challenges in their work to support Hispanic and Latino communities through advocacy-as-care approaches. This thesis contributes to scholarly literature on CHWs in the United States at a time when the profession is working to legitimize itself through professional advocacy, which includes the organization of state CHW associations, regional CHW networks, and the National Association of Community Health Workers (NACHW). Their work to support communities is, at times, made more difficult because of their positioning within formalized neoliberal systems of care, while also being marginalized by their lack …

Governance Of Drug Development Alliances, Devashish Chandrashekhar Thakar

Theses and Dissertations

Innovative biotechnology firms (hereafter, biotechs or biotech firms) consider drug development alliances with incumbent pharmaceutical firms (hereafter, pharmas or pharma firms) as a means to access complementary commercialization capabilities, enhance their managerial skillset through close interactions, and maintain financial stability. However, biotechs face challenges in designing and developing alliance contracts that (a) enable them to retain and refine valuable alliance assets and (b) ensure that the alliance makes tangible scientific progress. Designing contracts to achieve these dual purposes is therefore a salient concern for the biotechs.

Given these challenges, the first essay of this dissertation explores the factors driving the …

Customer Discovery And Applied Research And Development For An Environmental Nanotechnology, Paul Michael Vecchiarelli

Theses and Dissertations

Technology transfer is a process by which an innovative technology, typically produced in a non-commercial setting such as academia, is developed into a potential market opportunity. The first phase of technology transfer, once a technology has been developed, is to identify a customer segment and determine a value proposition that describes what need the technology will fulfill for them. This phase has been systematized into a framework known as customer discovery. Success in customer discovery will indicate technological gaps, such as scale-up, prototyping, and realistic testing, that are needed to deliver the value proposition to the initial customer. Both phases …

Navigating Age Of Majority-Related Issues In Special Education: The Current Needs And A Potential Means For Aligning Professional Values With Policy And Practice, Charles Blayne Walters

Theses and Dissertations

The paper that follows serves to collect three articles that investigate policy and practice regarding adult decision-making support for students with disabilities receiving special education services. Each has been led by the author of this multiple-manuscript dissertation, Charles Walters. Following a short introduction to these works as Chapter One, Chapter Two provides a reformatted version of an interview-based study with special education directors at the school district level. It was originally published in Volume 35, Issue One of the Journal of Special Education Leadership and titled “An Exploratory Study of Special Education Director Experiences with Issues Related to Age of …

Substance Use Disorder Treatment Among African American Men Living In The Rural South Of The United States, Serge Raoul Wandji

Theses and Dissertations

Substance use disorders (SUD) affect more than 40 million Americans. African American (AA) men are disproportionally affected by the negative health and social consequences of SUD, and men in rural areas may be particularly at risk due to disadvantaged socioeconomic conditions and persistent race-related stressors such as perceived discrimination. The overall purpose of this study is to advance the understanding of factors associated with SUD treatment acceptance and relapse potential among Southern rural AA men.

This purpose was achieved by determining differences in treatment acceptance and relapse potential by race and gender among rural residents admitted in a SUD treatment …

Stories From North Carolina Teachers Of Color: An Inquiry Of Racialized Experiences In The Workplace., Deborah Stephanie Harrison

Theses and Dissertations

Growing educational research shows that teachers of color are finding themselves working in racially hostile schools through experiencing racism from their White colleagues in explicit and inexplicit ways. There is a need to further categorize how North Carolina teachers of color are experiencing racism in the workplace and identify how they are affected by it through experiential knowledge and analysis underpinned by critical race theory. Through action research, this study’s goals incorporated the implementation and evaluation of a collaborative book as a method of intervention on the effects of racial trauma. The collaborative book presents full counternarratives of teachers of …

An Investigation Of The Galenic Influence On The Artistic Depiction Of Anatomical Concepts During The Renaissance, Fatima Amjad

Theses and Dissertations

The Renaissance era was a period marked by an intellectual and artistic resurgence in Europe, during which artists sought inspiration from Classical sources. This resulted in a move away from stylized medieval aesthetics and towards a renewed emphasis on accuracy and humanity in art. Renaissance artists developed art styles that emphasized perspective, proportion, and anatomy, creating more lifelike and naturalistic representations of the human figure and the natural world. The adoption of naturalism and individualism in the arts paired with the rediscovery and retranslation of ancient anatomical texts propelled artists and anatomists to deepen their understanding of the human body. …

Jewish Genetic Diseases: Knowledge Of Reproductive Risk And Cancer Predisposition Among Young Adults Of Ashkenazi Descent, Hayley Kathleen Granger

Theses and Dissertations

Founder mutations within the Ashkenazi Jewish (AJ) population are associated with significantly higher carrier rates for certain severe, life-limiting conditions collectively called Jewish Genetic Diseases (JGDs), and for pathogenic variants in the BRCA1 and BRCA2 (BRCA1/2) cancer susceptibility genes. Efforts to educate AJ individuals about the implications of these founder mutations and available testing have increased the past forty years; however, studies suggest AJ individuals are not well educated on the topic (Hardy et al., 2022; Kaback, 2001; Warsch et al., 2014). Studies evaluating the reason for this gap in knowledge of young AJ adults are lacking. This study aimed …

An Examination Of Measurement Invariance With A Multi-Group Confirmatory Factor Analysis Approach, Ruiqin Gao

Theses and Dissertations

This multiple-manuscript dissertation explored the measurement invariance (MI) testing with multiple-group confirmatory factor analysis (MG-CFA) approach from different perspectives. Study 1 explored MI from a theoretical perspective by conducting a systematic review study on MI practices in education. The findings of this study indicated inconsistency in MI practices and showcased the limitations of the MI practices conducted by researchers in the field of education. Study 2 examined MI from an empirical perspective by implementing a cultural MI test of Strengths and Difficulties Questionnaires for elementary school students in the United States and China. The study provided a step-by-step demonstration of …

Using Factor Mixture Modeling To Counter Faking, Raul Corrêa Ferraz

Theses and Dissertations

Self-reports (SRs) of typical behavior are often the only existing feasible method to gather data on important drivers of human performance. In applications such as personnel selection, SRs are vulnerable to intentional distortions, often referred to as faking. A review of the literature suggests that so far, the methods proposed to address faking are unsatisfactory. In a recent breakthrough, Pavlov et al. (2019) showed that high-stakes scale scores are best modeled as a function of a) propensity to fake, b) honest scores, and c) the interaction of these two terms. Pavlov et al. did not, however, propose any method to …

“It Looks Like The Future But Feels Like The Past”: Oral (Hi)Stories Of Appalachia As Covid-19 News Stories, Ashley Reid Mcgraw

Theses and Dissertations

Oral historians have often felt obligated to collect stories during disasters and crises, to preserve recollections of experiences and trauma of those affected. During the onset of COVID-19 in the United States, this surge was certainly present. Appalachia, although its boundaries are contested, has a strong association with oral histories, and thus was the focus of one project in particular: a collaboration with the Blue Ridge Public Radio and the Foxfire Appalachian Heritage Museum to collect, curate, publish, and broadcast oral histories of "local" individuals. But what does it mean to be local, in a region as broad as Appalachia? …

Load Rating Evaluation Of Deteriorated Prestressed Channel Girders, Alexander Zane Henderson

Theses and Dissertations

The South Carolina Department of Transportation (SCDOT) is conducting a multi-year effort to load rate its inventory of over 9,400 bridges. This includes many bridges that are load posted due to potential structural considerations (e.g., outdated design loads, members whose capacity is difficult to assess, structural degradation). The number of load-posted bridges in South Carolina is expected to increase significantly due to recent efforts from SCDOT to assess the current state of bridge infrastructure. It is expected that the increased scrutiny may result in more load postings, which in turn may lead to restrictions on truck routes, potential bridge closures, …

From Derby Tracks To Surf Shacks: Reflections Of California’S Changing Cultural Landscape Through Artistic Renditions Of Recreation 1930s-1960s, David Walls

Theses and Dissertations

The aim of this thesis is to analyze works of art originating in the state of California during the 20^th century to better understand how sports and recreation were used as a subject matter to reflect upon the state’s changing cultural landscape. This changing landscape encompasses a wide range of social, cultural, economic, and political topics, however, the topics of race, migration, and economic strife are the most consistently reflected in the artistic production of this time and must be emphasized. Scholarship of art created within this region and timeframe has neglected the impact of recreational subject matter and …

Analysis Of The Economic Impact Of A Green Bank In South Carolina, Eric Luther Baxley

Theses and Dissertations

Green banks are an innovative financial tool for climate-conscious economic development. Green banks sustainably facilitate the expansion of renewable energy and disaster-resistant infrastructure by strategically allocating and growing an initial endowment of funds. This paper explores how a hypothetical green bank could operate in South Carolina and models the potential economic impacts a green bank could have on the state’s economy.

“Speak For Yourself”: Ovidian Women And The Suppression Of Voice And Complaint In Metamorphoses And Heroides, Grayson Elizabeth Newman

Theses and Dissertations

Ovid’s portrayal and attitude towards women is one that is particularly puzzling and contradictory throughout his Metamorphoses and Heroides. Recent scholarship on Ovidian literature is only divided on whether or not Ovid’s intentions within these two works were to sympathize with the Roman woman’s experience or to reinforce the lack of female representation in Roman society; however, I argue that Ovid fails to achieve empathy for the Roman woman. In Heroides, these women are pining and tragic, often meeting some terrible fate shortly after being abandoned by their suitors and putting forth a complaint. Conversely, women in Metamorphoses …

Deficit Thinking In Teacher Course Level Recommendations, Andrew Hogan

Theses and Dissertations

The purpose of this study was to analyze teacher perceptions of the impact of deficit thinking in student course level placement to derive greater insight into the causes of the over-representation of students of color in lower-tracked classes. This study was conducted as a virtual focus group using Google Meet that took place across 3 meetings in which 6 teachers participated in activities designed to promote dialogue around the impact of deficit thinking in the placement of students into course levels.

This study found that teachers perceived deficit thinking in institutional deficiencies in meeting the needs of students and the …