Digital Commons Network^™

Examining The Relationships Between Stress, Depressive Symptoms, And The Neighborhood Food Environment On Diet Quality Among Racially-Diverse Pregnant Women In South Carolina, Alycia K. Boutté

Theses and Dissertations

Background

Women’s diet quality during pregnancy often falls short of U.S. Dietary Guidelines and poor mental health and poor access to healthy food may be important barriers to improving diet quality during pregnancy. The purpose of this study was to 1) synthesize existing literature on the relationship between mental health and diet quality during pregnancy, 2) examine the relationship between mental health and diet quality in pregnancy, and 3) examine the relationship between healthy food density and diet quality in pregnancy.

Methods

For Aim 1 (systematic review), articles were obtained from five databases; study characteristics and findings were extracted and …

Amish Perspectives Of The Genetic Counseling Process, Brianna Teapole

Theses and Dissertations

The Amish are a population with a high concentration of genetic disorders who have informed our understanding of several genetic conditions. This culturally unique group has special need for genetic services. While clinics have been established to care for Amish individuals, such as the Community Health Clinic in Indiana, little research has been done on Amish perspectives of these services, specifically genetic counseling. Amish individuals who received genetic counseling from the Community Health Clinic were sent recruitment letters and a questionnaire via mail. The questionnaire consisted of demographic questions, a 7-item adapted Genetic Counseling Satisfaction Scale (GCSS), and open-response questions. …

Endolithic Microbial Carbon Cycling In East Antarctica, Natalie Tyler

Theses and Dissertations

Microbes adapt to inhospitable conditions by colonizing niches that protect them from severe environmental conditions, making them model organisms in the search for life on other planets. Endoliths are globally ubiquitous microbes that colonize structural cavities within rocks, which protect them from environmental stressors while maintaining access to nutrition and light sources. Despite harsh katabatic winds, extreme temperature fluctuations, harmful UV radiation and exposure to desiccation, endolithic communities have been observed in Antarctica. Previous studies have found viable and abundant microbial biomass through microscopy and the addition of isotopic labels. However, due to the slow metabolic activity of these microbes, …

Assessing Readiness For A Physical Activity Intervention In Positive Youth Development Afterschool Programs, Brittany Skiles Cook

Theses and Dissertations

Physical inactivity has been identified as a primary health threat to youth, and existing afterschool programs (ASP) are a promising context for implementing physical activity (PA) interventions. However, few PA interventions have been effective and generalizability of programs has been poor. Assessing organizational readiness during the testing of a PA intervention can help inform generalizability and sustainability. The R=MC2 heuristic separates readiness into motivation, innovation-specific capacity, and general capacity, each of which are further divided into subcomponents. The current multiple-case study pilot tests the feasibility and effectiveness/efficacy of a readiness assessment tool based on R=MC2 developed for the Connect through …

The Impact Of Student-Centered Coaching On The Implementation Of Project-Based Learning: An Action Research Study, Wanda Nicole Littlejohn

Theses and Dissertations

The present study describes a student-centered in-service that was implemented with four new teachers. The purpose of the study was to determine the level of confidence the four teachers felt after the coaching sessions. The study took place with teachers who teach in a high poverty school located in Greenville, South Carolina. The teacher-researcher is an Instructional Specialist at the school and she designed a project- based (PBL) learning unit with the teachers for ninth-grade students that was used in the coaching sessions in the fall of 2018. Data sources include: focus group interviews with the teachers; observations in the …

Regression For Pooled Testing Data With Biomedical Applications, Juexin Lin

Theses and Dissertations

Since first introduced by Dorfman in 1943, pooled testing has been widely used as a cost and time effective testing protocol in the variety of applications. This dis- sertation consists of three projects that reveal the use of pooling techniques in the disease prevention from the perspective of regression. For disease monitoring and control, individual covariates information are often of practical interest and yield meaningful interpretations. It is natural to model the outcome of interest, which can be either a disease status (binary) or a biomarker concentration index (continuous), with individual-specific covariates through a regression analysis. Chapter 2 focuses on …

Food Insecurity And Violence In A Prospective Cohort Of Women At Risk For Or Living With Hiv In The U.S., Amy A. Conroy, Mardge H. Cohen, Edward A. Frongillo Jr., Alexander C. Tsai, Tracey E. Wilson, Eryka L. Wentz, Adaora A. Adimora, Daniel Merenstein, Ighovwerha Ofotokun, Lisa Metsch, Mirjam-Colette Kempf, Adebola Adedimeji, Janet M. Turan, Phyllis C. Tien, Sheri D. Weiser

Faculty Publications

Background Food insecurity and violence are two major public health issues facing U.S. women. The link between food insecurity and violence has received little attention, particularly regarding the temporal ordering of events. The present study used data from the Women’s Interagency Human Immunodeficiency Virus Study to investigate the longitudinal association of food insecurity and violence in a cohort of women at risk for or living with HIV.

Methods Study participants completed six assessments from 2013–16 on food insecurity (operationalized as marginal, low, and very low food security) and violence (sexual or physical, and psychological). We used multi-level logistic regression, controlling …

Garnet & Black Spring 2019, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

The Daily Gamecock, Monday, February 25, 2019, University Of South Carolina, Office Of Student Media

February

No abstract provided.

The Daily Gamecock, Monday, February 11, 2019, University Of South Carolina, Office Of Student Media

February

No abstract provided.

Knowledge And Awareness Of Human Papillomavirus Among College Students In South Carolina, Salima Kasymova, Sayward Harrison, Caroline Pascal

Faculty Publications

Despite the existence of a safe and effective vaccine, human papillomavirus (HPV) remains prevalent in the United States, with late adolescence and early adulthood being periods of increased risk. Thus, targeting college-aged individuals for HPV prevention and vaccination promotion is critical—particularly in regions such as the Deep South where vaccination rates remain low. This study sought to examine awareness and knowledge of HPV as well as experiences and attitudes regarding HPV vaccination among college students in the Deep South. Specifically, we completed a cross-sectional survey of 256 undergraduate students from a large public university in South Carolina. Although a majority …

Development And Validation Protocol For An Instrument To Measure Household Water Insecurity Across Cultures And Ecologies The Household Water Insecurity Experiences (Hwise) Scale, Sera L. Young, Shalean M. Collins, Godfred O. Boateng, Torsten B. Neilands, Zeina Jamaluddine, Joshua D. Miller, Alexandra A. Brewis, Edward A. Frongillo Jr., Wendy E. Jepson, Hugo Melgar-Quiñonez, Roseanne C. Schuster, Justin B. Stoler, Amber Wutich, Jonathan Maupin, Monet Niesluchowski, Asiki Gershim, Divya Krishnakumar

Faculty Publications

Introduction A wide range of water-related problems contribute to the global burden of disease. Despite the many plausible consequences for health and well-being, there is no validated tool to measure individual- or household-level water insecurity equivalently across varying cultural and ecological settings. Accordingly, we are developing the Household Water Insecurity Experiences (HWISE) Scale to measure household-level water insecurity in multiple contexts.

Methods and analysis After domain specification and item development, items were assessed for both content and face validity. Retained items are being asked in surveys in 28 sites globally in which waterrelated problems have been reported (eg, shortages, excess …

The Daily Gamecock, Monday, January 14, 2019, University Of South Carolina, Office Of Student Media

January

No abstract provided.

An Evaluation Of Galleria Mellonella As A Model For Aspergillus Ustus Infections, Isak Jatoi

Journal of the South Carolina Academy of Science

Invasive aspergillosis is a serious cause of mortality and morbidity in immunocompromised hosts. In particular, the emergence of multidrug-resistant fungi, such as Aspergillus calidoustus, poses a concern for both doctors and patients. Rapid screening in vivo of novel antifungals is essential for discovering new treatments to combat invasive aspergillosis and improve prognosis of patients. As such, this study proposed the use of the greater wax moth, Galleria mellonella, as a quick way to model A. calidoustus infection. Due to the dangers of working with A. calidoustus in a high school setting, A. ustus was used in experimentation. It was …

2018-2019 Faculty Senate Annual Report, University Of South Carolina

Faculty Senate

The primary file includes the 2018-2019 Committee on Academic Responsibility Annual Report. Additional annual reports are attached.

Nutrition Interventions Integrated Into An Existing Maternal, Neonatal, And Child Health Program Reduce Food Insecurity Among Recently Delivered And Pregnant Women In Bangladesh, Edward A. Frongillo Jr., Phuong H. Nguyen, Tina Sanghvi, Zeba Mahmud, Bachera Aktar, Silvia Alayon, Purnima Menon

Faculty Publications

Background

Antenatal care may be a means to reduce food insecurity in pregnancy and postpartum periods.

Objective

With the use of a cluster-randomized design, we tested whether participation in nutrition-focused antenatal care intending to improve household knowledge about the importance of nutrition for pregnant and lactating women and encourage allocation of household resources to ensure sufficient quality and quantity of foods, without providing food assistance, would reduce household food insecurity.

Methods

Alive & Thrive integrated nutrition interventions into an existing Maternal, Neonatal, and Child Health (MNCH) program in Bangladesh. The nutrition-focused MNCH package was delivered in 10 subdistricts through antenatal …

The Role Of Food Processing In The Inflammatory Potential Of Diet During Pregnancy, Carolina Assis Silva, Izabela Da Silva Santos, Nitin Shivappa, James R. Hebert, Livia Castro Crivellenti, Daniela Saes Sartorelli

Faculty Publications

The aim was to investigate the relationship between the energy contribution (E%) of foods according to the degree of industrial processing and the energy-adjusted dietary inflammatory index (E-DII) in pregnancy. Two 24-hour dietary recalls were obtained from each of the 784 pregnant women. Adjusted linear regression models allowed observing an inverse association between E-DII scores and E% from minimally processed foods β = -0.049 (95%CI -0.055– -0.042) and a direct association with the E% of ultra-processed foods β = 0.052 (95%CI 0.045–0.058), indicating a relationship between the dietary inflammatory potential and the degree of industrial processing of foods.

Digital Information Technology Use And Patient Preferences For Internet-Based Health Education Modalities: Cross-Sectional Survey Study Of Middle-Aged And Older Adults With Chronic Health Conditions, Nancy P. Gordon, Elizabeth L. Crouch

Faculty Publications

Background: Health information, patient education, and self-management (health information and advice, HIA) tools are increasingly being made available to adults with chronic health conditions through internet-based health and mobile health (mHealth) digital information technologies. However, there is limited information about patient preferences for using specific types of health information and advice resources and how preferences and usage differ by age group and education.

Objective:The objective of this study was to examine how use of digital information technologies and preferred methods for obtaining health information and advice varies by age group and education among middle-aged and older adults with chronic …

Prevalence And Factors Influencing Use Of Internet And Electronic Health Resources By Middle-Aged And Older Adults In A Us Health Plan Population: Cross-Sectional Survey Study, Elizabeth L. Crouch, Nancy P. Gordon

Faculty Publications

Background: Health care organizations are increasingly using electronic health (eHealth) platforms to provide and exchange health information and advice (HIA). There is limited information about how factors beyond internet access affect use of eHealth resources by middle-aged and older adults.

Objective: We aimed to estimate prevalence of use of the internet, health plan patient portal, and Web-based HIA among middle-aged and older adults; investigate whether similar sociodemographic-related disparities in eHealth resource use are found among middle-aged and older adults; and examine how sociodemographic and internet access factors drive disparities in eHealth resource use among adults who use the internet.

Methods: …

Concentration-Dependent Effects Of A Dietary Ketone Ester On Components Of Energy Balance In Mice, Sarah E. Deemer, Rachel A. Davis, Barbara A. Gower, Andrew P. Koutnik, Angela M. Poff, Stephanie L. Dickinson, David B. Allison, Dominic P. D'Agostino, Eric P. Plaisance

Faculty Publications

Exogenous ketones may provide therapeutic benefit in treatment of obesity. Administration of the ketone ester (KE) R,S-1,3-butanediol acetoacetate diester (BD-AcAc) decreases body weight in mice, but effects on energy balance have not been extensively characterized. The purpose of this investigation was to explore concentration-dependent effects of BD-AcAc on energy intake and expenditure in mice. Forty-two male C57BL/6J mice were randomly assigned to one of seven isocaloric diets ( = 6 per group): (1) Control (CON, 0% KE by kcals); (2) KE5 (5% KE); (3) KE10 (10% KE); (4) KE15 (15% KE); (5) KE20 (20% KE); (6) KE25 (25% KE); and …

Resveratrol Attenuates Allergic Asthma And Associated Inflammation In The Lungs Through Regulation Of Mirna-34a That Targets Foxp3 In Mice, Esraah Alharris, Hasan Alghetaa, Ratanesh K. Seth, Saurabh Chatterjee, Narendra P. Singh, Mitzi Nagarkatti, Prakash Nagarkatti

Faculty Publications

Asthma is a chronic inflammatory disease of airways mediated by T-helper 2 (Th2) cells involving complex signaling pathways. Although resveratrol has previously been shown to attenuate allergic asthma, the role of miRNA in this process has not been studied. We investigated the effect of resveratrol on ovalbumin-induced experimental allergic asthma in mice. To that end, BALB/c mice were immunized with ovalbumin (OVA) intraperitoneally followed by oral gavage of vehicle (OVA-veh) or resveratrol (100 mg/kg body) (OVA-res). On day 7, the experimental groups received intranasal challenge of OVA followed by 7 days of additional oral gavage of vehicle or resveratrol. At …

Positive Association Between Dietary Inflammatory Index And The Risk Of Osteoporosis: Results From The Koges_Health Examinee (Hexa) Cohort Study, Hye Sun Kim, Cheongmin Sohn, Minji Kwon, Woori Na, Nitin Shivappa, James R. Hébert, Mi Kyung Kim

Faculty Publications

Previous studies have found that diet’s inflammatory potential is related to various diseases. However, little is known about its relationship with osteoporosis. The aim of this study was to investigate the association between the dietary inflammatory index (DII®) and osteoporosis risk in a large-scale prospective cohort study in Korea. This prospective cohort study included 159,846 participants (men 57,740; women 102,106) from South Korea with a mean follow-up of 7.9 years. The DII was calculated through a validated semi-quantitative FFQ (SQFFQ), and information on osteoporosis was self-reported by the participants. Analyses were performed by using a multivariable Cox proportional hazard model. …

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Marvella E. Ford, Mathew J. Gregoski, Rita M. Kramer, Kendrea D. Knight, Laura Spruill, Lourdes M. Nogueira, Bradley A. Krisanits, Van Phan, Amanda C. La Rue, Michael B. Lilly, Stefan Ambs, King Chan, Tonya F. Turner, Heidi Varner, Shweta Singh, Jaime Uribarri, Elizabeth Garrett-Mayer, Kent E. Armeson, Ebony J. Hilton, Mark J. Clair, Marian H. Taylor, Andrea M. Abbott, Victoria J. Findlay, Lindsay L. Peterson, Gayenell Magwood Phd, Rn, Faha, Faan, David P. Turner

Publications

PURPOSE: Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A Western lifestyle also promotes AGE accumulation in the body which is associated with disease phenotypes through modification of the genome, protein crosslinking/dysfunction, and aberrant cell signaling. Given the links between lifestyle, AGEs, and disease, we examined the association between dietary-AGEs and breast cancer. METHODS: We evaluated AGE levels in bio-specimens from estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast cancer patients, examined …

The Daily Gamecock, Thursday, October 4, 2018, University Of South Carolina, Office Of Student Media

October

No abstract provided.

Stories Of Experience: Economic Inequality In Mediation, Robert Rubinson

South Carolina Law Review

No abstract provided.

Neighborhood Socioeconomic Environment And Its Influence On Cardiorespiratory Fitness And Physical Activity In Youth, Morgan N. Clennin

Theses and Dissertations

Among youth, inadequate cardiorespiratory fitness and physical inactivity are powerful markers of health associated with numerous health outcomes across the lifespan. Unfortunately, a majority of U.S. youth have inadequate cardiorespiratory fitness levels and do not meet physical activity guidelines. While previous research has identified several individual-level factors associated with youth cardiorespiratory fitness and physical activity, environmental factors have been increasingly recognized. Of particular interest is the neighborhood socioeconomic environment, which has been consistently associated with several health outcomes among adults. However, little is known regarding the relationship between the neighborhood socioeconomic environment, cardiorespiratory fitness, and physical activity among younger populations. …

The Association Of Hospital Practices To Breastfeeding Behaviors In South Carolina: Analysis Of 2013-2015 Pregnancy Risk Assessment Monitoring System (Prams) Data, Larisa Donnette Bruner

Theses and Dissertations

Objective: The purpose of this study was to determine whether hospital practices are associated with breastfeeding initiation and breastfeeding duration for ≥10 weeks.

Methods: We analyzed the 2013-2015 South Carolina Pregnancy Risk Assessment Monitoring System (PRAMS) data. The population of interest was mothers who delivered a single live birth in the hospital. The infant was alive and living with the mother at the time of the survey. Chi-square and logistic regression were used to examine breastfeeding initiation and duration among all women who delivered in a hospital and those who stated that they initiated breastfeeding while in the …

Identification Of The Mechanisms Through Which Botanicals Attenuate Pathogenesis Of Human Diseases, Esraah Alharris

Theses and Dissertations

Plant products have been used for a long time in treatment of diseases. In fact, more than half of approved medicines are derived from plants or other natural products. Even though the synthetic drugs are effective in treating many human diseases, there is no cure against several clinical disorders. Moreover, a significant number of diseases can be prevented thereby causing less burden on societal healthcare costs as well as promoting healthy lifestyles. Thus, botanicals offer a unique opportunity to explore novel compounds to prevent and treat various clinical disorders as well as understand their mode of action so that new …

Sites Seen And Unseen: Mapping African American Women’S Public Memorialization, Alexandria Russell

Theses and Dissertations

Beginning in the late nineteenth century, black clubwomen began naming organizations after formerly enslaved women like Phillis Wheatley to keep their public memory alive. In doing so, they created a culture of recognition that acknowledged the organizational namesake as well as the contributions of members. Named memorialization celebrated the very best of African American women and continued to expand as Jim Crow laws encroached on black citizenship. Catalyzed by African American women while also supported by black journalists and local bureaucracies, named memorialization was the primary public history medium used to honor the legacies of African American women in the …

The Role Of Cdk8 In Metastatic Growth Of Colon Cancer, Jiaxin Liang

Theses and Dissertations

Unresectable hepatic metastases of colon cancer poorly respond to existing therapies and are a major cause of colon cancer lethality. Transcription- regulating Mediator kinase CDK8, an early clinical stage drug target, is amplified or overexpressed in many colon cancers and CDK8 expression correlates with shorter patient survival. Here we show that CDK8 inhibition does not generally suppress proliferation of CDK8-overexpressing colon cancer cells but nevertheless CDK8 knockdown by shRNA or CDK8 kinase inhibition by a selective small-molecule drug candidate suppresses metastatic growth of mouse and human colon cancer cells in the liver. This effect is due at least in part …