Digital Commons Network^™

An Evaluation Of A School Mental Health Program For Underserved Youth In Rural South Carolina, Tristan Collier

Theses and Dissertations

School, community, and youth-serving system partnerships can support implementing comprehensive school mental health (SMH) systems including services beyond direct therapy for students (i.e., multiple tiers of support). Utilizing a comprehensive approach to SMH allows clinicians to form stronger relationships with administrators, school staff, and most importantly, students who may need services. This comprehensive approach to SMH includes incorporating the SMH clinician into the culture and daily activities of the schools (e.g., helping direct students in the bus line), to increase the visibility of the clinician and services available as well as provide opportunities for direct outreach to students. One such …

Methyltransferase Mystery: Epigenetic Mechanisms Induced By Food Limitation In Daphnia Pule, Trenton C. Agrelius

Theses and Dissertations

Daphnia are ecologically important organisms that have been well studied in the context of evolution, ecology, ecotoxicity, and genomics. Daphnia have strong maternal effects in which the environment experienced by the mother can alter offspring disease resistance, life history traits, and morphology, as well as gene expression and methylation for multiple generations. Coupled with their ability to reduce genetic differences via parthenogenesis, Daphnia are an ideal system for epigenetic studies involving the transmission of maternal effects. Using two clones of Daphnia pulex, we investigated the plasticity of life history and DNA methyltransferase (Dnmt) gene expression with respect to food …

Correlates Of Zero-Dose Vaccination Status Among Children Aged 12–59 Months In Sub-Saharan Africa: A Multilevel Analysis Of Individual And Contextual Factors, Chamberline E. Ozigbu, Bankole Olatosi Ph.D., Zhenlong Li, James W. Hardin, Nicole L. Hair

Faculty Publications

Despite ongoing efforts to improve childhood vaccination coverage, including in hard-to-reach and hard-to-vaccinate communities, many children in sub-Saharan Africa (SSA) remain unvaccinated. Considering recent goals set by the Immunization Agenda 2030 (IA2030), including reducing the number of zero-dose children by half, research that goes beyond coverage to identify populations and groups at greater risk of being unvaccinated is urgently needed. This is a pooled cross-sectional study of individual- and country-level data obtained from Demographic and Health Surveys Program and two open data repositories. The sample includes 43,131 children aged 12–59 months sampled between 2010 and 2020 in 33 SSA countries. …

Correlates Of Zero-Dose Vaccination Status Among Children Aged 12-59 Months In Sub-Saharan Africa: A Multilevel Analysis Of Individual And Contextual Factors, Chamberline Ozigbu, Bankole Olatosi, Zhenlong Li, James W. Hardin, Nicole L. Hair

Faculty Publications

Despite ongoing efforts to improve childhood vaccination coverage, including in hard-to-reach and hard-to-vaccinate communities, many children in sub-Saharan Africa (SSA) remain unvaccinated. Considering recent goals set by the Immunization Agenda 2030 (IA2030), including reducing the number of zero-dose children by half, research that goes beyond coverage to identify populations and groups at greater risk of being unvaccinated is urgently needed. This is a pooled cross-sectional study of individual- and country-level data obtained from Demographic and Health Surveys Program and two open data repositories. The sample includes 43,131 children aged 12–59 months sampled between 2010 and 2020 in 33 SSA countries. …

Association Between The Dietary Inflammatory Index And Gastric Disease Risk: Findings From A Korean Population-Based Cohort Study, Sundara Raj Sreeja, Trong-Dat Le, Bang Wool Eom, Seung Hyun Oh, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Mi Kyung Kim

Faculty Publications

Evidence suggests that diets with high pro-inflammatory potential may play a substantial role in the origin of gastric inflammation. This study aimed to examine the association between the energy-adjusted dietary inflammatory index (E-DIITM) and gastric diseases at baseline and after a mean follow-up of 7.4 years in a Korean population. A total of 144,196 participants from the Korean Genome and Epidemiology Study_Health Examination (KoGES_HEXA) cohort were included. E-DII scores were computed using a validated semi-quantitative food frequency questionnaire. Multivariate logistic regression and Cox proportional hazards regression were used to assess the association between the E-DII and gastric disease risk. In …

Household Food Insecurity Is Associated With Diabetic Ketoacidosis But Not Severe Hypoglycemia Or Glycemic Control In Youth And Young Adults With Youth‐Onset Type 2 Diabetes, Lauren A. Reid, Jason A. Mendoza, Anwar T. Nerchant, Marco Geraci, Beth A. Reboussin, Faisal S. Malik, Alice M. Ellyson, Dana Dabelea, Lina Merjaneh, Santica M. Marcovina, Eva Lustigova, Jean .. Lawrence, Angela D. Liese Ph.D.

Faculty Publications

Objective: To examine the association between household food insecurity (HFI), glycemic control, severe hypoglycemia and diabetic ketoacidosis (DKA) among youth and young adults (YYA) with youth-onset type 2 diabetes.

Research design and methods: This cross-sectional study included 395 YYA with type 2 diabetes from the SEARCH for Diabetes in Youth Study (2015–2019). HFI was reported by young adult participants or parents of minor participants via the US Household Food Security Survey Module. Glycemic control was assessed by HbA1c and analyzed as a continuous and categorical variable (optimal:9.0%). Acute complications included self-reported severe hypoglycemia or DKA in the last 12 months. …

Adolescent Health Risk Behaviors, Adverse Experiences, And Self-Reported Hunger: Analysis Of 10 States From The 2019 Youth Risk Behavior Surveys, Kathryn L. Krupsky, Sarah Silwa, Hilary Seligman, Andrea D. Brown, Angela D. Liese Ph.D., Zewditu Demissie, Ellen Barnidge

Faculty Publications

We examined associations between adolescent self-reported hunger, health risk behaviors, and adverse experiences during the 2018–2019 school year. Youth Risk Behavior Survey data were pooled from 10 states. Prevalence ratios were calculated, and we assessed effect measure modification by sex. The prevalence of self-reported hunger was 13%. Self-reported hunger was associated with a higher prevalence of every health risk behavior/adverse experience analyzed, even after adjusting for sex, grade, and race/ethnicity. Sex did not modify associations. Findings underscore needs for longitudinal research with more robust measures of adolescent food insecurity to clarify the temporality of relationships.

Long Chain Fatty Acids And Virulence Repression In Intestinal Bacterial Pathogens, Mary K. Mitchell, Melissa Ellermann

Faculty Publications

When bacterial pathogens enter the gut, they encounter a complex milieu of signaling molecules and metabolites produced by host and microbial cells or derived from external sources such as the diet. This metabolomic landscape varies throughout the gut, thus establishing a biogeographical gradient of signals that may be sensed by pathogens and resident bacteria alike. Enteric bacterial pathogens have evolved elaborate mechanisms to appropriately regulate their virulence programs, which involves sensing and responding to many of these gut metabolites to facilitate successful gut colonization. Long chain fatty acids (LCFAs) represent major constituents of the gut metabolome that can impact bacterial …

Maternal Lineage And Habitat Use Patterns Explain Variation In The Fecundity Of A Critically Endangered Baleen Whale, Ana L. Bishop, Leah M. Crowe, Philip K. Hamilton, Erin L. Meyer-Gutbrod

Faculty Publications

The critically endangered North Atlantic right whale population (Eubalaena glacialis) has experienced multiple periods of decreased reproduction within its observable history, which have played a role in the overall decline of the species. In addition to this synchronized variation in reproduction across the population, there exists considerable individual variation in fecundity. To determine the impacts of family history and habitat use behavior on these individual variations in fecundity, photo identification data collected during four decades of visual monitoring were used to create a calving index for sexually mature females that could be used to evaluate matrilineal influence on …

Development, Validity, And Cross-Context Equivalence Of The Child Food Insecurity Experiences Scale For Assessing Food Insecurity Of School-Age Children And Adolescents, Edward A. Frongillo Jr., Maryah S. Fram, Hala Ghattas Ph.D., Jennifer Bernal, Zeina Jamaluddine, Sharon I. Kirkpatrick, David Hammond, Elisabetta Aurino, Sharon Wolf, Sophie M. Goudet, Mara Nyawo, Chika Hayashi

Faculty Publications

Background: Children ages 6 to 17 years can accurately assess their own food insecurity, whereas parents are inaccurate reporters of their children's experiences of food insecurity. No globally applicable scale to assess the food insecurity of children has been developed and validated.

Objectives: We aimed to develop a globally applicable, experience-based measure of child and adolescent food insecurity and establish the validity and cross-contextual equivalence of the measure.

Methods: The 10-item Child Food Insecurity Experiences Scale (CFIES) was based on items previously validated from questionnaires from the United States, Venezuela, and Lebanon. Cognitive interviews were conducted to check understanding of …

Food Insecurity And Suicidal Behaviors Among Us High School Students*, Andrea D. Brown, Hilary Seligman, Sarah Silwa, Ellen Barnidge, Kathryn L. Krupsky, Zewiditu Demissie, Angela D. Liese

Faculty Publications

BACKGROUND: Food insecurity (FI) rates in the United States are particularly high among households with children. This research set aims to analyze if high school students experiencing FI had higher risk for mental health and suicidal behaviors.

METHODS: Using combined data from 11 states that conducted the 2017 Youth Risk Behavior Survey, a total of 26,962 and24,051 high school students were used to estimate race/ethnicity and sex-stratified prevalence ratios (PRs) from Poissonregression models. A single-question was used to measure the exposure of FI and outcomes of mental health and suicidalbehaviors.

RESULTS: Overall, 10.8% of students reported FI. Students experiencing FI …

Shining A Light On Marginal Food Insecurity In An Understudied Population Comment, Angela D. Liese

Faculty Publications

No abstract provided.

Stakeholder Perspectives On In-Home Passive Remote Monitoring To Support Aging In Place In The Province Of New Brunswick, Canada: Rapid Qualitative Investigation, Emily A. Read, Danie A. Gagnon, Lorie Donelle Phd, Rn, Fcan, Kathleen Ledoux, Grace Warner, Brad Hiebert, Ridhi Sharma

Publications

BACKGROUND: The province of New Brunswick (NB) has one of the oldest populations in Canada, providing an opportunity to develop and test innovative strategies to address the unique health challenges faced by older adults. Passive remote monitoring technology has the potential to support independent living among older adults. Limited research has examined the benefits of and barriers to the adoption of this technology among community-dwelling older adults. OBJECTIVE: This study aimed to explore perceptions of in-home passive remote monitoring technology designed to support aging in place from the perspective of older adults, their family or friend caregivers, social workers, and …

Dietary Score Associations With Markers Of Chronic Low-Grade Inflammation: A Cross-Sectional Comparative Analysis Of A Middle- To Older-Aged Population, Seán R. Miller, Pilar Navarro, Janas M. Harrington, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ivan J. Perry, Catherine M. Phillips

Faculty Publications

Purpose

To assess relationships between the Dietary Approaches to Stop Hypertension (DASH), Mediterranean Diet (MD), Dietary Inflammatory Index (DII^®) and Energy-adjusted DII (E-DII™) scores and pro-inflammatory cytokines, adipocytokines, acute-phase response proteins, coagulation factors and white blood cells.

Methods

This was a cross-sectional study of 1862 men and women aged 46–73 years, randomly selected from a large primary care centre in Ireland. DASH, MD, DII and E-DII scores were derived from validated food frequency questionnaires. Correlation and multivariate-adjusted linear regression analyses with correction for multiple testing were performed to examine dietary score relationships with biomarker concentrations.

Results

In fully …

The Heritage Family Study: A Review Of The Effects Of Exercise Training On Cardiometabolic Health, With Insights Into Molecular Transducers, Mark A. Sarzynski Ph.D., Faha, Facsm, Treva K. Rice, Jean-Pierre Després, Louis Pérusse, Angelo Tremblay, Philip R. Stanforth, André Tchernof, Jacob L. Barber, Francesco Falciani, Clary Clish, James S. Skinner, D. C. Rao, Claude Bouchard

Faculty Publications

The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and cardiovascular disease and diabetes risk factors. Here we summarize the findings and their potential implications for cardiometabolic health and cardiorespiratory fitness. It begins with overviews of background and planning, recruitment, testing and exercise program protocol, quality control measures, and other relevant organizational issues. A summary of findings is then provided on cardiorespiratory fitness, exercise hemodynamics, insulin and glucose metabolism, lipid and lipoprotein profiles, adiposity and …

Home-Grown School Feeding: Implementation Lessons From A Pilot In A Poor Ethnic Minority Community In Vietnam, Sabina Di Prima, Dai Nguyen Dinh, Demi D. Reurings, E Pamela Wright Phd, Ms, Med, Rn, Cen, Dirk Essink, Jacqueline E. Broerse

Publications

BACKGROUND:

Undernutrition threatens the health and future of preschool children in disadvantaged remote communities. Home-grown school feeding (HGSF) in nursery schools could positively impact children's nutrition while creating multiple benefits for the whole community. However, evidence is lacking on implementation of HGSF within multi-sectoral programs in remote areas.

OBJECTIVE:

This study assessed an HGSF pilot intervention, part of a nutrition-sensitive agriculture (NSA) program, in a mountain ethnic minority community in Vietnam. It aimed to identify the changes brought about by the intervention, in particular diversity of children's food, food sources, barriers and facilitators to change, and future challenges and strategies. …

Editorial For Gels 6th Anniversary Special Issue, Esmaiel Jabbari, Gulden Camci-Unal

Faculty Publications

Note: In lieu of an abstract, this is an excerpt from the first page.

This Special Issue celebrates many outstanding quality papers published in Gels over the past six years since its first issue was published in 2015 [...]

The Daily Gamecock, Remember When, April 2022, University Of South Carolina, Office Of Student Media

April

No abstract provided.

The Interplay Between Hydrogen Sulfide And Phytohormone Signaling Pathways Under Challenging Environments, Muhammad Saad Shoaib Khan, Faisal Islam, Yajin Ye, Matthew Ashline, Daowen Wang, Biying Zhao, Zheng Qing Fu, Jian Chen

Faculty Publications

Hydrogen sulfide (H₂S) serves as an important gaseous signaling molecule that is involved in intra- and intercellular signal transduction in plant–environment interactions. In plants, H₂S is formed in sulfate/cysteine reduction pathways. The activation of endogenous H₂S and its exogenous application has been found to be highly effective in ameliorating a wide variety of stress conditions in plants. The H₂S interferes with the cellular redox regulatory network and prevents the degradation of proteins from oxidative stress via post-translational modifications (PTMs). H₂S-mediated persulfidation allows the rapid response of proteins in signaling networks …

Pro-Inflammatory Diet Pictured In Children With Atopic Dermatitis Or Food Allergy: Nutritional Data Of The Lina Cohort, Olivia Schütte, Larissa Bachmann, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Janine F. Felix, Stefan Röder, Ulrich Sack, Michaek Borte, Wieland Kiess, Ana C. Zenclussen, Gabriele I. Stangl

Faculty Publications

Background: Lifestyle and environmental factors are known to contribute to allergic disease development, especially very early in life. However, the link between diet composition and allergic outcomes remains unclear. Methods: In the present population-based cohort study we evaluated the dietary intake of 10-year-old children and analyses were performed with particular focus on atopic dermatitis or food allergy, allergic diseases known to be affected by dietary allergens. Dietary intake was assessed via semi-quantitative food frequency questionnaires. Based on these data, individual nutrient intake as well as children’s Dietary Inflammatory Index (C-DII™) scores were calculated. Information about atopic manifestations during the first …

The Cornbread Country: Cornbread And The Development Of Southern Identity, Ashton Doar

Senior Theses

Following the chronological development of the American South from the pre-colonial era to the present day, this thesis analyzes the importance of cornbread in relation to historical circumstances. Native Americans, British settlers, early Americans, and self-identifying Southerners all related to the land and to its food in unique ways. Narrowing the scope of this broad topic to the specific point of cornbread allows for an analysis of the continuity and change of people's circumstances and life experience, as well as the ways in which people define themselves by their food.

Doctors & Diets: The Return Of Nutrition To American Medical Education, Luke Hollingsworth

Senior Theses

The purpose of this honors graduation thesis is to analyze the role of nutrition in the prevention, management, and treatment of chronic diseases and to argue that clinical nutrition should be reintegrated into American medical education as a high priority subject. The thesis begins with a historical review of clinical nutrition beginning in the fifth century B.C. with Hippocrates in Classical Greece and ending in 21st century America. Following the historical review, five of some of the most prevalent chronic diseases in America are examined through a nutritional lens. This thesis concludes with a discussion of the outlook of American …

Covid-19 & Mental Health: The Impact On The Future Of Younger Generations, Greyson A. Fox Tran

Senior Theses

The aim of this research is to identify any existing correlations between the COVID-19 pandemic and negative mental health outcomes in younger populations. This paper examines the impact of the COVID-19 pandemic on the mental health of those younger than 25 years of age, specifically focusing on students. It will investigate how various factors of the pandemic have affected people and how they have coped with psychological distress induced by the pandemic. Through a review of scientific data and scholarly literature, the impacts of the pandemic on mental health will be assessed. Coping mechanisms and the effects of physical activity …

Slow Violence And Racial Capitalism: Understanding Mass Incarceration Through A Case Study Of The California Prison System, Mason Joiner

Senior Theses

This thesis will analyze the growth of the California prison system, situating it in the national context of mass incarceration in the United States. In Ruth Wilson Gilmore’s book Golden Gulag: Prisons, Surplus, Crisis, and Opposition in Globalizing California, Gilmore utilizes the theory of racial capitalism to explain the history and development of the California prison system. By analyzing Gilmore’s arguments about racial capitalism and integrating them with Rob Nixon’s theory of slow violence from his book Slow Violence and the Environmentalism of the Poor, this thesis provides a new perspective in the current discourse around mass incarceration. …

Acute Kynurenine Challenge Upregulates Activation Of Orexinergic Neurons In The Lateral Hypothalamus, Hayley Nicholson

Senior Theses

Abnormalities in the kynurenic pathway (KP) of tryptophan catabolism are implicated in various neurocognitive disorders, including schizophrenia, bipolar disorder, and Alzheimer’s disease. Elevated levels of the astrocyte-derived metabolite kynurenic acid (KYNA) are found in the postmortem brain of individuals with these illnesses. KYNA is a neuroactive metabolite and acts as an antagonist at glutamatergic N-methyl-D-aspartate (NMDA) and cholinergic α7 nicotinic acetylcholine (α7nACh) receptors. As glutamatergic and cholinergic transmission are critically involved in sleep-dependent plasticity and cognition, KYNA is hypothesized to play a key role in cognitive and sleep disruptions present in these brain disorders. Sleep and cognitive disturbances are pathophysiologically …

The Dental Health Of Rural Elderly People And Its Social Justice Implications, Health In The Hills: Understanding The Impact Of Health Care Law In Rural Communities, Jacqueline R. Fox

Faculty Publications

No abstract provided.

Determining The Role Of High-Sugar Diets On Ovarian Function In Drosophila Melanogaster, Emma Otey

Senior Theses

The prevalence of obesity in the United States has increased drastically and the effects of obesity on human physiology are not fully known at this point. It has been noted that there is a significant decrease of fertility rates in obese women. In order to study how exactly these high-sugar or high-fat diets are impacting fertility, Drosophila can be used as a model organism. The use of Drosophila as a model organism for humans is due to the many conserved molecular and systematic mechanisms, namely ovarian function, as well as conserved physiological responses to obesity and obesogenic diets. This study …

Examination Of Energy Needs In Male And Female Physically Active Individuals, Savanna Griffin

Senior Theses

Content: The Female Athlete Triad refers to three interrelated components: 1) low energy availability (LEA), with or without an eating disorder (ED); 2) harmful and physiologically impactful hormonal changes; and 3) alterations in bone mineral density, which are often experienced by individuals engaged in organized sports or other intense physical activities. This phenomenon is called the Female Athlete Triad because the relationship of components has thus far been observed primarily in females. A new term, the Male Athlete Triad, has been recently developed to describe the same phenomenon in males. LEA occurs when dietary energy intake (EI) is inadequate to …

Self Reported Cardiovascular Health And Health Behaviors In Women Veterans, Seth Byland

Theses and Dissertations

Objective: The purpose of this study is to describe self-reported cardiovascular health (CVH) and health behaviors in women veterans (WV). A cardiovascular score will be adapted from the existing American Heart Association CVH score. This score will be used to describe CVH in WV.

Methods: Data was collected from WV using an anonymous online survey. This survey asked questions about CVH, CVH behavior, and military specific questions. CVH scoring was determined by asking 6 questions that scored individuals for a total score from 0 to 12, with 12 being most ideal for CVH health. Scores were tallied and mean scores …

Associations Among Plant-Based Dietary Indexes, The Dietary Inflammatory Index, And Inflammatory Potential In Female College Students In Saudi Arabia: A Cross-Sectional Study, Ghadeer S. Aljuraiban, Rachel Gibson, Leenah Al-Freeh, Sara Al-Musharaf, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Linda M. Oude, Queenie Chan

Faculty Publications

Background Saudi Arabian diets are transitioning to more Western dietary patterns that have been associated with higher levels of inflammation. Emerging evidence suggests plant-based diets are related to lower levels of inflammation; however, the definition of plant-based diets varies. Objective The purpose of this study was to identify the extent to which an overall Plant-Based Diet Index (PDI), Healthy-PDI (hPDI), and Unhealthy-PDI (uPDI) vs Energy-Adjusted Dietary Inflammatory Index correlate with high-sensitivity C-reactive protein (hs-CRP) level. Design This was a cross-sectional study carried out at King Saud University. Data on dietary intake, anthropometrics, and hs-CRP were collected. Participants/setting Female students aged …