Digital Commons Network^™

Parsing The Effects Of Physical Microenvironmental Cues On Stem Cell Adhesion And Lineage Specification, Greg M. Harris

Theses and Dissertations

Tissue engineering is a broad field geared toward improving or replacing biological material and comprises an immense collection of biological nuances to consider before strategies for clinical applications can be fully realized. Physical and biochemical signals are responsible for making up a cell's microenvironment to guide morphology and function through cell-extracellular matrix signaling, cell-cell signaling, and soluble signaling. In particular, a deeper understanding of these cell-extra cellular matrix factors guiding stem cell adhesion, spreading, and differentiation is crucial to harnessing the potential to develop tissue for regenerative purposes. Mounting evidence suggests that physical cues are a key to understanding the …

The Role Of Recovery In Attenuating The Negative Effects Of Perceived Stigmatizing Attitudes For Persons With Psychiatric Disabilities, Betsy Alison Davis

Theses and Dissertations

For many people who experience psychiatric disabilities (PD), community experiences are largely characterized by stigmatizing interactions, discrimination, and losses of opportunities for employment, housing, or relationships. Social withdrawal and loss of self-esteem can be secondary consequences of such negative experiences. However, research has also explored various mechanisms through which people in historically stigmatized social groups can minimize some of the negative effects of stigma. Many of these strategies are theorized to be similar to a mental health recovery orientation which emphasizes the empowerment, capabilities, and strengths of mental health consumers. The present investigation explores the possibility of recovery attenuating some …

Youth Citizenship, Civic Education, And Spaces Of Belonging In Tallinn, Estonia, Catherine Michelle Cottrell

Theses and Dissertations

This dissertation investigated the ways that young people in Tallinn, Estonia conceptualize citizenships, identities, and belongings in national and post-national communities. Focus groups were conducted with 29 students from ethnic Estonian and Russophone backgrounds in their final year of secondary school; in-depth interviews were conducted with 16 civic education teachers from the students' schools. Theories of citizenship and nationalism, as well as civic education research, were used to explore the ways in which young people conceptualize the terms of belonging and negotiate cultural difference as they move within and through their everyday spaces, particularly in the school. The study demonstrated …

A New Perspective On Dante’S Dream Of The Siren, Tomás Antonio Valle

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

The Oswald Review Undergraduate Research And Criticism In The Discipline Of English: Volume 15 Fall 2013

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Parent Perceptions Of Audiology And Speech-Language Services And Support For Young Children With Cochlear Implants, Patrick Michael Kelly

Theses and Dissertations

Parents of children diagnosed with severe-profound sensorineural hearing loss are selecting cochlear implants at an increasing rate and when their children are very young. Audiologists and speech-language pathologists are typically involved in habilitation activities following implantation in an effort to increase children's access to listening and spoken language. These clinicians depend upon parents to participate in habilitation activities that may lead to favorable outcomes for children. However, little evidence exists regarding parents' perspectives on the services and supports audiologists and speech-language pathologists provide in this team effort. Parents can offer valuable feedback to clinicians regarding the type and quality of …

Determining The Differences In Hurricane Perception And Evacuation Behavior In The Elderly Of South Carolina, Gregg C. Bowser

Theses and Dissertations

The United States is becoming a "grayer" nation. U.S. Administration of Aging projections indicate that by 2030 nearly 20 percent of the national population will be aged 65 or older, with a significant portion of this growth occurring along the hurricane-prone Atlantic and Gulf coasts. This demographic shift creates new challenges for emergency management. Previous research shows that the elderly do not perceive risks and warnings the same way as other groups, and as a result may react differently to risk. Disproportionately high fatality rates for the elderly in recent disasters indicate that these differences are a key determinant of …

Evaluation Of Mass Media Campaigns To Change Smokers' Knowledge, Attitudes, And Behaviors In China And Taiwan, Li-Ling Huang

Theses and Dissertations

Research in high income countries (HICs) suggest that anti-smoking television advertisements are most effective if they contain emotionally evocative graphic messages or personal testimonials that depict serious consequences from smoking. The ability to effectively translate these messaging strategies to low- and middle-income (LMICs) countries outside of Western cultures remains understudied. It is critical to determine which smoking cessation messages work best in LMICs because they increasingly bear the global burden of tobacco-related disease. To date there is limited evidence on the efficacy of tobacco control mass media campaigns and the relative effectiveness of different tobacco control messaging strategies in China …

Three Musical Translations For Trumpet And Organ Based On Visual Artwork., John Harrison Bryant

Theses and Dissertations

Composers Petr Eben, Anthony Plog, and Jennifer Mitchell were each inspired by works of visual art to write pieces of music for trumpet and organ that sonically reflect their visual experiences. The main purpose of this document is to explore the unique "musical translation" the composers made of each respective work of visual art. In addition to providing valuable commentary and advice for informed performance, this document offers a complete formal analysis of each work.

A Model Experiment To Assess The Effects Of Inclusions On Wave Propagation In Soil Media, Thomas Houston

Theses and Dissertations

The research described involved analyzing and characterizing changes to propagating surface waves that are caused by items embedded in a half-space consisting of a soil medium. Numerical and experimentally obtained data of three-dimensional surface wave responses to dynamic impulse loading were examined. Results from this research are compared to changes to surface waves observed in previous investigations that were caused by the presence of voids and inclusions embedded in an elastic half space. The focus of this work was to identify whether the characteristic responses identified in previous studies, based substantially on analytical and finite element analyses results, can be …

Renewable Bio-Based Polymers And Degradable Functional Polymers, Kejian Yao

Theses and Dissertations

In this dissertation, polymers derived from renewable bio-based resources and degradable functional polymers with stimuli-responsive properties by various polymerization techniques were investigated. The properties of these polymeric materials were characterized and discussed.

In Chapter 1, the overall background and recent development of renewable bio-based polymers as well as degradable stimuli-responsive polymers was introduced. Major research objectives of my doctoral work were described.

The first section of the dissertation, on the preparation of renewable bio-based polymers was provided from Chapter 2 to Chapter 4. In Chapter 2, the preparation of novel polymers derived from renewable gum rosin by atom transfer radical …

Adverse Outcome Pathways: A Framework For Identifying Chemical Mode Of Action During Zebrafish Embryogenesis, Krystle Yozzo

Theses and Dissertations

Human health and ecological risk assessors are currently facing increased demands and public pressure to evaluate the potential risk of hundreds to thousands of chemicals based on limited toxicity data. Therefore, scientifically sound models are needed to predict toxicity without sole reliance on conventional whole-organism (vertebrate) bioassays. To help address this challenge, adverse outcome pathways (AOPs) have recently been proposed as conceptual tools to help link direct, molecular-level initiating events to adverse outcomes at higher levels of biological organization. Additionally, using AOPs as frameworks, high-throughput screening (HTS) and high-content screening (HCS) assays have been recently proposed as key components of …

A New Class Of Solid Oxide Metal-Air Redox Batteries For Advanced Stationary Energy Storage, Xuan Zhao

Theses and Dissertations

Cost-effective and large-scale energy storage technologies are a key enabler of grid modernization. Among energy storage technologies currently being researched, developed and deployed, rechargeable batteries are unique and important that can offer a myriad of advantages over the conventional large scale siting- and geography- constrained pumped-hydro and compressed-air energy storage systems. However, current rechargeable batteries still need many breakthroughs in material optimization and system design to become commercially viable for stationary energy storage.

This PhD research project investigates the energy storage characteristics of a new class of rechargeable solid oxide metal-air redox batteries (SOMARBs) that combines a regenerative solid oxide …

Environmental Effects On Mechanical And Thermal Behaviors Of Zinc Oxide Nanobelts And Dispersion Of Carbon Nanostructures, Yingchao Yang

Theses and Dissertations

One-dimensional (1-D) nanostructures, such as nanowires, nanobelts, and nanotubes of different materials, have significant applications as nanoscale interconnects and active/functional components of electronic and optoelectronic devices, sensors, actuators, nanoelectromechanical systems (NEMS), and energy generation/conversion systems. The thermal and mechanical stabilities of those nanodevices and nanoenabled energy systems are of both theoretical and practical interests. Thermodynamic properties of nanomaterials are different from those of bulk materials. As the size of a solid particle reduces to the nanometer scale, the surface-to-volume ratio increases and the melting temperature may remarkably decrease. The functionality and/or reliability of those nanodevices and nanoenabled energy systems are …

The Glass Cliff: An Examination Of The Female Superintendency In South Carolina, Blanche Boyd Bowles

Theses and Dissertations

South Carolina public school districts are confronted with a series of difficult circumstances and rely more on female superintendents than the national average. The investigation of female South Carolina superintendents was guided by the glass cliff conceptual framework. The glass cliff represents situations where females are promoted over males to risky or precarious leadership positions where the chance of failure is high

The purpose of this quantitative, non-experimental study was to examine the relationship between the sex of South Carolina public school superintendents to (a) self-reported transformational leadership behaviors and (b) select district indicators indicative of the difficult circumstances confronted …

Race, Ethnicity, And Differential Perceptions Of Sexual Victimization (Assault), Kaleea Regina Lewis

Theses and Dissertations

The purpose of this pilot study is to ascertain how a sample of female college students perceives a hypothetical victim of a fabricated sexual assault. Participant perceptions of the sexual assault were explored through three distinct parameters: (1) victim responsibility attributes, (2) levels of trauma suffered due to the experience, and (3) levels of social support. This study addressed the two following research questions: (1) how does the hypothetical sexual assault victim's race and ethnicity affect how the study parameters are assessed and (2) how do participants perceive a hypothetical sexual assault victim, when presented in different races and ethnicities, …

The Anti-Angiogenic Effects Of Sparstolonin B, Henry Rhodes Bateman

Theses and Dissertations

Sparstolonin B (SsnB) is a novel bioreactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has demonstrated anti-inflammatory properties, inhibiting Toll-like receptor mediated inflammation in isolated macrophages and in mice. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including atherosclerosis, diabetic retinopathy, and tumor growth. The goal of the project was to investigate the anti-angiogenic effects of SsnB.

The first part of the project utilized in vitro functional assays to study how SsnB affected endothelial cells. SsnB inhibited endothelial cell tube …

Delivery System Capacities For Recovery-Oriented System Of Care (Rosc) For Substance Abuse Disorders: An Examination Of Organizational Readiness, Jonathan Peter Scaccia

Theses and Dissertations

Adopting and implementing a Recovery-Oriented System of Care (ROSC) (innovation) requires that organizations have recovery-specific systems and features (capacities) in place. Organizations, however, may requires more than specific capacities, they require the motivation to put recovery-based innovations into place. This thesis reviews the literature to examine which capacities have been identified as integral to providing recovery-oriented services within a ROSC. Surveys were distributed electronically to delivery and support staff at organizations that provide substance abuse services under the jurisdiction of the South Carolina Department of Alcohol and Drug Abuse Services. Confirmatory Factor Analysis (CFA) was used to examine how these …

Passive Equalizer Topology Analysis For Signal Integrity Applications, Kuo-Lun Yen

Theses and Dissertations

In high-speed, high density PCB bus systems, high frequency signal losses and crosstalk can have great impacts on signal integrity and digital timing, which can distort transmitted signals, worsen eye diagrams, and attenuate signal amplitudes. Also, these impacts make digital signals and their energy smearing over multiple bit positions as known as jitters, and cause the phenomenon of inter-symbol interference (ISI) in digital signal transmissions.

The main objective of this thesis is to analyze and develop efficient topology circuits for compensating bus system high frequency losses by using equalization techniques. The thesis has focused on study of various practical and …

Three-Dimensional Evolution Of Mechanical Percolation In Nanocomposites With Random Microstructures, Bethany Suzanne Fralick

Theses and Dissertations

One mechanism that is expected to play a large role in the enhanced, and sometimes novel, mechanical properties of nanocomposites is the probabilistic formation of percolated or connected microstructures. The majority of the models used to describe mechanical percolation have the functional form of a power law and depend on prior knowledge of a percolation threshold or critical volume fraction. While these models have been fairly accurate predictors of electrical conductivity in composites, they do not take any microstructural mechanisms, other than connectivity, into consideration. Classic mean-field micromechanics models, however, do not capture the variability in effective properties due to …

Multi-Physicochemical Modeling Of Solid Oxide Fuel Cells And Electrolyzer Cells, Yuanyuan Xie

Theses and Dissertations

Multi-physicochemical models are developed for solid oxide fuel cells and electrolysis cells. The models describe the complicated transport processes of charge (electron/ion) conservation, mass/species conservation, momentum conservation, and energy conservation. Transport processes are coherently coupled with chemical reforming processes, surface elementary reaction processes, as well as electro-oxidation processes of both hydrogen and carbon monoxide. The models are validated with experimental data and utilized for fundamental mechanism studies of SOFCs fueled with different type of fuels, such as hydrogen, hydrocarbon, e.g., methane, H2S, and their mixtures. The fundamental mechanisms associated with syngas generation using electrolysis cell are also extensively investigated using …

Microstructural-Based Modeling Of Electrical Percolation In Polymer Nanocomposites, Neelima Yellepeddi

Theses and Dissertations

Polymer nanocomposites (PNCs) represent a radical alternative to conventional filled polymers or polymer blends. In contrast to conventional composites, where the included phase is on the order of micrometers, PNCs are defined as those that have discrete constituents on the order of a few hundred nanometers. The value of PNCs is not solely based on tailoring mechanical properties, as in traditional composite design and manufacture, but rather on the potential for the design and optimization of multi-functional properties. There is major interest in these polymeric materials embedded with a conductive nanoscale filler. This is due to the possibility of designing …

Estimation Of Aerosolized Antibiotic Resistant Bacteria Concentrations From Wastewater Treatment Facilities Using Spatially-Based Dispersion Modeling, Renee Nichole Dickman

Theses and Dissertations

Pathogenic bacteria can develop resistance to antibiotics to which they were previously sensitive, resulting in increased morbidity and mortality worldwide [1]. The increase in drug resistance in bacteria is an emerging public health concern. The activated sludge tanks of wastewater treatment plants are known sources of antibiotic resistant bacteria. These resistant bacteria can become aerosolized and disperse downwind. Using previously sampled aerosol concentrations and meteorological data, a Gaussian dispersion model was developed to estimate the concentration downwind from a selected wastewater treatment facility. The emission rate was calculated to be 7,941 CFU/m²/sec ± 2,149 CFU/m²/sec. This value was used in …

Readiness For Positive Behavior Interventions And Supports (Pbis) And School Mental Health (Smh) Interconnection: Development Of A Stakeholder Survey, Vittoria Anello

Theses and Dissertations

Positive behavior interventions and supports (PBIS) and school mental health (SMH) are prominent initiatives in the United States to improve student behavior and promote mental health and wellness, led by education and mental health systems, respectively. Unfortunately, PBIS and SMH are often separate initiatives in districts and schools, which usually results in many missed opportunities from this failed interconnection. The current paper details a necessary first step in the process by describing the development of a measure of assessing readiness to interconnect PBIS and SMH within the schools. Relevant literature, pilot data, and methodology are discussed, in addition to psychometric …

A Teacher's Perceptions Of Inquiry: Where Inquiry Experiences, Beliefs And Practice Intersect, Michelle Avila Vanderburg

Theses and Dissertations

Linda Darling-Hammond (2008), a member of President Obama's education transition team, published a collection of chapters, each written by prominent researchers in the field of education. Throughout this compilation, the idea of using inquiry in the classroom was heralded again and again. Darling-Hammond argued for the "implementation of inquiry-based curriculum that engages children in extended, constructive work, often in collaborative groups, and subsequently demands a good deal of self-regulated inquiry" (p. 13). Significant in Darling-Hammond's message was that educators need to provide students with experiences that allow them to become inquirers who can construct their own knowledge. However, while the …

The Effect Of Αct-1 Peptide On Bone Marrow Stromal Cells Following Injury, Adam Clay Vandergriff

Theses and Dissertations

Connexin43 (Cx43) is a component of gap junctions and is involved in intercel- lular signaling following injury to tissues. The carboxyl terminus of Cx43 binds to the PDZ2 domain of ZO-1 in order to form gap junction plaques and connect to the cytoskeleton. A biomimetic peptide known as αCT-1, replicating the last 9 amino acids found in the carboxyl terminus of CX43, has been shown to improve wound healing by preferentially binding to the PDZ2 domain of ZO-1. A possible mecha- nism for its action is through the Epithelial-Mesenchymal Transformation (EMT). Scratch assays were performed on rat bone marrow stromal …

Climate Change Effects On Vibrio Bacteria In The Winyah Bay Estuary And The Projected Spread Of Vibrio Under Future Climatic Scenarios., Reem Deeb

Theses and Dissertations

While there are several studies on the distribution ofVibrio vulnificusandVibrio parahaemolyticusin estuarine waters around the world, there is little information on the distribution of both organisms in South Carolina waters. Monthly sampling of surface and bottom water from 9 sites in Winyah Bay was conducted over the period April-October 2012. Both organisms were enumerated on CHROMagarVibriomedia. TheVibriocounts obtained were mainly less than 20 Colony Forming Units (CFU)/ml which is typical for what was found elsewhere along the coast of the Carolinas. TheVibrio vulnificuscounts were the highest when salinity ranged between 5 ppt and 20 ppt.Vibrio parahaemolyticusdid not show a clear …

What Can Reader Comments To News Online Contribute To Engagement And Interactivity? A Quantitative Approach, Brett A. Borton

Theses and Dissertations

This dissertation addresses the relationship between journalism and computer-mediated communication by exploring the degree to which newly empowered audience members are using the reader comment forum on newspaper websites to participate in democratic discourse - a key component of civic engagement. Twenty-first century journalism has evolved from the traditional asynchronous, 'one-to-many' model into a process involving producers, content and audiences. The interactive capabilities of Internet-based news products have enabled legacy media to connect with audiences in unprecedented fashion. Perhaps more than any other interactive platform, the reader comment forum on online news sites reflects the ideal of the 'public sphere,' …

Characterization Of The Role Of Fro6 In Metal Homeostasis In Arabidopsis Thaliana, Margo Ellen Maynes

Theses and Dissertations

Iron deficiency is the most common human nutritional disorder in the world today, affecting approximately 2 billon people worldwide, almost a third of the world's population. For most of the world's population, plant foods serve as the major source of dietary iron. One approach that may contribute towards the solution of iron deficiency is the development of crop plants that contain higher levels of bioavailable iron. This project focuses on FRO6, a ferric chelate reductase in Arabidopsis thaliana that is thought to reduce apoplastic iron for transport across the plasma membrane in leaf cells. We hypothesize therefore that FRO6 controls …

Gelation Characteristics And Osteogenic Differentiation Of Stromal Cells In Inert Hydrolytically Degradable Micellar Polyethylene Glycol Hydrogels, Danial Barati

Theses and Dissertations

The use of polyethylene glycol (PEG) hydrogels in tissue engineering is limited by their persistence in the site of regeneration. In an attempt to produce degradable PEG-based hydrogels while preserving the unique properties of PEG, linear (LPELA) and star (SPELA) poly(ethylene glycol-co-lactide) acrylate, star (SPEDA) poly(ethylene glycol-co-dioxanone), star (SPEGA) poly(ethylene glycol-co-glycolide) acrylate as the least hydrophobic and (SPECA) poly(ethylene glycol-co-caprolactone) as the most hydrophobic macromonomers with short hydrophobic segments were synthesized. The hydrogels were characterized with respect to gelation time, modulus, water content, sol fraction, degradation, and osteogenic differentiation of encapsulated marrow stromal cells (MSCs). Chain extension of PEG with …