Digital Commons Network^™

Waning Effectiveness Of Mrna Covid-19 Vaccines Against Inpatient And Emergency Department Encounters, Theodoros V. Giannouchos, Nicole L. Hair Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations. More data is needed to understand how the benefits of vaccination may vary across US populations with disparate risk profiles and policy contexts. We aimed to provide estimates of mRNA COVID-19 vaccine effectiveness against moderate and severe outcomes of COVID-19 based on state population-level data sources. Using statewide integrated administrative and clinical data and a test-negative case-control study design, we assessed mRNA COVID-19 vaccine effectiveness against SARS-CoV-2-related hospitalizations and emergency department visits among adults in South Carolina. …

Town & Gown…& Jerseys? Ncaa Division Iii Athletics As Social Anchors, Matthew Katz, Aaron W. Clopton

Journal of Issues in Intercollegiate Athletics

No abstract provided.

Sexual Orientation And Gender Identity Measures And Viral Suppression For People Living With Hiv: A Protocol For A Population-Based Cohort Study, Xueying Yang, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Introduction The measure of sexual orientation and gender identity (SOGI) data in electronic health records (EHR) has been critical for addressing health disparities and inequalities, especially for HIV care. Given that gender and sexual minorities (eg, transgender, men who have sex with men and intersex) are key groups in people living with HIV (PLWH), SOGI data can facilitate a more accurate understanding about the HIV outcomes (eg, viral suppression) among this key group and then lead to tailored therapeutic services. The two-step SOGI collection method as an emerging gender measurement can be used to measure SOGI status in medical settings. …

A Baker’S Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2022, Reagan K. Barfield, Matthew L. Brown, Benjamin Albrecht, Katie E. Barber, Jeannette Bouchard, Amy L. Carr, Elias B. Chahine, David Cluck, Elizabeth W. Covington, Connor R. Deri, Spencer H. Durham, Carmen Faulkner-Fennell, Lauren K. Freeman, Timothy P. Gauthier, Geneen M. Gibson, Sarah B. Green, Athena L.V. Hobbs, Bruce M. Jones, P. Brandon Bookstaver Pharm.D., Et. Al.

Faculty Publications

Keeping abreast of the antimicrobial stewardship–related articles published each year is challenging. The Southeastern Research Group Endeavor identified antimicrobial stewardship–related, peer-reviewed literature that detailed an actionable intervention during 2022. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight actionable interventions used by antimicrobial stewardship programs to capture potentially effective strategies for local implementation.

Digital Health Literacy, Vaccine Information Sources, And Vaccine Acceptance Among Parents In Ontario: Quantitative Findings From A Mixed Methods Study, Sarah Ashfield, Lorie Donelle Phd, Rn, Fcan, Panagiota Tryphonopoulos, Ève Dubé, Maxwell Smith

Publications

Parents make important vaccination decisions for their children and many variables affect parents' decisions to accept or decline vaccines. Parents are tasked with locating, understanding, and applying information to inform health decisions often using online resources; however, the digital health literacy levels of parents are unknown. The purpose of this study was to investigate parents' digital health literacy levels, their sources for vaccine information, and analyze how demographics, digital health literacy, health literacy, parental attitudes and vaccine beliefs, trust, and vaccine information sources predict vaccine acceptance. Quantitative findings of a mixed methods study that examined parental vaccine decision making across …

Use Of Machine Learning Approaches To Predict Transition Of Retention In Care Among People Living With Hiv In South Carolina: A Real-World Data Study, Ruilie Cai, Xueying Yang Ph.D., Yunqing Ma, Hao H. Zhang, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Maintaining retention in care (RIC) for people living with HIV (PLWH) helps achieve viral suppression and reduce onward transmission. This study aims to identify the best machine learning model that predicts the RIC transition over time. Extracting from the enhanced HIV/AIDS reporting system, this study included 9765 PLWH from 2005 to 2020 in South Carolina. Transition of RIC was defined as the change of RIC status in each two–year time window. We applied seven classifiers, such as Random Forest, Support Vector Machine, eXtreme Gradient Boosting and Long–short–term memory, for each lagged response to predict the subsequent year's RIC transition. Classification …

Medicaid Managed Care Restrictions On Medications For The Treatment Of Opioid Use Disorder, Maureen T. Stewart, Christina M. Andrews Ph.D., Sage R. Feltus, Dominic Hodgkin, Constance M. Horgan, Cindy Parks Thomas, Thuong Nong

Faculty Publications

Objective: To examine whether Medicaid managed care plan (MCP) utilization management policies for buprenorphine–naloxone and injectable naltrexone are related to key state Medicaid program policy decisions. Data Sources and Study Setting: We abstracted data on state Medicaid regulatory and policy information from publicly available sources and publicly available insurance benefit documentation from all 241 Medicaid MCPs operating in 2021. Study Design: In this cross-sectional study, we used bivariate and multivariate analyses to examine whether Medicaid MCP prior authorization and quantity limits on receipt of buprenorphine and injectable naltrexone were associated with key state Medicaid choices to leverage federal funds to …

Human Mobility And The Infectious Disease Transmission: A Systematic Review, M. Naser Lessani, Zhenlong Li, Fengrui Jing, Shan Qiao Ph.D., Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Recent decades have witnessed several infectious disease outbreaks, including the coronavirus disease (COVID-19) pandemic, which had catastrophic impacts on societies around the globe. At the same time, the twenty-first century has experienced an unprecedented era of technological development and demographic changes: exploding population growth, increased airline flights, and increased rural-to-urban migration, with an estimated 281 million international migrants worldwide in 2020, despite COVID-19 movement restrictions. In this review, we synthesized 195 research articles that examined the association between human movement and infectious disease outbreaks to understand the extent to which human mobility has increased the risk of infectious disease outbreaks. …

Challenges And Opportunities In Recruiting Research Participants Using Facebook: Lessons Learned From An Exemplar Study, Sarah Ashfield, Lorie Donelle Phd, Rn, Fcan, Maxwell Smith, Ève Dubé, Panagiota Tryphonopoulos

Publications

BACKGROUND: Facebook is a prominent social medial platform frequently used for business marketing. Researchers are starting to recognize the utility of this platform for developing research awareness, information dissemination, and more recently participant recruitment. PURPOSE: This paper will provide an overview of methods used in Facebook recruitment through an exemplar study. It will highlight successes and challenges and provide insight into future opportunities for its' use. METHODS: Two methods of Facebook recruitment are outlined in this paper: the use of Facebook groups and paid advertising. A step-by-step guide highlights how researchers can implement these specific methods of Facebook recruitment. RESULTS: …

October 4, 2023 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Increasing Hpv Vaccination Uptake In Female College Students Aged 18-26, Gabrielle B. Scott

Doctor of Nursing Practice Scholarly Projects

Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. Most people infected with HPV remain asymptomatic, but infections may result in several types of cancer. Three HPV vaccines are available with the recommended initiation of vaccination between 11–12 years, but the vaccine may be administered to females through 45 years old. Despite HPV vaccine efficacy, vaccination rates among college-age students remain low, particularly in certain geographical areas such as the Southeastern United States. This project aimed to increase HPV vaccination uptake among females between the ages of 18-26 in the Women’s Health Clinic through patient education …

Application Of Computational Tools To Identify Variations Associated With Peromyscus Dominant Spot, Zhenhua Shang

Theses and Dissertations

Peromyscus are the most prevalent mammalian species in North America, and they're employed extensively in both laboratory and field studies. P. maniculatus and P. polionotus, the deer mouse and the old-field mouse, are closely related and can produce viable and fertile hybrid offspring. However, a comprehensive database of polymorphisms, particularly in those kept as living stocks and supplied to university researchers, is lacking. In chapter 2, we performed comparative genomic study on P. maniculatus and P. polionotus and used the polymorphic data to identify the range of genetic complexity that underlies physiological and behavioral differences between two species. We also …

The Intersectionality Of Rurality And Race On Covid-19 Vaccination Among Adults In The United States, Shiba Simon Bailey

Theses and Dissertations

Background Vaccination remains a cornerstone of public health, significantly contributing to the prevention and control of infectious diseases. During the COVID-19 pandemic, vaccine development was critical to prevent new SARS-Cov-2 infections. However, COVID-19 vaccination uptake among racial and ethnic minority populations and rural residents in the United States (US) lags behind their urban non-Hispanic White counterparts. Underlying causes of these disparities are unclear, but vaccine hesitancy, access to care barriers, and structural racism may be to blame. Such barriers may vary by residential urbanicity, leading to different racial/ethnic disparities in rural and urban America. Understanding the variations in vaccine uptake …

Antimicrobial Polymers And Small Molecules From Multicyclic Compounds And Engineering Of Sustainable Polymers, Leman Buzoglu Kurnaz

Theses and Dissertations

In this dissertation, the synthesis of polymers and small molecules from multicyclic compounds and the development of sustainable polymers from renewable feedstock were investigated. The antimicrobial biomaterials and sustainable polymers were characterized and their properties were discussed. In Chapter 1, the overall background and recent developments of antimicrobial biomaterials and their application were discussed. Later, sustainable polymers from renewable biomass and their synthesis methods were given. Afterward, the main research objectives of this doctoral research study were described. In Chapter 2, the synthesis of multiple charged small molecules from multicyclic compounds was discussed. These compounds were obtained by using various …

From Oceans To Public Health: Impact Of Climate Change And Socioecological Factors On Non-Cholera Vibrio Spp., Karlen Enid Correa Vélez

Theses and Dissertations

Climate change-induced stressors, such as temperature, salinity, pH, and wildfire, are contributing factors to the increase in frequency of Vibrio infections, altering Vibrio geographical constraints. At the same time, the expansion of the coastal population is resulting in increased input of treated municipal wastewater into areas that are also experiencing Vibrio proliferation. Given that increases in ocean temperature and sea level coupled with increases in human activity in coastal waters support greater Vibrio-human interactions, it is important to examine factors and mechanisms within this socio-ecological coupled system that may further strengthen this interaction. This study aimed to better understand the …

Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek

Theses and Dissertations

Disregard for soil, an essential natural resource, hinders global food production. Food insecurity is a major concern for both public health officials and environmental scientists due to soil quality decline, pollution, and climate change. Alternatives or targeted additions to chemical fertilizers can bolster soil quality, improve crop yields, lengthen crop shelf life, and mitigate environmental pollution. One potential alternative to chemical fertilizers is replacement of them with biological soil amendments, including algae, to enhance crop growth and improve soil health. Research was conducted at the University of South Carolina-Columbia campus garden to determine impacts of non-toxic freshwater algae on crop …

Correlates Of Immunization Timeliness In Three South Asian Countries: Secondary Analysis Of Demographic And Health Surveys, Tanzir Ahmed Shuvo

Theses and Dissertations

Despite the availability of effective vaccines, 1.5 million children under the age of 5 years die every year because of vaccine preventable diseases. Improvements in vaccine delivery infrastructure have resulted in relatively high coverage of vaccines, but many children are not receiving their vaccines on a timely basis. Timely administration of routine vaccines recommended by the Expanded Programme on Immunization (EPI) ensures maximum efficacy. It is vital to explore rates of vaccination timeliness and the correlates of timely vaccination among children to design targeted interventions for improving both coverage and timeliness. We conducted a secondary data analysis of the Demographic …

The Effect Of Antibiotics On Immune Cell Infiltration Of Colon In A Mouse Model Of Early Onset Colorectal Cancer, Valerie Hinsch

Theses and Dissertations

Early onset colorectal cancer (EOCRC) is an aggressive form of colorectal cancer diagnosed before the age of 50. While colorectal cancer cases in patients 50 years and older have been declining, EOCRC cases have been steadily increasing globally in the last few decades, and the cause is unknown. Many agents, called exposomes, have been associated with EOCRC based on their emergence and prevalence prior to and in parallel with the rise in EOCRC cases. Among these are antibiotics (Abx). Abx are indispensable in our fight against infectious diseases, however their overuse is becoming a global epidemic. They are prescribed globally, …

Weathering The Covid-19 Pandemic: A Study Examining How The Lived Experience Affected English Learners, Mary Kathryn Maxwell

Theses and Dissertations

The COVID-19 pandemic profoundly impacted many students, especially the English learners who require specialized instruction and additional support to develop English language proficiency. This study examines how the pandemic created barriers that caused a decline in the academic achievement and engagement in the learning process of sixth-eighth grade English learners in an urban district in Ohio. In this mixed-methods study, using an explanatory sequential research design, quantitative data were collected through an online Likert survey while qualitative data were gathered from semi-structured interviews, artifacts, and researcher field notes. A total of 21 participants completed the survey and interviews. The merged …

The Utility Of Bayesian Predictive Models To Forecast Arboviruses In The United States Of America And Territories, Maggie Suzanne Jennave Mccarter

Theses and Dissertations

Statistical models have been utilized to understand and forecast infectious diseases across the globe. However, these models have historically been difficult to access and interpret for non-specialist audiences. This dissertation focuses on one computationally efficient model fitting method, the integrated nested LaPlace approximation approach, to forecast three arboviruses in hopes of encouraging accessibility to statistical modelling. Such accessibility could provide areas who simultaneously are most susceptible to infection, and have the least resources, an invaluable tool for informing policy and prevention decisions. The resulting models included biological, land cover, and environmental factors and produced accurate forecasts of neuroinvasive West Nile …

September 6, 2023 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Developing A Safe And Effective Papillomavirus Screen To Be Used On College Students At A South Carolina University, Owen R. Smith, Nicole E. Frantz, Emily E. Bishop, Rahjai G. Thomas, Paul E. Richardson

Journal of the South Carolina Academy of Science

No abstract provided.

Identification Of A Small Regulatory Rna Usps Associated With The Universal Stress Protein In Lactobacillus Species, Zarah M. Fowler, Sasha S. Bronovitskiy, Finn K. Rose, Brian M. Lee

Journal of the South Carolina Academy of Science

The gut microbiome is a complex habitat with many bacterial species, each playing crucial roles in regulating various physiological processes in the body. As the use of probiotics to combat human disease continues to increase, it is important to understand the mechanisms by which probiotic bacteria regulate their interactions with other bacteria and their host. Our exploration of the physiological functions of probiotic bacteria hopes to elucidate the role of small regulatory RNA (sRNA) in regulating gene expression within the microbiome. The goal of this project was to characterize the structure and function of the sRNA, UspS, which is found …

Developing An Ethical Framework-Guided Instrument For Assessing Bias In Ehr-Based Big Data Studies: A Research Protocol, Shan Qiao Ph.D., George Khushf, Xiaoming Li, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D.

Faculty Publications

Introduction The emergence of Big Data health research has exponentially advanced the fields of medicine and public health but has also faced many ethical challenges. One of most worrying but still under-researched aspects of the ethical issues is the risk of potential biases in data sets (eg, electronic health records (EHR) data) as well as in the data curation and acquisition cycles. This study aims to develop, refine and pilot test an ethical framework-guided instrument for assessing bias in Big Data research using EHR data sets.

Methods and analysis Ethical analysis and instrument development (ie, the EHR bias assessment guideline) …

Perceptions Of Covid-19 And The Use Of Health Information Technology Among People Who Are Uninsured: Multimethod Survey Study, Khushi S. Patel, Cynthia F. Corbett Phd, Rn, Faan, Elizabeth M. Combs, Sara B. Donevant, Margaret J. Selph, Lynette M. Gibson, Robin Dawson Phd, Rn, Cpnp-Pc, Amit P. Sheth, Ronda G. Hughes

Publications

BACKGROUND: As of May 2023, the novel SARS-CoV-2 has claimed nearly 7 million lives globally and >1.1 million lives in the United States. Low-income populations are often disproportionately affected by risk factors such as lifestyle, employment, and limited health literacy. These populations may lack the knowledge of appropriate infection precautions or have reduced access to care during illness, particularly in countries without universal health care.

OBJECTIVE: We aimed to explore the perceptions and experiences of COVID-19, including symptoms and risk factors among uninsured individuals seeking care at a free medical clinic, and to obtain respondents' perceptions of and suggestions for …

Whose Social Capital?: Citation And Co-Citation Patterns Of A Fragmented Concept, Jimi Adams, Kate Vinita Fitch

Faculty Publications

Despite its wide use across the social sciences, social capital research has been regularly criticized as having fuzzy conceptualization, resulting in multiple (potentially conflicting) operationalizations. Our analyses employ bibliometric analytic tools to demonstrate the disconnected structure of social capital research. The resulting visualization illustrates one potential source of the confusion surrounding social capital—that there are many, potentially nonoverlapping versions of the idea rather than one unified social capital concept.

Implementation Of Daily Multidisciplinary Rounding Audits Of Adherence To An Indwelling Catheter Protocol Impact On Catheter-Associated Urinary Tract Infections, Jacqueline April Wright

Doctor of Nursing Practice Scholarly Projects

Problem Statement: Catheter-associated urinary tract infections (CAUTIs) among critical care patients negatively impact the trajectory of the patient’s hospitalization through increased mortality, morbidity, length of stay, and cost. To combat this, hospitals have implemented bundles in compliance with evidence-based practice models to reduce CAUTIs. Purpose: Determine if implementing a daily multidisciplinary rounding audit of established CAUTI prevention protocol decreases the occurrence of CAUTIs in critical care patients with indwelling urinary catheters. Methods: Participants in this quality improvement project included critical care nurses and providers participating in daily multidisciplinary rounds on all critical care patients with indwelling urinary catheters admitted to …

Laboratory Management Models In Core Facilities, Karmen Michael Owen

Theses and Dissertations

Core biotechnology facilities are often defined as laboratories that house shared resources for research. These laboratories are of great importance to research communities because a large portion of scientific research data is generated at these facilities. Different investigators can use core facilities to help further their research. In a university setting, there are several management strategies from small cores that house a specific type of instrument, to large cores that house many different technologies. Funding strategies also differ significantly, from those that are funded by a small group of well-funded investigators, to cores managed by a specific department or school, …

Long-Chain Fatty Acid Sensing And Catabolism In Commensal Escherichia Coli Impact Murine Gut Colonization, Tessa Carolina Cox

Theses and Dissertations

The gastrointestinal tract is home to trillions of microbes that collectively influence host physiology, immunity, nutrient metabolism, and infectious disease. The overgrowth of naturally-occurring Escherichia coli in the gut is a common signifier of microbiome dysfunction and occurs in many chronic diseases including obesity. Recent studies have shown that higher fat intake is associated with increased gut E. coli growth. However, it remains unknown whether gut E. coli utilize lipids such as long chain fatty acids (LCFAs) as carbon sources to colonize the mammalian gut. Therefore, the central objective of my dissertation was to utilize bacterial genetics and various mouse …

Bayesian Spatial And Spatio-Temporal Models For Complex Data Sets, Rongjie Huang

Theses and Dissertations

The cost of testing for infectious diseases can be high, and analyzing large amounts of historical data to forecast disease prevalence can be a time-consuming process. Group testing techniques offer a way to decrease the expenses associated with testing, but this comes at the cost of increased complexity of the data structure due to grouping and imperfect testing when compared to individual-level testing. In this dissertation research, we propose two Bayesian mixed effects spatial group testing regression models: one for areal data and the other for point process data. The former model utilizes a conditional autoregressive (CAR) prior for areal …