Digital Commons Network^™

An Evidence-Based Intervention To Increase Trypanosoma Cruzi, A Neglected Parasitic Infection, Diagnosis In Rural And Moderate-Size-City Us Clinics, M K. Lynn, Hunter M. Boehme, Jeffrey Hall, Patrick Kent, Alain H. Litwin, Quang H. Pham, Melissa Nolan Ph.D., Mph, Prisma Chagas Team

Faculty Publications

Background

Chagas disease is a chronic, insidious parasitic infection (Trypanosoma cruzi) that slowly develops to irreversible organomegaly over several decades. The disease is traditionally acquired in endemic Latin American countries during childhood; < 1% of foreign-born adult residents in the United States have been diagnosed or treated with this potentially fatal disease. Low physician knowledge is a primary factor leading to misdiagnosis.

Methods

Starting in April 2022, a 4-part T cruzi clinical education intervention began, which included (i) 2 grand rounds presentations to >100 internal medicine providers; (ii) implementation of a “clinical Chagas champions program” incorporating 14 key clinical staff at varying departments and administrative levels educated on their specific role related to T cruzi screening, diagnosis confirmation, clinical management, and medical billing; ( …

Exploring The Association Between Smartphone-Based Place Visitation Data And Neighborhood-Level Coronary Heart Disease In The United States, Temitope Akinboyewa, Zhenlong Li, Huan Ning, M. Naser Lessani, Louisa M. Holmes, Shan Qiao Ph.D.

Faculty Publications

Coronary Heart Disease (CHD) is the leading cause of death in the United States, affecting over 20.5 million adults. Previous studies link health behaviors – such as dietary behavior, physical activity, smoking, and alcohol consumption – to CHD risk. These studies typically use surveys and interviews, which, despite their benefits, are resource-intensive and limited by small sample sizes. Using large-scale national level anonymized smartphone-based location data, our study examines whether health behaviors that are proxy measured by place visitation are associated with CHD prevalence across US census tracts. This study utilized data from multiple sources, including demographic and socioeconomic characteristics, …

Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu

Faculty Publications

No abstract provided.

Expanding Functionalities Of Immune Receptors Through Simultaneous Transfer Of Sensor And Helper Nlrs, Dongjiao Wang, Qibin Wu, Daowen Wang, Youxiong Que, Zheng Qing Fu

Faculty Publications

No abstract provided.

Spatial And Clinical Epidemiology Of Spotted Fever Rickettsioses And Ehrlichiosis, North Carolina, 2010–2019, Amanda Brown Marusiak, Dana A. Giandomenico, Brandon D. Hollingsworth Ph.D., Neha V. Mokashi, Paul L. Delamater, Michael Reiskind, Alexis M. Barbarin, Carl Williams, Ross M. Boyce

Faculty Publications

No abstract provided.

South Carolina Alternative Route Teacher Pipeline Report For 2023–24, Svetlana Dmitrieva, Brian Cartiff, Angela Starrett

Reports

This report presents a detailed analysis of South Carolina’s alternative route teacher workforce for the 2023–24 academic year, with a focus on preparation and retention. As part of SC TEACHER’s ongoing commitment to providing statewide educator workforce profiles, this publication, along with SC TEACHER’s broader research, offers timely, actionable data to inform educators, policymakers, and other stakeholders.

The findings presented here are based on educator-level data provided by the South Carolina Department of Education (SCDE) for 2023–24, along with longitudinal data from the 2019–20 through 2022–23 academic years. The 2023–24 analyses reflect a sample of 5,079 educators affiliated with state-approved …

Integrated Algorithm And Hardware Design For Hybrid Neuromorphic Systems, James Seekings, Mahsa Ardakani, Peyton Chandarana, Arshia Eslami, Mohammadreza Mohammadi, Ramtin Zand

Faculty Publications

This paper investigates the combined potential of neuromorphic and edge computing to develop a flexible machine learning (ML) system designed for processing data from dynamic vision sensors. We build and train hybrid models that integrate spiking neural networks (SNNs) and artificial neural networks (ANNs) using the PyTorch and Lava frameworks. We explore the effects of quantization on ANN models to assess its impact on both accuracy and energy efficiency. Additionally, we address the challenges of deploying hybrid models on hardware by implementing individual components on specific edge platforms. We also propose an accumulator circuit to bridge the spiking and non-spiking …

Growth Of Cylindrical Micelles And Their Use To Prepare Porous Materials With Tailored Dimensions And Alignment, Mengxue Zhang, Xiaomeng Li, Chuanbing Tang, Morgan Stefik

Faculty Publications

Materials with cylindrical pores are optimal for electrochemical devices and filtration due to their straight paths with minimal tortuosity when aligned. Polymer templates have led to many individual cylindrical architectures however the independent tailoring of pore and wall dimensions has remained elusive. Here short cylindrical micelle templates (PEO-b-PS) with glassy cores enabled the fabrication of sample series with constant cylindrical pore diameter (∼63 nm) and tailored wall thickness (TiO₂, ∼45–100 nm). This ShortCyl series (aspect ratio 4.25) had modest alignment that was attributed to the low free-energy cost for misalignment. Though the plasticized micelles (DCM present) …

Changes In Mental Health Care Utilisation Before And During The Covid-19 Pandemic Among People Living With Hiv In The Usa: A Retrospective Cohort Study Using The All Of Us Dataset, Atena Pasha, Shan Qiao, Jiajia Zhang Ph.D., Ruilie Cai, Buwei He, Xueying Yang, Chen Liang Ph.D., Sharon Weissman, Xiaoming Li Ph.D.

Faculty Publications

Introduction Despite the profound impact of the COVID-19 pandemic on people living with HIV (PLWH) mental health, large-scale, real-world data on mental healthcare utilisation and associated factors among PLWH remain limited. This study explores mental healthcare utilisation and associated factors among PLWH during the COVID-19 pandemic.

Methods Using a retrospective cohort design, we identified and included 4575 PLWH through computational phenotyping based on relevant Observational Medical Outcomes Partnership Common Data Model concept sets from the All of Us programme between March 2018 and March 2022. Mental healthcare utilisation was measured using the yearly count of mental healthcare visits and compared …

Mental Distress And Resource Insecurity In The Kingdom Of Tonga After The 2022 Volcanic Eruption: Associations Of Water And Food Insecurity With Mental Distress, Hilary J. Bethanancourt, Indira Bose, Lupe Moala Tupou, Melissa Meinhart, Edward A. Frongillo Jr. Ph.D., Amelia Greaves, Sera L. Young

Faculty Publications

Background Water and food insecurity can harm mental health; all 3 may, in turn, be exacerbated by humanitarian crises. The linkages between food insecurity, water insecurity, and mental health are gaining attention but have not been investigated after a natural disaster.

Objective To investigate the associations between food insecurity, water insecurity, and mental distress, and how these relationships may differ between women and men, in the aftermath of the January 15, 2022, volcanic eruption in the Kingdom of Tonga.

Design Secondary analysis of nationally representative cross-sectional data from the Equality Insights Rapid survey collected 4 to 5 months after the …

Neighborhood Socioeconomic Status And Overall Survival Among Children With Acute Lymphoblastic Leukemia, Anna Hoppmann, Debroah M. Hurley, Stuart Cramer, Monique J. Brown Ph.D., Mph

Faculty Publications

A disadvantaged neighborhood, as represented by area-level socioeconomic status (SES) has been associated with adverse outcomes among children with acute lymphoblastic leukemia (ALL) in the US, but the duration of impact after ALL diagnosis is not well understood. This retrospective cohort study utilized the National Cancer Database (NCDB) to examine the impact of area-level SES on overall survival among children with ALL. Median income and education quartiles based on residential zip code were used to create a composite area-level SES variable. Individual-level variables included age, sex, race, year of diagnosis, primary payer, distance to care, rurality, time to treatment, and …

Sex-Related Measurement Bias In Autism Spectrum Disorder Symptoms In The Baby Siblings Research Consortium, Catherine A. Burrows, Sooyeon Sung, Shuting Zheng, Greg S. Young, Tony Charman, Cherly Klaiman, Ami Klin, Natasha Marrus, Sally Ozonoff, Joseph Piven, Diana L. Robins, Rebecca J. Schmidt, A. J. Schwichtenberg, Sara Jane Webb, Lonnie Zwaigenbaum, Leslie J. Carver, Katarzyna Chawarska, Suzanne Curtin, Shafali S. Jeste, Jana M. Iverson, Jane E. Roberts

Faculty Publications

Importance Disparities exist in age of diagnosis and prevalence of autism spectrum disorder (ASD) for female compared with male children. Correcting for sources of bias is critical for improving equitable ASD identification.

Objective To determine whether sex differences exist in measurement of ASD symptoms using the Autism Diagnostic Observation Schedule (ADOS) among young children at high familial likelihood (HFL) and low familial likelihood (LFL) of ASD.

Design, Setting, and Participants This cohort study collected longitudinal, prospective data from the Baby Siblings Research Consortium between January 1, 2003, and December 31, 2021. Participants included 3106 children who had an older sibling …

Sex-Related Measurement Bias In Autism Spectrum Disorder Symptoms In The Baby Siblings Research Consortium, Catherine A. Burrows, Sooyeon Sung, Shuting Zheng, Tony Charman, Cheryl Klaiman, Ami Klin, Natasha Marrus, Sally Ozonof, Joseph Piven, Diana L. Robins, Rebecca J. Schmidt, A. J. Schwichtenberg, Sara Jane Webb, Lonnie Zwaigenbaum, Leslie J. Carver, Katarzyna Chawarska, Suzanne Curtin, Shafali S. Jeste, Jana M. Iverson, Rebecca J. Landa, Daniel S. Messinger, Jane E. Roberts, Wendy L. Stone, Helen Tager-Flusberg, Amy N. Esler, Meghan Miller, Somer L. Bishop, Jed T. Elison

Faculty Publications

IMPORTANCE Disparities exist in age of diagnosis and prevalence of autism spectrum disorder (ASD) for female compared with male children. Correcting for sources of bias is critical for improving equitable ASD identification. OBJECTIVE To determine whether sex differences exist in measurement of ASD symptoms using the Autism Diagnostic Observation Schedule (ADOS) among young children at high familial likelihood (HFL) and low familial likelihood (LFL) of ASD. DESIGN, SETTING, AND PARTICIPANTS This cohort study collected longitudinal, prospective data from the Baby Siblings Research Consortium between January 1, 2003, and December 31, 2021. Participants included 3106 children who had an older sibling …

Assessing The Costs Of Constructed Floating Wetlands For The Treatment Of Surface Waters And Wastewater, John Awad, Christopher Walker, Declan Page, Muhammad Arslan, Sarah A. White, Terry Lucke, Simon Beecham, Ryan J. Winston, William H.J. Stonsnider, Phil Nicodemus, Chris Streb, John Van Leeuwen

Faculty Publications

The development of constructed floating wetlands (CFWs) as a nature-based solution for water treatment has progressed over the last 25 years. However, full-scale CFW adoption remains relatively limited due in part to the uncertainty regarding the costs of CFWs in terms of capital and operational expenditure (CAPEX and OPEX) and treatment capacity. This study reports on the costs of 11 international CFW schemes including the factors affecting CAPEX and OPEX and levelized costs of nitrogen and phosphorus removal. The estimated levelized CAPEX and OPEX ranged from US$15/m² to $2537/m² and from $0.5/m² y⁻¹ to $181/m² y⁻¹, respectively, for CFW schemes …

“I Want To Continue Athletics And I Also Want To Study”: Exploring International Student Athletes’ Transition Experiences To The Naia Affiliated Colleges, Kibaek Kim, Karina Jolly, Chris Corr, Jinwook Han

Journal of Issues in Intercollegiate Athletics

There are over a million international students pursuing their degrees in U.S. universities. Among them are 25,000 international student-athletes (ISAs) who are enrolled in National Collegiate Athletic Association (NCAA) affiliated Universities. While studies have been striving to foster and support this population’s successful transition to the U.S., few studies are available that deal with international student-athletes competing in the National Association of Intercollegiate Athletics (NAIA) affiliated universities. Hence, based on the transition theory, this study utilized focus group interviews to explore the transition experiences of ISAs competing in NAIA. Based on previous studies that explored the transition experiences of ISAs …

Meet The Fars: An Examination Of The Background, Roles, And Appointment Of Faculty Athletic Representatives At National Collegiate Athletic Association Member Institutions, Chris Corr, Christopher Atwater, Mark S. Nagel, Richard Southall, Rick Eckstein, Marek Taškár

Journal of Issues in Intercollegiate Athletics

As many National Collegiate Athletic Association (NCAA) member institutions continue to engage in athletic centric decision-making processes, academic integrity and the campus experience for college athletes is often marginalized. Mandated by the NCAA to represent athletes’ academic interests, the faculty athletics representative (FAR) position is designed to occupy a central role in maintaining the primacy of academia among college athletes. FARs, however, exist within an institutional setting muddled by competing and contradictory logics. Accordingly, given the inherent juxtaposition between the operation of collegiate athletics and the stated role of FARs, the present study sought to examine the characteristics and positional …

Proactive Planning For Contextual Fit: The Role Of The Implementation Premortem, Guillermo M. Wippold, Kaylyn A. Garcia, Ariel Domlyn, Dylan Wong, Maria E. Fernandez

Faculty Publications

Background

Implementation failure is a major barrier to program success. It is widely acknowledged that context matters—individual, community, and organizational norms, values, environment, and priorities influence successful program implementation. A mismatch between how the program was intended to be delivered and the constraints of the context in which it was delivered is a major cause of implementation failure. The barriers to implementation are usually understood after a program has failed. Although there are tools that can help accommodate for, or overcome, contextually-driven sources of implementation failure, there remains a significant gap – a tool and structured approach to analyze data …

October 7 And International Police Cooperation: The Silence Of Interpol, Mathieu Deflem

Faculty Publications

Aim: The aim of this study is to explore the background and interpretation of Interpol’s silence following the terrorist attacks committed by Hamas against Israel on October 7, 2023. The author examines the international policing im-plications of the events, with special attention to why the world’s largest police organization failed to issue any substantive response.

Methodology: The research is based on asociological analysis combining ahistorical and institutional overview of Interpol’s counterterrorism activities with the examination of the organization’s communications and institutional decisions. It relies on qualitative sources and an interpretive, case study-based approach using public documents, records, and statements.

Findings: …

Application And Comparison Of Satellite-Derived Sea Surface Temperature Gradients To Identify Seasonal And Interannual Variability Off The California Coast: Preliminary Results And Future Perspectives, Jorge Vazquez-Cuervo, Marisol García-Reyes, David S. Wethey, Daniele Ciani, Jose Gomez-Valdes

Faculty Publications

The application of satellite-derived sea surface temperature in coastal regions is critical for resolving the dynamics of frontal features and coastal upwelling. Here, we examine and compare sea surface temperature (SST) gradients derived from two satellite products, the Multi-Scale Ultra-High Resolution SST Product (MUR, 0.01° grid scale) and the Operational SST and Ice Analysis (OSTIA, 0.05° grid scale), available through the Group for High Resolution SST (GHRSST). Both products show similar seasonal variability, with maxima occurring in the summer time frame. Additionally, both products show an increasing trend of SST gradients near the coast. However, differences exist between the two …

A 12,800-Year-Old Layer With Cometary Dust, Microspherules, And Platinum Anomaly Recorded In Multiple Cores From Baffin Bay, Christopher R. Moore, Vladimir A. Tselmovich, Malcolm A. Lecompte, Allen West, Stephen J. Culver, David J. Mallinson, Mohammed Baalousha M.Sc, Ph.D., James P. Kennett, William M. Napier, Michael Bizimis, Victor Adedeji, Seth R. Sutton, Gunther Kleteschka, Kurt A. Langworthy, Jesus P. Perez, Timothy Witwer, Marc D. Young, Jordan Jeffreys, Richard C. Greenwood, James A. Malley

Faculty Publications

The Younger Dryas Impact Hypothesis (YDIH) posits that ~12,800 years ago Earth encountered the debris stream of a disintegrating comet, triggering hemisphere-wide airbursts, atmospheric dust loading, and the deposition of a distinctive suite of extraterrestrial (ET) impact proxies at the Younger Dryas Boundary (YDB). Until now, evidence supporting this hypothesis has come only from terrestrial sediment and ice-core records. Here we report the first discovery of similar impact-related proxies in ocean sediments from four marine cores in Baffin Bay that span the YDB layer at water depths of 0.5–2.4 km, minimizing the potential for modern contamination. Using scanning electron microscopy …

Radioactive Contamination And Climate Warming Affect Physiological Performance Of Chornobyl Barn Swallows, Zbyszek Boratyríski, Timothy Mousseau, Anders Pape Møller

Faculty Publications

Global warming and degradation of natural habitats are the two main factors causing ecophysiological stress on individuals and risk for biodiversity. Hyperthermia is a common response to stress in homeothermic animals, in particular to heat, pathogens and environmental contamination. Resilience of biological systems to global warming may be deteriorated in polluted habitats. Here we investigated how body temperature of a wild bird, the barn swallow (Hirundo rustica), responded to global warming while simultaneously exposed to radioactive contamination from the Chernobyl accident. Our results showed that both high air temperatures (t = 15.55, df = 335, p <  0.0001) and elevated environmental radioactive contamination (t = 5.18, df = 8.09, p = 0.0008) increased internal body temperature of individuals. The additive effect suggests that birds might suffer hyperthermia in locally contaminated habitat (1.47% body temperature increase) while simultaneously exposed to globally rising temperatures (1.95% body temperature increase), potentially reducing the fitness of individual and the maintenance of breeding colonies. The cumulative and interactive negative effects of multiple stressors, such as those emerging from increasing habitat degradation and climate change, will likely contribute to biodiversity losses globally.

“I Laughed Along For Years But Hated It Inside:” Understanding Nuance In Peer Teasing Experiences Using A Thematic Analysis, Naomi C.Z. Andrews, Molly Dawes Ph.D.

Faculty Publications

Introduction

Peer teasing is ubiquitous, yet ambiguous in nature. Despite recent attempts to delineate and clarify differences in teasing experienced as playful versus harmful, there remains overlap and complexity in these interactions. In the current study, we present a conceptual model of teasing, which includes many nested features that dynamically interact within a teasing episode. Using this conceptual model to guide our work, the goal of the current study was to use qualitative inquiry to bring further conceptual clarity to the overlap between teasing that is experienced as playful versus harmful.

Method

Using semi-structured interviews, we asked university students ( …

Absence Of Phonon Softening Across A Charge Density Wave Transition Due To Quantum Fluctuations, Yubi Chen, Terawit Kongruengkit, Andrea Capa Salinas, Runqing Yang, Yujie Quan, Fanghao Zhang, Ganesh Pokharel, Linus Kautzsch, Stephen D. Wilson, Sai Mu

Faculty Publications

Kagome metals have emerged as a frontier in condensed matter physics due to their potential to host exotic quantum states. Among these, CsV₃Sb₅ has attracted significant attention for the unusual coexistence of charge density wave (CDW) order and unconventional superconductivity, presenting an ideal system for exploring the emergent phenomena from the interplay of phonons, electronic fluctuations, and topological effects. The nature of CDW formation in CsV3Sb5 is unconventional and has sparked considerable debate. In this study, we examine the origin of the CDW state via ab initio finite-temperature simulations of the lattice dynamics. Through a comparative study …

Expanded Genetic And Functional Diversity Of Oceanic Fungi, Xuefeng Peng, David L. Valentine

Faculty Publications

Background

Fungi are known members of marine microbiomes that can act as saprotrophs, parasites, and pathogens. Although a few studies utilizing cultivation-based methods and metabarcoding have been conducted, the diversity, ecological roles, and functional activities of fungi in the open ocean remain vastly underexplored. This gap in knowledge is particularly notable in oxygen minimum zones (OMZ) of the ocean, which have expanded over the past 50 years, affecting marine ecosystems and biogeochemical cycles. The eastern tropical North Pacific Ocean (ETNP) is the largest oxygen minimum zone where fungi have been implicated in the production of the potent greenhouse gas nitrous …

The Ring-Finger Ubiquitin E3 Ligase Rfel1 Targets Wheat Npr3 For Degradation To Confer Broad-Spectrum Resistance Against Biotrophic Fungal Pathogens, Liuhui Qiao, Kunpu Zhang, Jinyan Li, Ziming Zhang, Xiao Sun, Huiyun Liu, Ziyue Li, Nannan Ni, Ximei Ma, Jianhui Zhao, Guangwei Li, Xiaohuan Jin, Wenming Zheng, Daowen Wang, Zheng Qing Fu, Huan Wang

Faculty Publications

No abstract provided.

Examining The Effects Of Firearm Lethality And Aggressors’ Intentions To Kill On Injurious Firearm Violence At American Schools: A Research Note, Brent R. Klein, Cory Schnell, Steven M. Chermak, Joshua D. Freilich

Faculty Publications

This study examined firearm lethality and aggressors’ lethal intent on injurious fatal and nonfatal school shootings using data from The American School Shooting Study, which covers 329 school shootings in the United States from 1990 to 2016. We developed a new multidimensional construct for measuring shooters’ determination to kill and examined firearm characteristics while considering confounding factors. We identified 11 distinct categories of shooters’ intent, with most showing a strong desire to kill. Both intent and weapon lethality significantly impacted school shooting homicides. Overall, we recommend that prevention and theoretical models should address both factors.

Scaling Laws Of Political Regime Dynamics: Stability Of Democracies And Autocracies In The Twentieth Century, Paula Pirker-Diaz, Matthew Wilson, Soenke Beier, Karoline Wiesner

Faculty Publications

In light of the current rise of authoritarian regimes and the anti-liberal tendencies in some established democracies, understanding the dynamic and statistical properties of political regimes is of critical importance. Despite their relevance, a comprehensive quantitative assessment of these dynamics on a historical scale remains largely unexplored, and the notion that democratization is an irreversible process has gone mostly unchallenged. This study provides a rigorous and quantitative analysis of political regimes worldwide by examining changes in freedoms of expression, association and electoral quality throughout the twentieth century. Utilizing the multidimensional V-Dem dataset, which covers over 170 countries across more than …

Sccosmix: A Mixed-Effects Framework For Differential Coexpression And Transcriptional Interactions Modeling In Single-Cell Rna-Seq, Anderson Bussing, Giampiero Marra, Daping Fan, Russell Shinohara, Danni Tu, Yen-Yi Ho

Faculty Publications

Advancements in single-cell RNA-sequencing (scRNA-seq) technologies generate a wealth of gene expression data that provide exciting opportunities for studying gene-gene interactions systematically at individual cell resolution. Genetic interactions within a cell are tightly regulated and often highly dynamic in response to internal cellular signals and external stimuli. Evidence of these dynamic interactions can often be observed in scRNA-seq data by examining conditional co-expression changes. Existing approaches for studying these dynamic interaction changes in scRNA-seq data do not address the multi-subject hierarchical design commonly considered in single-cell experiments. In this paper, we propose a Mixed-effects framework for differential Coexpression and transcriptional …

Activation And Suppression Mechanisms Of The Nrg1 Helper Nlrs, Yu-Ru Wang, Ruize Zhang, Daowen Wang, Yong Wang, Zheng Qing Fu

Faculty Publications

No abstract provided.

Curved Confinement Directs Anchoring-Mediated Structural Transitions In Highly Chiral Liquid Crystal Shells, Sepideh Norouzi, Jeremy Money, Stiven Villada-Gil, José Martínez-Gonález, Monirosadat Sadati

Faculty Publications

Cholesteric liquid crystals (CLCs) confined in curved geometries exhibit a rich spectrum of defectmediated morphologies governed by the interplay between chirality, curvature, surface anchoring, and confinement. This study systematically investigates structural transitions in highly chiral CLC shells under asymmetric anchoring conditions, focusing on the effects of shell thickness and curvature on pitch axis reorientation and defect formation. Utilizing microfluidic techniques, we generate core–shell droplets with independently tunable anchoring at inner and outer aqueous interfaces. Transitioning from planar–planar to planar-homeotropic boundary conditions via surfactant-mediated modulation induces profound reorganizations in the director field, giving rise to focal conic domains (FCDs), stripe patterns, …