Digital Commons Network^™

Emotions And Cognition, Krystal D. Becks

Theses and Dissertations

Background: Cognitive functioning is linked to emotional processes, with this relationship shaped by various biological (e.g., age, sex, diseases, and genetics), psychological (e.g., emotional well-being, coping strategies, mental health), and sociological (e.g., income and education) factors. Understanding these interactions is critical for advancing research on cognitive-emotional health across diverse populations. Purpose: To examine the relationship between positive and negative emotions and cognitive functioning among healthy adults. Methods: This was a cross-sectional analysis of data from the Aging Brain Cohort (ABC) study (n=434). The independent variables were subsets from the NIH toolbox emotional battery. The dependent variables were from the NIH …

Iq Trends In Preschoolers With Autism And Co-Occurring Developmental Delay Are Associated With Autism Severity Not Anxiety, Chandler Elizabeth Knott

Theses and Dissertations

Intellectual functioning constitutes a significant source of heterogeneity in individuals with autism spectrum disorder (ASD); however, little is known about how intellectual functioning manifests over development in preschool children with non-syndromic ASD (nsASD) and co-occurring global developmental delay (GDD) or how this relates to functionally impairing co-occurring conditions, such as anxiety. Study participants included 57 children with nsASD and co-occurring global developmental delay (ASD+GDD), 24 categorized with mild GDD, and 33 categorized with moderate GDD. Drawing on dynamic systems theory, the present study explored developmental trends within the context of multiple complex systems, including intelligence, social-emotional, and behavioral functioning. Moderated …

Self-Regulation In Children With Fragile X Syndrome: Biobehavioral Underpinnings, Familial Predictors, And Outcomes, Erin Evelyn Hunt

Theses and Dissertations

Self-regulation is a multifaceted construct that occurs on biological, cognitive, emotional, and behavioral levels. Self-regulatory abilities typically emerge in the first years of life and continuously develop through early adulthood. There is considerable interindividual variability in developmental trajectories of self-regulation which are associated with numerous adaptive and maladaptive outcomes. Factors influencing the development of self-regulation include interacting genetic and social environmental factors. Given the high heritability of self-regulation, within-family associations are common.

Individuals with Fragile X syndrome (FXS), an inherited, single-gene neurodevelopmental disorder, have heightened vulnerability for self-regulation deficits that are evident in early infancy; however, the developmental trajectories and …

Cerebellar Contributions To Speech And Clinical Outcomes In Stroke: A Multimodal Investigation Of Structural Integrity Across Chronic And Acute Cohorts, Makayla Joy Gibson

Theses and Dissertations

This dissertation investigates the critical role of the cerebellum in speech production, with a focus on chronic post-stroke apraxia of speech (AOS), lesion-related cerebellar degeneration, and age-related changes in cerebellar structure among healthy individuals. While speech deficits have traditionally been attributed to cortical lesions, mounting evidence suggests that the cerebellum contributes significantly to speech-motor planning, execution, and error correction. Using multimodal neuroimaging, lesion-symptom mapping, and standardized speech assessments, this research examines cerebellar gray matter volume (GMV) across three complementary studies.

Aim 1 evaluates the association between cerebellar GMV and AOS severity in individuals with chronic left hemisphere stroke. Findings support …

Examining Effects Of A Cultural And Family Resilience Program On Improving Physical Activity And Eating Behaviors Among Overweight Black Adolescents, Mary Quattlebaum

Theses and Dissertations

Black adolescents have higher rates of physical inactivity, lower quality dietary intake, and fewer family meals compared to their White peers. These health inequities place Black adolescents at greater risk for overweight and obesity, as well as long-term health consequences, including chronic disease and early mortality. However, few health promotion programs have been successful in improving health behaviors among Black adolescents and families. Elevated rates of chronic stress, namely racial stress, among Black families may be a prominent obstacle for engagement in and effectiveness of health promotion initiatives. Limited family-based health promotion programs with Black families have incorporated cultural and …

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

Choice Overload In The Digital Age: A Cognitive Neuroscience Approach, Jacob Matthew Stanley

Theses and Dissertations

This dissertation examines the neural mechanisms of value-based multiattribute decision making through the lens of choice overload during consumer choice. Two behavioral experiments established that choice sets of a moderate size with nine options were perceived as most optimal compared to choice sets with three and 24 options, and options chosen from the largest set size were judged to be the least satisfying. A functional MRI study then examined how the brain responds to choice sets varying in size and complexity by manipulating the number of options presented as well as the presence of asymmetrically dominated decoy alternatives during a …

Origen Of Alexandria On Cancticles: Exegeses And Homilies As Forming Christian Identity, Annaline Bethany Cely

Theses and Dissertations

This dissertation focuses on how Origen of Alexandria, through both homilies and exegetical commentary practice, presents Canticles as a piece of literature fittingly understood as Scripture. For Origen, Scripture is the source text by which Christians can engage with God and mold their lives upon Christ. This dissertation mimics Origen's own methodology by performing a line-by-line reading of his work, which allows the reader immediate access to Origen's work while also acting as a commentary of Origen's commentary. As of Fall 2025, there are no commentaries in English on any Church Father (only translations) which is concerning as the reading …

Modification Of Nanoparticles For Designed Interfaces, Tony Lee Neely, Jr.

Theses and Dissertations

The work contained herein, is focused on the design, synthesis, and characterization of polymer nanocomposite interfaces and the property enhancement afforded from said interface design. Through the use of reversible addition fragmentation chain transfer (RAFT) polymerization for the grafting of polymer chains to silica nanoparticles, the surface of silica nanoparticles can be manipulated to tune the properties of the nanocomposite as a whole.

In the first part of this work, heterogeneity is introduced onto the surface of silica nanoparticles via a sequential RAFT polymerization to afford a bimodal brush system. A densely grafted, short brush population is polymerized from the …

Longitudinal Viral Load Clustering For People With Hiv Using Functional Principal Component Analysis, Yunqing Ma, Xueying Yang Ph.D., Jiayang Xiao, Xiaoming Li Ph.D., Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Background: Longitudinal measures of viral load (VL) are critical in monitoring the HIV status. While multiple lab indicators exist for monitoring measures of VL, research on clustering historical/longitudinal VL measures is limited. Analyzing longitudinal VL patterns rather than aggregated measures offers deeper insights into HIV status. This study uses functional data clustering to classify longitudinal VL patterns and characterize each cluster by demographics, comorbidities, social behaviors, and CD4 count.

Methods: Adult PWH diagnosed from 2005 to 2015 in South Carolina with a 5-year minimum follow-up were included. We compared functional principal component analysis (FPCA), K-means, hierarchical clustering, and Gaussian mixture …

Temporal Changes In Racial Disparities Of Hiv Linkage To Care From 2013 To 2020: A Statewide Cohort Analysis, Fanghui Shi, Katherine E. Weaver, Chen Zhang, Bankole Olatosi Ph.D., Jiajia Zhang Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Xueying Yang

Faculty Publications

Background: Racial disparities have historically existed regarding HIV care outcomes, including linkage to care. This study aims to explore the contribution of contextual features (e.g., socioeconomic and structural environmental factors) to the temporal change of county-level racial disparities in linkage to care.

Methods: This is a statewide population-based retrospective cohort study. The patient-level variables in the South Carolina HIV registry system were used to calculate the aggregated county-level linkage to care percentage. Then, we used four indices to measure racial disparities in the county-level percentage of timely linkage to care, i.e., the Black-White ratio, index of disparity (ID), weighted ID, …

Harnessing Big Heterogeneous Data To Evaluate The Potential Impact Of Hiv Responses Among Key Populations In Sub-Saharan Africa: Protocol For The Boloka Data Repository Initiative, Refilwe Nancy Phaswana Mafuya, Edith Phalane, Amrita Rao, Kalai Willis, Katherine Rucinski, K. Alida Voet, Amal Abdulrahman, Claris Siyamayambo, Betty Sebati, Mohlago Seloka, Musa Jaiteh, Lerato Lucia Olifant, Katharine Journeay, Haley Sisel, Xiaoming Li Ph.D., Bankole Olatosi Ph.D., Neset Hikmet, Prashant Duhoon, Francois Wolmarans, Yegnanew A. Shiferaw, Lifutso Motsieloa, Mashudu Rampilo, Stefan Baral

Faculty Publications

Background: In South Africa, there is no centralized HIV surveillance system where key populations (KPs) data, including gay men and other men who have sex with men, female sex workers, transgender persons, people who use drugs, and incarcerated persons, are stored in South Africa despite being on higher risk of HIV acquisition and transmission than the general population. Data on KPs are being collected on a smaller scale by numerous stakeholders and managed in silos. There exists an opportunity to harness a variety of data, such as empirical, contextual, observational, and programmatic data, for evaluating the potential impact of HIV …

Longitudinal Assessments Of Viral Rebound Among People With Hiv In South Carolina: A Population-Based Cohort Study, Jiayang Xiao, Xueying Yang Ph.D., Yunqing Ma, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Routinely monitoring viral rebound (VR) is important in the life course of people with HIV (PWH). This study examined risk factors for time to the first VR, the number of VRs and their association with VR history in men who have sex with men (MSM). It includes 8176 adult PWH diagnosed from January 2005 to December 2018, followed until July 2021. We used the Cox model for time to the first VR, the Poisson model for a number of VRs, and logistic regression for VR history in MSM. Younger individuals (50–59 years vs 18–29 years, aHR: 0.43, 95% CI: [0.34, …

Maternal Vulnerability Index And Severe Maternal Morbidity, Nansi S. Boghossian, Joshua Radack, Molly Passarella, Ciaran S. Phibbs, Lucy T. Greenberg, Jeffrey S. Buzas, George R. Saade, Jeannette Rogowski, Scott A. Lorch

Faculty Publications

Importance: Few studies have investigated the association of composite measures of neighborhood social determinants of health with severe maternal morbidity (SMM), and no research has examined this association for indices tailored to maternal health. Objective: To examine the association of scores in the Maternal Vulnerability Index (MVI), a tool developed to measure maternal risk of adverse health outcomes, with SMM. Design, Setting, and Participants: This retrospective, population-based cohort study was conducted in 5 states (2008-2020 for Michigan, Oregon, and South Carolina; 2008-2018 for Pennsylvania; and 2008-2012 for California) among individuals delivering a fetal death or a live birth between 22 …

Caregiving Burdens Of Task Time And Task Difficulty Among Paid And Unpaid Caregivers Of Persons Living With Dementia, Matthew Lee Smith, Jodi L. Southerland, Malinee Neelamegam, Gang Han, Shinduk Lee, Chung Lin Kew, Juanita Dawne R. Bacsu, Elyse Couch, Steffi M. Kim, Monique J. Brown Ph.D., Mph, Ayse Malatyali, Lucas Wilson, Zahra Rahemi, Jeremy Holloway, Marcia G. Ory

Faculty Publications

Background: Demands of caregivers of persons living with dementia (PLWD) are often influenced by the context of their caregiving situation. This study examines common and unique factors associated with caregiving burden in terms of task time and task difficulty among paid and unpaid caregivers of PLWD. Methods: Cross-sectional baseline survey data were analyzed from 107 paid and unpaid caregivers of PLWD participating in a larger NIH-funded study assessing the feasibility of using a novel in-situ sensor system. Oberst Caregiving Burden Scale constructs of task time and task difficulty served as dependent variables. Two least squares regression models were fitted, controlling …

Investing In The Development Of The Next Generation Of Mch Leaders, Karen A. Mcdonnell, Jamal Percy, Lisa Anders, Monique J. Brown Ph.D., Mph, Alice R. Richman, Julianna Deardorff, Monica S. Ruiz, Jihong Liu Sc.D., Kelli Russell, Audrey Snyder, Cassondra Marshall

Faculty Publications

The public health landscape is constantly evolving to address the strengths and needs of the community. Training for the public health workforce is leading the way, establishing an ecosystem approach that integrates individuals within social, political, and environmental contexts to promote health equity within a framework of social justice. One area of public health that is innovatively preparing the next generation of leaders is maternal and child health (MCH). In the United States, key indicators of health disparities within MCH remain stagnant, highlighting the need for training programs that develop future MCH professionals from diverse backgrounds. These professionals will deliver …

Associations Between County-Level E-Cigarette-Inclusive Tobacco 21 Law Population Coverage And E-Cigarette Use Behaviors Among United States Adolescents In Monitoring The Future, James H. Buszkiewicz, Catherine A. Vander Woude, Yanmei Xie, Steven Cook, Bukola Usidame Peters, Megan E. Patrick, Michael R. Elliott, James F. Thrasher Ph.D., Ma, Ms, Nancy L. Fleischer

Faculty Publications

Background and aims: In the United States (US), Tobacco 21 (T21) laws set the minimum legal sale age for all tobacco products to 21 years. This study aimed to examine whether e-cigarette-inclusive T21 laws were associated with e-cigarette use behaviors and related disparities among US adolescents. Design: We used nationally representative, repeated cross-sectional Monitoring the Future data to compare self-reported current e-cigarette use (2014–2022) and first e-cigarette initiation (2015–2022) among adolescents in counties with 100% ('full') versus < 100% ('partial or no') e-cigarette-inclusive T21 law population coverage using modified Poisson regression, examining differences by sex, race and ethnicity, parental educational attainment and college educational expectations through interactions. Setting: United States. Participants: 8th, 10th and 12th graders. Measurements: County-level e-cigarette-inclusive T21 law population coverage was determined using Tobacco 21 Population Coverage Database and US Census Bureau population data. Current e-cigarette …

Healthcare Providers’ Perspective On Hiv Testing And Hypothetical Mhealth-Connected Linkage To Care Among Men Who Have Sex With Men (Msm) In South Carolina, Tony Brown, Prince Nii Ossah Addo, Monique J. Brown Ph.D., Mph, Xiaoming Li, Oluwafemi Adeagbo

Faculty Publications

Background: HIV continues to be an important public health concern in South Carolina (SC). However, an examination of providers’ willingness to use mHealth technologies to address ongoing barriers to HIV care and prevention strategies, particularly among men who have sex with men (MSM) is currently lacking in SC. We therefore explored HIV care providers’ perceptions of HIV testing and treatment uptake among MSM, and providers’ willingness to use mHealth technology to address barriers to HIV testing and treatment in SC. Methods: Between August and December 2021, we conducted semistructured virtual interviews with 10 HIV care providers recruited purposively based on …

Sars-Cov-2 Detection And Persistence In A Remote Amazonian Settlement, Glauco M. Silva, Roberto C. Ilacqua, Franciely G. Gonçalves, Carla M. Santana, Felipe T. Jordão, Paula R. Prist, Melissa S. Nolan Ph.D., Mph, Andreia F. Brilhante, Marcia A. Sperança, Gabriel Z. Laporta

Faculty Publications

Background: COVID-19 continues to pose a major global health challenge. Despite its geographic distance from Brazil’s major urban centers, Acre state has experienced notable outbreaks. This study assessed the detection and persistence of SARS-CoV-2 in the rural settlement of Santa Luzia, located in the remote municipality of Cruzeiro do Sul, Acre state, Brazil. Methods: In July 2022, a cross-sectional survey was conducted at 40 sites from an ongoing environmental study, selected by deforestation patterns and proximity to health posts. Saliva samples were collected from residents aged 5–90 years, followed by nucleic acid extraction and multiplex RT-qPCR for SARS-CoV-2 detection. Results: …

Safe Data-Enabled Control Of Human-In-The-Loop Robotic Manipulator Systems, Ritirupa Dey, Avimanyu Sahoo, Vignesh Narayanan

Publications

Safe control of human-in-the-loop (HIL) robotic manipulators is critical for applications such as assistive robotics, teleoperation in hazardous environments, and collaborative manufacturing. However, this remains challenging due to the lack of a unified framework that simultaneously addresses safety constraints, external disturbances, unmodeled dynamics, and dynamic role switching in the HIL setting. In this paper, we propose a novel NN-driven HIL control framework in which human–robot dyadic interaction occurs through the haptic channel. Using Lyapunov stability analysis, we theoretically show that the proposed NN-based controller ensures accurate joint trajectory tracking, compensates for system uncertainties, and adapts to human inputs modeled as …

Battery Energy Storage, Control, Dc Microgrid, Integrated Power Systems, Power Electronics, Supercapacitor, Jack Elliott Hannum

Theses and Dissertations

DC distribution has enabled a variety of new features and opportunities for naval power systems. At the same time, pulsed loads are proliferating, and pose unique challenges to power systems, especially smaller systems like those onboard ships. Energy storage resources, including Battery Energy Storage Systems (BESS) and supercapacitors, can be used to compensate pulsed loads of varying frequencies with proper control. However, standard methods of frequency-based load allocation have only limited ability to integrate sources with diverse power and energy capabilities. To overcome this limitation, a new droop control scheme, Frequency Targeting Droop (FTDC), has been devised that increases the …

Multirotor Aerial Vehicle Morphology Design, Modeling, And Control, Samuel Allen Dauchert

Theses and Dissertations

Multirotor aerial vehicles (MAVs) have seen explosive popularity since the early 2000s, with microprocessors enabling small-scale Autonomous Aerial Vehicles (AAVs) or First Person Aerial Vehicles (FPVs). Additionally, the use of these MAVs in commercial applications has continued to grow since then with expansion into delivery, search and rescue, and smart farming applications. With this rise in popularity, specialized MAVs have undergone development for these applications due to the environments in which these vehicles operate.

From this development, a new area of Morphological Multirotor Aerial Vehicles (MMAVs) has emerged. Unlike traditional MAVs, these platforms adjust their shape based on environmental factors. …

Secondary Ell Students’ Perception Of Ell And Stem Courses And Its Impact On Enrollment In Stem Courses, Prakash Patel

Theses and Dissertations

This action research study examined experiences of eight secondary-level English Language Learners (ELL) that lead to perceptions of being in ELL and STEM courses and how those perceptions impact academic pathways in subsequent course enrollment, specifically STEM courses. The study aimed to identify secondary level ELLs’ lived experiences while concurrently enrolled in ELL and STEM courses through the use of a mixed-methods explanatory sequential design to capture specific lived experiences that promote enrollment in STEM courses through intrinsic motivation. The study employed the use of ClassMaps (CMS) (Doll et al., 1999) and the Intrinsic Motivation Inventory (IMI) (CSDT, 2025) surveys …

The "Not Seen" Effect Of International Financial Centers: Innovation In The Global Financial Ecosystem, Charlotte Ku, Andrew P. Morriss

South Carolina Journal of International Law and Business

International Financial Centers (IFCs) are hubs of legal and financial innovation, developing specialized frameworks that facilitate cross-border investment, enhance global capital mobility, and support economic growth. Through jurisdictional competition, professional clustering, and adaptive regulatory frameworks, IFCs have pioneered legal structures that enable enterprises of all sizes to participate in the global economy. Using case studies of the International Business Company, the Limited Liability Company, the Protected Cell Company, and advances in trust law and applying the theoretical frameworks of social scientist Richard Florida and psychologist Mihalyi Csikszentmihalyi, this article illustrates how IFCs serve as laboratories for financial experimentation, generating widely …

Lambat Asal Selamat: The Slow But Safe Twenty-Five Year Recalibration Of Personal Bankruptcy In Malaysia, Jason J. Kilborn

South Carolina Journal of International Law and Business

A popular Malay proverb advises, “[L]et it be slow, as long as it is safe” (biar lambat asal[kan] selamat),1 combining the sentiments of two similar English proverbs: “haste makes waste,” and “slow and steady wins the race.” These principles certainly seem to have guided Malaysian lawmakers in the quarter-century, multistage development of the most important element of modern bankruptcy law: the discharge. Adopted in 1967,2 Malaysian bankruptcy law has long included a very limited debt discharge, but as it left more and more economically debilitated debtors in perpetual bankruptcy limbo, policymakers became dissatisfied with leaving a huge and growing mass …

Exploratory Clinical Assessment And Treatment Of Autonomic Nervous System Dysregulation Post Concussion: A Case Study, Megan Coker, James May

Clinical Practice in Athletic Training

The physiological alterations in autonomic nervous system (ANS) function due to concussion are suggested to play a role in persistent post-concussion symptoms (PPCS). Currently, there are few objective and clinically feasible measurements to assess ANS vitality in patients experiencing PPCS. The following case study details an assessment and treatment protocol targeted towards regulating the ANS in an adolescent female suffering from PPCS one month after injury. Pre-intervention, patient-reported outcome measures (PROMs) used to assess perceived pain, anxiety, stress, and breathing function were administered as well as a physical assessment performed for breath function and vagus nerve integrity. The patient was …

Concussions In Women’S Rugby: A Timely Review Of Available Data, Shannon M. Wright

Clinical Practice in Athletic Training

Rugby is a growing full-contact sport across the world for both men and women; as a full-contact sport with no protective equipment, it has a reputation for high injury rates, including concussions. Organized men’s rugby has been established for over a century, whereas organized women’s rugby has struggled to achieve the same success over the years. With a much shorter amount of time to track injuries, women’s rugby lacks data to assess when, where, and what kinds of injuries are most common. The guiding study attempts to examine epidemiological trends for concussion in women’s rugby union and league. After pooling …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Is Increased Mutation Driving Genetic Diversity In Dogs Within The Chornobyl Exclusion Zone?, Megan N. Dillon, Allison N. Dickey, Reade B. Roberts, Jennifer A. Betz, Timothy Mousseau, Norman J. Kleiman, Matthew Breen

Faculty Publications

Environmental contamination can have lasting impacts on surrounding communities, though the long-term impacts can be difficult to ascertain. The disaster at the Chornobyl Nuclear Power Plant in 1986 and subsequent remediation efforts resulted in contamination of the local environment with radioactive material, heavy metals, and additional environmental toxicants. Many of these are mutagenic in nature, and the full effect of these exposures on local flora and fauna has yet to be understood. Several hundred free-roaming dogs occupy the contaminated area surrounding the Chornobyl Nuclear Power Plant, and previous studies have highlighted a striking level of genetic differentiation between two geographically …

Challenges And Opportunities In Implementing And Enforcing India’S Loose Cigarette Sales Ban: A Qualitative Stakeholder Analysis, Mayank Sakhuja, Daniela B. Friedman Ph.D., Mark M. Macauda Phd, Mph, James R. Hebert Scd, Mangesh S. Pednekar, Prakash C. Gupta, James F. Thrasher Ph.D., Ma, Ms

Faculty Publications

Introduction Several Indian states have banned the sale of loose cigarettes, and India is considering a national ban. This study examines the perceptions of policymakers, implementers, and law enforcement officials regarding the implementation and enforcement of this ban. Methods Between May–October 2022, we conducted in-depth interviews with 26 key stakeholders involved in tobacco control in two Indian cities, Delhi (where the ban was not implemented) and Mumbai (where the ban was in effect). Participants included representatives from various government departments such as police, municipal corporations, FDA, health, and civil society organizations / NGOs such as Vital Strategies, World Health Organization, …