Digital Commons Network^™

Comparing The Health Information Practices Of Sapphic People By Age Group And Generation, Vanessa Lynn Kitzie

Faculty Publications

This qualitative research examines how sapphic people (i.e., umbrella term inclusive of lesbian, bisexual, and pansexual trans femmes, mascs, nonbinary people, and ciswomen) in South Carolina navigate informational barriers within healthcare systems. An information practices lens that examines how sapphic people create, seek, use, and share information to achieve desired healthcare outcomes describes such navigation. The research focuses on how intersectional identities, with a particular emphasis on age and considerations of race/ethnicity, geography, and gender, mediate these practices and their outcomes. The research uses participant data from semi-structured interviews and focus groups with 34 sapphic people about their health information …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Publications

INTRODUCTION: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic. MATERIAL AND METHODS: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Exploring Barriers To Effective Covid-19 Risk Mitigation, Recovery, And Chronic Disease Self-Management: A Qualitative Multilevel Perspective, Gayenell S. Magwood Phd, Rn, Faha, Faan, Charles Ellis Jr, Chanita Hughes Halbert, Ebony Allen Toussaint, Jewel Scott Phd, Rn, Fnp-C, Lynne S. Nemeth

Faculty Publications

Introduction: Many research activities have focused on SARS-CoV-2 infection and subsequent COVID-19 respiratory illness during the pandemic. However, significant racial inequities emerged months after the COVID-19 pandemic began. The similarity between racial/ ethnic disparities in COVID-19 and those for other diseases raised awareness about the context for risk exposure and healthcare access. The purpose of this study is to examine social and structural determinants of health among COVID-19 survivors, carepartners, and the perspectives of healthcare stakeholders who experienced disruption during the early pandemic.
Material and methods: A purposive sample of interviews (n=9) and focus groups (n=10) were used to collect …

Utilizing Lentinula Edodes And Pleurotus Ostreatus To Decrease Saccharomyces Cerevisiae Growth With Oxidative Stress Present As A Model For Cancer, Abdullah Amir

Journal of the South Carolina Academy of Science

Cancer is the second leading cause of death in the United States, and its effects can be worsened when high levels of oxidative stress are present. Lentinula edodes and Pleurotus ostreatus are two edible mushroom species that have been shown to contain many anticancer agents. However, the effects of these mushrooms have not been tested on cancer in the presence of oxidative stress. Therefore, the purpose of the present study was to test the effectiveness of L. edodes and P. ostreatus in reducing Saccharomyces cerevisiae growth when oxidative stress was present. It was hypothesized that these two mushroom species would …

A Comparative Study To Predict Ovarian Cancer, Binadie Wickramasinghe, Gloria Regisford

Journal of the South Carolina Academy of Science

Ovarian cancer is considered the fifth most common cancer type among females in the United States. Furthermore, ovarian cancer accounts for 25% of all gynecologic cancers, and usually, this cancer is diagnosed at a late stage. A patient can live at least five years longer if ovarian cancer is diagnosed early. Therefore, the early diagnosis of ovarian cancer is essential. This study aims to classify ovarian cancer using biomarkers such as ovarian cancer antigen (CA125), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), human epididymis protein 4 (HE4), and anti-TP53 antibodies. Rising or persistent CA125 blood levels provide a highly …

Cortisol And Alpha-Synuclein Stability In Saliva Under Varying Storage And Handling Conditions, Mo Zheng, Sujata Srikanth, Jeremiah Carpenter, Delphine Dean

Journal of the South Carolina Academy of Science

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments and non-motor symptoms, significantly impacting patients' quality of life. Currently, cerebrospinal fluid (CSF) is the primary biofluid used for PD biomarker studies, notably α-synuclein, despite the invasive nature of lumbar puncture procedures. Recent work has shown that some of these PD biomarkers have been measured in saliva. As an alternative to CSF, saliva can be non-invasively self-collected by patients repeatedly over time to monitor biomarker levels. However, the stability of these biomarkers in saliva needs to be evaluated before saliva can be considered for patient self-collection studies. Therefore, …

Neurosymbolic Cognitive Methods For Enhancing Foundation Model-Based Reasoning, Kaushik Roy, Siyu Wu, Alessandro Oltramari

Faculty Publications

Foundation models have emerged as powerful tools, exhibiting extraordinary performance across various tasks, such as language processing, visual recognition, code generation, and human-centered engagement. However, recent studies have highlighted their limitations when grounded, abstract, and generalized reasoning capabilities are required. Complex tasks often involve multiple hierarchical reasoning steps, which are typical features of human thinking processes. In fact, in this chapter we claim that cognitively-inspired computational models, such as the so-called Common Model of Cognition, are key to enable complex reasoning within foundation model-based artificial intelligence (AI) systems. We investigate neurosymbolic approaches for mapping AI system components to those of …

September 11, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Synergistic Inhibition Of Hiv-1 Regulatory Function Using A Dual Expression Shrna Plasmid, Christine Sanderson, William H. Jackson

Journal of the South Carolina Academy of Science

HIV infection of CD4⁺ T Helper lymphocytes results in a gradual loss of immune competence, which ultimately leads to development of the acquired immune deficiency syndrome (AIDS). HIV-1 expresses two regulatory proteins, Tat and Rev, which act to upregulate viral transcription and facilitate mRNA transport enhancing the rate of translation. Inhibition of Tat and Rev have been shown to block virus replication. Therefore, Tat and Rev represent critical key points in the virus replication cycle. This study investigated the potential of RNA interference (RNAi) to inhibit these proteins using short hairpin RNAs (shRNAs). For this, plasmids expressing shRNAs targeting …

Presentation Of Bilateral Acetabular Labral Tears In A Collegiate Women’S Lacrosse Player: A Level 3 Clinical Case Study, W Giannelli, K Herraiz, A Mercer

Clinical Practice in Athletic Training

Background: The hip and groin injury rate in female collegiate lacrosse players has been reported to be 35.06 per 100,000 athlete exposures yet the frequency of acetabular labral tears (ATL) remains unclear. Sports which involve repeated bouts of running in combination with frequent twisting and pivoting motions, have been suggested to have a higher prevalence rate of ALT. This level 3 case study will discuss the unique presentation of bilateral ALTs in a female collegiate lacrosse player. Patient: Patient is a 19-year-old Division I collegiate women’s lacrosse player who first presented with pain in her left hip while at home …

September 4, 2024 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Hpv Prevalence In A College-Aged Sample Group And Its Link To Sexual Behaviors And Attitudes, Emily E. Bishop, Rahjai Thomas, Katelyn Ambrose, Gabriela Lewczyk, Paul E. Richardson

Journal of the South Carolina Academy of Science

HPV, or Human Papilloma Virus, is the most common Sexually Transmitted Infection (STI). It is the number one STI in men and women. There are over 460 subtypes; a majority of the subtypes are able to be cleared by the human immune system within 3 years after initial infection. However fifteen of these subtypes have been classified as ‘high-risk’ for carcinoma development, accounting for almost 100% of cervical cancers. This STI has an age prevalence starting at 19 for oral and genital infections. The overall goal of this research is to provide students with an equally represented and unbiased database …

Association Between Seated Trunk Control And Cortical Sensorimotor White Matter Brain Changes In Patients With Chronic Low Back Pain, John R. Gilliam, Pradeep K. Sahu, Jennifer M.C. Vendemia, Sheri P. Silfies

Faculty Publications

Trunk control involves integration of sensorimotor information in the brain. Individuals with chronic low back pain (cLBP) have impaired trunk control and show differences in brain structure and function in sensorimotor areas compared with healthy controls (HC). However, the relationship between brain structure and trunk control in this group is not well understood. This cross-sectional study aimed to compare seated trunk control and sensorimotor white matter (WM) structure in people with cLBP and HC and explore relationships between WM properties and trunk control in each group. Thirty-two people with cLBP and 35 HC were tested sitting on an unstable chair …

Improvement Of Single-Crystal Structures Of Very Heavy Element Compounds By Refining Anomalous Dispersion Parameters, Florian Meurer, Gregory Morrison, Birgit Hischa, Hans Conrad Zur Loye, Christoph Hennig, Michael Bodensteiner

Faculty Publications

Refining the anomalous dispersion parameters of the four uranium compounds NaUF5, NaU2F9, Cs2(UO2)TiO4, and Cs2(UO2)Ti2O6 gave insights into the crystallographic model improvement of very heavy atoms. We found that the values for the dispersive and absorptive parts, f′ and f″, closely followed the X-ray absorption spectra on their L3, L2, and L1 edges. The obtained values are sensitive to the chemical environment at each crystallographically independent position. An incorrect treatment of the anomalous dispersion correction can lead to a wrong crystallographic model. The above-mentioned, already published structures were improved by this process. General guidelines were given for the crystal structure …

Achieving Destination Sustainability: How Tourist-To-Tourist Interaction Quality Affects Tourist Loyalty?, Junli Gao, Fang Meng Ph.D., Weifeng Guo, Baomin Lin

Faculty Publications

Although tourist-to-tourist interaction (TTI) has been identified as an essential element in tourist experiences, the effect of TTI quality on tourist loyalty, and the mechanism underlying this effect is scarcely discussed in the literature. Based on the self-determination theory, this study aims to examine whether and how TTI quality influences tourist loyalty, representing a significant means to achieve destination sustainability. More specifically, this study tested a moderated mediation model in which basic psychological needs satisfaction mediated the relationship between TTI quality and tourist loyalty, while sociability moderated the link between TTI quality and basic psychological needs satisfaction. A survey research …

Brain-Hand Function Relationships Based On Level Of Grasp Function In Chronic Left-Hemisphere Stroke, Elizabeth Rizor

Faculty Publications

Background and Objective

The biomarkers of hand function may differ based on level of motor impairment after stroke. The objective of this study was to determine the relationship between resting state functional connectivity (RsFC) and unimanual contralesional hand function after stroke and whether brain-behavior relationships differ based on level of grasp function.

Methods

Sixty-two individuals with chronic, left-hemisphere stroke were separated into three functional levels based on Box and Blocks Test performance with the contralesional hand: Low (moved 0 blocks), Moderate (moved >0% but < 90% of blocks relative to the ipsilesional hand), and High (moved ≥90% of blocks relative to the ipsilesional hand).

Results

RsFC in the ipsilesional and interhemispheric motor networks was reduced in the Low group compared …

Mild Hydrothermal Crystal Growth Strategies For Complex Inorganic Metal Fluorides, Navindra Keerthisinghe

Theses and Dissertations

Inorganic metal fluorides have been investigated for their interesting magnetic and optical properties, their electrochemical behavior, and their ionic conductivity. Fluoride materials can accommodate metals in very low oxidation states, which can be advantageous for designing new magnetic materials. Specifically, mixed metal fluorides incorporating transition metal cations often exhibit interesting magnetic behavior, such as frustrated magnetism. However, many challenges are encountered during the synthesis of such fluoride materials, including the inability to perform reactions under ambient conditions and the involvement of toxic gases for fluorination during solid-state reactions. Therefore, solution growth techniques such as mild hydrothermal synthesis are currently utilized …

Informatics-Based Discovery Of New Natural Products, Their Biosynthesis, And Their Biological Roles, Ethan Older

Theses and Dissertations

In this work, genome mining and biosynthetic knowledge are applied for the discovery of new natural products, their biosynthetic pathways, and their promising biological activities and roles through the development of two unique new informatics-based approaches.

In chapter one, an overview of microbial natural product biological functions and biosynthesis is provided. The use of bioinformatics leveraging microbial natural product biosynthetic knowledge is also introduced. This chapter highlights the importance and need for developing innovative approaches to accessing microbial natural products, a vastly untapped source of new molecules with promising biological activities.

In chapter two, a correlational network linking the gene-encoded …

Approximate Computing And In-Memory Computing: The Best Of The Two Worlds!, Mohammed Essa Fawzy Essa

Theses and Dissertations

Machine learning (ML) has become ubiquitous, integrating into numerous real-life applications. However, meeting the computational demands of ML systems is challenging, as existing computing platforms are constrained by memory bandwidth, and technology scaling no longer yields substantial improvements in system performance. This work introduces novel hardware architectures to accelerate ML workloads, addressing both compute and memory challenges. In the compute domain, we explore various approximate computing techniques to assess their efficacy in accelerating ML computations. Subsequently, we propose the Approximate Tensor Processing Unit (APTPU), a hardware accelerator that utilizes approximate processing elements to replace direct quantization of inputs and weights …

Evaluation Of A Statewide Suicide Awareness And Prevention Program, Darien Collins

Theses and Dissertations

Mental health challenges are prevalent among young people in South Carolina, with suicide being a leading cause of death for individuals aged 10 to 24. Ending the Silence (ETS) serves as a gatekeeper training to engage students, school staff, families, and community members in conversations surrounding mental health challenges and suicide awareness. The University of South Carolina School Behavioral Health Team (SBHT), led by Dr. Mark Weist, with funding from the South Carolina (SC) Blue Cross Blue Shield Foundation (BCBS), worked with the South Carolina National Alliance on Mental Illness (NAMI) on a three-year evaluation of their ETS program. Results …

Deconvolving Provenance Signatures Of Pliocene-Pleistocene Coastal Loess Deposits Along The Atlantic Margin Of Argentina, Will Robert Quanrud

Theses and Dissertations

Dust derived from southern South America provides critical nutrients for autotropic marine biota in the South Atlantic Ocean, such that fluxes of wind-blown sediment may ultimately affect the concentration of atmospheric CO2. Expansive sand, silt, and loess deposits are exposed in Central Argentina, recording millions of years of eolian processes; however, the provenance and transport pathways of this dust remains unclear. Coastal loess deposits ranging in age from Pliocene to upper Pleistocene are present along the Atlantic margin of Argentina and provide information on sediment transport pathways for the last 4 million years. Nine samples of loess were collected and …

Metal-Organic Frameworks For Global Environmental Challenges, Kyoungchul Park

Theses and Dissertations

Over the past few decades, there has been a demand for improving nuclear waste administration due to a significant increase in the utilization of nuclear energy. The driving force for proper nuclear waste disposal is evident when considering past nuclear catastrophes—such as Chernobyl and Fukushima—where radionuclide contamination of large bodies of water sparked public concern. In order to manage such radioactive species, the emerging areas of radionuclide sequestration, storage, separation, and sensing must be addressed in the upcoming years. This dissertation presents a potential candidate for addressing these challenges, called metal-organic frameworks (MOFs). Due to their porosity, high surface area, …

Modeling, Analysis, Approximation, And Application Of Viscoelastic Structures And Anomalous Transport, Yiqun Li

Theses and Dissertations

(Variable-order) fractional partial differential equations are emerging as a competitive means to integer-order PDEs in characterizing the memory and hereditary properties of physical processes, e.g., anomalously diffusive transport, viscoelastic mechanics and financial mathematics, and thus have attracted widespread attention. In particular, optimal control problems governed by fractional partial differential equations are attracting increasing attentions since they are shown to provide competitive descriptions of challenging physical phenomena. Nevertheless, variable-order fractional models exhibit salient features compared with their constant-order analogues and introduce mathematical difficulties that are not typical encountered in the context of integer-order and constant-order fractional partial differential equations.

This dissertation …

Macro–Micro-Coupled Simulations Of Bead–Spring Breaking-Reforming Networks, Andrei Medved

Theses and Dissertations

In this work we investigate the dynamic behavior of bead-spring polymer solutions in viscoelastic fluids, which are essential in industries like materials science, biotechnology, and pharmaceuticals. The study leverages GPU-accelerated simulations and detailed modeling of polymer chain dynamics at the mesoscale, which enables efficient analysis of intricate fluid behaviors and the microscale dynamics of polymer chains. Additionally, the research examines the breaking-reforming dynamics of polymer chains, crucial for understanding phenomena such as shear thinning and thickening. The findings have broad applications, from improving inkjet printing and 3D printing technologies to developing new drug delivery systems and biocompatible materials. This work …

Businesses Or Beneficiaries: The Submerged Consequences Of Workfare Policy Design, Morgan Alexander Lowder

Theses and Dissertations

This dissertation critically analyzes the policy association between the Supplemental Nutrition Assistance Program (SNAP) and the Work Opportunity Tax Credit (WOTC), and in doing so, sheds light on the employer-uplifting design of the U.S. welfare state. I examine this association in three stand-alone Chapters with the intent of answering the following questions: 1) Is the SNAP-WOTC association mutually beneficial to SNAP recipients and the employers that access the WOTC; 2) Is the SNAP-WOTC association truly intended to be mutually beneficial; and 3) What are the perceptive consequences of revealing how SNAP benefits employers through the WOTC. Using both quantitative and …

Bayesian Methods In Analyzing The Diagnostic Accuracy\\ For Ordinal Ratings, Yun Yang

Theses and Dissertations

This dissertation focuses on ordinal classification ratings, which are commonly used in medical practice to assess the severity of a disease or condition. For example, a group of radiologists rate a set of mammograms and assign BI-RADS (Breast Imaging Reporting Data System) score for each mammogram. A Bayesian probit hierarchical model is first proposed to analyze this type of data. It links the ordinal ratings with both rater diagnostic skills and patient latent disease severity. Each rater diagnostic skills are quantified with two parameters, diagnostic bias and diagnostic magnifier. Patient latent disease severity is assumed to follow a different normal …

Object Classification, Detection And Tracking In Challenging Underwater Environment, Md Modasshir

Theses and Dissertations

The main contributions of this thesis is the applicability and architectural designs of deep learning algorithms in underwater imagery. In recent times, deep learning techniques for object classification and detection have achieved exceptional levels of accuracy that surpass human capabilities. However, the effectiveness of these techniques in underwater environments has not been thoroughly researched. This thesis delves into various research areas related to underwater environments, such as object classification, detection, semantic segmentation, pose regression, and semi-supervised retraining of detection models.

The first part of the thesis studies image classification and detection. Image classification is a fundamental process that involves assigning …

Classifying Floor Accelerations For Gait Estimation And Detection, Jean Michel Franco Lozada

Theses and Dissertations

Structural vibrations are traditionally used to learn about structural systems, such as determining the dynamic characteristics of a structure and evaluating its structural performance under certain dynamic loads. Recently, researchers have proposed the use of structural vibrations to know more about the occupants of the structure in addition to the structure itself. One example of such would be to determine when a person falls, or to identify the location of a person walking in a building. Using structural vibrations to study occupants can be directly applicable to many fields, ranging from healthcare to security applications. One powerful use of structural …

Tax Client Goals, Regulatory Pressure, And Professional Decision-Making, Spenser G. Seifert

Theses and Dissertations

Drawing on goal theory, I illuminate how client preferences become internalized goals for tax professionals and how these client goals influence the motivated reasoning and ultimate decision-making of tax professionals. Using this theoretical framework, I then utilize an experiment to explore how the presence of salient situational factors – goal specificity, goal progress, and regulatory pressure – influence tax professionals’ decision-making. The results suggest that, as a result of their roles as both client advocates and CPAs, tax professionals default to non-specific “do your best” goals regardless of client preference specificity. Additionally, I find that increased regulatory pressure may curb …

Thermodynamic Modeling Of Uranium Nitride With Select Actinides And Fission Products, Eric Reece Mcmanus

Theses and Dissertations

Uranium mononitride fuel is being investigated as a potential nuclear fuel for a Westinghouse lead-cooled fast reactor due to factors such as its high uranium density, high melting point, and favorable thermal conductivity. To obtain an understanding of the thermochemical behavior of UN fission products and minor actinides, thermodynamic data was obtained from various resources to create a database to represent the behavior of the fuel. This database was used to generate an Ellingham diagram to represent the relative thermodynamic stability of the phases over the reactor temperature range. A simulation was run computing the equilibrium state of the fuel, …