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Analysis Of Genes Responsible For Neuronal Morphological Changes In Down Syndrome Hipsc-Derived Neurons, Juhi Patel

Senior Theses

Down syndrome (DS) is a complex neurodevelopmental disorder caused by the trisomy of chromosome 21. DS is the largest genetic cause of intellectual disability, which occurs in varying severity among affected individuals. It is associated with a variety of developmental and cognitive defects, including reduced brain size, impaired synaptic function, and altered neuronal morphology. A number of genes have been identified to play critical roles in the development and maintenance of neuronal morphology, and alterations in the expression of some of these genes are implicated in the morphological changes observed in DS. Knocking out or altering their expression leads to …

Predictors And Barriers To Vaccination Among Older Syrian Refugees In Lebanon: A Cross-Sectional Analysis Of A Multi-Wave Longitudinal Study, Berthe Abi Zeid, Tanya El Khoury, Hala Ghattas Ph.D., Marwan F. Alawieh, Zeinab Ramadan, Sirine Anouti, Sawsan Abdulrahim, Stephen J. Mccall

Faculty Publications

Background:

Vaccination is important to prevent morbidity and mortality due to COVID-19 among older Syrian refugees. We aimed to elucidate the predictors of COVID-19 vaccine uptake among Syrian refugees aged 50 years or older in Lebanon and to understand their main reasons for not receiving the vaccine.

Methods:

This was a cross-sectional analysis of a five-wave longitudinal study, conducted through telephone interviews between Sept 22, 2020, and March 14, 2022, in Lebanon. For this analysis, data were extracted from wave 3 (Jan 21–April 23, 2021), which included a question on vaccine safety and on whether participants intended to receive the …

Trends In The Incidence Of Head And Neck Cancer: A Nationwide Population-Based Study, Tzong-Hann Yang, Sudha Xirasagar Mbbs., Ph.D., Yen-Fu Cheng, Chin-Shyan Chen, Wei-Pin Chang, Herng-Ching Lin

Publications

OBJECTIVE: This study aimed to demonstrate the temporal trend in incidence of head and neck cancer (HNC) in Taiwan. MATERIALS AND METHODS: Patients with a HNC were retrieved from the Taiwan's Health Insurance Database. We identified 16,894 patients aged ≥20 years who had received a first-time diagnosis of cancer of the oral cavity, oropharynx, larynx, hypopharynx, nasopharynx, sinonasal, salivary gland or thyroid gland between 2010 and 2018. We calculated the annual incidence rate per 100,000 population, overall, and classified by gender and cancer type. We also used the annual percent change (APC) to characterize trends in head and neck cancer …

Micro-Targeting Consumers To Reduce Consumptive Externalities, Tamara L. Sheldon, J. R. Deshazo, Bronwyn Lewis Friscia

Faculty Publications

When correcting for consumption externalities policymakers may employ economic incentives, a uniform moral suasion intervention, or various micro-targeted moral suasion interventions. To assess the relative effectiveness of these policy interventions, we randomly assign consumers to different moral suasion treatments designed to increase their willingness to pay for energy efficient light bulbs. Both economic incentives and single moral suasion interventions have similar modest effects on household willingness to pay for this durable good. However, we find that optimally targeting moral suasion messages increases consumers' choice of the most efficient light bulbs even more than large subsidies.

April 25, 2023 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

April 19, 2023 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Microcanonical Thermodynamics Of Small Ideal Gas Systems, David S. Corti, Donya Ohadi, Ricardo Fariello, Mark J. Uline

Faculty Publications

We consider the thermal, mechanical, and chemical contact of two subsystems composed of ideal gases, both of which are not in the thermodynamic limit. After contact, the combined system is isolated, and the entropy is determined through the use of its standard connection to the phase space density (PSD), where only those microstates at a given energy value are counted. The various intensive properties of these small systems that follow from a derivative of the PSD, such as the temperature, pressure, and chemical potential (evaluated via a backward difference), while equal when the two subsystems are in equilibrium are nevertheless …

April 5, 2023 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Why Word Problems Are Hard For High School Math Students: Problem Formulation And Disciplinary Literacy, Emily Charlotte Elliott

Senior Theses

This thesis is an extensive literature review designed to better understand the obstacles high school math students encounter when solving word problems (WPs). While many high school students find math difficult in general, students especially struggle with WPs. Often they are unable to provide correct solutions to WPs even when they are successful in solving computational problems using the same mathematical concepts (Cummins, 1988). Data from the 2007 National Survey of Algebra Teachers suggests that solving WPs is one of the skills that students are most unprepared for when entering Algebra 1 (Hoffer et al.). Additionally, many students try to …

Local Translation And Focal Adhesions Are Dysregulated In Down Syndrome, Ashlyn Gotberg, Nikita Kirkise M.S., Kristy Welshhans Ph.D.

Senior Theses

During cellular migration, fibroblasts sense extracellular cues through membrane complexes at their leading edge and can respond to these cues via local translation. Local translation is the process in which mRNAs are transported to subcellular regions and translated in response to specific cues. There is evidence that local translation may be dysregulated in the neurodevelopmental disorder, Down syndrome, which is caused by the triplication of chromosome 21 and results in genome-wide dysregulation of protein expression. To determine if dysregulated local translation contributes to Down syndrome, we used three sets of primary fibroblasts from individuals with Down syndrome and apparently healthy …

Modeling The Probability Of A Successful Stolen Base Attempt In Major League Baseball, Cade Stanley

Senior Theses

In Major League Baseball (MLB), the outcome of a stolen base attempt has important implications. Success moves the runner closer to scoring, while failure records an out and removes the runner from the basepaths altogether. Therefore, it is important that the decision by a coach or player to steal a base is well-informed. In this thesis, I explore a statistical approach to making this decision. I train logistic regression and random forest models, using data about the game situation and about the runner, pitcher, and catcher involved in the stolen base attempt, to estimate the probability that a stolen base …

Atomic Utopia: Nuclear Power At The Oconee Power Station In Seneca, South Carolina, Dalton Bridges

Senior Theses

In this thesis, I propose that South Carolina residents have developed a perception of their communities as “nuclear utopias.” I focus specifically on the Oconee Nuclear Power station in Seneca in the northwestern part of the state. I argue that the state’s extensive connections to the nuclear industry, coupled with the fact that many individuals have profited from the job opportunities and economic benefits that this sector provides, have led to a general acceptance of and even appreciation for nuclear power. Nuclear utopia suggests that individuals in South Carolina may view the nuclear industry as a source of hope and …

Accessibility Of Medical School To Students With Physical Disabilities, Shelby A. Cowan

Senior Theses

This thesis is an exploration of perceived and institutional barriers to matriculation into medical school for students with physical disabilities. Factors such as the lived admissions experience, available accommodations and supportive resources, and legal considerations surrounding a student's disclosure of their disability are examined; however, future work is needed to better access this population of students and empower them to become physicians and use their unique perspective to benefit patients.

Using Podcasts To Bring National Estuarine Research Reserves Into The Classroom For Grades 6-12, Kaitlyn M. Dirr

Senior Theses

In a typical classroom setting, there are significant challenges to exposing students to concepts related to earth sciences and the environment. These challenges are exacerbated when conveying lessons about geographic areas with limited access, such as oceans and coastlines (Louv, 2010). It is now more important than ever for environmental education to improve and adapt to our changing world. Educators may have the opportunity to bring these subjects to life by using media content such as podcasts to introduce students to new places and the scientists, managers and educators that work in those spaces. In the United States, there exists …

Learning Law Young: Towards A More Robust, Impactful Civics Education Modeled Off Of Jewish Law Learning, Michael J. Broyde, Ariel J. Lieberman

The Journal of Law and Education

No abstract provided.

A Semantic Web Approach To Fault Tolerant Autonomous Manufacturing, Fadi El Kalach

Theses and Dissertations

The next phase of manufacturing is centered on making the switch from traditional automated to autonomous systems. Future Factories are required to be agile, allowing for more customized production, and resistant to disturbances. Such production lines would have the capability to reallocate resources as needed and eliminate downtime while keeping up with market demands. These systems must be capable of complex decision making based on different parameters such as machine status, sensory data, and inspection results. Current manufacturing lines lack this complex capability and instead focus on low level decision making on the machine level without utilizing the generated data …

Title Page

South Carolina Law Review

No abstract provided.

Guilty, But Mentally Ill, But Not Insane? Making Sense Of South Carolina's Approach To Mentally Ill Offenders, Mason J. Rajaee

South Carolina Law Review

No abstract provided.

Warning, No Lifeguard On Duty - Swim At Your Own Risk: Dual-Role Lifeguarding And Municipal Liability Under S.C Code Ann. § 5-7-145, S. Quinn Mann

South Carolina Law Review

No abstract provided.

Impact Of An Evidence-Based Order Set On Pneumonia Length Of Stay, Troy Wayne Spires

Doctor of Nursing Practice Scholarly Projects

Problem Statement: Among adult patients admitted with pneumonia, what is the effect of Computerized Provider Order Entry (CPOE) sets for pneumonia, as compared to usual practice, on the length of stay over three months.

Purpose: The project aimed to determine if inpatient LOS related to pneumonia could be impacted by utilizing appropriately completed computerized physician order entry (CPOE). The current pneumonia order set was evaluated and updated to reflect the latest evidence-based standards of care. Pneumonia order sets with evidence-based practice treatment algorithms was the intervention focus as they have been shown to impact the length of stays …

Reducing Falls Among Adult Psychiatric Inpatients Using K-Cards With The Epi, Epfrat Factors, And Nursing Judgment, Katelyn Dunn

Doctor of Nursing Practice Scholarly Projects

In the United States, the highest rates of falls are in the psychiatric inpatient population. Fall reduction was as an organizational goal of the project site, a 352-bed hospital in the Southeastern United States. The Epic Predictive Index (EPI), an automated fall risk assessment tool, had recently been adopted. This project evaluated the impact of an enhanced fall reduction strategy involving the use of Kamishibai Cards (K-Cards), which are a compliance reminder for healthcare staff, to support additional evidence-based identification of fall risk among adults receiving inpatient psychiatric care at the facility. The use of K-Cards with each patient’s current …

Our Social Packaging: How Labels In Society Affect Our Perceptions Of Ourselves And What This Implicates For The Overdiagnosis And Self-Diagnosis Crisis In Mental Health Conditions, Alexandra X. Cortez

Senior Theses

This paper examines the effects of labeling theory in regard to mental health diagnoses. Specifically, it examines how the self-fulfilling prophecy plays a role after an individual is assigned a label. To view labels and their effects in action, this paper looks to the television show Survivor, specifically Season 37 and uses a television content analysis. Survivor provides an analogy for today’s society and a culturally relevant representation of how individuals are internalizing labels and stereotyping others based on their label. An analysis of season 37 revealed that contestants strongly associated with their assigned label and the specific characteristics that …

An Exploration Of Manipulating Serotonin To Foster A Successful Life, Grace Rose Paskalides

Senior Theses

This thesis is broken into three sections: methods of naturally increasing serotonin levels, increased serotonin levels impacts on the body and mind and how those physical and mental impacts translate into a fulfilled life. This thesis presents health effects and measures a fulfilled life in terms of: relationship success, academic and professional achievement, and societal impact. The goal is to explore and expand upon existing scientific inferences of the complex neurotransmitter serotonin. It is not a treatment plan. It investigates benefits of imposing serotonin-increasing behavior into one’s life and speculates tangible measures of success that would likely be consequences of …

Accuracy Of Therapeutic Drug Monitoring In Vancomycin And The Pharmacist Role: A Retrospective Case-Series, Kateryna Parkhomenko

Senior Theses

Vancomycin is a mainstay of therapy for treating virulent and resistant infections, especially methicillin-resistant Staphylococcus aureus (MRSA). However, vancomycin requires therapeutic drug monitoring (TDM) for optimal dosing and treatment. This requires pharmacists to calculate a dosing regimen that correlates to appropriate goal vancomycin concentrations in the blood. Dosing vancomycin can be difficult, as it varies on a patient’s weight, renal function, age, etc. Doses may have to be adjusted in response to out-of-range concentrations, which requires further pharmacy calculations. Inaccurate dosing poses a risk to patient safety and places a resource and time burden on pharmacists. If vancomycin dosing methods …

The Virtual Classroom: What Can Be Learned From The Covid-19 Lockdown, James L. Nations

Senior Theses

This paper seeks to examine the teaching practices utilized during the initial COVID-19 lockdown in higher education. This forced switch to the virtual classroom forced many professors to make innovative changes to adapt to this change in teaching modality. These changes can now be examined and evaluated for potential future application. By reviewing the current literature, performing an analysis of grades from Fall 2017 through Summer 2022, and interviewing select professors at the University of South Carolina, this paper seeks to illuminate some of the potential issues that arise when adapting in-person curriculums to the virtual classroom as well as …

The Benefits And Implementation Of Open Science Practices In Exercise Science Research, Brendan Moore

Senior Theses

This article has the purpose of addressing the need for open science practices in the field of exercise science research. Open science is best defined as the call for greater accessibility and transparency in research (Chakravorty et al., 2022). With more accessible and transparent research, research can be conducted more thoroughly and efficiently. Additionally, the implementation of these practices would discourage many shady and unethical practices. The idea of open science is not without debate however. There are many concerns over the theft of scientific data and ideas, as well as the increased time and monetary costs associated with many …

Bad Blood: Octavia E. Butler Takes A Bite Out Of Gender And Racial Stereotypes In Fledgling, Abigail Cole

Senior Theses

For contemporary audiences the word “vampire” typically conjures two figures: a Damon Salvatore-esque[1] man with devil may care eyes, dark hair and an equally dark past. Dripping with sex and charm, he struggles with an internal dilemma, his animalistic urge to kill constantly at war with his human morality. On the other hand, we have the sexy, scantily clad white female vampire who uses her feminine wiles and socially “perfect” body to prey upon poor, unsuspecting men, until she is eventually corralled into domestic submission, or killed. While this description fits the broader scale of what the vampiric figure …

A Comparative Investigation Of Tonal Memory Improvements With Electronic And Vocal Pitch Stimulus Training, Grayson M. Fletcher

Senior Theses

The study described herein compares improvements in tonal memory for young adults (age 19- 22), specifically retention of pitches, between two groups (n1=8, n2=8) with nearly identical training programs. One group was provided electronic pitch stimuli for the training program, while the other group was given human vocal stimuli. Self-paced computerized training sessions were conducted in a soundproofed testing room and interposed between pre-test and post-test measurements. A pre-test—post-test randomized experimental design allowed for assessment of whether the training was effective for each group in addition to comparing effectiveness of training between groups. Analyses with demographic factors, particularly previous musical …

The Fate Of The Language Is The Fate Of The People: A Cultural Analysis Of Language Education Policy In Central Asia, Bethany A. Reeve

Senior Theses

With a shared history under the Soviet Union, the five Central Asian republics of Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan have spent the past one hundred years dealing with quickly changing language policy and ethnic relations. Under the policy of the USSR, native languages of Central Asia were repressed, and Russian was introduced as the main language of interethnic communication. After they gained independence in 1991, however, each of the five countries embarked on missions to restore the strength of each of their national languages and de-Russify their political, economic, and educational systems. Throughout the region, one of the main …

Face Validation Of A Spanish Non-Invasive Prenatal Screening Knowledge Scale, Kenya Michelle De Leon

Theses and Dissertations

Non-invasive prenatal screening (NIPS) provides risk assessment for chromosome aneuploidy in pregnancy. Previous studies in the United Kingdom and United States have attempted to measure patient knowledge, decisional conflict, and informed choice in cohorts of English-speaking pregnant patients who elected NIPS (Griffin et al., 2023; Lewis et al., 2016). However, knowledge scales utilized in these studies have not been validated. The current study was conducted in order to assess face validity of a Spanish NIPS knowledge scale that was originally written in English. This scale was developed as part of a larger project to ultimately provide more validated research measures …