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Structures Of Human Thymidylate Synthase R163k With Dump, Fdump And Glutathione Show Asymmetric Ligand Binding, Lydia M. Gibson, Lesa R. Celeste, Leslie L. Lovelace, Lukasz Lebioda Nov 2010

Structures Of Human Thymidylate Synthase R163k With Dump, Fdump And Glutathione Show Asymmetric Ligand Binding, Lydia M. Gibson, Lesa R. Celeste, Leslie L. Lovelace, Lukasz Lebioda

Faculty Publications

Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal form of the R163K variant of human TS (hTS) with five subunits per asymmetric part of the unit cell, all with loop 181-197 in the active conformation, is reported. This form allows binding studies by soaking crystals in artificial mother liquors containing ligands that bind in the active site. Using this approach, crystal structures of hTS complexes with FdUMP and dUMP were obtained, indicating that this form should facilitate high-throughput analysis of hTS complexes with drug candidates. Crystal soaking experiments using oxidized glutathione revealed that …


Perfect Little Feminists? Young Girls In The Us Interpret Gender, Violence, And Friendship In Cartoons, Spring-Serenity Duvall Nov 2010

Perfect Little Feminists? Young Girls In The Us Interpret Gender, Violence, And Friendship In Cartoons, Spring-Serenity Duvall

Faculty Publications

Girls’ studies has emerged as a dynamic area of scholarship that examines the cultural construction of girlhood, the role that girls play in society, their identity formation, and their representation in media. This paper extends previous research by interviewing young girls about their interactions with each other as they view and interpret animated cartoons. Expanding claims that Girl Power programs such as The Powerpuff Girls empower viewers, I also discuss the role of third wave, commodity, and post feminism in influencing girls’ expectations of gender equality even as they embrace gender role differences. In discussing the importance of researchers engaging …


The Daily Gamecock, Monday, November 1, 2010, University Of South Carolina, Office Of Student Media Nov 2010

The Daily Gamecock, Monday, November 1, 2010, University Of South Carolina, Office Of Student Media

November

No abstract provided.


Together We Can: Collaborating To Meet The Needs Of At-Risk Students., Karen Gavigan, Stephanie Kurtts Nov 2010

Together We Can: Collaborating To Meet The Needs Of At-Risk Students., Karen Gavigan, Stephanie Kurtts

Faculty Publications

No abstract provided.


More Collaboration - More Power In Combating Ill Health, Ilkka Vuori, Steven N. Blair, Fiona C. Bull, Peter T. Katzmarzyk Nov 2010

More Collaboration - More Power In Combating Ill Health, Ilkka Vuori, Steven N. Blair, Fiona C. Bull, Peter T. Katzmarzyk

Faculty Publications

This symposium highlighted the position of physical activity as one of the most important factors causally related to common non-communicable diseases (NCDs), and discussed the need for including physical activity in comprehensive prevention strategies and policies to combat the major NCDs. Lifestyle factors such as smoking, physical inactivity, and obesity are all major risk factors for ischemic heart disease, cerebrovascular disease, and several cancers, and physical inactivity globally ranks as the fourth leading risk factor for mortality. Despite the solid evidence that physical activity is related to several NCDs, stronger advocacy actions are required because physical activity is not viewed …


The Daily Gamecock, Friday, October 29, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Friday, October 29, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Wednesday, October 27, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Wednesday, October 27, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Tuesday, October 26, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Tuesday, October 26, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Monday, October 25, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Monday, October 25, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Friday, October 22, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Friday, October 22, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Thursday, October 21, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Thursday, October 21, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Wednesday, October 20, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Wednesday, October 20, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Monday, October 18, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Monday, October 18, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Wednesday, October 13, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Wednesday, October 13, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


Garnet & Black Anthropology 101 Extended Style Shoot, University Of South Carolina, Office Of Student Media Oct 2010

Garnet & Black Anthropology 101 Extended Style Shoot, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.


The Daily Gamecock, Monday, October 11, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Monday, October 11, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Friday, October 8, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Friday, October 8, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


The Daily Gamecock, Thursday, October 7, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Thursday, October 7, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


October 6, 2010 Faculty Senate Minutes, University Of South Carolina Oct 2010

October 6, 2010 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


The Daily Gamecock, Monday, October 4, 2010, University Of South Carolina, Office Of Student Media Oct 2010

The Daily Gamecock, Monday, October 4, 2010, University Of South Carolina, Office Of Student Media

October

No abstract provided.


Garnet & Black Fall 2010, University Of South Carolina, Office Of Student Media Oct 2010

Garnet & Black Fall 2010, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.


Parent Speech And The Courts, Ann Hassenpflug Oct 2010

Parent Speech And The Courts, Ann Hassenpflug

The Journal of Law and Education

No abstract provided.


Globalizing No Child Left Behind: A Viable Catalyst In Implementing Progress For Social Integration Programs For Immigrant, English Language Learner, And Limited English Proficient Students, Jamie Lashawn Izlar Oct 2010

Globalizing No Child Left Behind: A Viable Catalyst In Implementing Progress For Social Integration Programs For Immigrant, English Language Learner, And Limited English Proficient Students, Jamie Lashawn Izlar

The Journal of Law and Education

No abstract provided.


Empowerment, Innovation, And Service: Law School Programs Provide Access To Justice And Instill A Commitment To Serve, Lisa V. Martin, Dale Margolin, Steve Berenson, Karen Pearlman, Maryann Zavez Oct 2010

Empowerment, Innovation, And Service: Law School Programs Provide Access To Justice And Instill A Commitment To Serve, Lisa V. Martin, Dale Margolin, Steve Berenson, Karen Pearlman, Maryann Zavez

Faculty Publications

Law schools around the country seek to fill the legal needs of their communities in ways that are both innovative and mutually beneficial to clients and students. This article describes five pro bono and clinical programs, at the University of Richmond School of Law, The Earle Mack School of Law at Drexel University, Catholic University Columbus School of Law, the Thomas Jefferson School of Law, and Vermont Law School, where law students, under the supervision of law professors or community professionals, provide assistance or legal representation to underserved and often marginalized populations needing help with family law problems, including parents …


A Tale Of Prosecutorial Indiscretion: Ramsey Clark And The Selective Non-Prosecution Of Stokley Carmichael, Lonnie T. Brown Jr. Oct 2010

A Tale Of Prosecutorial Indiscretion: Ramsey Clark And The Selective Non-Prosecution Of Stokley Carmichael, Lonnie T. Brown Jr.

South Carolina Law Review

No abstract provided.


Reaching Equilibrium In Tobaccoo Litigation, James Henderson Jr., Aaron D. Twerski Oct 2010

Reaching Equilibrium In Tobaccoo Litigation, James Henderson Jr., Aaron D. Twerski

South Carolina Law Review

No abstract provided.


Preaching What They Don't Practice: Why Law Faculties' Preoccupation With Impractical Scholarship And Devaluation Of Practical Competencies Obstruct Reform In The Legal Academy, Brent E. Newton Oct 2010

Preaching What They Don't Practice: Why Law Faculties' Preoccupation With Impractical Scholarship And Devaluation Of Practical Competencies Obstruct Reform In The Legal Academy, Brent E. Newton

South Carolina Law Review

No abstract provided.


The First Amendment Degraded: Milkovich V. Lorain And A Continuing Sense Of Loss On Its 20th Birthday, Richard H. Weisberg Oct 2010

The First Amendment Degraded: Milkovich V. Lorain And A Continuing Sense Of Loss On Its 20th Birthday, Richard H. Weisberg

South Carolina Law Review

No abstract provided.


In Memoriam: Gil Friedman, Harvey Starr Oct 2010

In Memoriam: Gil Friedman, Harvey Starr

Faculty Publications

Gil Friedman, lecturer in political science at Tel Aviv University, passed away on July 16, 2009, at the age of 42 after a short bout with cancer. Much too young, and with so much promise, Gil's death was an unexpected shock to his relatives, friends, and colleagues. His loss is all the more tragic because those who knew Gil were struck by his seemingly boundless energy, his enormous intellectual curiosity, his constant stream of ideas, and his incredible work ethic—all fed by a seemingly insatiable desire to read everything (ever) written in the areas of his current interest.


No Child Left Behind: Disincentives To Focus Instruction On Students Above The Passing Threshold, Christina Payne-Tsoupros Oct 2010

No Child Left Behind: Disincentives To Focus Instruction On Students Above The Passing Threshold, Christina Payne-Tsoupros

The Journal of Law and Education

No abstract provided.