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David Lindsay And The Shape Of Inner Being, Eric Wills

Studies in Scottish Literature

Explores the influence of German Idealist philosophy, specifically Nietzsche and Hegel, in the work of the 20th century Scottish writer David Lindsay (1876-1945), now best-known for his novel A Voyage to Arcturus (1920) with primary attention to the role and character of symbolic imagery in Lindsay's stories, focusing on his novels Sphinx (1923) and Devil’s Tor (1932), and countering the broadly gnostic worldview sometimes attributed to him.

Study Of The Effect Of B-Cell-Intrinsic Mhcii Antigen Presentation On Germinal Center B Cell Evolution Using The Brainbow Mouse Model, Nia Hall

Theses and Dissertations

Major histocompatibility complex class II (MHCII) are molecules that are essential for B cell activation, as well as clonal competition among activated B cell clones during germinal center (GC) reactions. However, it is unknown to what extent MHCII drives the selection of some clones over others. This is of particular importance since MHCII is highly polymorphic with the ability to indirectly alter gutmicrobiome composition by altering the immunoglobulin A (IgA) repertoire. To study this, we utilized a novel triple-transgenic mouse model to assess how B-cellintrinsic MHCII influences GC responses and GC clonal diversity, with an eyeforward to understanding the relevance …

Age-Dependent Increase In Tyrosine Level Depletes Tyrosyl-Trna Synthetase And Causes Neuronal Oxidative Dna Damage In Alzheimer’S Disease, Megha Jhanji

Theses and Dissertations

Alzheimer’s disease (AD) is the most common form of dementia, and it currently affects more than 50 million people worldwide. Much of the population develop late-onset AD after 65 and constitute more than 95% of the cases. Currently, there is no definitive cure or way to slow down the progression of this disease that addresses the neurodegeneration and loss of cognitive functions. Although the underlying cause of AD is still unknown, the “amyloid cascade hypothesis” attributed it to the aggregation of amyloid beta (AU+03B2) peptides and has been the focus for targeting most disease-modifying drugs in clinical trials. However, emerging …

The Immune Modulatory Role Of Endocannabinoid Anandamide To Suppress Inflammation Through Regulation Of Microrna And Microbiome, Muthanna Ali Sultan

Theses and Dissertations

Cannabinoids are group of compounds that exerts their anti-inflammatory action through activation of CB1 and CB2 receptors and other minor receptors. In the current study, we investigated the effect of Anandamide (AEA) on Acute Respiratory Distress Syndrome (ARDS) induced by exposure to Staphylococcus Enterotoxin B (SEB) intranasally. We found that C57BL/6 mice treated with AEA showed improvement in the clinical functions of the lungs, accompanied by a decrease in the infiltration of inflammatory cells in the lung tissue, and a decrease in the secretion of pro-inflammatory cytokines. Furthermore, AEA regulated the miRNA profile of the mononuclear cells in the lungs …

The Development Of Novel Cdk8 And Cdk19 Inhibitors And Degraders As Potential Anti-Cancer Agents, Li Zhang

Theses and Dissertations

CDK8 and its homolog CDK19 are essential for transcription regulation and their dysregulation has been identified in numerous diseases, especially in cancers. CDK8 and CDK19 have been implicated in cancer development through their kinase activity and kinase independent functions. Despite the existing CDK8/19 inhibitors, there is still a need to develop novel CDK8/19 inhibitors with improved potency and PK profile. It is also necessary to develop CDK8/19 degraders that are able to eliminate the kinase-independent functions. Although two CDK8-degrading PROteolysis Activating Chimeras (PROTACs) have been reported, they have limited CDK8 degradation efficacy and no effect on CDK19. PROTACs with improved …

Recent Advances In Catalytic Ethylene Epoxidation: Synthesis, Characterization, And Evaluation, Benjamin Thomas Egelske

Theses and Dissertations

First synthesized in 1859 by French chemist Charles-Adolphe Wurtz, ethylene oxide (EO) is produced from the direct epoxidation of ethylene and molecular oxygen over a low surface area α-Al₂O₃ supported silver (Ag) catalyst [1-6]. With a production capacity over 35 Mt/year, EO is the largest chemical by volume synthesized from a heterogeneously catalyzed process and is used in the production of ethylene glycol, ethoxylates, and ethanolamines [6, 7]. State-of-the-art catalyst formulations contain high loadings of Ag, typically 12-30wt%, required to recover activity in the presence of promoter elements which increase EO selectivity from ~75% for unsupported Ag to 80% for …

The Role Of The School-Based Speech-Language Pathologist In The Identification, Assessment, And Remediation Of Dyslexia In Secondary Students, Lisa Marie Alves

Theses and Dissertations

The purpose of this mixed methods action research study was to increase the awareness and knowledge of secondary school professionals on dyslexia, including the role of the school-based speech-language pathologist. Two research questions guiding the quantitative data collection centered on the impact of a PowerPoint dyslexia training on the participants' knowledge and attitudes about dyslexia in the schools. In addition, two qualitative research questions guided the study involving the participants’ perceptions of the role of speech-language pathologists in a dyslexia protocol, and how to implement a dyslexia protocol in secondary-level schools. The results of the study indicate that the training …

Pedagogical Solo Piano Nocturnes: A Progressive Leveling With Annotations On Stylistic, Technical, And Musical Challenges And Benefits, Michaela Anne Boros

Theses and Dissertations

Nocturnes have remained in the standard piano literature for over two hundred years. However, students may not study this genre of repertoire until the advanced level of playing, and might therefore lack the full skills or knowledge necessary for successful nocturne performance. The purpose of this study is to provide a current, comprehensive, didactic resource on Romantic-style pedagogical piano nocturne literature from early elementary to early advanced levels, to aid teachers in the education of their students.

This study comprises four chapters, a bibliography, and two appendices. Chapter 1 consists of an introduction, purpose of the study, need for the …

Secondary Administrators’ Perspectives On Their Involvement In And Barriers To Supporting Secondary Transition Programs For Students With Disabilities, Dottie H. Brown

Theses and Dissertations

To address disparities in post-school outcomes for students with disabilities, federal legislation mandates appropriate education programs to include transition planning and programs for students with disabilities. Because administrators are held responsible for ensuring appropriate educational programs for all learners including those with disabilities, it is important to understand their perspectives on secondary transition; however, research on administrators’ involvement in secondary transition activities is limited. Using a single-state survey, this study examined the perspectives of secondary school administrators on their involvement and engagement in providing effective transition programs and services for students with disabilities and their perceptions of barriers to providing …

Middle And High School Experiences That Lead First-Generation College Students To Select A Stem Major, James A. Byrum

Theses and Dissertations

Careers in science, technology, engineering, and mathematics (STEM) fields are increasing but the number of qualified individuals to fill these positions are not meeting the demand. One way to increase the number of qualified STEM employees is to garner the interest of students from underrepresented groups in the STEM fields. One of these underrepresented groups are first generation college students (FGCS). Understanding what experiences led FGCS to pursue a degree in a STEM field may help attract more students to STEM and help meet the demand of filling future STEM jobs.

In this study, FGCS in the Opportunity Scholars Program …

Planning And Teaching For Student Learning In Mathematics: How Graduate Student Instructors Develop And Implement Instruction, Jennifer S. Crooks-Monastra

Theses and Dissertations

The purpose of this study was to explore undergraduate mathematics teaching from the perspective of a graduate student serving as a first-time precalculus instructor of record. A multiple case study was designed to follow three mathematics graduate student instructors (MGSIs) through one semester of teaching to understand their goals for student learning, efforts to achieve these goals, influences on planning, and to identify challenges they encountered. For each MGSI, data collection included four interviews, three observations of teaching, weekly journal entries, and written assignments from a pedagogy course. A focus group, field notes from the pedagogy course, audio from mentor …

The Impact Of The Teacher-Student Relationship On Students’ Educational Expectations, Amanda Lynn Davis

Theses and Dissertations

Students benefit both academically and psychosocially from close, supportive relationships with their teachers. Students who have close relationships with their teachers tend to adjust better to school, perform better academically, and engage in fewer problem behaviors. These benefits begin as early as preschool and mitigate several barriers to educational success for students from low-resource environments. However, it is unclear how changes in these relationships over time differentially influence positive outcomes. In this study, I test how changes in relationship closeness between students and teachers influence students’ expectations about future educational achievement. I also test how the strength of this association …

Student’S Perspectives Of Chronic Absenteeism In A Suburban High School, Herbert Allen Gray

Theses and Dissertations

For many students, school attendance is a critical issue. There have been several studies conducted concerning attendance numbers. These studies have shown that poor attendance often affects grades, graduation rates, and socioeconomic status post-high school. The purpose of this study was to first investigate the reasons behind absences and attitudes towards school and classes because of missed days. The second purpose was to determine if a weekly mentoring meeting had any noticeable effect on attendance. The targeted pool of students consisted of those who had been identified as chronically absent the previous semester. An initial set of open-ended questions and …

Pre-Exposure Prophylaxis (Prep) Knowledge, Willingness To Use & Uptake Among Black Heterosexual Men, Akeen Lowell Hamilton

Theses and Dissertations

INTRODUCTION: Pre-exposure prophylaxis (PrEP) is a pill, taken orally, that has been shown to be effective at reducing the chance that someone who is HIV-negative and at-risk for HIV will contract the disease during sexual intercourse with someone who is living with HIV. One demographic group that has been under-researched is Black heterosexual men. This dissertation presents research on evaluating the heterosexual Black men’s awareness of, prior use, and network of friends/family’s perceived interest in learning more about PrEP.

METHODS: Two-hundred and six Black heterosexual men living in Brooklyn, New York City, were surveyed about their sexual behaviors and PrEP …

Impact Of Student-Led Discussions On Student Engagement And Involvement, Samantha Hefel

Theses and Dissertations

The purpose of this action research was to investigate the relationship between student engagement and student-led discussions for middle school students, focusing specifically on seventh graders. There was increased student engagement for the students that participated in the discussions. The study was based on both cognitive and social constructivism, where students are developing their critical thinking as well as socializing with their peers. This research explored three questions related to the impact of student-led discussions. The first question looked at how discussions impacted student engagement and involvement. The second question centered on students’ willingness to voice their ideas. Finally, the …

Bayesian Calibration Of The Icrp Zirconium Biokinetic Model And Use Of Canned Priors For The Evaluation Of Bioassay, Thomas Raymond Labone

Theses and Dissertations

The International Commission on Radiological Protection (ICRP) publishes biokinetic models that relate measurements of radioactive material in the body and excreta (bioassay) to the amount of the material taken into the body (intake). Given the intake and the biokinetic model, radiation dose to organs and tissues can be calculated. The ICRP approximates the biokinetics of radioactive materials in the body with compartmental models expressed mathematically as a system of ordinary differential equations, for which they provide point estimates of the rate constants. Inaccurate estimates of intake and radiation dose can result in cases where the biokinetics of an individual differ …

Satellite Observations And Spatiotemporal Assessment Of Salt Marsh /Dieback Along Coastal South Carolina (1990-2019), Huixuan Li

Theses and Dissertations

Coastal wetland mapping is often difficult because of the heterogeneous vegetation compositions and associated tidal effects. Past studies in the Gulf/Atlantic coast states have reported acute marsh dieback events in which marsh rapidly browned and thinned, leaving stubble of dead stems or mudflad with damaged ecosystem services. Reported marsh dieback in South Carolina (SC), USA, however, have been limited. Previous studies have suggested a suite of possibly abiotic and biotic attributes responsible for salt marsh dieback. However, there are no consensus answers in current literature explaining what led to marsh dieback in past decades, especially from the spatiotemporal perspective. In …

Helping High School Students Succeed Academically By Meeting Their More Basic Needs, Karen Eyler Martin

Theses and Dissertations

In this action research, I seek to show the connection between breakfast consumption and student academic achievement. Students skip breakfast for a variety of reasons, including not allowing enough time and not having enough resources for it. Others eat what they can obtain, including snack foods that are highly processed. In addition, school districts have gotten away from making their meals from scratch, and instead, use a third-party catering service that often serves food that is cheap and easy to heat up, which often means it is highly processed and does not have the same nutritional content as whole foods. …

An Action Research Mixed Methods Study For The Development Of Information And Communication Technology (Ict) Programming For First-Year Students At A Historically Black University, Krystinq Mccauley

Theses and Dissertations

The purpose of this action research was to explore the information and communication technology (ICT) literacy skills of first-year minority students at Saint Augustine’s University in order to develop a plan for an ICT professional development program. ICT skills are essential in our rapidly changing and technology-driven society. While there is a growing awareness of the importance of ICT, universities are lagging behind in their approach to provide students with the much-needed digital competencies (Murray & Perez, 2014). This study focused on three research questions to determine (a) the ICT skills of first-year minority college students at Saint Augustine’s University, …

Individualized E-Book Experiences: Personalized Reading Plans’ Impact On First-Grade Students’ Reading Motivation And Engagement, Hannah Brunson Miles

Theses and Dissertations

The purpose of this action research was to address the issue of first-grade students being unengaged and unmotivated to read independently for the recommended 20-minute block of time in class. Students were also not electing to read independently during any free time they had in class. This research was designed to investigate how implementing a personalized e-book reading plan (PRP) affected students’ reading motivation and engagement during independent reading. The research questions that guided this study were: (a) How and to what extent do the personalized e-book reading plans impact students’ motivation to read? (b) How and to what extent …

Ultrawide Bandgap Algan-Channel Metal Oxide Semiconductor Heterostructure Field Effect Transistors With High-K Gate Dielectrics, Md Abu Shahab Mollah

Theses and Dissertations

Ultra-wide Band Gap (UWBG) (E_G > 3.4 eV) Al_xGa_1-xN channel devices are promising candidates for compact next-generation power electronics due to the scaling of the breakdown field with alloy composition. The huge opportunity in consumer electronics is the major driving force behind the recent developments of UWBG AlGaN-channel HEMTs. One of the most critical issues limiting the device performance at high power level is device degradation primarily caused by gate leakage current. Use of SiO₂ gate insulator is a standard method to suppress gate leakage but it causes threshold voltage shift towards more negative requiring …

Evaluating The Health Impact Of Centeringpregnancy Program Versus Traditional Prenatal Care In Midland Obstetric Clinics And Validating Selected Item On Birth Certificate, Oluwatosin A. Momodu

Theses and Dissertations

The primary focus of this dissertation is to evaluate the health impact of the CenteringPregnancy (CP) program versus traditional prenatal care (TPNC) on important maternal outcomes of pregnancy. This is looked at in two outcomes-gestational weight gain (GWG) and pregnancy induced hypertension (PIH). The specific aims are to examine the: (1) effects of CenteringPregnancy program versus traditional prenatal care on gestational weight gain (GWG); (2) effects of CenteringPregnancy program versus traditional prenatal care on pregnancy induced hypertension (PIH).

Birth certificate (BC) data were linked to hospital discharge records of women who delivered in midland’s obstetric clinics of South Carolina between …

Inquiry-Based Teaching In A Secondary English Classroom, Jennifer L. Norman

Theses and Dissertations

Teaching and learning need to move away from a transactional model found in a traditional classroom to support the growth of 21st century skills and abilities. Inquiry-based teaching is a model that places the student at the center of instruction and allows the teacher to facilitate and guide learning. The classroom fueled by inquiry is a classroom that (a) breaks free from the traditional and transactional model to promote connections to past knowledge and build new understandings, (b) allows students to direct their own learning, and (c) promotes moments of self-reflection and metacognition. The purpose of this study was to …

Evaluating Fit Indices In A Multilevel Latent Growth Model With Unbalanced Design: A Monte Carlo Study, Fan Pan

Theses and Dissertations

This dissertation informed researchers about the performance of different levelspecific and target-specific model fit indices in Multilevel Latent Growth Model (MLGM) using unbalanced design and different trajectories. As the use of MLGMs is a relatively new field, this study helped further the field by informing researchers interested in using various specific model fit indices.

We evaluated the descriptive information of the various model fit indices under various simulation conditions and the extent to which the fit indices could be influenced by different design factors, based on simulated data with different conditions derived from a correctly specified MLGM. Our simulation design …

Social-Motivational Influences On Physical Activity Engagement For Adolescent Girls, Mariajosé Jhamira Paton

Theses and Dissertations

Rates of youth physical activity (PA) drastically decrease during adolescence, with a steeper decline for adolescent girls (Belcher et al., 2010; CDC, 2010). Although afterschool programs (ASPs) have been identified as an ideal context for promoting youth PA, ASPs vary in quality with girls having the highest rates of inactivity (Zarrett et al., 2018). Theory and previous studies have identified social-motivational climate-based factors within ASPs that are critical for promoting adolescents’ PA (Basch, 2011; Eccles et al., 2002; Zarrett et al., 2013, 2015). The present study first examines gender differences in the social-motivational quality of middle school ASPs for promoting …

Food Choice Decision-Making Among School-Going Adolescents Amidst The Nutrition Transition In Urban Accra, Ghana, Krystal Krsna Rampalli

Theses and Dissertations

Like many countries of the world, Ghana is experiencing a nutrition transition and rising non-communicable diseases. Adolescents are susceptible to diet-related health risks as they experience significant physical and psychological changes, which are happening in tandem with food environment changes, including widespread proliferation of large portion and package sizes of energy-dense, nutrient-poor foods. Both local and multinational food and beverage companies have encouraged consumption of their products through various marketing tactics targeted directly to adolescents. Some of these tactics include the use of characters or celebrity endorsement, promotional discounts, and appeal to sociocultural values, including messages about body size preferences. …

An Action Research Study Implementing A Livescribe™ Pen And Cornell Note-Taking Strategy In A Personal And Community Health Course To Support Note-Taking And Comprehension Of College Student-Athletes With Learning Disabilities, Ivana Rich

Theses and Dissertations

The purpose of this study was to examine the impact of the Livescribe™ Symphony smartpen and the Cornell note-taking strategy on the lecture comprehension and quality of written notes of college student-athletes with learning disabilities. To explore educational tools and strategies that can assist students with learning disabilities in overcoming academic challenges, this study focused on three research questions: (1) how does the use of the Cornell note-taking strategy supported with a Livescribe™ pen affect the note-taking quality of student-athletes with learning disabilities (2) how does the use of the Cornell note-taking strategy supported with a Livescribe™ pen affect the …

Supporting The African American Prekindergarten Student Through Standard Academic English Instruction, Trent Gibson Rogerson

Theses and Dissertations

The objective for this research was to determine if prekindergarten African American students would show gains on English language assessments after receiving targeted Standard Academic English instruction. The research question asks, “How can a specialized English language intervention be utilized to identify the strengths and areas of improvement for African American preschool students?” The hypothesis was the students who received targeted instruction in Standard Academic English would perform better on the post-test than on the pre-test given before the instruction period. For this study, eight prekindergarten students were allowed to participate in the research. The students were administered an English …

Multi-Objective Routing For Distributed Controllers, Konstantin Y. Rubin

Theses and Dissertations

A long-term goal of future naval shipboard power systems is the ability to manage energy flow with sufficient flexibility to accommodate future platform requirements such as better survivability, continuity, and support of pulsed and other demanding loads. To facilitate scalable, low-latency global distributed system control, each control module can include an integrated network interface connected through multiple channels onto a direct, multi-hop network topology. In this work, we focus on a 2D Torus, in which control nodes are arranged in a regular 2D grid, with each node connected through point-to-point connections to its four immediate neighbors. An important advantage of …

The Spatial Variability Of Crime: A Review Of Methodological Choice, Proposed Models, And Methods For Illustrating The Phenomenon, Matthew D. Spencer

Theses and Dissertations

The spatial analysis of crime has occurred for nearly two centuries. Within criminology, research interests that have developed from the use of spatial methodologies seek to identify the spatial variability and concentration of crime. The first focus utilizes spatial statistics and mapping to describe and illustrate spatial variability. The second focus uses statistical techniques to describe levels of concentration such as the percentage of crime attributed to a unit. Due to the larger breadth of work and multiple analytical components the former will be the focus of this research.

This multi-study dissertation explores the methods currently used to study the …