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Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle Jul 2023

Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle

Theses and Dissertations

In its 2022 commercial market outlook, Boeing forecasted an 80% increase in the global fleet through 2041 compared to 2019 pre-pandemic levels. This sharp rise in demand will drive pressure onto airframe manufacturers to ramp up production and find more efficient ways to design and manufacture airplanes. Complicating this challenge is the industry’s recent transformation from traditional metal-based airframes towards hybrid composite-metal aircraft. While composites have been used in aviation for decades, aircraft manufacturers are still struggling to design and manufacture quality parts at a high rate. Automated Fiber Placement (AFP) is one of the main manufacturing techniques used to …


Faculty Perceptions Of Readiness And Confidence For Teaching Online: An Evaluation Of Online Professional Development, Kevin Brent Forman Jul 2023

Faculty Perceptions Of Readiness And Confidence For Teaching Online: An Evaluation Of Online Professional Development, Kevin Brent Forman

Theses and Dissertations

Regardless of how prepared faculty were to teach online classes, the COVID-19 pandemic forced leaders of universities and colleges and faculty nationwide to pivot to emergency remote teaching and forced students to take online classes. To prepare faculty for the shift to online instruction, administrators in colleges and universities provided resources, such as online trainings, to orient less experienced instructors to principles of online education. The Online Pedagogy Program (OPP) at Midwest Community College was developed quickly in response to the need for urgent training in effective online instruction. After 300 faculty completed the training, an evaluation of the Online …


The Effect Of Computer-Based Learning Modules On Pre-Algebra Student Proficiency And Self-Efficacy In Manipulating Math Expressions Involving Negative Signs, Brian Charles Grimm Jul 2023

The Effect Of Computer-Based Learning Modules On Pre-Algebra Student Proficiency And Self-Efficacy In Manipulating Math Expressions Involving Negative Signs, Brian Charles Grimm

Theses and Dissertations

Middle school students who need help understanding how to manipulate math expressions involving the negative sign have demonstrated difficulty learning pre-algebra content that prepares them for higher-level math courses. This study involved a multi-media intervention to improve student negative sign proficiency and math self-efficacy. The following research questions were explored: (1) How and to what extent did the computer-based intervention influence students’ math proficiency in manipulating math expressions involving negative signs? (2) How and to what extent did the computer-based intervention influence students’ math self-efficacy in manipulating math expressions involving negative signs? and (3) What were students’ perceptions about the …


The Moderating Role Of Patient-Centered Culturally Sensitive Health Care On The Relationship Between Health Self-Efficacy And Patient Engagement Among Black American Adults, Kaylyn Ann Garcia Jul 2023

The Moderating Role Of Patient-Centered Culturally Sensitive Health Care On The Relationship Between Health Self-Efficacy And Patient Engagement Among Black American Adults, Kaylyn Ann Garcia

Theses and Dissertations

Black Americans continue to embody strength and resilience in the face of systemic racism and oppression. However, as health disparities experienced by Black Americans continue to widen, it cannot be expected that they be solely responsible to leverage cultural strengths to improve health and well-being in the face of systemic injustice. Instead, it is equally as important to consider the wealth of opportunities that exist for systems, organizations, and policies to dismantle barriers to health and well-being experienced by Black Americans. Therefore, the present study examined the moderating role of patient-centered culturally sensitive health care (PC-CSHC) on the relationship between …


Parenting During A Pandemic: Understanding The Impact Of Covid-19 On Early Childhood Development, Jessica A. Manes Jul 2023

Parenting During A Pandemic: Understanding The Impact Of Covid-19 On Early Childhood Development, Jessica A. Manes

Senior Theses

The early years of a child's life are crucial for their development, shaping their ability to process information, communicate, and form their identity. However, the COVID-19 pandemic disrupted essential elements necessary for optimal early childhood development, including quality education, nurturing environments, and social stimulation. This study explored how parents in South Carolina perceived the pandemic's impact on their children's development. Five themes emerged from the study. Firstly, remote work due to pandemic protocols significantly affected the parent-child relationship. Secondly, the family's socioeconomic status influenced their ability to cope with and protect their children from the pandemic's impact. Thirdly, isolation resulting …


A Descriptive Study Of Factors That Support And Hinder Classroom Discourse With English Learners, Jillian Camille Plum Jul 2023

A Descriptive Study Of Factors That Support And Hinder Classroom Discourse With English Learners, Jillian Camille Plum

Theses and Dissertations

The population of English Learner (EL) students in the United States is increasing and is projected to represent 40% of our country by 2030 (Flynn and Hill, 2005). Many educators do not feel prepared to teach this marginalized group of students effectively. Therefore, EL coaches in this urban district in the Midwest collaborate with teachers to support instruction for EL students. However, teachers in this district still have a difficult time implementing classroom discourse, one of many EL components to help EL students achieve Fluent English Proficiency (FEP) status. This dissertation in practice (DIP) seeks to investigate and answer two …


An Exploration Of Racial Trauma And Protective Factors In Black Youth, Daria Chantal Thompson Jul 2023

An Exploration Of Racial Trauma And Protective Factors In Black Youth, Daria Chantal Thompson

Theses and Dissertations

Black students’ experiences in school can vary due to racism and discrimination within and outside of the classroom, which can impact their academic progress and overall well-being. In this three-part study, the impact of discrimination is observed to determine if there is a long-term effect of these situations and, if so, determine if there is utility to implement school-based resources to decrease these negative effects. The first study examined whether ethnic-racial socialization in childhood could moderate against symptoms of trauma in young adulthood that were potentially caused by discrimination from peers and teachers in childhood through hierarchical regressions. The second …


Molecular Mediators Of Axonal Transport And Local Translation Of Cdc42, Rhoa Molecular Mediators Of Axonal Transport And Local Translation Of And Calreticulin Mrnas And Their Implications For Axon Growth And Regeneration, Matthew Davis Zdradzinski Jul 2023

Molecular Mediators Of Axonal Transport And Local Translation Of Cdc42, Rhoa Molecular Mediators Of Axonal Transport And Local Translation Of And Calreticulin Mrnas And Their Implications For Axon Growth And Regeneration, Matthew Davis Zdradzinski

Theses and Dissertations

Neurons are highly polarized cells with expansive cytoplasmic processes, axons and dendrites, which create unique subcellular domains. Localization and translation of mRNAs in these subcellular regions is now recognized as a critical mechanism through which polarized cells establish and maintain the specialized domains that are needed for their functions. RNA profiling studies have uncovered hundreds to thousands of mRNAs in axons and these axonal mRNA profiles differ across neuronal populations, physiological conditions, and developmental growth states. Functionally organizing these mRNA populations into cohorts of coregulated mRNAs via RNA binding proteins allows us to better understand how the transcriptome is regulated …


Laboratory Management Models In Core Facilities, Karmen Michael Owen Jul 2023

Laboratory Management Models In Core Facilities, Karmen Michael Owen

Theses and Dissertations

Core biotechnology facilities are often defined as laboratories that house shared resources for research. These laboratories are of great importance to research communities because a large portion of scientific research data is generated at these facilities. Different investigators can use core facilities to help further their research. In a university setting, there are several management strategies from small cores that house a specific type of instrument, to large cores that house many different technologies. Funding strategies also differ significantly, from those that are funded by a small group of well-funded investigators, to cores managed by a specific department or school, …


Shakespeare In Virtual Reality: Social Presence Of Students In A Virtual Reality Book Club, John Funchess Ott Jr. Jul 2023

Shakespeare In Virtual Reality: Social Presence Of Students In A Virtual Reality Book Club, John Funchess Ott Jr.

Theses and Dissertations

The purpose of this mixed methods study was to implement and evaluate the impact of a virtual reality book club on the social presence of students. This research examined participants using virtual reality headsets to study the works of William Shakespeare. This study examined two research questions: 1) How does the implementation of a virtual reality technological innovation affect students’ knowledge of Shakespearean works? 2) How does the implementation of a virtual reality technological innovation affect social presence in students? Participants interacted within virtual worlds with one another and the researcher. Data was collected using a pre-post assessment test, writing …


Expanding On The Solid State Chemistry Of F-Element Chalcogenides, Logan Skyler Breton Jul 2023

Expanding On The Solid State Chemistry Of F-Element Chalcogenides, Logan Skyler Breton

Theses and Dissertations

An overarching goal in solid state chemistry is to achieve predictability regarding the synthesis of compounds with desired properties. While this goal is far from being reached, solid state chemists are hard at work synthesizing and characterizing new materials to further our understanding of structure-property relationships, and to expand our fundamental knowledge to rationalize the outcomes of solid-state syntheses. With the advent of new solid state synthetic methods, novel compounds exhibiting exciting properties are still being discovered today. The infancy of these synthetic methods promises a myriad of undiscovered compounds with potentially interesting properties which has resulted in a recent …


Parent Facilitation Of Child Emotion Regulation In Autism Spectrum Disorder, Aimee K. Rovane Jul 2023

Parent Facilitation Of Child Emotion Regulation In Autism Spectrum Disorder, Aimee K. Rovane

Theses and Dissertations

Parents play a substantial role in their children's emotional regulation (ER) abilities, promoting both adaptive and maladaptive development. Children with autism spectrum disorder (ASD) often have difficulties regulating their emotions, manifesting in externalizing behavioral issues (Mazefsky & White 2014). Though there are many similarities to parents of typically developing (TD) children, parents of children with ASD facilitate their children's ER development (i.e., emotion socialization) in response to unique challenges, often developing resiliency but other times contributing to their children’s dysregulation and behavioral challenges. Using Morris et al.'s (2007) Tripartite Model of Family Impact of Children's Emotion Regulation and Adjustment as …


The Effect Of Visual Feedback On Vocal Compensation Abilities In Individuals With Post-Stroke Aphasia, Marissa Rylee Olson Jul 2023

The Effect Of Visual Feedback On Vocal Compensation Abilities In Individuals With Post-Stroke Aphasia, Marissa Rylee Olson

Theses and Dissertations

Speech production is a complex and highly organized process comprised of various sensory and perceptual components. Post-stroke aphasia can impair speech production abilities by interrupting individuals’ ability to detect and correct speech errors and produce their targeted behavior. Contemporary models of speech production aim to understand the relationship between sensory systems and the human ability to produce perceptually accurate speech. This study seeks to understand the relationship between visual feedback and vocal compensation abilities in individuals with post-stroke aphasia to determine the effectiveness of incorporating visual feedback into therapeutic expressive language intervention. It was hypothesized that that the multi-sensory experimental …


1, 2, 3: Counting On Problem Based Learning To Improve Mathematical Achievement In African American Students, Kelley P. Spahr Jul 2023

1, 2, 3: Counting On Problem Based Learning To Improve Mathematical Achievement In African American Students, Kelley P. Spahr

Theses and Dissertations

Mathematics is an important component of our everyday lives. It involves necessary skills, such as computation, problem solving, and critical thinking. In spite of this, a significant portion of our students are unable to demonstrate proficiency. These students are typically the underserved, marginalized students who are over represented in remedial classes and behavioral statistics (Gibson, 2022; Harper, 2010, 2021; Zilanawala, et al., 2018). This research study presented two instructional interventions, culturally relevant pedagogy and problem-based learning, to examine the impact of self-efficacy, critical thinking, and mathematical achievement. This study utilized a mixed-methods triangulation design. The participants of this study were …


A Study Of Computational Thinking Skills And Attitudes Towards Computer Science With Middle School Students, Lorien W. Cafarella Jul 2023

A Study Of Computational Thinking Skills And Attitudes Towards Computer Science With Middle School Students, Lorien W. Cafarella

Theses and Dissertations

Many middle school students come to Computer Science (CS) classes without any previous CS instruction or any Computational Thinking (CT) skills that are needed to be successful. To overcome this, many curriculums and programming environments have been used to engage students and to instill a love of CS. Which curriculum should be used to develop CT skills that will also increase positive attitudes towards CS so students will continue in this field of study in higher grades? The purpose of this mixed method action research study was to evaluate how Code.org’s block-based programming curriculum affects middle school CS students’ CT …


Words Evaporate, The Images Remain: Testing Visual Warnings In The Context Of Intentions To Vape Among U.S. Adults As An Expansion Of The Theory Of Planned Behavior (Tpb), Carl Arland Ciccarelli Jul 2023

Words Evaporate, The Images Remain: Testing Visual Warnings In The Context Of Intentions To Vape Among U.S. Adults As An Expansion Of The Theory Of Planned Behavior (Tpb), Carl Arland Ciccarelli

Theses and Dissertations

This dissertation applied the Theory of Planned Behavior (TPB) model variables of attitudes, subjective norms, and perceived behavioral control, along with the variable of fear to explain individuals’ behavioral intentions to vape. Previous studies have explored the social appeal, intrigue, and potential consequences of vaping among adolescent and college student populations. However, these past studies have largely relied upon focus groups and self-reported data conducted among samples of teen, adolescent, and college student populations. Thus, the aims and designs of these previous vaping studies may have been lacking in construct validity and a theoretical approach from which to explain behavioral …


Effects Of Parenting And Self-Efficacy On Diet, Family Mealtime And Weight-Related Outcomes In African American Adolescents, Haylee Michele Loncar Jul 2023

Effects Of Parenting And Self-Efficacy On Diet, Family Mealtime And Weight-Related Outcomes In African American Adolescents, Haylee Michele Loncar

Theses and Dissertations

Despite substantial research and concern, adolescent overweight and obesity continues to be a significant public health problem. Theory based on developmental literature emphasizes the role of adolescent self-regulatory factors, like self-efficacy, in health behavior engagement and weight-related outcomes. There is also extensive literature that highlights parents’ role in promoting self-regulatory development through warm and responsive behaviors and practices. However, few studies have considered longitudinal associations and changes in weight-related outcomes over time, as well as moderated effects by parenting. This study assessed longitudinal associations between adolescent self-efficacy parenting factors and adolescent BMI, diet, and family mealtime to fill gaps in …


Multimodal Digital Literacy Practices: Perspectives Of L2 Academic Writing Instructors, Priscila Jovazino Bastos Medrado Costa Jul 2023

Multimodal Digital Literacy Practices: Perspectives Of L2 Academic Writing Instructors, Priscila Jovazino Bastos Medrado Costa

Theses and Dissertations

The purpose of my dissertation study was to explore the experiences and perceptions of English language instructors about the use of multimodal digital technologies in the teaching of academic writing. Writing academically in English as a second language (L2) is complex and multilayered for international students, and multimodal digital literacy practices are essential in the writing process in the age of information technology. The literature on multimodal digital literacies applied to L2 English instruction and to academic writing and the literature on teachers’ impressions about instructional technologies are vast. However, there is a need for further studies that address the …


Analysis, Measurement, And Modeling Of Millimeter Wave Channels For Aviation Applications, Zeenat Afroze Jul 2023

Analysis, Measurement, And Modeling Of Millimeter Wave Channels For Aviation Applications, Zeenat Afroze

Theses and Dissertations

Millimeter wave (mmWave) communication systems can employ a large amount of spectrum, and can consequently offer large data rates, e.g., multi-Gigabits-per-second. This technology can be used in many sectors: aviation, vehicles, public transportation, robotics, autonomous factories, etc. Yet mmWave communication systems suffer from some propagation challenges, including large free space path loss (PL), large penetration loss, and large diffraction loss. Hence, it is vital to quantify these and other channel effects to ensure link reliability. Most mmWave systems will employ directional antennas to enable acceptable link distances. In many settings this will require directional receiver antennas to rotate in azimuth …


Online Information-Seeking And Cancer Screening Intention: An Analysis Of The Health Information National Trends Survey 2022, Rachel Aileen Ford Jul 2023

Online Information-Seeking And Cancer Screening Intention: An Analysis Of The Health Information National Trends Survey 2022, Rachel Aileen Ford

Theses and Dissertations

Online information-seeking has become common in modern life, including when patients search for health information to make informed healthcare decisions. Previous research into the effect of online information-seeking on health maintenance behaviors has been mixed. This study sought to expand the current literature concerning the online information-seeking habits of cancer patients and integrate the concept of competence to analyze the effect on cancer screening adherence. The study analyzed HINTS 6 data to examine the relationship between online information-seeking and cancer screening intention as well as the relationship between social media habits and cancer beliefs. Results showed support for competence resulting …


Nitrous Oxide Cycling In The Eastern Tropical North Pacific Oxygen Deficient Zone From Concentrations, Stable Isotopes And Isotopomers, Margaret Ann Gaspar Jul 2023

Nitrous Oxide Cycling In The Eastern Tropical North Pacific Oxygen Deficient Zone From Concentrations, Stable Isotopes And Isotopomers, Margaret Ann Gaspar

Theses and Dissertations

Nitrous oxide (N2O) is a potent greenhouse gas and ozone depleting substance. It is estimated that the ocean accounts for about one third of total atmospheric emissions, which mostly occur in Oxygen Deficient Zones (ODZs) connected to coastal upwelling regions. Modeling efforts and high-resolution datasets are starting to provide a clearer picture of global marine N2O fluxes, spatiotemporal variability, and the impacts of submesoscale processes on N2O distributions. We measured nitrous oxide concentrations, stable isotope ratios and isotopomers at 7 open ocean stations along a transect crossing the Eastern Tropical North Pacific ODZ as …


Extreme Persuasion: Analyzing Meaning Creation And Persuasive Strategies Within Extreme Discourse On Alternative Social Media, Naomi Kathryn Lawrence Jul 2023

Extreme Persuasion: Analyzing Meaning Creation And Persuasive Strategies Within Extreme Discourse On Alternative Social Media, Naomi Kathryn Lawrence

Theses and Dissertations

Despite a long history of counterterrorism strategy, the U.S. has seen a drastic increase in domestic attacks over the past decade. Previous studies have found that, due to increasing content-related restrictions, many individuals who participate in extremist-related discourse have migrated away from mainstream social media and toward alternative social media platforms. This study consists of a comprehensive content analysis based on Multimedia Critical Discourse Analysis theories to study how meaning is created via the combination of text, image, and symbols, as well as how various persuasive narratives and rhetorical appeals are used within extreme discourse on social media. This research …


Unlocking Population-Specific Treatments To Render Equitable Approaches And Management In Cardiovascular Disease (Upstream Cvd): African American Emerging Adults, Shannon Bright Smith Jul 2023

Unlocking Population-Specific Treatments To Render Equitable Approaches And Management In Cardiovascular Disease (Upstream Cvd): African American Emerging Adults, Shannon Bright Smith

Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death in America. African American people have disparate CVD outcomes, and African American emerging adults (AAEAs) aged 18-25 have CVD risk factors. This study aimed to examine the state of CVD risk factors in AAEAs, assess upstream and population factors in AAEAs attending a southeastern historically black college/university (HBCU), compare their perceived and objective CVD risk, explore their level of CVD knowledge, and examine responses when they learn their objective CVD risk.

Chapter 1 presents background literature on CVD in AAEAs and the research plan. Chapter 2 presents a newly synthesized situation-specific …


What Are They Thinking?: A Qualitative Study Of Secondary Students’ Critical Thinking In Online Classes, Scott Allan Nolt Jul 2023

What Are They Thinking?: A Qualitative Study Of Secondary Students’ Critical Thinking In Online Classes, Scott Allan Nolt

Theses and Dissertations

This action research study emerged in response to students’ struggle to understand what critical thinking is and teachers’ corresponding struggle to develop students’ critical thinking skills. In my role as an instructional designer, I studied student and teacher reactions to interdisciplinary course design that used disciplinary inquiry, problem-posing, and concept-based online learning. The primarily qualitative study focused on students’ reflections across five different social studies and English courses, along with interview data from their teachers and post-course survey data. Exploring how students experience instruction designed to develop their critical thinking skills and how instruction in critical thinking impacts students’ critical …


Southeastern Conference (Sec) International Student-Athlete (Isa) Career Transitions - A Cultural Intelligence (Cq) Perspective, Tsu-Lin Yeh Jul 2023

Southeastern Conference (Sec) International Student-Athlete (Isa) Career Transitions - A Cultural Intelligence (Cq) Perspective, Tsu-Lin Yeh

Theses and Dissertations

This dissertation investigated international student-athletes’ (ISAs’) transition experiences of being recruited for, matriculating in, and then leaving high-performance and commercialized Southeastern Conference (SEC) institutions. Adopting the Cultural Intelligence (CQ) theory, this dissertation specifically examined how the four CQ elements (metacognition CQ, cognition CQ, motivation CQ, and behavior CQ) existed in an ISA’s transition process. CQ explains a person’s capability for performing well in culturally diverse environments (Fang et al., 2018). Traditional CQ studies have been utilized to manage international organizations’ diversity and inclusion (Triandis, 2006), particularly regarding employee retention, career transition and development (Mangla, 2021). However, although sports management is …


Leveraging Programmable Switches To Enhance The Performance Of Networks: Active And Passive Deployments, Elie Kfoury Jul 2023

Leveraging Programmable Switches To Enhance The Performance Of Networks: Active And Passive Deployments, Elie Kfoury

Theses and Dissertations

The performance of networks today is drastically affected by: 1) switches equipped with large buffers, referred to as “bloated buffers”: due to the lack of programmability and traffic visibility in legacy switches, operators nowadays configure large buffers statically without considering the characteristics or dynamics of flows. Such buffers increase the delays on packets, causing the Quality of Service (QoS) of networked applications (e.g., voice over IP, web browsing) to degrade; 2) switches forwarding packets on a best-effort basis: traffic crossing a switch is heterogeneous in many ways. Mixing such traffic in a single queue without any QoS measures can drastically …


Statistical Methods For Single Cell Sequencing Data Analysis, Fei Qin Jul 2023

Statistical Methods For Single Cell Sequencing Data Analysis, Fei Qin

Theses and Dissertations

The recent emergence of single cell sequencing (SCS) technology has provided us with single-cell DNA or RNA sequencing (scDNA/RNA-seq) information to investigate cellular evolutionary relationships. Despite many analysis methods have been developed to infer intra-tumor genetic heterogeneity, cluster cellular subclones, detect genetic mutations, and investigate spatially variable (SV) genes, exploring SCS data remains statistically challenging due to its noisy nature.

To identify subclones with scDNA-seq data, many existing studies use an independent statistical model to detect copy number profile in the first step, followed by classical clustering methods for subclone identification in downstream analyses. However, spurious results might be generated …


Archetypes Revisited: Investigating The Power Of Universals In Soviet And Hollywood Cinema, Iana Guselnikova Jul 2023

Archetypes Revisited: Investigating The Power Of Universals In Soviet And Hollywood Cinema, Iana Guselnikova

Theses and Dissertations

This paper examines the concept of archetypes in Soviet and Hollywood films, drawing perspectives from ancient philosophy and the thought of Carl Jung and post-Jungians. While psychoanalysis provides a valuable framework for understanding the human psyche and the idea of archetypes, it has its limitations and gaps that require further exploration. To address these issues, this paper proposes the adoption of a structuralist approach, with reference to the work of Vladimir Propp on the morphology of the fairy tale. Incorporating Propp's ideas can complement psychoanalytic theory and provide a more comprehensive understanding of the underlying patterns and structures that shape …


The Role Of Geographic Context In Tornado Risk, Risk Perception, And Protective Action Behavior, Sarah L. Jackson Jul 2023

The Role Of Geographic Context In Tornado Risk, Risk Perception, And Protective Action Behavior, Sarah L. Jackson

Theses and Dissertations

Our current understanding of tornado risk, risk perception, and protective action behavior lacks proper spatial consideration of local physical and social geographic contexts. This investigation asks how the conceptual drivers of tornado risk (geographic context, risk perception, and response) interact to create the spatiality of tornado risk. The study proposes that the inclusion of geographic context and its influence on perception and behavior produces differential tornado risk and seeks to determine which factors contribute to such variability. A novel, researcher-designed Tornado Risk of Place (TROP) conceptual model guides the methodological framework, incorporating statistical and geospatial analytics in an Illinois State …


Modulation Of Eif2Α Signaling And The Integrated Stress Response By Targeted Therapeutic Attenuation Of Pkr Activity Contributes To Protection Of Dyt-Prkra Cells From Apoptosis, Kenneth L. Frederick Jul 2023

Modulation Of Eif2Α Signaling And The Integrated Stress Response By Targeted Therapeutic Attenuation Of Pkr Activity Contributes To Protection Of Dyt-Prkra Cells From Apoptosis, Kenneth L. Frederick

Theses and Dissertations

Luteolin is a natural flavonoid present in vegetables, fruits, and medicinal herbs that possesses anti-oxidative, anti-cancer, and anti-inflammatory properties. In this study, we investigated the effect of luteolin on the integrated stress response (ISR), which is an evolutionarily conserved intracellular signaling network essential for adapting to environmental stresses to maintain healthy cells. Dysregulated ISR is involved in the etiology of many human diseases including the movement disorder DYT-PRKRA which is caused by mutations in the PRKRA gene. PRKRA encodes for PACT, the protein activator of interferon-induced, double-stranded RNA (dsRNA)-activated protein kinase PKR.PACT-mediated PKR activation regulates the …