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Moderation Of The Association Between Primary Language And Health By Race And Gender: An Intersectional Approach, Neelam H. Ahmed, Mary L. Greaney, Steven Cohen Jan 2022

Moderation Of The Association Between Primary Language And Health By Race And Gender: An Intersectional Approach, Neelam H. Ahmed, Mary L. Greaney, Steven Cohen

Public Health Faculty Publications

In the United States (US), limited English proficiency is associated with a higher risk of obesity and diabetes. “Intersectionality”, or the interconnected nature of social categorizations, such as race/ethnicity and gender, creates interdependent systems of disadvantage, which impact health and create complex health inequities. How these patterns are associated with language-based health inequities is not well understood. The study objective was to assess the potential for race/ethnicity, gender, and socioeconomic status to jointly moderate the association between primary language (English/Spanish) and having obesity and diabetes. Using the 2018 Behavioral Risk Factor Surveillance System (n = 431,045), weighted generalized linear …

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A Ribosomal Protein Homolog Governs Gene Expression And Virulence In A Bacterial Pathogen, Hannah S. Trautmann, Kathryn M. Ramsey Jan 2022

A Ribosomal Protein Homolog Governs Gene Expression And Virulence In A Bacterial Pathogen, Hannah S. Trautmann, Kathryn M. Ramsey

Cell and Molecular Biology Faculty Publications

The molecular machine necessary for protein synthesis, the ribosome, is generally considered constitutively functioning and lacking any inherent regulatory capacity. Yet ribosomes are commonly heterogeneous in composition and the impact of ribosome heterogeneity on translation is not well understood. Here, we determined that changes in ribosome protein composition govern gene expression in the intracellular bacterial pathogen Francisella tularensis. F. tularensis encodes three distinct homologs for bS21, a ribosomal protein involved in translation initiation, and analysis of purified F. tularensis ribosomes revealed they are heterogeneous with respect to bS21. The loss of one homolog, bS21-2, resulted in significant changes …

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A Decade Of Time Series Sampling Reveals Thermal Variation And Shifts In Pseudo-Nitzschia Species Composition That Contribute To Harmful Algal Blooms In An Eastern Us Estuary, Katherine M. Roche, Alexa R. Sterling, Tatiana A. Rynearson, Matthew J. Bertin, Bethany D. Jenkins Jan 2022

A Decade Of Time Series Sampling Reveals Thermal Variation And Shifts In Pseudo-Nitzschia Species Composition That Contribute To Harmful Algal Blooms In An Eastern Us Estuary, Katherine M. Roche, Alexa R. Sterling, Tatiana A. Rynearson, Matthew J. Bertin, Bethany D. Jenkins

Cell and Molecular Biology Faculty Publications

In 2016-17, shellfish harvesting closed for the first time in Narragansett Bay, Rhode Island, USA, from domoic acid (DA), a neurotoxin produced by diatoms of the Pseudo-nitzschiagenus. Pseudo-nitzschia have occurred frequently for over 60 years in Narragansett Bay’s Long-Term Plankton Time Series (NBPTS), therefore it is surprising that the first closure only recently occurred. Pseudo-nitzschia species are known to vary in their toxin production, thus species identification is critical for understanding the underlying ecological causes of these harmful algal blooms (HABs). DNA in plankton biomass can be preserved for many years, so molecular barcoding of archived samples is useful …

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Water Quality Observations From Space: A Review Of Critical Issues And Challenges, Cameron Murray, Albert Larson, Joseph E. Goodwill, Yeqiao Wang, Dawn Cardace, Ali S. Akanda Jan 2022

Water Quality Observations From Space: A Review Of Critical Issues And Challenges, Cameron Murray, Albert Larson, Joseph E. Goodwill, Yeqiao Wang, Dawn Cardace, Ali S. Akanda

Geosciences Faculty Publications

Water is the basis of all life on this planet. Yet, approximately one in seven people in the world do not have access to safe water. Water can become unsafe due to contamination by various organic and inorganic compounds due to various natural and anthropogenic processes. Identifying and monitoring water quality changes in space and time remains a challenge, especially when contamination events occur over large geographic areas. This study investigates recent advances in remote sensing that allow us to detect and monitor the unique spectral characteristics of water quality events over large areas. Based on an extensive literature review, …

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Analysis Of Botanicals And Botanical Supplements By Lc-Ms/Ms-Based Molecular Networking: Approaches For Annotating Plant Metabolites And Authentication, Terra Marie M. Jouaneh, Neil Motta, Christine Wu, Cole Coffey, Christopher W. Via, Riley D. Kirk, Matthew Bertin Jan 2022

Analysis Of Botanicals And Botanical Supplements By Lc-Ms/Ms-Based Molecular Networking: Approaches For Annotating Plant Metabolites And Authentication, Terra Marie M. Jouaneh, Neil Motta, Christine Wu, Cole Coffey, Christopher W. Via, Riley D. Kirk, Matthew Bertin

Biomedical and Pharmaceutical Sciences Faculty Publications

Prior to the advent of modern medicine, humans have used botanicals extensively for their therapeutic potential. With the majority of newly approved drugs having their origins in natural products, plants remain at the forefront of drug discovery. Continued research and discovery necessitate the use of high-throughput analytical methods to screen and identify bioactive components and potential therapeutic molecules from plants. Utilizing a pre-generated plant extract library, we subjected botanicals to LC-MS/MS-based molecular networking to determine their chemical composition and relatively quantify already known metabolites. The LC-MS/MS-based molecular networking approach was also used to authenticate the composition of dietary supplements against …

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Quantitative Proteomics Of Hepatic Drug-Metabolizing Enzymes And Transporters In Patients With Colorectal Cancer Metastasis, Areti-Maria Vasilogianni, Zubida M. Al-Majdoub, Brahim Achour, Sheila Annie Peters, Jill Barber, Amin Rostami-Hodjegan Jan 2022

Quantitative Proteomics Of Hepatic Drug-Metabolizing Enzymes And Transporters In Patients With Colorectal Cancer Metastasis, Areti-Maria Vasilogianni, Zubida M. Al-Majdoub, Brahim Achour, Sheila Annie Peters, Jill Barber, Amin Rostami-Hodjegan

Biomedical and Pharmaceutical Sciences Faculty Publications

The impact of liver cancer metastasis on protein abundance of 22 drug-metabolizing enzymes (DMEs) and 25 transporters was investigated using liquid chromatography-tandem accurate mass spectrometry targeted proteomics. Microsomes were prepared from liver tissue taken from 15 healthy individuals and 18 patients with cancer (2 primary and 16 metastatic). Patient samples included tumors and matching histologically normal tissue. The levels of cytochrome P450 (CYPs 2B6, 2D6, 2E1, 3A4, and 3A5) and uridine 5′-diphospho-glucuronosyltransferases (UGTs 1A1, 1A6, 1A9, 2B15, 2B4, and 2B7) were lower in histologically normal tissue from patients relative to healthy controls (up to 6.6-fold) and decreased further in tumors …

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Dengue Virus Downregulates Tnfr1- And Tlr3-Stimulated Nf-Kb Activation By Targeting Ripk1, Darshika J. Udawatte, Diane M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman Jan 2022

Dengue Virus Downregulates Tnfr1- And Tlr3-Stimulated Nf-Kb Activation By Targeting Ripk1, Darshika J. Udawatte, Diane M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman

Cell and Molecular Biology Faculty Publications

Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a productive infection. Here we report that the DENV NS3 protein targets RIPK1 (Receptor Interacting Protein Kinase I), a central mediator of inflammation and cell death, and decreases intracellular RIPK1 levels during DENV infection. The interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation. Also, we observed that the effects of NS3 …

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Assessing The Role Of Multiple Mechanisms Increasing The Age Of Dengue Cases In Thailand, Angkana T. Huang, Saki Takahashi, Henrik Salje, Lin Wang, Bernardo Garcia-Carreras, Kathryn Anderson, Timothy Endy, Stephen Thomas, Alan L. Rothman, Chonticha Klungthong, Anthony R. Jones, Stefan Fernandez, Sopon Iamsirithaworn, Pawinee Doung-Ngern, Isabel Rodriguez-Barraquer, Derek A.T. Cummings Jan 2022

Assessing The Role Of Multiple Mechanisms Increasing The Age Of Dengue Cases In Thailand, Angkana T. Huang, Saki Takahashi, Henrik Salje, Lin Wang, Bernardo Garcia-Carreras, Kathryn Anderson, Timothy Endy, Stephen Thomas, Alan L. Rothman, Chonticha Klungthong, Anthony R. Jones, Stefan Fernandez, Sopon Iamsirithaworn, Pawinee Doung-Ngern, Isabel Rodriguez-Barraquer, Derek A.T. Cummings

Cell and Molecular Biology Faculty Publications

The mean age of dengue hemorrhagic fever (DHF) cases increased considerably in Thailand from 8.1 to 24.3 y between 1981 and 2017 (mean annual increase of 0.45 y). Alternative proposed explanations for this trend, such as changes in surveillance practices, reduced mosquito–human contact, and shifts in population demographics, have different implications for global dengue epidemiology. To evaluate the contribution of each of these hypothesized mechanisms to the observed data, we developed 20 nested epidemiological models of dengue virus infection, allowing for variation over time in population demographics, infection hazards, and reporting rates. We also quantified the effect of removing or …

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Mechanisms Of Cannabidiol (Cbd) In Cancer Treatment: A Review, Camren G. Heider, Sasha A. Itenberg, Jiajia Rao, Hang Ma, Xian Wu Jan 2022

Mechanisms Of Cannabidiol (Cbd) In Cancer Treatment: A Review, Camren G. Heider, Sasha A. Itenberg, Jiajia Rao, Hang Ma, Xian Wu

Biomedical and Pharmaceutical Sciences Faculty Publications

Cannabis sativa L. (Cannabis) and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied for their biological effects in recent decades. Cannabidiol (CBD), a major non-intoxicating cannabinoid in Cannabis, has emerged as a promising intervention for cancer research. The purpose of this review is to provide insights into the relationship between CBD and cancer based on recent research findings. The anticancer effects of CBD are mainly mediated via its interaction with the endocannabinoid system, resulting in the alleviation of pain and the promotion of immune regulation. Published reviews have focused on the applications of CBD in cancer pain …

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Urinformed Summer 2022, Urinformed Jan 2022

Urinformed Summer 2022, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

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Seasonal Hypoxia Impacts Nutrient Fluxes And Microbial Communities In Narragansett Bay Sediments, Katherine Elizabeth Bell Jan 2022

Seasonal Hypoxia Impacts Nutrient Fluxes And Microbial Communities In Narragansett Bay Sediments, Katherine Elizabeth Bell

Open Access Master's Theses

Global climate and environmental changes have led to declines in oxygen content in both marine and fresh water systems globally. Hypoxia (dissolved oxygen (≤2 mg/L) is enhanced at the sediment water interface, where organic matter and the microbial communities it supports accumulate and boost respiration rates. When dissolved O2 concentrations fall below the threshold for hypoxia, bacterial communities shift to reflect species better suited to low oxygen conditions. Many of these microbes participate in metabolisms that affect water column nutrient cycles by regulating exchange across the sediment-water interface. Understanding community shifts that may impact nutrient cycling and how quickly …

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Appearance And Performance Enhancing Drug Usage And Body Image Across Three Age Cohorts Of Fitness Enthusiast Men, Jessica Strübel, Rose Leger, Xintong Guan Jan 2022

Appearance And Performance Enhancing Drug Usage And Body Image Across Three Age Cohorts Of Fitness Enthusiast Men, Jessica Strübel, Rose Leger, Xintong Guan

Textiles, Fashion Merchandising and Design Faculty Publications

Background: Because research findings on men’s body image and compensatory behaviors (e.g., appearance and performance enhancing drug (APED) usage) across the lifecycle in men is contradictory, the purpose of this study was to examine the relationship between age and body image concerns, and to investigate the specific types of APEDs used across the three age cohorts (emerging, established, and middle-aged men). Methods: Using an online survey and a sample of 1020 fitness enthusiast men, we investigated (1) type of APED/supplements used across three periods of life (emerging adulthood, established adulthood, middle age), and (2) any relationship between period …

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Uri Libraries' Ai Lab--Evolving To Meet The Needs Of Students And Research Communities, Harrison Dekker, Angel Ferria, Indrani Mandal Jan 2022

Uri Libraries' Ai Lab--Evolving To Meet The Needs Of Students And Research Communities, Harrison Dekker, Angel Ferria, Indrani Mandal

Technical Services Faculty Publications

No abstract provided.

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Reference-Free Discovery Of Nuclear Snps Permits Accurate, Sensitive Identification Of Carya (Hickory) Species And Hybrids, Robert A. Literman, Brittany M. Ott, Jun Wen, L. J. Grauke, Rachel S. Schwartz, Sara M. Handy Jan 2022

Reference-Free Discovery Of Nuclear Snps Permits Accurate, Sensitive Identification Of Carya (Hickory) Species And Hybrids, Robert A. Literman, Brittany M. Ott, Jun Wen, L. J. Grauke, Rachel S. Schwartz, Sara M. Handy

Biological Sciences Faculty Publications

Premise: DNA-based species identification is critical when morphological identification is restricted, but DNA-based identification pipelines typically rely on the ability to compare homologous sequence data across species. Because many clades lack robust genomic resources, we present here a bioinformatics pipeline capable of generating genome-wide single-nucleotide polymorphism (SNP) data while circumventing the need for any reference genome or annotation data. Methods: Using the SISRS bioinformatics pipeline, we generated de novo ortholog data for the genus Carya, isolating sites where genetic variation was restricted to a single Carya species (i.e., species-informative SNPs). We leveraged these SNPs to identify both full-species and hybrid …

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Making Science Communication Inclusive: An Exploratory Study Of Choices, Challenges And Change Mechanisms In The United States From An Emerging Movement, Sunshine Menezes, Kayon Murray-Johnson, Hollie Smith, Hannah Trautmann, Mehri Azizi Jan 2022

Making Science Communication Inclusive: An Exploratory Study Of Choices, Challenges And Change Mechanisms In The United States From An Emerging Movement, Sunshine Menezes, Kayon Murray-Johnson, Hollie Smith, Hannah Trautmann, Mehri Azizi

Natural Resources Science Faculty Publications

This qualitative study explores perspectives of U.S.A.-based science communication researchers and practitioners who attended a symposium focused on advancing inclusive science communication (ISC). ISC is a growing global movement that aims to center equity, inclusion, and marginalized perspectives in science communication. Findings underscore the complexity of systemic barriers to ISC, the critical need for resource sharing and network building, and the importance of evaluation frameworks. The authors also highlight critical dialogue as a strategic tool that might help support intentional, reciprocal, and reflexive practices in science communication.

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Rethinking Habitat Occupancy Modeling And The Role Of Diel Activity In An Anthropogenic World, Kimberly Rivera, Mason Fidino, Zach J. Farris, Seth B. Magle, Asia Murphy, Brian Gerber Jan 2022

Rethinking Habitat Occupancy Modeling And The Role Of Diel Activity In An Anthropogenic World, Kimberly Rivera, Mason Fidino, Zach J. Farris, Seth B. Magle, Asia Murphy, Brian Gerber

Natural Resources Science Faculty Publications

Current methods to model species habitat use through space and diel time are limited. Development of such models is critical when considering rapidly changing habitats where species are forced to adapt to anthropogenic change, often by shifting their diel activity across space. We use an occupancy modeling framework to specify the multistate diel occupancy model (MSDOM), which can evaluate species diel activity against continuous response variables that may impact diel activity within and across seasons or years. We used two case studies, fosas in Madagascar and coyotes in Chicago, Illinois, to conceptualize the application of this model and to quantify …

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Behavioral Therapies For Treating Female Sexual Dysfunctions: A State-Of-The-Art Review, Gemma Mestre-Bach, Gretchen R. Blycker, Marc D. Potenza Jan 2022

Behavioral Therapies For Treating Female Sexual Dysfunctions: A State-Of-The-Art Review, Gemma Mestre-Bach, Gretchen R. Blycker, Marc D. Potenza

College of Nursing Faculty Publications

No abstract provided.

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Ser-109: An Oral Investigational Microbiome Therapeutic For Patients With Recurrent Clostridioides Difficile Infection (Rcdi), Sahil Khanna, Sims, Thomas J. Louie, Monika Fischer, Kerry L. Laplante, Jessica Allegretti, Brooke R. Hasson, Allyson T. Fonte, Christopher Mcchalicher, David S. Ege, Jessica A. Bryant, Timothy J. Straub, Christopher B. Ford, Matthew R. Henn, Elaine E.L. Wang, Lisa Von Moltke, Mark H. Wilcox Jan 2022

Ser-109: An Oral Investigational Microbiome Therapeutic For Patients With Recurrent Clostridioides Difficile Infection (Rcdi), Sahil Khanna, Sims, Thomas J. Louie, Monika Fischer, Kerry L. Laplante, Jessica Allegretti, Brooke R. Hasson, Allyson T. Fonte, Christopher Mcchalicher, David S. Ege, Jessica A. Bryant, Timothy J. Straub, Christopher B. Ford, Matthew R. Henn, Elaine E.L. Wang, Lisa Von Moltke, Mark H. Wilcox

Pharmacy Practice and Clinical Research Faculty Publications

Clostridioides difficile infection (CDI) is classified as an urgent health threat by the Centers for Disease Control and Prevention (CDC), and affects nearly 500,000 Americans annually. Approximately 20–25% of patients with a primary infection experience a recurrence, and the risk of recurrence increases with subsequent episodes to greater than 40%. The leading risk factor for CDI is broad-spectrum antibiotics, which leads to a loss of microbial diversity and impaired colonization resistance. Current FDA-approved CDI treatment strategies target toxin or toxin-producing bacteria, but do not address microbiome disruption, which is key to the pathogenesis of recurrent CDI. Fecal microbiota transplantation (FMT) …

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Generalizing Trial Evidence To Target Populations In Non-Nested Designs: Applications To Aids Clinical Trials, Fan Li, Ashley L. Buchanan, Stephen R. Cole Jan 2022

Generalizing Trial Evidence To Target Populations In Non-Nested Designs: Applications To Aids Clinical Trials, Fan Li, Ashley L. Buchanan, Stephen R. Cole

Pharmacy Practice and Clinical Research Faculty Publications

Comparative effectiveness evidence from randomized trials may not be directly generalizable to a target population of substantive interest when, as in most cases, trial participants are not randomly sampled from the target population. Motivated by the need to generalize evidence from two trials conducted in the AIDS Clinical Trials Group (ACTG), we consider weighting, regression and doubly robust estimators to estimate the causal effects of HIV interventions in a specified population of people living with HIV in the USA. We focus on a non-nested trial design and discuss strategies for both point and variance estimation of the target population average …

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Jammed Disks Of Two Sizes And Weights In A Channel: Alternating Sequences, Dan Liu, Gerhard Müller Jan 2022

Jammed Disks Of Two Sizes And Weights In A Channel: Alternating Sequences, Dan Liu, Gerhard Müller

Physics Faculty Publications

Disks of two sizes and weights in alternating sequence are confined to a long and narrow channel. The axis of the channel is horizontal and its plane vertical. The channel is closed off by pistons that freeze jammed microstates out of loose disk configurations subject to moderate pressure, gravity, and random agitations. Disk sizes and channel width are such that under jamming no disk remains loose and all disks touch one wall. We present exact results for the characterization of jammed macrostates including volume and entropy. The rigorous analysis divides the disk sequences of jammed microstates into overlapping tiles from …

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Free-Energy Landscapes And Insertion Pathways For Peptides In Membrane Environment, Ganga P. Sharma, Aaron C. Meyer, Suhail Habeeb, Michael Karbach, Gerhard Müller Jan 2022

Free-Energy Landscapes And Insertion Pathways For Peptides In Membrane Environment, Ganga P. Sharma, Aaron C. Meyer, Suhail Habeeb, Michael Karbach, Gerhard Müller

Physics Faculty Publications

Free-energy landscapes for short peptides—specifically for variants of the pH low insertion peptide (pHLIP)—in the heterogeneous environment of a lipid bilayer or cell membrane are constructed, taking into account a set of dominant interactions and the conformational preferences of the peptide backbone. Our methodology interprets broken internal H-bonds along the backbone of a polypeptide as statistically interacting quasiparticles, activated from the helix reference state. The favored conformation depends on the local environment (ranging from polar to nonpolar), specifically on the availability of external H-bonds (with H2O molecules or lipid headgroups) to replace internal H-bonds. The dominant side-chain contribution is accounted …

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Building A Global Community: An Intercultural Communication Perspective, Guo-Ming Chen Jan 2022

Building A Global Community: An Intercultural Communication Perspective, Guo-Ming Chen

Communication Studies Faculty Publications

Built on the author's previous work, this paper lays down a theoretical framework for building a global community from an intercultural communication perspective. The rapid development of new media in recent decades has accelerated globalization and transformed human society into a highly interconnected place through changing the way people think and interact. This indicates that a global society is gradually emerging due to the convergence of new media and globalization trend in the 21st century. However, the emergence of a global society does not necessarily mean that a new sense of community will follow. This paper calls for using "community" …

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Identification Of Sars-Cov-2 Main Protease Inhibitors From A Library Of Minor Cannabinoids By Biochemical Inhibition Assay And Surface Plasmon Resonance Characterized Binding Affinity, Chang Liu, Tess Puopolo, Huifang Li, Ang Cai, Navindra P. Seeram, Hang Ma Jan 2022

Identification Of Sars-Cov-2 Main Protease Inhibitors From A Library Of Minor Cannabinoids By Biochemical Inhibition Assay And Surface Plasmon Resonance Characterized Binding Affinity, Chang Liu, Tess Puopolo, Huifang Li, Ang Cai, Navindra P. Seeram, Hang Ma

Biomedical and Pharmaceutical Sciences Faculty Publications

The replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its main protease (Mpro), which is a plausible therapeutic target for coronavirus disease 2019 (COVID-19). Although numerous in silico studies reported the potential inhibitory effects of natural products including cannabis and cannabinoids on SARS-CoV-2 Mpro, their anti-Mpro activities are not well validated by biological experimental data. Herein, a library of minor cannabinoids belonging to several chemotypes including tetrahydrocannabinols, cannabidiols, cannabigerols, cannabichromenes, cannabinodiols, cannabicyclols, cannabinols, and cannabitriols was evaluated for their anti-Mpro activity using a biochemical assay. Additionally, the binding affinities …

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Final Design Report, Team 31: The Mighty Ducks, Tim Pickard, Victor Gervasini, Emma Schram, Eric Gattoni Jan 2022

Final Design Report, Team 31: The Mighty Ducks, Tim Pickard, Victor Gervasini, Emma Schram, Eric Gattoni

Mechanical Engineering Capstone Design Projects

An experimental, numerical, research and design investigation is conducted to formulate a nonlethal avian deterrent system for aquacultural applications. As the ocean is itself a dynamic system, so too must its passengers be. This ethos is carried throughout each stage of the design process described herewith. The true cost is outlined in time, energy, and dollars to account for every facet involved. The team driven decisions seek balance between the meticulous selection of materials favorable for their properties and design specifications prescribed by customer and sponsor requirements. Each members initial concepts are outlined and weighed by proven and practiced engineering …

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Pfas Fluidize Synthetic And Bacterial Lipid Monolayers Based On Hydrophobicity And Lipid Charge, Aleksandra Naumann, Jessica Alesio, Monika Poonia, Geoffrey D. Bothun Jan 2022

Pfas Fluidize Synthetic And Bacterial Lipid Monolayers Based On Hydrophobicity And Lipid Charge, Aleksandra Naumann, Jessica Alesio, Monika Poonia, Geoffrey D. Bothun

Chemical, Biomolecular, and Materials Engineering Faculty Publications

Poly- and Perfluoroalkyl substances (PFASs) are pollutants of emerging concern that persist in nature and pose environmental health and safety risks. PFAS disrupt biological membranes resulting in cellular inhibition, but the mechanism of disruption and the role of lipid composition remain unclear. We examine the role of phospholipid saturation and headgroup charge on the interactions between PFASs and phospholipid monolayers comprised of synthetic phosphocholine (PC) and phosphoglycerol (PG) lipids and prepared from bacteria membrane extracts rich in PG lipids from an environmentally relevant marine bacterium Alcanivorax borkumensis. When deposited on a buffered subphase containing PFAS, PFAS mixed within and …

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Investigating The Role Corynebacterium Matruchotii Has Within Supragingival Plaque Spatial Organization And Its Response To Oral Streptococci And Saliva, Eric Ganeto Almeida Jan 2022

Investigating The Role Corynebacterium Matruchotii Has Within Supragingival Plaque Spatial Organization And Its Response To Oral Streptococci And Saliva, Eric Ganeto Almeida

Open Access Dissertations

Human supragingival plaque (SUPP) is a polymicrobial biofilm on the tooth surface above the gumline, comprised of ordered structures with spatial associations between specific bacterial taxa. Recent microscopy and microbiome data have suggested that some plaque structures are scaffolded by the abundant filamentous bacterium Corynebacterium matruchotii decorated with Streptococcus species. These taxa are able to make a reproducible structure known as the ‘Hedgehog’ model in vivo where Streptococcus species tend to form 'corncob' like structures around the terminal ends of C. matruchotii. As these species colocalize in vivo, we hypothesize that they also interact biochemically with one another. …

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Emerging Investigator Series: Moving Beyond Resilience By Considering Antifragility In Potable Water Systems, Joseph E. Goodwill, Patrick Ray, Destenie Nock, Christopher M. Miller Jan 2022

Emerging Investigator Series: Moving Beyond Resilience By Considering Antifragility In Potable Water Systems, Joseph E. Goodwill, Patrick Ray, Destenie Nock, Christopher M. Miller

Civil & Environmental Engineering Faculty Publications

It is inherently difficult to plan water systems for a future that is non-predictive. This paper introduces a novel perspective for the design and operation of potable water systems under increasing water quality volatility (e.g., a relatively rapid and unpredicted deviation from baseline water quality). Increased water quality volatility and deep uncertainty stress water systems, confound design decisions, and increase the risk of decreased water system performance. Recent emphasis on resilience in drinking water treatment has partly addressed this issue, but still establishes an adversarial relationship with change. An antifragile system benefits from volatile change. By incorporating antifragility, …

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Neo-Emancipatory Sex Education In Germany: Sexual Abuse And Gender Confusion, Bernd Ahrbeck, Karla Etschenberg, Marion Felder Jan 2022

Neo-Emancipatory Sex Education In Germany: Sexual Abuse And Gender Confusion, Bernd Ahrbeck, Karla Etschenberg, Marion Felder

Dignity: A Journal of Analysis of Exploitation and Violence

This article focuses on two related areas of concern with regard to sex education and implications for children and youth in Germany. The first one is the history of the currently dominant neo-emancipatory sexual education and its implications for today. This direction of sex education is highly influenced by theories of Helmut Kentler who with the help of the German city of Berlin youth protection services department sent homeless and troubled boys to known pedophiles for care. This experiment went on for 30 years, ending in 2001. Only now has the extend of this horrific practice been fully discovered. The …

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My Deep Sea, My Backyard: A Pilot Study To Build Capacity For Global Deep-Ocean Exploration And Research, Diva J. Amon, Randi D. Rotjan, Brian R.C. Kennedy, Gerard Alleng, Rafael Anta, Eriatera Aram, Thera Edwards, Marcia Creary-Ford, Kristina M. Gjerde, Judith Gobin, Laura Ashley Henderson, Alexis Hope, Raquel Khan Ali, Sebastian Lanser, Keith Lewis, Hannah Lochan, Scott Maclean, Nabuti Mwemwenikarawa, Brennan Phillips, Betarim Rimon, Stacey Ann Sarjursingh, Tooreka Teemari, Aranteiti Tekiau, Alan Turchik, Henri Vallès, Kareati Waysang, Katherine L.C. Bel Jan 2022

My Deep Sea, My Backyard: A Pilot Study To Build Capacity For Global Deep-Ocean Exploration And Research, Diva J. Amon, Randi D. Rotjan, Brian R.C. Kennedy, Gerard Alleng, Rafael Anta, Eriatera Aram, Thera Edwards, Marcia Creary-Ford, Kristina M. Gjerde, Judith Gobin, Laura Ashley Henderson, Alexis Hope, Raquel Khan Ali, Sebastian Lanser, Keith Lewis, Hannah Lochan, Scott Maclean, Nabuti Mwemwenikarawa, Brennan Phillips, Betarim Rimon, Stacey Ann Sarjursingh, Tooreka Teemari, Aranteiti Tekiau, Alan Turchik, Henri Vallès, Kareati Waysang, Katherine L.C. Bel

Graduate School of Oceanography Faculty Publications

The deep ocean is the largest ecosystem on the planet, constituting greater than 90% of all habitable space. Over three-quarters of countries globally have deep ocean within their Exclusive Economic Zones. While maintaining deep-ocean function is key to ensuring planetary health, deficiencies in knowledge and governance, as well as inequitable global capacity, challenge our ability to safeguard the resilience of this vast realm, leaving the fate of the deep ocean in the hands of a few. Historically, deep-ocean scientific exploration and research have been the purview of a limited number of nations, resulting in most of humankind not knowing the …

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Patterns Of Relative Bacterial Richness And Community Composition In Seawater And Marine Sediment Are Robust For Both Operational Taxonomic Units And Amplicon Sequence Variants, Zak Kerrigan, Steven D'Hondt Jan 2022

Patterns Of Relative Bacterial Richness And Community Composition In Seawater And Marine Sediment Are Robust For Both Operational Taxonomic Units And Amplicon Sequence Variants, Zak Kerrigan, Steven D'Hondt

Graduate School of Oceanography Faculty Publications

To understand the relative influences of operational taxonomic units (OTUs) and amplicon sequence variants (ASVs) on patterns of marine microbial diversity and community composition, we examined bacterial diversity and community composition of seawater from 12 sites in the North Atlantic Ocean and Canadian Arctic and sediment from two sites in the North Atlantic. For the seawater analyses, we included samples from three to six zones in the water column of each site. For the sediment analyses, we included over 20 sediment horizons at each of two sites. For all samples, we amplified the V4–V5 hypervariable region of the 16S ribosomal …

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