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Articles 1171 - 1200 of 7470
Full-Text Articles in Entire DC Network
A Philosophy Of Health: Life As Reality, Health As A Universal Value, Julian M. Saad, James O. Prochaska
A Philosophy Of Health: Life As Reality, Health As A Universal Value, Julian M. Saad, James O. Prochaska
Psychology Faculty Publications
Emphases on biomarkers (e.g. when making diagnoses) and pharmaceutical/drug methods (e.g. when researching/disseminating population level interventions) in primary care evidence philosophies of health (and healthcare) that reduce health to the biological level. However, with chronic diseases being responsible for the majority of all cause deaths and being strongly linked to health behavior and lifestyle; predominantly biological views are becoming increasingly insufficient when discussing this health crisis. A philosophy that integrates biological, behavioral, and social determinants of health could benefit multidisciplinary discussions of healthy publics. This manuscript introduces a Philosophy of Health by presenting its first five principles of health. The …
Molecular Characterization Of Haemaphysalis Species And A Molecular Genetic Key For The Identification Of Haemaphysalis Of North America, Alec T. Thompson, Kristen Dominguez, Christopher A. Cleveland, Shaun J. Dergousoff, Kandai Doi, Richard C. Falco, Talleasha Greay, Peter Irwin, L. Robbin Lindsay, Jingze Liu, Thomas N. Mather, Charlotte L. Oskam, Roger I. Rodriguez-Vivas, Mark G. Ruder, David Shaw, Stacey L. Vigil, Seth White, Michael J. Yabsley
Molecular Characterization Of Haemaphysalis Species And A Molecular Genetic Key For The Identification Of Haemaphysalis Of North America, Alec T. Thompson, Kristen Dominguez, Christopher A. Cleveland, Shaun J. Dergousoff, Kandai Doi, Richard C. Falco, Talleasha Greay, Peter Irwin, L. Robbin Lindsay, Jingze Liu, Thomas N. Mather, Charlotte L. Oskam, Roger I. Rodriguez-Vivas, Mark G. Ruder, David Shaw, Stacey L. Vigil, Seth White, Michael J. Yabsley
Plant Sciences and Entomology Faculty Publications
Haemaphysalis longicornis (Acari: Ixodidae), the Asian longhorned tick, is native to East Asia, but has become established in Australia and New Zealand, and more recently in the United States. In North America, there are other native Haemaphysalis species that share similar morphological characteristics and can be difficult to identify if the specimen is damaged. The goal of this study was to develop a cost-effective and rapid molecular diagnostic assay to differentiate between exotic and native Haemaphysalis species to aid in ongoing surveillance of H. longicornis within the United States and help prevent misidentification. We demonstrated that restriction fragment length polymorphisms …
The Reliability Of Foot And Ankle Bone And Joint Kinematics Measured With Biplanar Videoradiography And Manual Scientific Rotoscoping, Jayishni N. Maharaj, Sarah Kessler, Michael J. Rainbow, Susan E. D'Andrea, Nicolai Konow, Luke A. Kelly, Glen A. Lichtwark
The Reliability Of Foot And Ankle Bone And Joint Kinematics Measured With Biplanar Videoradiography And Manual Scientific Rotoscoping, Jayishni N. Maharaj, Sarah Kessler, Michael J. Rainbow, Susan E. D'Andrea, Nicolai Konow, Luke A. Kelly, Glen A. Lichtwark
Kinesiology Faculty Publications
The intricate motion of the small bones of the feet are critical for its diverse function. Accurately measuring the 3-dimensional (3D) motion of these bones has attracted much attention over the years and until recently, was limited to invasive techniques or quantification of functional segments using multi-segment foot models. Biplanar videoradiography and model-based scientific rotoscoping offers an exciting alternative that allows us to focus on the intricate motion of individual bones in the foot. However, scientific rotoscoping, the process of rotating and translating a 3D bone model so that it aligns with the captured x-ray images, is either semi- or …
Carbon Assimilation Strategies In Ultrabasic Groundwater: Clues From The Integrated Study Of A Serpentinization-Influenced Aquifer, Lauren M. Seyler, William J. Brazelton, Craig Mclean, Lindsay I. Putman, Alex Hyer, Michael Dy Kubo, Tory Hoehler, Dawn Cardace, Matthew O. Schrenk
Carbon Assimilation Strategies In Ultrabasic Groundwater: Clues From The Integrated Study Of A Serpentinization-Influenced Aquifer, Lauren M. Seyler, William J. Brazelton, Craig Mclean, Lindsay I. Putman, Alex Hyer, Michael Dy Kubo, Tory Hoehler, Dawn Cardace, Matthew O. Schrenk
Geosciences Faculty Publications
Serpentinization is a low-temperature metamorphic process by which ultramafic rock chemically reacts with water. Such reactions provide energy and materials that may be harnessed by chemosynthetic microbial communities at hydrothermal springs and in the subsurface. However, the biogeochemistry mediated by microbial populations that inhabit these environments is understudied and complicated by overlapping biotic and abiotic processes. We applied metagenomics, metatranscriptomics, and untargeted metabolomics techniques to environmental samples taken from the Coast Range Ophiolite Microbial Observatory (CROMO), a subsurface observatory consisting of 12 wells drilled into the ultramafic and serpentinite mélange of the Coast Range Ophiolite in California. Using a combination …
Anthropogenic Electromagnetic Fields (Emf) Influence The Behaviour Of Bottom-Dwelling Marine Species, Zoe L. Hutchison, Andrew B. Gill, Peter Sigray, Haibo He, John W. King
Anthropogenic Electromagnetic Fields (Emf) Influence The Behaviour Of Bottom-Dwelling Marine Species, Zoe L. Hutchison, Andrew B. Gill, Peter Sigray, Haibo He, John W. King
Graduate School of Oceanography Faculty Publications
Many marine animals have evolved sensory abilities to use electric and magnetic cues in essential aspects of life history, such as to detect prey, predators and mates as well as to orientate and migrate. Potential disruption of vital cues by human activities must be understood in order to mitigate potential negative influences. Cable deployments in coastal waters are increasing worldwide, in capacity and number, owing to growing demands for electrical power and telecommunications. Increasingly, the local electromagnetic environment used by electro- and magneto-sensitive species will be altered. We quantified biologically relevant behavioural responses of the presumed, magneto-receptive American lobster and …
Exploring And Interpreting Spatiotemporal Interactions Between Native And Invasive Carnivores Across A Gradient Of Rainforest Degradation, Zach J. Farris, Brian Gerber, Sarah Karpanty, Asia Murphy, Erin Wampole, Felix Ratelolahy, Marcella J. Kelly
Exploring And Interpreting Spatiotemporal Interactions Between Native And Invasive Carnivores Across A Gradient Of Rainforest Degradation, Zach J. Farris, Brian Gerber, Sarah Karpanty, Asia Murphy, Erin Wampole, Felix Ratelolahy, Marcella J. Kelly
Natural Resources Science Faculty Publications
Studies of elusive carnivores often rely on passive sampling when investigating either spatial or temporal interactions. However, inference on behavioral mechanisms are usually lacking. We present an analysis that combines previously published spatial co-occurrence estimates and temporal kernel density estimates to explore spatiotemporal interspecific interactions. We do so by deriving a spatiotemporal value (STV) that is a relative measure of potential interaction in both niche dimensions, across a gradient of degradation, for rainforest carnivore pairs in Madagascar. We also use a conceptual framework to provide insight into the potential behavioral mechanisms of habitat selection. Of the six native and three …
The Art Of Jin Shin Jyutsu, Kaitlyn Willis
The Art Of Jin Shin Jyutsu, Kaitlyn Willis
Senior Honors Projects
There are many times a day that I find myself feeling worried, anxious, or fearful. With these discomforts building, I find that each month I am getting more headaches, stomach aches, and even neck/back pain. In an attempt to find relief for my pain and discomfort, I find myself reaching for some type of medication, only to find they have moderate effects. For my honors project, I sought to find a noninvasive, alternative form of treatment in order to help relieve illness, tension, or discomfort. I found a Japanese, integrative therapy that is complementary with the already well-known Western medicine. …
Assessment Of Salt Marsh Change On Assateague Island National Seashore Between 1962 And 2016, Anthony Campbell, Yeqiao Wang
Assessment Of Salt Marsh Change On Assateague Island National Seashore Between 1962 And 2016, Anthony Campbell, Yeqiao Wang
Natural Resources Science Faculty Publications
Salt marshes provide extensive ecosystem services, including high biodiversity, denitrification, and wave attenuation. In the mid-Atlantic, sea level rise is predicted to affect salt marsh ecosystems severely. This study mapped the entirety of Assateague Island with Very High Resolution satellite imagery and object-based methods to determine an accurate salt marsh baseline for change analysis. Topobathymetric light detection and ranging was used to map the salt marsh and model expected tidal effects. The satellite imagery, collected in 2016 and classified at two hierarchical thematic schemes, were compared to determine appropriate thematic richness. Change analysis between this 2016 map and both a …
Molecular Basis For Receptor Tyrosine Kinase A-Loop Tyrosine Transphosphorylation, Lingfeng Chen, William M. Marsiglia, Huaibin Chen, Joseph Katigbak, Hediye Erdjument-Bromage, David J. Kemble, Lili Fu, Jinghong Ma, Gongqin Sun, Yingkai Zhang, Guang Liang, Thomas A. Neubert, Xiaokun Li, Nathaniel J. Traaseth, Moosa Mohammadi
Molecular Basis For Receptor Tyrosine Kinase A-Loop Tyrosine Transphosphorylation, Lingfeng Chen, William M. Marsiglia, Huaibin Chen, Joseph Katigbak, Hediye Erdjument-Bromage, David J. Kemble, Lili Fu, Jinghong Ma, Gongqin Sun, Yingkai Zhang, Guang Liang, Thomas A. Neubert, Xiaokun Li, Nathaniel J. Traaseth, Moosa Mohammadi
Cell and Molecular Biology Faculty Publications
A long-standing mystery shrouds the mechanism by which catalytically repressed receptor tyrosine kinase domains accomplish transphosphorylation of activation loop (A-loop) tyrosines. Here we show that this reaction proceeds via an asymmetric complex that is thermodynamically disadvantaged because of an electrostatic repulsion between enzyme and substrate kinases. Under physiological conditions, the energetic gain resulting from ligand-induced dimerization of extracellular domains overcomes this opposing clash, stabilizing the A-loop-transphosphorylating dimer. A unique pathogenic fibroblast growth factor receptor gain-of-function mutation promotes formation of the complex responsible for phosphorylation of A-loop tyrosines by eliminating this repulsive force. We show that asymmetric complex formation induces a …
Inquiry Into Cell And Molecular Biology Cmb 395, Michael Cerbo
Inquiry Into Cell And Molecular Biology Cmb 395, Michael Cerbo
Library Impact Statements
No abstract provided.
Prioritizing Water Security In The Management Of Vector Borne Diseases: Lessons From Oaxaca Mexico, Ali S. Akanda, Kristin Johnson, Howard S. Ginsberg, Janelle Couret
Prioritizing Water Security In The Management Of Vector Borne Diseases: Lessons From Oaxaca Mexico, Ali S. Akanda, Kristin Johnson, Howard S. Ginsberg, Janelle Couret
Civil & Environmental Engineering Faculty Publications
Changes in human water use, along with temperature and rainfall patterns, are facilitating habitat spread and distribution of Aedes aegypti and Aedes albopictusmosquitoes, the primary vectors for the transmission of Dengue, Chikungunya, and Zika viruses in the Americas. Artificial containers and wet spots provide major sources of mosquito larval habitat in residential areas. Mosquito abatement and control strategies remain the most effective public health interventions for minimizing the impact of these vector borne diseases. Understanding how water insecurity is conducive to the establishment and elimination of endemic mosquito populations, particularly in arid or semi‐arid regions, is a vital component …
Aquaculture And Fisheries Internship Afs 399, Michael Cerbo
Aquaculture And Fisheries Internship Afs 399, Michael Cerbo
Library Impact Statements
No abstract provided.
Curricular Report No. 2019-20-8 From The Graduate Council To The Faculty Senate (Courses), University Of Rhode Island Faculty Senate
Curricular Report No. 2019-20-8 From The Graduate Council To The Faculty Senate (Courses), University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Curriculum And Standards Committee Report #2019-20-8: Curricular Proposals, University Of Rhode Island Faculty Senate
Curriculum And Standards Committee Report #2019-20-8: Curricular Proposals, University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Curriculum And Standards Committee Report No. #2019-20-8 (Courses), University Of Rhode Island Faculty Senate
Curriculum And Standards Committee Report No. #2019-20-8 (Courses), University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Climate‐Induced Changes In The Suitable Habitat Of Cold‐Water Corals And Commercially Important Deep‐Sea Fishes In The North Atlantic, Telmo Morato, Andrew Davies, Et Al
Climate‐Induced Changes In The Suitable Habitat Of Cold‐Water Corals And Commercially Important Deep‐Sea Fishes In The North Atlantic, Telmo Morato, Andrew Davies, Et Al
Biological Sciences Faculty Publications
The deep sea plays a critical role in global climate regulation through uptake and storage of heat and carbon dioxide. However, this regulating service causes warming, acidification and deoxygenation of deep waters, leading to decreased food availability at the seafloor. These changes and their projections are likely to affect productivity, biodiversity and distributions of deep‐sea fauna, thereby compromising key ecosystem services. Understanding how climate change can lead to shifts in deep‐sea species distributions is critically important in developing management measures. We used environmental niche modelling along with the best available species occurrence data and environmental parameters to model habitat suitability …
Impact Of A Nutritional Supplement During Gestation And Early Childhood On Child Salivary Cortisol, Hair Cortisol, And Telomere Length At 4–6 Years Of Age: A Follow-Up Of A Randomized Controlled Trial, Brietta M. Oaks, Seth Adu-Afarwuah, Sika Kumordzie, Mark L. Laudenslager, Dana L. Smith, Jue Lin, Rebecca R. Young, Charles D. Arnold, Helena Bentil, Harriet Okronipa, Maku Ocansey, Kathryn G. Dewey
Impact Of A Nutritional Supplement During Gestation And Early Childhood On Child Salivary Cortisol, Hair Cortisol, And Telomere Length At 4–6 Years Of Age: A Follow-Up Of A Randomized Controlled Trial, Brietta M. Oaks, Seth Adu-Afarwuah, Sika Kumordzie, Mark L. Laudenslager, Dana L. Smith, Jue Lin, Rebecca R. Young, Charles D. Arnold, Helena Bentil, Harriet Okronipa, Maku Ocansey, Kathryn G. Dewey
Nutrition Faculty Publications
Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of nutritional supplementation during gestation and early childhood on child cortisol and buccal telomere length (a marker of cellular aging) at 4–6 years of age. We conducted a follow-up study of children born to women who participated in a nutritional supplementation trial in Ghana. In one group, a lipid-based nutrient supplement (LNS) was provided to women during gestation and the first 6 months postpartum and to their infants from age 6 to 18 months. The control …
Biphasic Mathematical Model Of Cell–Drug Interaction That Separates Target-Specific And Off-Target Inhibition And Suggests Potent Targeted Drug Combinations For Multi-Driver Colorectal Cancer Cells, Jinyan Shen, Li Li, Tao Yang, Paul S. Cohen, Gongqin Sun
Biphasic Mathematical Model Of Cell–Drug Interaction That Separates Target-Specific And Off-Target Inhibition And Suggests Potent Targeted Drug Combinations For Multi-Driver Colorectal Cancer Cells, Jinyan Shen, Li Li, Tao Yang, Paul S. Cohen, Gongqin Sun
Cell and Molecular Biology Faculty Publications
Quantifying the response of cancer cells to a drug, and understanding the mechanistic basis of the response, are the cornerstones for anti-cancer drug discovery. Classical single target-based IC50 measurements are inadequate at describing cancer cell responses to targeted drugs. In this study, based on an analysis of targeted inhibition of colorectal cancer cell lines, we develop a new biphasic mathematical model that accurately describes the cell–drug response. The model describes the drug response using three kinetic parameters: ratio of target-specific inhibition, F1, potency of target-specific inhibition, Kd1, and potency of off-target toxicity, Kd2. …
Three-Dimensional Digital Mapping Of Ecosystems: A New Era In Spatial Ecology, Tim D'Urban Jackson, Gareth J. Williams, Guy Walker-Springett, Andrew J. Davies
Three-Dimensional Digital Mapping Of Ecosystems: A New Era In Spatial Ecology, Tim D'Urban Jackson, Gareth J. Williams, Guy Walker-Springett, Andrew J. Davies
Biological Sciences Faculty Publications
Ecological processes occur over multiple spatial, temporal and thematic scales in three-dimensional (3D) ecosystems. Characterizing and monitoring change in 3D structure at multiple scales is challenging within the practical constraints of conventional ecological tools. Remote sensing from satellites and crewed aircraft has revolutionized broad-scale spatial ecology, but fine-scale patterns and processes operating at sub-metre resolution have remained understudied over continuous extents. We introduce two high-resolution remote sensing tools for rapid and accurate 3D mapping in ecology—terrestrial laser scanning and structure-from-motion photogrammetry. These technologies are likely to become standard sampling tools for mapping and monitoring 3D ecosystem structure across currently under-sampled …
Fundamentals Of The Medical Laboratory Mls 360, Michael Cerbo
Fundamentals Of The Medical Laboratory Mls 360, Michael Cerbo
Library Impact Statements
No abstract provided.
Ultrasound-Enhanced Chemiluminescence For Bioimaging, Duong Le, Danesh Dhamecha, Andrea Gonsalves, Jyothi Menon
Ultrasound-Enhanced Chemiluminescence For Bioimaging, Duong Le, Danesh Dhamecha, Andrea Gonsalves, Jyothi Menon
Biomedical and Pharmaceutical Sciences Faculty Publications
Tissue imaging has emerged as an important aspect of theragnosis. It is essential not only to evaluate the degree of the disease and thus provide appropriate treatments, but also to monitor the delivery of administered drugs and the subsequent recovery of target tissues. Several techniques including magnetic resonance imaging (MRI), computational tomography (CT), acoustic tomography (AT), biofluorescence (BF) and chemiluminescence (CL), have been developed to reconstruct three-dimensional images of tissues. While imaging has been achieved with adequate spatial resolution for shallow depths, challenges still remain for imaging deep tissues. Energy loss is usually observed when using a magnetic field or …
Sleep In The Social World Of College Students: Bridging Interpersonal Stress And Fear Of Missing Out With Mental Health, Sue K. Adams, Karla K. Murdock, Meada Daly-Cano, Meredith Rose
Sleep In The Social World Of College Students: Bridging Interpersonal Stress And Fear Of Missing Out With Mental Health, Sue K. Adams, Karla K. Murdock, Meada Daly-Cano, Meredith Rose
Human Development and Family Science Faculty Publications
Introduction: The college years are characterized by psychosocial and biological phenomena that may impact mental health, such as heightened sensitivity to social stressors and compromises in sleep quantity and quality. The current study uses a biopsychosocial approach to examine the associations among interpersonal stress, Fear of Missing Out (FoMO), insomnia, and mental health. Methods: Survey data were collected from 283 undergraduate students (90% female) with a mean age of 21.4 years. A path analysis was utilized to test a mediational model linking interpersonal stress and FoMO with mental health through a mediator of insomnia. We hypothesized that higher levels of …
Influence Of Solvent And Molecular Weight In Wrinkle Formation In Spin-Cast Polystyrene Thin Films, Chunyi Tang, Matthew Mullen, William B. Euler
Influence Of Solvent And Molecular Weight In Wrinkle Formation In Spin-Cast Polystyrene Thin Films, Chunyi Tang, Matthew Mullen, William B. Euler
Chemistry Faculty Publications
The surface morphology of polystyrene thin films formed from various molecular weight polystyrene and solvent conditions is studied. When spin-cast from tetrahydrofuran (THF) wrinkles are formed at the extremities that have periodicity with wavelengths in the μm range and amplitudes in the nm range but varies with molecular weight. A mixed solvent system consisting of THF and dimethylformamide (DMF) leads to periodic structures only with THF-rich compositions. THF and DMF have similar properties relevant to spin-casting: density, surface tension, molecular weight, and viscosity but different boiling points and room temperature vapor pressures, demonstrating that formation periodicity requires a volatile solvent. …
Parents As Pimps: Survivor Accounts Of Trafficking Of Children In The United States, Jody Raphael
Parents As Pimps: Survivor Accounts Of Trafficking Of Children In The United States, Jody Raphael
Dignity: A Journal of Analysis of Exploitation and Violence
This article discusses four survivor accounts of survivors of being sold for sexual exploitation by their parents for monetary gain. These narratives, supplemented by other accounts from 100 newspaper stories between 2012 and 2018, reveal the fact that many survivors were sold as very young children, and the abuse continued through their teen years, blurring distinctions between pedophilia and the sex trade industry. In their accounts, survivors described the motivations of their parents as well as the buyers, who used excessive force and violence. Some researchers are beginning to document the existence of parental pimping and its prevalence, which ranges …
Thermal Transport And Flow In Polymeric Materials, David C. Venerus
Thermal Transport And Flow In Polymeric Materials, David C. Venerus
Amgen Seminar Series in Chemical Engineering
The strong coupling of mechanical and thermal effects in polymer processing flows has profound implications on both the processability and final properties of polymeric materials. Simple molecular arguments suggest that Fourier’s law must be generalized to allow for anisotropic thermal conductivity in flowing polymer melts. In addition, theoretical results suggest a linear relationship between the thermal conductivity tensor and stress tensor, or a stress-thermal rule. Using a novel optical method based on Forced Rayleigh Scattering (FRS) developed in our laboratory, we obtain quantitative measurements of all components of the thermal diffusivity tensor in polymers subjected to deformation. These data have …
Curriculum And Standards Committee Report #2019-20-7: Curricular Proposals, University Of Rhode Island Faculty Senate
Curriculum And Standards Committee Report #2019-20-7: Curricular Proposals, University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Curriculum And Standards Committee Report No. #2019-20-7 (Courses), University Of Rhode Island Faculty Senate
Curriculum And Standards Committee Report No. #2019-20-7 (Courses), University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Curriculum And Standards Committee Report #2019-20-7: Transfer Health And Physical Education Track From Kinesiology To Education In The Alan Shawn Feinstein College Of Education And Professional Studies, University Of Rhode Island Faculty Senate
Curriculum And Standards Committee Report #2019-20-7: Transfer Health And Physical Education Track From Kinesiology To Education In The Alan Shawn Feinstein College Of Education And Professional Studies, University Of Rhode Island Faculty Senate
Faculty Senate Bills
No abstract provided.
Common Temperature-Growth Dependency And Acclimation Response In Three Herbivorous Protists, Gayantonia Franze, Susanne Menden-Deuer
Common Temperature-Growth Dependency And Acclimation Response In Three Herbivorous Protists, Gayantonia Franze, Susanne Menden-Deuer
Graduate School of Oceanography Faculty Publications
Phytoplankton growth dependence on temperature is recognized and has been quantified comprehensively. However, no similar relationship exists for the major phytoplankton predators, the herbivorous protists, especially at low temperatures representing polar and coastal oceans during most seasons. Their acclimation to changing temperatures is also largely unexplored. Here we report acclimated growth and acclimation rates from 0 to 22°C for 3 cosmopolitan herbivorous dinoflagellates. Due to interactive effects between size and temperature, growth increased 40% more rapidly with increasing temperature for production- compared to division-based growth rates (0.043 and 0.062 d-1 °C-1, respectively). Biomass-based growth rates were 10-fold …
Cell-Mediated Immunity Generated In Response To A Purified Inactivated Vaccine For Dengue Virus Type 1, Heather Friberg, Luis J. Martinez, Leyi Lin, Jason M. Blaylock, Rafael A. De La Barrera, Alan L. Rothman, J. Robert Putnak, Kenneth H. Eckels, Stephen J. Thomas, Richard G. Jarman, Jeffrey R. Currier
Cell-Mediated Immunity Generated In Response To A Purified Inactivated Vaccine For Dengue Virus Type 1, Heather Friberg, Luis J. Martinez, Leyi Lin, Jason M. Blaylock, Rafael A. De La Barrera, Alan L. Rothman, J. Robert Putnak, Kenneth H. Eckels, Stephen J. Thomas, Richard G. Jarman, Jeffrey R. Currier
Institute for Immunology and Informatics Faculty Publications
Dengue is the most prevalent arboviral disease afflicting humans, and a vaccine appears to be the most rational means of control. Dengue vaccine development is in a critical phase, with the first vaccine licensed in some countries where dengue is endemic but demonstrating insufficient efficacy in immunologically naive populations. Since virus-neutralizing antibodies do not invariably correlate with vaccine efficacy, other markers that may predict protection, including cell-mediated immunity, are urgently needed. Previously, the Walter Reed Army Institute of Research developed a monovalent purified inactivated virus (PIV) vaccine candidate against dengue virus serotype 1 (DENV-1) adjuvanted with alum. The PIV vaccine …