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The Good 5 Cent Cigar (2/22/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (2/15/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Metabolic Response Of Pteropods To Acidification Reflects Natural Co2-Exposure In Oxygen Minimum Zones, A. E. Maas, K. F. Wishner, B. A. Seibel

Graduate School of Oceanography Faculty Publications

Shelled pteropods (Thecosomata) are a group of holoplanktonic mollusks that are believed to be especially sensitive to ocean acidification because their aragonitic shells are highly soluble. Despite this concern, there is very little known about the physiological response of these animals to conditions of elevated carbon dioxide. This study examines the oxygen consumption and ammonia excretion of five pteropod species, collected from tropical regions of the Pacific Ocean, to elevated levels of carbon dioxide (0.10 %, 1000 ppm). Our results show that pteropods that naturally migrate into oxygen minimum zones, such as Hyalocylis striata, Clio pyramidata, Cavolinia longirostris and Creseis …

The Good 5 Cent Cigar (2/14/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (2/9/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (2/1/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (1/27/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

The Good 5 Cent Cigar (1/24/2012), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Association Of The 5-Htt Gene-Linked Promoter Region (5-Httlpr) Polymorphism With Psychiatric Disorders: Review Of Psychopathology And Pharmacotherapy, George A. Kenna, Nick Roder-Hanna, Lorenzo Leggio, William H. Zywiak, James Clifford, Steven Edwards, John A. Kenna, Jessica Shoaff, Robert M. Swift

College of Nursing Faculty Publications

Serotonin (5-HT) regulates important biological and psychological processes including mood, and may be associated with the development of several psychiatric disorders. An association between psychopathology and genes that regulate 5-HT neurotransmission is a robust area of research. Identification of the genes responsible for the predisposition, development, and pharmacological response of various psychiatric disorders is crucial to the advancement of our understanding of their underlying neurobiology. This review highlights research investigating 5-HT transporter (5-HTTLPR) polymorphism, because studies investigating the impact of the 5-HTTLPR polymorphism have demonstrated significant associations with many psychiatric disorders. Decreased transcriptional activity of the S allele (“risk allele”) …

A Partial Timeline Of Glbt Centric Events While Acting As Director Of The Glbt Center, Joseph A. Santiago

Lesbian Gay Bisexual Transgender Queer Center

At the end of the December 2011 semester, I was surprised to look back and see that it has been approximately one year since I have been fulfilling the role of Director of the GLBT Center in absence of Andrew Winters, the previous Director and the Assistant VP on LGBTQ in Student Affairs. This report will share a rough timeline of recent events that have happened in the URI-LGBTIQQ community. I am writing this to inform and update the new Director of the GLBT Center and the broader community with a general overview of the events and experiences I have …

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation In Adipose Tissue, And Increases Hepatic Steatosis In Leptin-Deficient Mice, Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, Angela L. Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep^ob/ob-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type 2 diabetes were measured in C57Bl/6J, Keap1-KD, Lep^ob/ob, and Lep^ob/ob-Keap1-KD mice. Lep^ob/ob-Keap1-KD mice exhibited less lipid accumulation, smaller adipocytes, decreased food intake, and reduced lipogenic gene expression. Enhanced Nrf2 activity impaired insulin signaling, prolonged hyperglycemia in response to glucose challenge, and induced insulin resistance in Lep^ob/ob background. Nrf2 augmented …

Division Of Research And Economic Development Annual Report For Fy2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

Annual report for the Division of Research and Economic Development of the University of Rhode Island for the year 2011-2012.

Includes statistics of project proposals, expenditures, URI Foundation Awards, previous annual report summaries and awards received by individual academic and administrative departments.

Division Of Research And Economic Development Monthly Report For January 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February-March 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For May-June 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For November 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July - October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Effect Of Hla Dr Epitope De-Immunization Of Factor Viii In Vitro And In Vivo, Leonard Moise, Chang Song, William D. Martin, Ryan Tassone, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3 × E16 mice. Consistent with immunoinformatic predictions, original epitopes …

Teaching Tolerance, Leslie P. Cousens, Federico Mingozzi, Sander Van Der Marel, Yan Su, Richard Garman, Valerie Ferreira, William Martin, David W. Scott, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely …

Research & Innovation For 2011-2012, University Of Rhode Island

Publications (Research and Economic Development)

The 2011-2012 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.

Hypolipidemic Agent Z-Guggulsterone: Metabolism Interplays With Induction Of Carboxylesterase And Bile Salt Export Pump, Dongfang Yang, Jian Yang, Deshi Shi, Da Xiao, Yi-Tzai Chen, Chris Black, Ruitang Deng, Bingfang Yan

Biomedical and Pharmaceutical Sciences Faculty Publications

Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is generally assumed that the antagonism leads to induction of cytochrome P450 7A1 (CYP7A1), the rate-limiting enzyme converting free cholesterol to bile acids. In this study, we tested whether Z-guggulsterone indeed induces human CYP7A1. In addition, the expression of cholesteryl ester hydrolase CES1 and bile salt export pump (BSEP) was monitored. Contrary to the general assumption, Z-guggulsterone did not induce CYP7A1. Instead, …

Metabolic Hypothesis For Human Altriciality, Holly M. Dunsworth, Anna G. Warrener, Terrence Deacon, Peter T. Ellison, Herman Pontzer

Sociology and Anthropology Faculty Publications

The classic anthropological hypothesis known as the “obstetrical dilemma” is a well-known explanation for human altriciality, a condition that has significant implications for human social and behavioral evolution. The hypothesis holds that antagonistic selection for a large neonatal brain and a narrow, bipedal-adapted birth canal poses a problem for childbirth; the hominin “solution” is to truncate gestation, resulting in an altricial neonate. This explanation for human altriciality based on pelvic constraints persists despite data linking human life history to that of other species. Here, we present evidence that challenges the importance of pelvic morphology and mechanics in the evolution of …

All Might Have Won, But Not All Have The Prize: Optimal Treatment For Substance Abuse Among Adolescents With Conduct Problems, Jayson Spas, Susan Ramsey, Andrea L. Paiva, L. A.R. Stein

Cancer Prevention Research Center Faculty Publications

Considerable evidence from the literature on treatment outcomes indicates that substance abuse treatment among adolescents with conduct problems varies widely. Treatments commonly used among this population are cognitive-behavioral therapy (CBT), 12-step facilitation, multisystemic therapy (MST), psychoeducation (PE), and motivational interviewing (MI). This manuscript thoroughly and systematically reviews the available literature to determine which treatment is optimal for substance-abusing adolescents with conduct problems. Results suggest that although there are several evidence-based and empirically supported treatments, those that incorporate family-based intervention consistently provide the most positive treatment outcomes. In particular, this review further reveals that although many interventions have gained empirical support …

Unesco, Uri, And Archaeology In The Deep Blue Sea: Archaeological Ethics And Archaeological Oceanography, William H. Krieger, Bridget Buxton

Philosophy Faculty Publications

Multiple groups have interests that intersect within the new field of deep submergence (beyond the 50 meter range of SCUBA) archaeology. These groups‟ differing priorities present challenges for interdisciplinary collaboration, particularly as there are no established guidelines for best practices in such scenarios. Associating the term 'archaeology' with projects directed at underwater cultural heritage that are are not guided by archaeologists poses a real risk to that heritage. Recognizing that the relevant professional organizations, local laws, and conventions currently have little ability to protect pieces of cultural heritage across disciplines and international boundaries, the authors propose institution-specific mechanisms, called Archaeology …

Adeno-Associated Virus Mediated Delivery Of Tregitope 167 Ameliorates Experimental Colitis, Sander Van Der Marel, Anna Majowicz, Karin Kwikkers, Richard Van Logtenstein, Anje A. Te Velde, Anne S. De Groot, Sybren L. Meijer, Sander J. Van Deventer, Harald Petry, Daniel W. Hommes, Valerie Ferreira

Institute for Immunology and Informatics Faculty Publications

Aim: To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis model.

Methods: The trinitrobenzene sulfonate (TNBS) model of induced colitis was used in Balb/c mice. Subsequently after intravenous adeno-associated virus-mediated regulatory T-cell epitopes (Tregitope) delivery, acute colitis was initiated by intra-rectal administration of 1.5 mg TNBS in 40% ethanol followed by a second treatment with TNBS (0.75 mg in 20% ethanol) 8 d later. Control groups included mice not treated with TNBS (healthy control group) and mice treated by TNBS only (diseased group). At the time of sacrifice colon weight, the disease activity …

Introduction To The Special Issue On Job Satisfaction In Fisheries In The Global South, Maarten Bavinck, Richard B. Pollnac, Iris Monnereau, Pierre Failler

Marine Affairs Faculty Publications

No abstract provided.