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Articles 11551 - 11580 of 11786
Full-Text Articles in Entire DC Network
Guanylyl Cyclase Activity Associated With Putative Bifunctional Integral Membrane Proteins In Plasmodium Falciparum, Dj Carucci, Aa Witney, Dk Muhia, Dc Warhurst, Et Al
Guanylyl Cyclase Activity Associated With Putative Bifunctional Integral Membrane Proteins In Plasmodium Falciparum, Dj Carucci, Aa Witney, Dk Muhia, Dc Warhurst, Et Al
School of Biomedical Sciences
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum. Unusually, the proteins appear to be bifunctional; their amino-terminal regions have strong similarity with P-type ATPases, and the sequence and structure of the carboxyl-terminal regions conform to that of G protein-dependent adenylyl cyclases, with two sets of six transmembrane sequences, each followed by a catalytic domain (C1 and C2). However, amino acids that are enzymatically important and present in the C2 domain of mammalian adenylyl cyclases are located in the C1 domain of the P. …
From Robotic Toil To Symbolic Theft: Grounding Transfer From Entry-Level To Higher-Level Categories1, A Cangelosi, A Greco, S Harnad
From Robotic Toil To Symbolic Theft: Grounding Transfer From Entry-Level To Higher-Level Categories1, A Cangelosi, A Greco, S Harnad
School of Engineering, Computing and Mathematics
Neural network models of categorical perception (compression of within-category similarity and dilation of between-category differences) are applied to the symbol-grounding problem (of how to connect symbols with meanings) by connecting analogue sensorimotor projections to arbitrary symbolic representations via learned category-invariance detectors in a hybrid symbolic/non-symbolic system. Our nets are trained to categorize and name 50 × 50 pixel images (e.g. circles, ellipses, squares and rectangles) projected on to the receptive field of a 7 × 7 retina. They first learn to do prototype matching and then entry-level naming for the four kinds of stimuli, grounding their names directly in the …
Effects Of Towed Demersal Fishing Gear On Biogenic Sediments: A 5-Year-Study, Jm Hall-Spencer
Effects Of Towed Demersal Fishing Gear On Biogenic Sediments: A 5-Year-Study, Jm Hall-Spencer
School of Biological and Marine Sciences
Experimental scallop fishing was carried out using towed commercial dredges on sediments deposited by unattached coralline algae in order to quantify their sensitivity to damage from current fishing practices. These biogenic sediments are patchily distributed in European coastal waters (to -30 m depth around the UK and to -120 m in the Mediterranean) and are of international conservation importance. This paper describes the short and long-term effects of scallop dredging on previously unfished and fished areas of biogenic algal sediment in SW Scotland. Sediment cores taken biannually from 1994-99 were used to assess live coralline abundance on marked test and …
Pesticide Demand Among Hybrid Vegetable And Cereal Seed Producers In Bangladesh: A Simultaneous Equation Analysis, S Rahman, Mz Hossain
Pesticide Demand Among Hybrid Vegetable And Cereal Seed Producers In Bangladesh: A Simultaneous Equation Analysis, S Rahman, Mz Hossain
School of Geography, Earth and Environmental Sciences
Demand for pesticides, inorganic and organic fertilizers were jointly estimated using survey data from a randomly selected 81 BRAC ‘contract hybrid vegetables and cereal seed growers’ in northwestern Bangladesh applying a simultaneous equation framework. Pesticide cost accounts for 6.9% of the gross value of output in hybrid seeds of vegetables and 3.2% in cereals. About 87% of farmers used pesticides at least once with mean number of application of 4.4 times. Twenty-seven brands of pesticides were used including a substantial number of banned pesticides. Price elasticity of demand for pesticides, fertilizers and biofertilizers were estimated at –0.83, –0.21 and –1.13, …
Molecular Cloning Of A Gene Encoding A 20s Proteasome Β Subunit From Plasmodium Falciparum, G-D Li, J-L Li, M Mugthin, Sa Ward
Molecular Cloning Of A Gene Encoding A 20s Proteasome Β Subunit From Plasmodium Falciparum, G-D Li, J-L Li, M Mugthin, Sa Ward
School of Biomedical Sciences
A novel gene was cloned from Plasmodium falciparum. Database searches indicated this gene to be a member of the 20S proteasome beta-subunit family. Comparison of the gene's genomic DNA sequence with cDNA sequence revealed a 156-bp intron 85 bp downstream from the start codon. The nucleotide sequence of the gene contains one open reading frame encoding 265 amino acids with a predicted molecular mass of 30.9 kDa and a pI of 6.2. Northern blot analysis showed the transcript size to be approximately 1.6 kb indicating that some 800 bp of the transcript is non-coding.
Managerial Decisions: A Discursive Analysis, Teresa Ann Mcconville
Managerial Decisions: A Discursive Analysis, Teresa Ann Mcconville
Plymouth Business School Theses
Decision making activity is at the heart of organisations and, as an essential managerial function, it has been the subject of an immense body of literature. As the majority of research has been undertaken within the disciplines of economics and psychology, studies have tended to emphasise economic rationality as the basis for cognitive reasoning, decision processes and judgement and as the analytic paradigm. However, in the face of new problems, and in times of profound change, conventional forms of thought may be problematic in themselves. This project suggests and assesses a Foucaultian framework as an alternative approach to the study …
Investigation Into The Feasibilty Of Providing Intelligent Support For Computer Mediation Decision Making Groups, Andrew Martyn Morley
Investigation Into The Feasibilty Of Providing Intelligent Support For Computer Mediation Decision Making Groups, Andrew Martyn Morley
School of Psychology Theses
This thesis investigated the claim that the adaptation to the keyboard interface of a computer-mediated (CM) decision making group leads to differences in the style of communication when compared to that of a face-to-face (FTF) group. More importantly it examined the possibility that changes in satisfaction with the process and the decision outcome are determined not by the mode of communication, but rather the style of communication the decision makers employed in response to the keyboard interface. The decision processes of CM and FTF groups were examined using a simulated panel of enquiry presented via computer databases and containing inconsistent …
Evolutionary Multi-Objective Decision Support Systems For Conceptual Design, Dragan Cvetkovic
Evolutionary Multi-Objective Decision Support Systems For Conceptual Design, Dragan Cvetkovic
School of Engineering, Computing and Mathematics Theses
In this thesis the problem of conceptual engineering design and the possible use of adaptive search techniques and other machine based methods therein are explored. For the multi-objective optimisation (MOO) within conceptual design problem, genetic algorithms (GA) adapted to MOO are used and various techniques explored: weighted sums, lexicographic order, Pareto method with and without ranking, VEGA-like approaches etc. Large number of runs are performed for findingZ Dth e optimal configuration and setting of the GA parameters. A novel method, weighted Pareto method is introduced and applied to a real-world optimisation problem. Decision support methods within conceptual engineering design framework …
Optimisation And Decision Support During The Conceptual Stage Of Building Design, Jim David Mathews
Optimisation And Decision Support During The Conceptual Stage Of Building Design, Jim David Mathews
School of Engineering, Computing and Mathematics Theses
Modern building design is complex and involves many different disciplines operating in a fragmented manner. Appropriate computer-based decision support (DS) tools are sought that can raise the level of integration of different activities at the conceptual stage, in order to help create better designs solutions. This project investigates opportunities that exist for using techniques based upon the Genetic Algorithm (GA) to support critical activities of conceptual building design (CBD). Collective independent studies have shown that the GA is a powerful optimisation and exploratory search technique with widespread application. The GA is essentially very simple yet it offers robustness and domain …
Sub-Surface Migration Of An Oil Pollutant Into Aquifers, Louise Ann Macdonald
Sub-Surface Migration Of An Oil Pollutant Into Aquifers, Louise Ann Macdonald
School of Geography, Earth and Environmental Sciences Theses
The risk to groundwater quality following a sub-surface spillage of immiscible pollutants such as oil, petroleum and other organic chemicals is an increasingly potent threat, through escalating industrial application of such pollutants. This study significantly enhances the understanding of the flow of immiscible pollutants within soil, through field scale investigations to define the spatial variability and extent of a contaminated area and the development of a comprehensive framework for the analysis of oil pollutant migration. This study represents a first attempt by researchers to analyse oil pollutant migration on a wide range of scales, from pore- to field-level. The research …
Implementation Of European Union Environmental Policy : The Case Of The Packaging Waste Directive, Ian Bailey
Implementation Of European Union Environmental Policy : The Case Of The Packaging Waste Directive, Ian Bailey
School of Geography, Earth and Environmental Sciences Theses
This thesis provides a critical review of the processes shaping the implementation of European Union (EU) environmental policy. It focuses on two aspects of this dynamic, the interpretation of EU law by Member States and the use of legislative and price-based policy instruments to achieve policy objectives. The overall aim of the study is to examine the extent to which price-based regulation can contribute to the EU's policy objective of sustainable development. The focus for the research is the formulation of the Packaging and Packaging Waste Directive and its implementation in two Member States, Britain and Germany. A variety of …
Nature And Justifiability Of The Act Of Collective Worship In Schools, Jeanette Gill
Nature And Justifiability Of The Act Of Collective Worship In Schools, Jeanette Gill
Plymouth Institute of Education Theses
This thesis, which moves through three stages, asks whether the compulsory provision of a daily act of collective worship can be justified in the schools of a liberal society. It begins with an analysis of the public debate which has surrounded its presence since legislation in 1944 formalised existing practice, and notes that its arguments are based on differing perceptions of the value of religious practice, the needs of the child, the relationship between religion and morality, and the nature of society. Because this public debate is often distanced from actual practice, research was undertaken in primary and secondary schools …
Extending Literacy : Pupils' Interactions With Texts, With Particular Emphasis On The Use Of Non-Fiction Texts, Maureen Lewis
Extending Literacy : Pupils' Interactions With Texts, With Particular Emphasis On The Use Of Non-Fiction Texts, Maureen Lewis
Plymouth Institute of Education Theses
The submitted works explore how children use texts in the classroom and how they can be supported in becoming more effective readers and writers. Most of the work is based around pupil's use of non-fiction texts and provides case study examples of what happens when children engage in tasks which require their use. I argue that we can elaborate a model to describe the processes involved in such encounters. This proposed model is described and compared to earlier attempts to create a model of the process of interacting with non-fiction texts. It is further argued that specific strategies can be …
Small Towns And The Rural Economy : A Study Of Their Contemporary Functions And Potential Role In Rural Development, Paul Richard Courtney
Small Towns And The Rural Economy : A Study Of Their Contemporary Functions And Potential Role In Rural Development, Paul Richard Courtney
Other Faculty of Science and Engineering Theses
As Rural Development assumes a greater importance in European policy, one strategy to stimulate economic activity across a broad range of sectors is to use small towns as a focal point for economic development. This may be particularly relevant in the UK where there is increasing concern over the future vitality and viability of these towns. However, such a strategy rests on the assumption that there is a strong level of interdependence between small towns and their surrounding areas. While their historical legacy suggests close integration, developments in the wider economy and resultant socio-economic restructuring have undermined the traditional functions …
Analysis Of Marketing Strategies In Polish Ports, Aleksandra Urszula Pieczek
Analysis Of Marketing Strategies In Polish Ports, Aleksandra Urszula Pieczek
Other Faculty of Science and Engineering Theses
The service sector of economy is a field of growing interest to marketing research and in particular such services as provided by seaports. However, these activities have rarely been considered to date. This project consists of three parts. Firstly a review of service marketing approaches, their status and development, the nature of marketing strategies and the marketing mix had to be provided. Also the development of marketing in seaports had to be examined. The focal elements discussed were the elements of the services provided by seaports, and competition between them in the context of Poland Secondly the situation in Eastern …
Live Interpretation: An Asset, Or An Indulgence? In The Fields Of Education And Entertainment, How Valuable Is Live Interpretation As An Effective Tool Of Communication?, Dawn Helen Stevens
Live Interpretation: An Asset, Or An Indulgence? In The Fields Of Education And Entertainment, How Valuable Is Live Interpretation As An Effective Tool Of Communication?, Dawn Helen Stevens
Other Faculty of Arts, Humanities and Business Theses
This thesis aims to assess the value of live interpretation as a tool of communication, by treating it as a form of design, and by comparing examples of practice in the field with other contemporary design techniques. Chapter two lists a selection of active practitioners across the field of informal and formal education, and entertainment within the area of Britain's cultural heritage. It provides a taste of the professional industry, and includes information like how many interpreters are employed, what techniques they favour, and what educational programmes they run. Likewise in the voluntary /hobbyist sector, the chapter notes membership numbers, …
Writing The Real: The Collages Of Hannelore Baron, Valerie James Reardon
Writing The Real: The Collages Of Hannelore Baron, Valerie James Reardon
Other Faculty of Arts, Humanities and Business Theses
Baron's work has not been extensively studied nor is it known in full. Critical writings and scholarly attention have focused on the work as representative of Holocaust suffering. This thesis intervenes in that assumption by arguing that it is possible to understand Baron's processes of making collage as a significant case study in the problematic of signification and a complex of differences none of which are reducible to or deducible from each other. Drawing together a range of biographical information, primary source material and close readings of many of Baron's collages (including two hitherto unseen series) traces are revealed of …
Acts Of Writing: Writings On Contemporary Performance, Richard David Allsopp
Acts Of Writing: Writings On Contemporary Performance, Richard David Allsopp
Other Faculty of Arts, Humanities and Business Theses
The work published between 1992- 2000 and presented here forms a continuing meditation on, and exploration of contemporary performance. The term 'contemporary performance' is used to refer to practices and discourses in the performance arts that have occurred over the last decade. There is a particular emphasis on those unstable, hybrid and interdisciplinary areas of performance (including performance art, installation, 'new' dance, 'experimental' theatre, 'live' art) which resist easy definition or categorisation, and which may be further characterised as postmodern in the sense of a reflexive, contextualised and knowingly problematic practice. More specifically the work builds a sustained thesis on …
Processing Writing: From Text To Textual Interventions, Caroline Bergvall
Processing Writing: From Text To Textual Interventions, Caroline Bergvall
Other Faculty of Arts, Humanities and Business Theses
This submission comprises the main bulk of the critical and textual work I have researched and developed over the last five years. Throughout this period, I have been particularly interested in exploring issues of interdisciplinarity for writers and text-practitioners, at both a critical and a methodological level. An interest in cross-media and site-related approaches to writing plays an important role in this. This is reflected in the thematics of the various critical texts, as well as in the fairly broad range of textual modes submitted. As a whole, this work can be seen in close continuity with my pedagogical involvement …
The Effects Of Hydrology And Nutrient Inputs At South Milton Ley On The Ecology Of The Common Reed Phragmites Australis (Cav. Trin. Ex Steudal), Paula Angele Powell
The Effects Of Hydrology And Nutrient Inputs At South Milton Ley On The Ecology Of The Common Reed Phragmites Australis (Cav. Trin. Ex Steudal), Paula Angele Powell
School of Geography, Earth and Environmental Sciences Theses
South Milton Ley is a small coastal wetland in Southern England. A sand-bar forms periodically at its seaward end and separates fresh water from the sea. The common reed Phragmites australis dominates the wetland and when a sand bar is present a shallow freshwater lake forms. Monthly water budgets were prepared for the years 1994, 1995 and 1996 and intermittent flooding of the Ley was also monitored. This information was used to calculate a range of residence times (between one hour and eleven days) and the characteristics of various flow regimes when the sandbar, which dams the Ley, is open …
The Chain Of Quality Through Integrated Product Development, Aj Robotham
The Chain Of Quality Through Integrated Product Development, Aj Robotham
School of Engineering, Computing and Mathematics
Today, it is almost impossible to find a manufacturer who has not been significantly influenced by the quality culture, but it is evident that some are doing more to improve their product quality than others are. The so-called "Chain of Quality" through integrated product development is a useful metaphor since it recognises that quality is a continuing topic of attention throughout the product development process and that discrete, quality related activities in the process are inter-linked. Depending upon how the product development process is modelled, the chain can be viewed as open or closed with single or parallel threads. In …
Tgf-Beta And Ifn-Gamma Direct Macrophage Activation By Tnf-Alpha To Osteoclastic Or Cytocidal Phenotype., Sw Fox, K Fuller, Ke Bayley, Tj Chambers
Tgf-Beta And Ifn-Gamma Direct Macrophage Activation By Tnf-Alpha To Osteoclastic Or Cytocidal Phenotype., Sw Fox, K Fuller, Ke Bayley, Tj Chambers
School of Biomedical Sciences
No abstract provided.
Evolutionary Decomposition Of Complex Design Spaces, Christopher Richard Bonham
Evolutionary Decomposition Of Complex Design Spaces, Christopher Richard Bonham
School of Engineering, Computing and Mathematics Theses
This dissertation investigates the support of conceptual engineering design through the decomposition of multi-dimensional search spaces into regions of high performance. Such decomposition helps the designer identify optimal design directions by the elimination of infeasible or undesirable regions within the search space. Moreover, high levels of interaction between the designer and the model increases overall domain knowledge and significantly reduces uncertainty relating to the design task at hand. The aim of the research is to develop the archetypal Cluster Oriented Genetic Algorithm (COGA) which achieves search space decomposition by using variable mutation (vmCOGA) to promote diverse search and an Adaptive …
A Predictive Fuzzy-Neural Autopilot For The Guidance Of Small Motorised Marine Craft, Ralph Richter
A Predictive Fuzzy-Neural Autopilot For The Guidance Of Small Motorised Marine Craft, Ralph Richter
School of Engineering, Computing and Mathematics Theses
This thesis investigates the design and evaluation of a control system, that is able to adapt quickly to changes in environment and steering characteristics. This type of controller is particularly suited for applications with wide-ranging working conditions such as those experienced by small motorised craft. A small motorised craft is assumed to be highly agile and prone to disturbances, being thrown off-course very easily when travelling at high speed 'but rather heavy and sluggish at low speeds. Unlike large vessels, the steering characteristics of the craft will change tremendously with a change in forward speed. Any new design of autopilot …
Design Models For Multimedia Learning Environments Based On Interactive Drama, Thomas John Rogers
Design Models For Multimedia Learning Environments Based On Interactive Drama, Thomas John Rogers
School of Engineering, Computing and Mathematics Theses
Interactive multimedia offers a degree of richness that lies outside the scope of conventional design methods for computer based learning. This research seeks to develop an interdisciplinary approach to design, that recognises the ways in which the combination and integration of different media forms can be exploited to stimulate experiential, intuitive, perceptual, and social/communicative aspects of learning. The goal of the project has been to develop a conceptual design model for the development of multimedia learning environments (MLEs), for humanistic learning applications, by using interactive drama. The models and methods developed though a practical design project have been founded upon …
Resin Infusion Under Flexible Tooling, James Antony Craen
Resin Infusion Under Flexible Tooling, James Antony Craen
School of Engineering, Computing and Mathematics Theses
Resin infusion under flexible tooling (RIFT) can be considered to be a variant of resin transfer moulding (RTM) in which one stiff mould face is replaced by a flexible film. It is seen as an alternative to conventional hand lay-up techniques as it offers many benefits, particularly with regards to health and safety whilst not involving the high tooling costs of a change to RTM. It is a vacuum driven process and as such fibre compaction may occur during vacuum bag preparation, prior to resin infusion and during resin infusion. The aim of the work was to examine the effect …
On Turbo Codes And Other Concatenated Schemes In Communication Systems, Adrian Ambroze
On Turbo Codes And Other Concatenated Schemes In Communication Systems, Adrian Ambroze
School of Engineering, Computing and Mathematics Theses
The advent of turbo codes in 1993 represented a significant step towards realising the ultimate capacity limit of a communication channel, breaking the link that was binding very good performance with exponential decoder complexity. Turbo codes are parallel concatenated convolutional codes, decoded with a suboptimal iterative algorithm. The complexity of the iterative algorithm increases only linearly with block length, bringing previously unprecedented performance within practical limits.. This work is a further investigation of turbo codes and other concatenated schemes such as the multiple parallel concatenation and the serial concatenation. The analysis of these schemes has two important aspects, their performance …
Development Of The Random Amplified Polymorphic Dna (Rapd) Technique To Measure The Effects Of Genotoxinsin Aquatic Organisms, Franck Andre Atienzar
Development Of The Random Amplified Polymorphic Dna (Rapd) Technique To Measure The Effects Of Genotoxinsin Aquatic Organisms, Franck Andre Atienzar
School of Biological and Marine Sciences Theses
Studies were undertaken to evaluate the potential of random amplified polymorphic DNA (RAPD) to detect DNA effects (including DNA damage and mutations) in aquatic invertebrates, following their exposure to a variety of environmental contaminants under laboratory conditions. After rigorous optimisation of the RAPD method, the protocol, which used a high annealing temperature (50"C for 10-mer primers), was found to generate good-quality DNA profiles from groups of organisms belonging to the bacterial, plant and animal kingdoms. The RAPD method was initially used to detect benzo(a)pyrene [B(a)P] and copper-induced DNA effects in the water flea Daphnia magna and ultraviolet-mediated DNA effects in …
Spatial Variation In Zooplankton Size And Taxonomic Community Structure Along A 50ºn To 50°S Transect Of The Atlantic, Rachel Sarah Woodd-Walker
Spatial Variation In Zooplankton Size And Taxonomic Community Structure Along A 50ºn To 50°S Transect Of The Atlantic, Rachel Sarah Woodd-Walker
School of Biological and Marine Sciences Theses
Zooplankton play a vital role in the world's oceans in terms of transport of carbon out of the surface layer and providing food for fish. Zooplankton are patchily distributed on all scales, and this has important consequences for both sampling and understanding their role in the ocean. The distribution of zooplankton on different scales forms the focus of this study. Three Atlantic Meridional Transect (AMT) cruises were carried out and data made available from three previous cruises. Zoo plankton data were collected using a combination of vertical nets and using an optical plankton counter (OPC) sampling from the pumped seawater …
From Rivers To Oceans: A Comparison Of Contrasting Aquatic Ecosystems Using Benthic Size Spectra, Ahmed El-Sayed Ahmed Abada
From Rivers To Oceans: A Comparison Of Contrasting Aquatic Ecosystems Using Benthic Size Spectra, Ahmed El-Sayed Ahmed Abada
School of Biological and Marine Sciences Theses
This thesis uses a range of different size spectra to compare contrasting benthic habitats in the aquatic realm. Temporal and spatial variation in benthic size spectra were investigated across a full salinity gradient (i.e. from freshwater, through estuarine to marine) in the River Yealm, south Devon, in order to gauge the influence of large differences in taxonomy and evolutionary history. Abundance and biomass size spectra showed a similar pattern among sites in all seasons but winter, suggesting that the size structure of benthic communities may be similar in sites with very different community compositions. A subsequent study comparing size spectra …