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Wikis, Blogs And Podcasts: A New Generation Of Web-Based Tools For Virtual Collaborative Clinical Practice And Education, Boulos Mn Kamel, Inocencio Maramba, Steve Wheeler Jan 2006

Wikis, Blogs And Podcasts: A New Generation Of Web-Based Tools For Virtual Collaborative Clinical Practice And Education, Boulos Mn Kamel, Inocencio Maramba, Steve Wheeler

School of Nursing and Midwifery

No abstract provided.


Expression Of Target And Reference Genes In Daphnia Magna Exposed To Ibuprofen., L-H Heckmann, R Connon, Th Hutchinson, Sj Maund, Rm Sibly, A Callaghan Jan 2006

Expression Of Target And Reference Genes In Daphnia Magna Exposed To Ibuprofen., L-H Heckmann, R Connon, Th Hutchinson, Sj Maund, Rm Sibly, A Callaghan

School of Geography, Earth and Environmental Sciences

No abstract provided.


Screening And Testing For Endocrine Disruption In Fish—Biomarkers As “Signposts,” Not “Traffic Lights,” In Risk Assessment, Th Hutchinson, Gt Ankley, H Segner, Cr Tyler Jan 2006

Screening And Testing For Endocrine Disruption In Fish—Biomarkers As “Signposts,” Not “Traffic Lights,” In Risk Assessment, Th Hutchinson, Gt Ankley, H Segner, Cr Tyler

School of Geography, Earth and Environmental Sciences

No abstract provided.


Phenotypic And Genetic Effects Of Chernobyl-Derived Radionuclide Contamination On The Red-Eyed Damselfly Erythromma Najas (Odonata, Coenagrionidae), Claire Rebecca Cailes Jan 2006

Phenotypic And Genetic Effects Of Chernobyl-Derived Radionuclide Contamination On The Red-Eyed Damselfly Erythromma Najas (Odonata, Coenagrionidae), Claire Rebecca Cailes

School of Biological and Marine Sciences Theses

The 1986 Chernobyl accident released large amounts of radioactive contamination into the surrounding environment. As a result, the Chernobyl region provides a suitable site for investigations into the effects of ionising radiation on non-human biota. Studies of this type are important in order to establish whether or not current anthropocentric radiation protection guidelines are appropriate for the protection of the wider environment. Despite the presence of many freshwater habitats in the region, there have been few studies investigating the effects of radiation on aquatic invertebrates. In the present study, the effects of Chernobyl-derived radionuclide contamination on the red-eyed damselfly, Erythromma …


Arch-Os V1.1 (Architecture Operating Systems), Software For Buildings, M Phillips, C Speed Jan 2006

Arch-Os V1.1 (Architecture Operating Systems), Software For Buildings, M Phillips, C Speed

School of Art, Design and Architecture

No abstract provided.


The Effect Of Cold-Acclimation On The Water Relations And Freezing Tolerance Of Hordeum Vulgare L, S Burchett, S Niven, Mp Fuller Jan 2006

The Effect Of Cold-Acclimation On The Water Relations And Freezing Tolerance Of Hordeum Vulgare L, S Burchett, S Niven, Mp Fuller

School of Biological and Marine Sciences

During a 5 degree C and a 5/-1 degree C cold acclimation (CA) regime there was a significant decline in the water potential of winter barley, and a concurrent decline in tissue water content of the 5/-1 degree C CA plants. Results of carbohydrate analysis illustrated a significant (P < 0.001) accumulation of sucrose, fructose and glucose in the 5/-1 degree C CA plants, which was inversely correlated to water potential. Using an infrared imaging radiometer during a convection frost test the water release time (WRT) of 5/-1 degree C CA was demonstrated to be significantly (P < 0.001) longer than that observed in non-cold acclimated plants. This observation is consistent with visual analysis of exotherm curves where the rate of cellular water release to extracellular ice is reduced in the 5/-1 degree C CA plants, compared to the non-cold acclimated plants. These biochemical and physiological changes were correlated to increased plant health following a non-lethal freezing test to -5 degree C, where non-cold acclimated plants produced 2.3 +/- 0.3 tillers and 5 degree C and 5/-1 degree C CA plants produced 2.4 +/- 0.3 and 4.7 +/- 0.7 tillers, respectively. Results from this study imply that cold acclimation leads to changes in the physical state of water that result in a less osmotically responsive cellular environment and subsequently significantly less damage to meristematic tissue.


Durum Wheat Quality I: Some Physical And Chemical Characteristics Of Syrian Durum Wheat Genotypes, Gh El-Khayat, A Samaan, Fa Manthey, Mp Fuller, Cs Brennan Jan 2006

Durum Wheat Quality I: Some Physical And Chemical Characteristics Of Syrian Durum Wheat Genotypes, Gh El-Khayat, A Samaan, Fa Manthey, Mp Fuller, Cs Brennan

School of Biological and Marine Sciences

Some physical and chemical characteristics of nine Syrian durum wheat genotypes were determined in order to investigate the relationships among individual kernel components and kernel quality. All genotypes were grown on fully irrigated plots in Syria. Test weight, 1000-kernel weight, kernel size distribution, hardness and semolina extraction rates were determined along with the chemical characteristics of the kernel (ash, moisture, protein, wet gluten, starch content and falling number). All tested genotypes had high test weight (83.1–85.9 kg hl−1) and 1000-kernel weight (42.5–55.5 g) indicating high milling yield potential. Additionally, all the wheat genotypes demonstrated high falling numbers (433–597 s). Correlation …


Evaluation Of Abiotic Stress Resistance In Mutated Populations Of Cauliflower (Brassica Oleracea Var. Botrytis), Mp Fuller, Emr Metwali, Mh Eed, Aj Jellings Jan 2006

Evaluation Of Abiotic Stress Resistance In Mutated Populations Of Cauliflower (Brassica Oleracea Var. Botrytis), Mp Fuller, Emr Metwali, Mh Eed, Aj Jellings

School of Biological and Marine Sciences

An efficient in vitro screening method has been developed for cauliflower to create NEU and NMU induced mutant lines selected on hydroxyproline containing medium. Mutant lines and control plants were sub-cultured many times on maintenance medium and stored at 5°C for 2 years and then tested for salt and hydroxyproline resistance as in vitro and in vivo plants. In vitro shoot tips were also sub-cultured to media containing hydroxyproline and NaCl for 28 days and then assessed for their leaf proline content. Non-acclimated and acclimated in vivo plants were also assessed for resistance to freezing. Populations of control and selected …


Sowing Date, Transplanting, Plant Density And Nitrogen Fertilization Affect Indigo Production From Isatis Species In A Mediterranean Region Of Spain, E Sales, R Kanhonou, C Baixauli, A Giner, D Cooke, K Gilbert, I Arrillaga, J Segura, R Ros Jan 2006

Sowing Date, Transplanting, Plant Density And Nitrogen Fertilization Affect Indigo Production From Isatis Species In A Mediterranean Region Of Spain, E Sales, R Kanhonou, C Baixauli, A Giner, D Cooke, K Gilbert, I Arrillaga, J Segura, R Ros

Peninsula Medical School

No abstract provided.


Amplification And Suppression Of Internal Waves By Tides Over Variable Bottom Topography, Vasiliy Vlasenko, Nataliya Stashchuk Jan 2006

Amplification And Suppression Of Internal Waves By Tides Over Variable Bottom Topography, Vasiliy Vlasenko, Nataliya Stashchuk

School of Biological and Marine Sciences

The energy exchange between internal waves and barotropic currents over inclined bottom topography is studied theoretically and in the framework of the numerical model. The energy balance equation derived for a continuously stratified fluid predicts that energy can either be transferred toward or away from the internal wave depending on the direction of propagation of both the wave and current. Four scenarios of wave-flow interaction over the inclined bottom were identified. An internal wave extracts energy from the background tidal flow during its propagation upslope-upstream or downslope-downstream and its amplitude grows. The wave loses energy propagating downslope-upstream or upslope-downstream and …


Preliminary Findings From A Study Of The Upper Reaches Of The Tamar Estuary, Uk, Throughout A Complete Tidal Cycle: Part I. Linking Sediment And Hydrodynamic Cycles, Sj Bass, Aj Manning, Kr Dyer Jan 2006

Preliminary Findings From A Study Of The Upper Reaches Of The Tamar Estuary, Uk, Throughout A Complete Tidal Cycle: Part I. Linking Sediment And Hydrodynamic Cycles, Sj Bass, Aj Manning, Kr Dyer

School of Biological and Marine Sciences

No abstract provided.


Impact Of Fish Farms On Maerl Beds In Strongly Tidal Areas, J Hall-Spencer, N White, E Gillespie, K Gillham, A Foggo Jan 2006

Impact Of Fish Farms On Maerl Beds In Strongly Tidal Areas, J Hall-Spencer, N White, E Gillespie, K Gillham, A Foggo

School of Biological and Marine Sciences

No abstract provided.


Lung Nodule Detection In Screening Computed Tomography, I Gori, R Bellotti, P Cerello, Sc Cheran, Et Al Jan 2006

Lung Nodule Detection In Screening Computed Tomography, I Gori, R Bellotti, P Cerello, Sc Cheran, Et Al

School of Biomedical Sciences

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images with 1.25 mm slice thickness is presented. The basic modules of our lung-CAD system, a dot-enhancement filter for nodule candidate selection and a neural classifier for false-positive finding reduction, are described. The results obtained on the collected database of lung CT scans are discussed.


The Development And Optimization Of Microbial Molecular Biomarkers For The In Situ Assessment Of Trace Metal Toxicity, Nicolas James Bouskill Jan 2006

The Development And Optimization Of Microbial Molecular Biomarkers For The In Situ Assessment Of Trace Metal Toxicity, Nicolas James Bouskill

School of Biological and Marine Sciences Theses

Microorganisms are fundamental components of many geochemical transformations occurring in the aquatic environment. Microbial redox and methylation of metals within the environment can alter metal speciation, mobility and ultimately, toxicity to eukaryotes. It is therefore practical that any environmental monitoring framework advocating the application of `early-warning biomarker system' should incorporate a holistic view of the environment beginning with microbial activity. This thesis describes the development of protocols for assessing the in situ condition of microbial ecosystems within a gradient of metal contaminated sites radiating downstream of the Anaconda Smelter, a USEPA-designated superfund site and within two control sites. Experiments focus …


Modulation Of The Health Status Of Ornamental Fish By Stress And Dietary Immuno-Stimulants, Stuart Maudling Jan 2006

Modulation Of The Health Status Of Ornamental Fish By Stress And Dietary Immuno-Stimulants, Stuart Maudling

School of Biological and Marine Sciences Theses

Three trials were conducted to investigate the effects of dietary immuno-stimulant supplementation on various physiological, haematological and immunological parameters of ornamental fish following stress and vaccination. The first series of experiments investigated the mucosal stress response of mirror carp, (Cyprinus carpio), using urinalysis strips and established stress indicators within peripheral blood. A netting stressor, which combined aerial exposure and confinement, of 6 minutes duration was applied and the response of fish was measured 1.5, 3, 5, 24 and 168 hours post-stress. Mucosal haemoglobin and protein were established as consistent indicators of stress and strong relationships could be drawn between them …


Molecular Ecology Of Marine Algal Viruses, Joaquin Martinez Martinez Jan 2006

Molecular Ecology Of Marine Algal Viruses, Joaquin Martinez Martinez

School of Biological and Marine Sciences Theses

In this study phytoplankton viruses were investigated from a point of view of their genotypic richness, ecology and role in controlling two microalgae species: Emiliania huxleyi and Phaeocystis pouchetii. Host specificity determined for Emiliania huxleyi-virus (EhV) isolates revealed a highly variable host range suggesting a relation between virus specificity and genetic or phenotypic variations within E. huxleyi strains and EhVs. Subsequently the dynamics and genetic richness of Emiliania huxleyi and EhVs were monitored in mesocosm experiments and during the progression of a natural bloom in the sea. The results confirmed the role of virus infection in regulating the intraspecific succession …


Identification Of Structural And Antigenic Components Of Bacillus Anthracis Spores And Their Application To Rapid Detection Using Biosensors, Tracey Elizabeth Love Jan 2006

Identification Of Structural And Antigenic Components Of Bacillus Anthracis Spores And Their Application To Rapid Detection Using Biosensors, Tracey Elizabeth Love

School of Biological and Marine Sciences Theses

The work presented in this thesis describes a rational design approach to the rapid detection of Bacillus anthracis spores. A range of assay formats are available for detection of B. anthracis, however none fulfil the criteria of speed, sensitivity or specificity. Optical biosensors have shown promise for the near real time detection of low molecular weight analytes, although exploitation of these systems for bacterial detection has been restricted due to a comparative lack of sensitivity. Electroporation was unsuitable as a disruption method for immunoassay based techniques, whereas preliminary experiments suggested sonication could be utilised. A novel tubular sonicator designed to …


Quantifying Inhabitation, Feeding And Connectivity Between Adjacent Estuarine And Coastal Regions For Three Commercially Important Marine Fishes, Christopher Douglas Bazett Leakey Jan 2006

Quantifying Inhabitation, Feeding And Connectivity Between Adjacent Estuarine And Coastal Regions For Three Commercially Important Marine Fishes, Christopher Douglas Bazett Leakey

School of Biological and Marine Sciences Theses

1. Estuaries are regarded as valuable nursery habitats for many commercially important marine fishes. Recruitment of fish from estuarine nursery habitats to adult marine populations is considered important for maintenance of fishable stocks, but most evidence for this is qualitative. Effective and timely implementation of estuarine conservation and fisheries management plans may be aided by quantitative assessment of this habitat connectivity. 2. This thesis reports upon the quantification of inhabitation, feeding and connectivity between adjacent estuarine and coastal regions for Common sole (Solea solea), European sea bass (Dicentrarchus labrax) and Whiting (Merlangius merlangus). Sample collection was focused in the Thames …


Multi-Scale Variability In Phytoplankton Populations Of The North Atlantic Basin: From Eddies To Global Change, Sophie C. Leterme Jan 2006

Multi-Scale Variability In Phytoplankton Populations Of The North Atlantic Basin: From Eddies To Global Change, Sophie C. Leterme

School of Biological and Marine Sciences Theses

The Continuous Plankton Recorder (CPR) survey has been deployed since 1931 to describe and analyze plankton variability in the North Atlantic and North Sea. This survey measures the presence and abundance of 437 phytoplankton and zooplankton taxa and provides an assessment of phytoplankton biomass, the Phytoplankton Colour Index (VCI). The diatoms and dinoflagellates are the two main phytoplankton groups identified by the CPR survey. The first part of this work provides insights into the space-time dynamics of phytoplankton communities through an analysis of diatom and dinoflagellate populations in the whole North Atlantic basin. Because the North Atlantic Ocean includes many …


Durum Wheat Quality: Ii. The Relationship Of Kernel Physicochemical Composition To Semolina Quality And End Product Utilisation, J Samaan, Gh El-Khayat, Fa Manthey, Mp Fuller, Cs Brennan Jan 2006

Durum Wheat Quality: Ii. The Relationship Of Kernel Physicochemical Composition To Semolina Quality And End Product Utilisation, J Samaan, Gh El-Khayat, Fa Manthey, Mp Fuller, Cs Brennan

School of Biological and Marine Sciences

Kernel quality characteristics, semolina milling potential, dough rheology and pasta making properties of kernels from nine fully irrigated Syrian durum wheat genotypes were observed. Protein content of the kernels exerted a significant affect on the physical characteristics hardness and the degree of kernel vitreousness, both of which were highly correlated with superior end‐use product. Gluten composition of semolina appeared as significant as overall protein content in determining the optimum end‐use product cooking quality (cooking time and pasta texture). The final viscosity of durum flour exhibited positive correlations with semolina recovery, protein content, gluten content, vitreousness, the optimum‐cooking time of pasta …


The Potential Use Of (1→3, 1→4)-Β-D-Glucan From Barley As A Functional Food Ingredient For Cereal Foods, Louise Jane Cleary Jan 2006

The Potential Use Of (1→3, 1→4)-Β-D-Glucan From Barley As A Functional Food Ingredient For Cereal Foods, Louise Jane Cleary

School of Biological and Marine Sciences Theses

The health related importance of dietary fibre as part of a balanced diet is well known. More recently, soluble fibres, such as (1→3, 1→4)-β-D-glucan (β-glucan), have been shown to influence glycaemic, insulin and cholesterol responses to foods. Barley is a rich source of β-glucan; however, consumption of products containing barley grain or flour is often limited by their negative organoleptic quality. A potential solution lies in the use of barley as an extraction source for β-glucan fractions. One problem with regards to this is the lack of clarity on the use of barley β-glucan fractions in food systems, particularly their …


Endogenous Human Cytomegalovirus Gb Is Presented Efficiently By Mhc Class Ii Molecules To Cd4+ Ctl, Nagendra R. Hegde, Claire Dunn, David M. Lewinsohn, Michael A. Jarvis, Jay A. Nelson, David C. Johnson Oct 2005

Endogenous Human Cytomegalovirus Gb Is Presented Efficiently By Mhc Class Ii Molecules To Cd4+ Ctl, Nagendra R. Hegde, Claire Dunn, David M. Lewinsohn, Michael A. Jarvis, Jay A. Nelson, David C. Johnson

School of Biomedical Sciences

Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity. Instead, it seems that class II presentation of endogenous HCMV antigens in these cells allows recognition of virus infection. We characterized class II presentation of HCMV glycoprotein B (gB), a membrane protein that accumulates extensively in endosomes during virus assembly. Human CD4+ T cells specific for gB were both highly abundant in blood and cytolytic in vivo. gB-specific CD4+ T cell clones recognized gB that was expressed in …


Climate Records From The Faroe-Shetland Channel Using Lophelia Pertusa (Linnaeus, 1758), Mj Risk, J Hall-Spencer, B Williams Aug 2005

Climate Records From The Faroe-Shetland Channel Using Lophelia Pertusa (Linnaeus, 1758), Mj Risk, J Hall-Spencer, B Williams

School of Biological and Marine Sciences

No abstract provided.


Simultaneous Determination Of Dissolved Organic Carbon And Total Dissolved Nitrogen On A Coupled High-Temperature Combustion Total Organic Carbon-Nitrogen Chemiluminescence Detection (Htc Toc-Ncd) System, X Pan, R Sanders, Ad Tappin, Pj Worsfold, Ep Achterberg Aug 2005

Simultaneous Determination Of Dissolved Organic Carbon And Total Dissolved Nitrogen On A Coupled High-Temperature Combustion Total Organic Carbon-Nitrogen Chemiluminescence Detection (Htc Toc-Ncd) System, X Pan, R Sanders, Ad Tappin, Pj Worsfold, Ep Achterberg

School of Geography, Earth and Environmental Sciences

The marine biogeochemistries of carbon and nitrogen have come under increased scrutiny because of their close involvement in climate change and coastal eutrophication. Recent studies have shown that the high-temperature combustion (HTC) technique is suitable for routine analyses of dissolved organic matter due to its good oxidation efficiency, high sensitivity, and precision. In our laboratory, a coupled HTC TOC-NCD system with a sample changer was used for the automated and simultaneous determination of dissolved organic carbon (DOC) and total dissolved nitrogen (TDN) in seawater samples. TOC control software was used for TOC instrument control, DOC data acquisition, and data analysis. …


Notch Signaling From Tumor Cells: A New Mechanism Of Angiogenesis, J-L Li, Al Harris Jul 2005

Notch Signaling From Tumor Cells: A New Mechanism Of Angiogenesis, J-L Li, Al Harris

School of Biomedical Sciences

Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular development and angiogenesis. Multiple components of the Notch pathway are expressed in vasculature, and mice deficient for a variety of these components display embryonic lethality with vascular remodeling defects. Alteration of Notch signaling in various endothelial cells generates profound effects on angiogenesis in vitro. New evidence shows that Notch signaling from tumor cells is able to activate endothelial cells and trigger tumor angiogenesis in vitro and in a xenograft mouse tumor model. Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy.


Distribution And Habitats Of Acesta Excavata (Bivalvia: Limidae) With New Data On Its Shell Ultrastructure, Jm Hall-Spencer, Ml Correa, A Freiwald, M Taviani Jun 2005

Distribution And Habitats Of Acesta Excavata (Bivalvia: Limidae) With New Data On Its Shell Ultrastructure, Jm Hall-Spencer, Ml Correa, A Freiwald, M Taviani

School of Biological and Marine Sciences

No abstract provided.


Report Of The Working Group On Deep-Water Ecology (Wgdec), 8-11 March 2005, Jm Hall-Spencer Mar 2005

Report Of The Working Group On Deep-Water Ecology (Wgdec), 8-11 March 2005, Jm Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.


Investigation Of The Multi-Scale Variability Of Beach Profiles, Ying Li Jan 2005

Investigation Of The Multi-Scale Variability Of Beach Profiles, Ying Li

School of Engineering, Computing and Mathematics Theses

This work focuses on the multi-scale variability of beach profiles. This includes the spatial variability over a range of scales of surveyed beach profiles and the complex temporal variability of beach elevation at given positions along the profile. The aims of this work are to characterize the variability of beach profiles in both time and space, to identify the predominant spatial and temporal patterns of beach profile changes, to identify the extreme profile changes due to infrequent storms/storm groups, to understand the nature of beach profile change in depth, to quantify the non-stationarity of beach profile and to provide insight …


Multi-Agent Fitness Functions For Evolutionary Architecture, Richard Holden Jan 2005

Multi-Agent Fitness Functions For Evolutionary Architecture, Richard Holden

School of Engineering, Computing and Mathematics Theses

The dynamics of crowd movements are self-organising and often involve complex pattern formations. Although computational models have recently been developed, it is unclear how well their underlying methods capture local dynamics and longer-range aspects, such as evacuation. A major part of this thesis is devoted to an investigation of current methods, and where required, the development of alternatives. The main purpose is to utilise realistic models of pedestrian crowds in the design of fitness functions for an evolutionary approach to architectural design. We critically review the state-of-the-art in pedestrian and evacuation dynamics. The concept of 'Multi-Agent System' embraces a number …


Evaluation Of Techniques For The Assessment Of Biomarker Responses In Selected Molluscs And Crustaceans For In Situ Environmental Assessment, Robert John Wedderburn Jan 2005

Evaluation Of Techniques For The Assessment Of Biomarker Responses In Selected Molluscs And Crustaceans For In Situ Environmental Assessment, Robert John Wedderburn

School of Biological and Marine Sciences Theses

There is a constant and increasing need for sensitive and relevant information regarding the effects of the chronic exposure of coastal and marine ecosystems to anthropogenically derived chemicals and stressors. If these environments are to be preserved and maintained then an increased availability of techniques to aid in the understanding of pollutant effect will be of significant advantage. This work examines the use of a suite of biomarkers of marine pollution exposure and effect to determine environmental quality and the effect of pollutants on marine organisms. The aim is to examine the sensitivity of a range of techniques and their …