Entire DC Network | Open Access Articles | Digital Commons Network™

Inventory Of Environmental Impact Monitoring Activities At Wave & Tidal Energy Sites In Europe, D Conley, R Leeney, D Greaves, B Holmes, Am O’Hagan, B Godley, C Mcclellan, M Witt, H Mouslim, J Sundberg

School of Biological and Marine Sciences

No abstract provided.

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Corals, Bryozoans And Gastropods Are Able To Calcify In Acidified Seawater, Jm Hall-Spencer, R Rodolfo-Metalpa

School of Biological and Marine Sciences

No abstract provided.

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Foraminifera Resist Ocean Acidification In The Wagner Basin Under Conditions Similar To High Co2 Environments Of The Cretaceous-Paleogene, Jm Hall-Spencer, L Pettit, Mb Hart, A Medina-Sánchez, Cw Smart, P Collins, R Rodolfo-Metalpa, Ledesma Rm Prol

School of Biological and Marine Sciences

No abstract provided.

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The Response Of Foraminifera To Modern Seawater Acidification: A Real-Time Proxy For Paleogene Hypothermal Events, Jm Hall-Spencer, Mb Hart, Bb Dias, Cw Smart, L Pettit

School of Biological and Marine Sciences

No abstract provided.

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Deep-Water Corals Along The Norwegian Contintental Margin: Multidisciplinary Studies On Sula Ridge, Traena Reef, Røst Reef, Floholmen And Sotbakken, Jm Hall-Spencer, Mk Söffker, L Thomsen, V Unnithan

School of Biological and Marine Sciences

No abstract provided.

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Population Structure Of The Christmas Island Blue Crab, Discoplax Hirtipes (Decapoda: Brachyura: Gecarcinidae) On Christmas Island, Indian Ocean., Lm Turner, Jp Hallas, S Morris

School of Biological and Marine Sciences

No abstract provided.

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Rn181 Suppresses Hepatocellular Carcinoma Growth By Inhibition Of The Erk/Mapk Pathway, S Wang, X Huang, Y Li, H Lao, Et Al

School of Biomedical Sciences

UNLABELLED: The activation of oncogenes and the inactivation of tumor suppressor genes by mutations or chronic hepatitis virus infections play key roles in the pathogenesis of hepatocellular carcinoma (HCC). Here we report that RN181, a really interesting new gene finger domain-containing protein, was down-regulated in highly malignant cell lines and in tumor cells of 139 HCC clinical samples in comparison with adjacent normal liver tissues. The expression of RN181 was strongly associated with the pathological grade of HCC. Alterations of the expression of RN181 by retrovirus-transduced up-regulation and short hairpin RNA-mediated down-regulation demonstrated the function of RN181 as a tumor …

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The Effect Of Dietary Inclusion Of Category 3 Animal By-Product Meals On Rainbow Trout (O. Mykiss Walbaum) Mineralised Tissues And Immune Function., Matthew Alun Griffiths Owen

School of Biological and Marine Sciences Theses

Aquaculture is growing rapidly worldwide and is projected to become the major source of fish used for human consumption. A major factor that limits aquaculture reaching its full potential is an adequate supply of the raw materials necessary for formulated fish feeds. The dependence of modern aquaculture on fishmeal obtained from wild fisheries is not environmentally sustainable and replacements for fishmeal must be found. Some animal by-products are viable replacements for fishmeal, and can provide sufficent nutrition for high growth rates, but little is known about the potential of animal by-products to adversely affect fish health. The objectives of these …

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Changes In Iron-Regulatory Gene Expression Occur In Human Cell Culture Models Of Parkinson's Disease., C. B. Carroll, M. L. Zeissler, N. Chadborn, K. Gibson, G. Williams, J. P. Zajicek, K. E. Morrison, C. O. Hanemann

Peninsula Medical School

BACKGROUND: Neuronal iron accumulation is thought to be relevant to the pathogenesis of Parkinson's disease (PD), although the mechanism remains elusive. We hypothesized that neuronal iron uptake may be stimulated by functional mitochondrial iron deficiency. OBJECTIVE: To determine firstly whether the mitochondrial toxin, 1-methyl-4-phenylpyridinium iodide (MPP(+)), results in upregulation of iron-import proteins and transporters of iron into the mitochondria, and secondly whether similar changes in expression are induced by toxins with different mechanisms of action. METHODS: We used quantitative PCR and Western blotting to investigate expression of the iron importers, divalent metal transporter, transferrin receptor 1 and 2 (TfR1 and …

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David Link – Machine Heart, G Cox

School of Art, Design and Architecture

In his work David Link generates (apparently) interactive projects, at the interface between art, science, and technology. For LoveLetters_1.0, Link reconstructed a functional replica of one of the earliest programmable computers, the Ferranti Mark I, and an equally early program, invented in 1952 by Christopher Strachey at the University of Manchester. To produce computer-generated love letters, written using a built-in random generator. Anonymously addressed to “Darling Love” or “Jewel Duck,” the letters talk to the reader in a surprisingly human and tender way. In his introduction, Geoff Cox highlights the question, already suggested by the apparently contradictory title of this …

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Air Temperature And Winter Mortality: Implications For The Persistence Of The Invasive Mussel, Perna Viridis In The Intertidal Zone Of The South-Eastern United States, Lb Firth, Am Knights, S Bell

School of Biological and Marine Sciences

Global climate change and invasive species represent two of the biggest threats to the environment. Biological communities are responding to global climate change through poleward shifts in distribution, and changes in abundance and phenology of both native and non-native species. An increase in the frequency and magnitude of extreme weather events is predicted with global climate change. Much is known about mortality events of marine organisms in relation to warm thermal stress with relatively little known about cold thermal stress, particularly in the tropics. Intertidal species are particularly susceptible to fluctuations in aerial conditions and many are considered indicators of …

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Mitigating Amphibian Disease: Strategies To Maintain Wild Populations And Control Chytridiomycosis., Douglas C. Woodhams, Jaime Bosch, Cheryl J. Briggs, Scott Cashins, Leyla R. Davis, Antje Lauer, Erin Muths, Robert Puschendorf, Benedikt R. Schmidt, Brandon Sheafor, Jamie Voyles

School of Biological and Marine Sciences

BACKGROUND: Rescuing amphibian diversity is an achievable conservation challenge. Disease mitigation is one essential component of population management. Here we assess existing disease mitigation strategies, some in early experimental stages, which focus on the globally emerging chytrid fungus Batrachochytrium dendrobatidis. We discuss the precedent for each strategy in systems ranging from agriculture to human medicine, and the outlook for each strategy in terms of research needs and long-term potential. RESULTS: We find that the effects of exposure to Batrachochytrium dendrobatidis occur on a spectrum from transient commensal to lethal pathogen. Management priorities are divided between (1) halting pathogen spread and …

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Nfatc1 Affects Mouse Splenic B Cell Function By Controlling The Calcineurin–Nfat Signaling Network, Sankar Bhattacharyya, Jolly Deb, Amiya K. Patra, Pham Da Thuy, Wen Chen, Martin Vaeth, Friederike Berberich-Siebelt, Stefan Klein-Hessling, Edward D. Lamperti, Kurt Reifenberg, Julia Jellusova, Astrid Schweizer, Lars Nitschke, Ellen Leich, Andreas Rosenwald, Cornelia Brunner, Swen Engelmann, Ursula Bommhardt, Andris Avots, Martin R. Müller, Eisaku Kondo, Edgar Serfling

Peninsula Medical School

By studying mice in which the Nfatc1 gene was inactivated in bone marrow, spleen, or germinal center B cells, we show that NFATc1 supports the proliferation and suppresses the activation-induced cell death of splenic B cells upon B cell receptor (BCR) stimulation. BCR triggering leads to expression of NFATc1/αA, a short isoform of NFATc1, in splenic B cells. NFATc1 ablation impaired Ig class switch to IgG3 induced by T cell–independent type II antigens, as well as IgG3+ plasmablast formation. Mice bearing NFATc1−/− B cells harbor twofold more interleukin 10–producing B cells. NFATc1−/− B cells suppress the synthesis of interferon-γ by …

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Response Of Pteropods And Foraminifera To Changing Pco2 And Ph: Examples From The Mediterranean Sea, M Hart, B Dias, J Hall-Spencer, D Wall-Palmer, C Smart

School of Biological and Marine Sciences

No abstract provided.

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Exploring Co2 Volcanic Vents At Vulcano Island, Mediterranean Sea, To Study The Planktonic Calcifier Response To Long-Term Changes In Carbonate Chemistry, Jm Hall-Spencer, M Passaro, P Ziveri, M Milazzo, R Rodolfo-Metalpa

School of Biological and Marine Sciences

No abstract provided.

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Exploring The Geochemistry And Shell Ultrastructure Of Bivalves As Archives Of Past Ocean Acidification Events: Recent Mytilidae In A Natural Acidic Setting In Ischia (Italy, Mediterranean Sea), S Hahn, R Rodolfo-Metalpa, E Griesshaber, Ww Schmahl, D Buhl, J Hall-Spencer, C Baggini, A Immenhauser

School of Biological and Marine Sciences

No abstract provided.

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Report Of The Ices/Nafo Joint Working Group On Deep-Water Ecology (Wgdec), Jm Hall-Spencer, Rj Brock

School of Biological and Marine Sciences

No abstract provided.

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Uncoupling Protein-2 Attenuates Glucose-Stimulated Insulin Secretion In Ins-1e Insulinoma Cells By Lowering Mitochondrial Reactive Oxygen Species., Charles Affourtit, Martin Jastroch, Martin D. Brand

School of Biomedical Sciences

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different Ucp2-ablated mouse models. By measuring mitochondrial bioenergetics in attached INS-1E insulinoma cells with and without UCP2, we show that UCP2 contributes to proton leak and attenuates glucose-induced rises in both respiratory activity and the coupling efficiency of oxidative phosphorylation. Strikingly, the GSIS improvement seen upon UCP2 knockdown in INS-1E cells is annulled completely by the cell-permeative antioxidant MnTMPyP. Consistent with this observation, UCP2 lowers mitochondrial reactive oxygen species at high glucose levels. We …

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Global Phylogeography Of The Widely Introduced North West Pacific Ascidian Styela Clava, Paul Hallas

School of Biological and Marine Sciences

The solitary ascidian Styela clava Herdman, 1882 is considered to be native to Japan, Korea, northern China and the RussianFederation in the NW Pacific, but it has spread globally over the last 80 years and is now established as an introducedspecies on the east and west coasts of North America, Europe, Australia and New Zealand. In eastern Canada it reachessufficient density to be a serious pest to aquaculture concerns. We sequenced a fragment of the cytochrome oxidasesubunit I mitochondrial gene (COI) from a total of 554 individuals to examine the genetic relationships of 20 S. clavapopulations sampled throughout the introduced …

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The Predictive Mirror: Interactions Of Mirror And Affordance Processes During Action Observation, P Bach, Ap Bayliss, Sp Tipper

School of Psychology

An important question for the study of social interactions is how the motor actions of others are represented. Research has demonstrated that simply watching someone perform an action activates a similar motor representation in oneself. Key issues include (1) the automaticity of such processes, and (2) the role object affordances play in establishing motor representations of others' actions. Participants were asked to move a lever to the left or right to respond to the grip width of a hand moving across a workspace. Stimulus-response compatibility effects were modulated by two task-irrelevant aspects of the visual stimulus: the observed reach direction …

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The Face Inhibition Effect: Social Contrast Or Motor Competition?, Sp Tipper, P Bach

School of Psychology

Merely viewing the faces of famous athletes affects the observers' motor system, suggesting that actionbased information is a core feature of person representations, even when no specific action is visible (Bach & Tipper, 2006). Unexpectedly, these person-based motor priming effects were inhibitory. Foot responses were slower when identifying footballers, and hand responses for tennis players. Here, we demonstrate that these inhibitory effects are only evoked when action is implicitly associated with the athletes; when the athletes are seen performing their skilled actions the effect reverses towards facilitation. The contrast between inhibition evoked by implicit action priming and facilitation evoked by …

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Unstable Territories Of Representation: Architectural Experience And The Behaviour Of Forms, Spaces And The Collective Dynamic Environment, Sana Murrani

Other Faculty of Arts, Humanities and Business Theses

This thesis applies an interdisciplinary cybernetic and phenomenological analysis to contemporary theories of representation and interpretation of architecture, resulting in a speculative theoretical model of architectural experience as a behavioural system. The methodological model adopted for this research defines the main structure of the thesis where the narrative and the contributing parts of its complexity emerge. The narrative is presented through objectives and hypotheses that shift and slide between architectural representation and its experience based on three key internal components in architecture: the architectural forms and spaces, the active observers that interact with their environment, and finally, the responsive environment. …

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Comparison Of Two Storage Methods For The Analysis Of Cholinesterase Activities In Food Animals., Ka Askar, Ac Kudi, Aj Moody

School of Biological and Marine Sciences

Cholinesterases (ChE) are specialized carboxylic ester hydrolases that catalyse the hydrolysis of choline esters. They are classified into either acetylcholinesterase (AChE) or butyrylcholinesterase (BChE). Determination of ChE in the tissues is the appropriate tool for the diagnosis of organophosphorus and carbamate exposures. In general, a significant inhibition was seen in both AChE and BChE activities after 6 months of freezing at -80°C and after 3 months of freezing at -20°C. Linear regression of mean AChE and BChE was observed in all individual samples during the months of the two freezing methods. Bland and Altman plot of the ratios of the …

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An Investigation Into Use Of The Freshwater Gastropod Viviparus As A Recorder Of Past Climatic Change, Melanie Bugler

Other Faculty of Science and Engineering Theses

Through isotopic analysis of Viviparus lentus (V. lentus) a high resolution record of stepwise changes in δ18O and δ13C across the Eocene / Oligocene transition and Oi-1 glacial maximum has been produced for the continental Solent Group strata, Isle of Wight (UK). Comparison of this V. lentus δ18Ocarb. record with high resolution marine δ18Ocarb. records shows that similar isotopic shifts exist in the near coastal continental and marine realms. In order to calculate palaeotemperatures from this new continental record an investigation into the biology of modern Viviparus and its effect on the isotopic composition of its shell carbonate was undertaken. …

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A Musical Instrument Using In Vitro Neural Networks., Eduardo R. Miranda, Slawomir J. Nasuto, Anna R. Troisi, Julia H. Downes, Antonino Chiaramonte, Matthew C. Spencer, Mark W. Hammond, Dimitris Xydas, Benjamin J. Whalley, Victor M. Becerra, Kevin Warwick

School of Art, Design and Architecture

This paper presents a musical instrument, which uses in vitro neuronal networks to synthesise sounds. Cultures of dissociated neurons are grown on a dish with an embedded rectangular array of electrodes (MEA). Isolated neurons reconnect with one another via an extensive network of synaptically connected projections to form a dense monolayer of neurons. Cultures are provided with stimulation, which influences their activity, and can modify the culture’s state. The core of the sound synthesis engine of our musical instrument is a monophonic additive synthesizer using sinusoidal oscillators. We devised a method to generate frequencies, phase and amplitude values for the …

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A Different Way To Think About Creativity: The Case Of Autism And Outsider Art, Rk Mckenzie

Plymouth Institute of Education

No abstract provided.

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Stratigraphy And Palaeoenvironment Of The Paleocene/Eocene Boundary Interval In The Indus Basin, Pakistan, Muhammad Hanif

School of Geography, Earth and Environmental Sciences Theses

Marine sedimentary sections across the Paleocene/Eocene (P/E) boundary interval are preserved in the Patala Formation (Upper Indus Basin) and Dungan Formation (Lower Indus Basin), Pakistan. The P/E interval of the Patala Formation is composed of limestone and shale inter-beds indicating deposition on a carbonate platform. The analysis of larger foraminifera across the P/E interval from the Patala Formation (Kala Chitta Ranges), allows the recognition of the Larger Foraminiferal Turnover (LFT). The Larger Foraminiferal Turnover (LFT) observed in the Patala Formation is associated with the PETM (Paleocene Eocene Thermal Maximum) global climatic event and allows the recognition of the P/E boundary …

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The Effect Of Psychosocial Information Resources On The Psychological Impact Of Genetic Testing For Patients, Celine Lewis

School of Nursing and Midwifery Theses

The effect of psychosocial information resources on the psychological impact of genetic testing for patients Background: The genetic testing process has been shown to have a profound psychosocial impact on patients and families, yet research suggests that there is a lack of practical and helpful psychosocial information written to support decision-making. Ideally, this should be available for use both before and after genetic testing and should be easily accessed through genetic clinics. The development of pre-written leaflets or on-line resources which draw on the experiences and advice of families who have been through similar experiences, and are readily available through …

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Informed Consent For Pharmacogenomic Testing In People With A Learning Disability, Lesley Goldsmith

School of Nursing and Midwifery Theses

Informed consent for pharmacogenomic testing in people with a learning disability Background Advances in genomic healthcare will enable medication to be tailored to each individual’s needs, based on subtle genetic variations. This will result in individuals being asked to consent to genetic testing for this purpose. The recent political agenda for social change has emphasised the right of people with learning disabilities to have more autonomy and make their own decisions. There have also been significant changes in the way healthcare practitioners relate to their patients, with a shift away from paternalism towards shared decision-making. Research Aim The aims of …

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Production And Preservation Of The Arctic Sea Ice Diatom Biomarker Ip25, Thomas Brown

School of Geography, Earth and Environmental Sciences Theses

The presence of the sea ice biomarker IP25 in Arctic marine sediments has previously been used as a proxy measure of past sea ice conditions in the Arctic. Although the sea ice diatom origin of IP25 was established previously, the nature of its production within sea ice, along with its transport through the water column to underlying sediments and its short-term preservation therein, had not been investigated in any significant detail. Variations in the concentration of the sea ice diatom biomarker IP25, were measured in sea ice collected from the eastern Beaufort Sea and Amundsen Gulf from January to June …

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Full-Text Articles in Entire DC Network

Inventory Of Environmental Impact Monitoring Activities At Wave & Tidal Energy Sites In Europe, D Conley, R Leeney, D Greaves, B Holmes, Am O’Hagan, B Godley, C Mcclellan, M Witt, H Mouslim, J Sundberg

School of Biological and Marine Sciences

Corals, Bryozoans And Gastropods Are Able To Calcify In Acidified Seawater, Jm Hall-Spencer, R Rodolfo-Metalpa

School of Biological and Marine Sciences

Foraminifera Resist Ocean Acidification In The Wagner Basin Under Conditions Similar To High Co2 Environments Of The Cretaceous-Paleogene, Jm Hall-Spencer, L Pettit, Mb Hart, A Medina-Sánchez, Cw Smart, P Collins, R Rodolfo-Metalpa, Ledesma Rm Prol

School of Biological and Marine Sciences

The Response Of Foraminifera To Modern Seawater Acidification: A Real-Time Proxy For Paleogene Hypothermal Events, Jm Hall-Spencer, Mb Hart, Bb Dias, Cw Smart, L Pettit

School of Biological and Marine Sciences

Deep-Water Corals Along The Norwegian Contintental Margin: Multidisciplinary Studies On Sula Ridge, Traena Reef, Røst Reef, Floholmen And Sotbakken, Jm Hall-Spencer, Mk Söffker, L Thomsen, V Unnithan

School of Biological and Marine Sciences

Population Structure Of The Christmas Island Blue Crab, Discoplax Hirtipes (Decapoda: Brachyura: Gecarcinidae) On Christmas Island, Indian Ocean., Lm Turner, Jp Hallas, S Morris

School of Biological and Marine Sciences

Rn181 Suppresses Hepatocellular Carcinoma Growth By Inhibition Of The Erk/Mapk Pathway, S Wang, X Huang, Y Li, H Lao, Et Al

School of Biomedical Sciences

The Effect Of Dietary Inclusion Of Category 3 Animal By-Product Meals On Rainbow Trout (O. Mykiss Walbaum) Mineralised Tissues And Immune Function., Matthew Alun Griffiths Owen

School of Biological and Marine Sciences Theses

Changes In Iron-Regulatory Gene Expression Occur In Human Cell Culture Models Of Parkinson's Disease., C. B. Carroll, M. L. Zeissler, N. Chadborn, K. Gibson, G. Williams, J. P. Zajicek, K. E. Morrison, C. O. Hanemann

Peninsula Medical School

David Link – Machine Heart, G Cox

School of Art, Design and Architecture

Air Temperature And Winter Mortality: Implications For The Persistence Of The Invasive Mussel, Perna Viridis In The Intertidal Zone Of The South-Eastern United States, Lb Firth, Am Knights, S Bell

School of Biological and Marine Sciences

Mitigating Amphibian Disease: Strategies To Maintain Wild Populations And Control Chytridiomycosis., Douglas C. Woodhams, Jaime Bosch, Cheryl J. Briggs, Scott Cashins, Leyla R. Davis, Antje Lauer, Erin Muths, Robert Puschendorf, Benedikt R. Schmidt, Brandon Sheafor, Jamie Voyles

School of Biological and Marine Sciences

Peninsula Medical School

Response Of Pteropods And Foraminifera To Changing Pco2 And Ph: Examples From The Mediterranean Sea, M Hart, B Dias, J Hall-Spencer, D Wall-Palmer, C Smart

School of Biological and Marine Sciences

Exploring Co2 Volcanic Vents At Vulcano Island, Mediterranean Sea, To Study The Planktonic Calcifier Response To Long-Term Changes In Carbonate Chemistry, Jm Hall-Spencer, M Passaro, P Ziveri, M Milazzo, R Rodolfo-Metalpa

School of Biological and Marine Sciences

Exploring The Geochemistry And Shell Ultrastructure Of Bivalves As Archives Of Past Ocean Acidification Events: Recent Mytilidae In A Natural Acidic Setting In Ischia (Italy, Mediterranean Sea), S Hahn, R Rodolfo-Metalpa, E Griesshaber, Ww Schmahl, D Buhl, J Hall-Spencer, C Baggini, A Immenhauser

School of Biological and Marine Sciences

Report Of The Ices/Nafo Joint Working Group On Deep-Water Ecology (Wgdec), Jm Hall-Spencer, Rj Brock

School of Biological and Marine Sciences

Uncoupling Protein-2 Attenuates Glucose-Stimulated Insulin Secretion In Ins-1e Insulinoma Cells By Lowering Mitochondrial Reactive Oxygen Species., Charles Affourtit, Martin Jastroch, Martin D. Brand

School of Biomedical Sciences

Global Phylogeography Of The Widely Introduced North West Pacific Ascidian Styela Clava, Paul Hallas

School of Biological and Marine Sciences

The Predictive Mirror: Interactions Of Mirror And Affordance Processes During Action Observation, P Bach, Ap Bayliss, Sp Tipper

School of Psychology

The Face Inhibition Effect: Social Contrast Or Motor Competition?, Sp Tipper, P Bach

School of Psychology

Unstable Territories Of Representation: Architectural Experience And The Behaviour Of Forms, Spaces And The Collective Dynamic Environment, Sana Murrani

Other Faculty of Arts, Humanities and Business Theses

Comparison Of Two Storage Methods For The Analysis Of Cholinesterase Activities In Food Animals., Ka Askar, Ac Kudi, Aj Moody

School of Biological and Marine Sciences

An Investigation Into Use Of The Freshwater Gastropod Viviparus As A Recorder Of Past Climatic Change, Melanie Bugler

Other Faculty of Science and Engineering Theses

A Musical Instrument Using In Vitro Neural Networks., Eduardo R. Miranda, Slawomir J. Nasuto, Anna R. Troisi, Julia H. Downes, Antonino Chiaramonte, Matthew C. Spencer, Mark W. Hammond, Dimitris Xydas, Benjamin J. Whalley, Victor M. Becerra, Kevin Warwick

School of Art, Design and Architecture

A Different Way To Think About Creativity: The Case Of Autism And Outsider Art, Rk Mckenzie

Plymouth Institute of Education

Stratigraphy And Palaeoenvironment Of The Paleocene/Eocene Boundary Interval In The Indus Basin, Pakistan, Muhammad Hanif

School of Geography, Earth and Environmental Sciences Theses

The Effect Of Psychosocial Information Resources On The Psychological Impact Of Genetic Testing For Patients, Celine Lewis

School of Nursing and Midwifery Theses

Informed Consent For Pharmacogenomic Testing In People With A Learning Disability, Lesley Goldsmith

School of Nursing and Midwifery Theses

Production And Preservation Of The Arctic Sea Ice Diatom Biomarker Ip25, Thomas Brown

School of Geography, Earth and Environmental Sciences Theses