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Articles 3241 - 3270 of 6798
Full-Text Articles in Entire DC Network
Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng
Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng
Peninsula Medical School
More individuals are requesting medical assistance for gender uncertainty or dysphoria and provision of adult NHS gender identity services (GIS) is changing. Despite minimal medical input to polarised debates, several issues are potentially concerning: reports of poor care; rapid rises in referrals of children and young people to GIS; public conflation of biological sex with socially influenced gender roles; and extensive uncertainty in the evidence base to guide practice. Medical practice should happen within robust human rights frameworks where individual patients always have their concerns heard. Generalists, with expertise in whole-person care, handling uncertainty and complexity, have a key role …
Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo
Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo
Peninsula Medical School
No abstract provided.
Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira
Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira
Peninsula Medical School
No abstract provided.
Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey
Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey
Peninsula Medical School
Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others’ data indicates that this practice risks excluding ‘Goldilocks’ effects in which a biological variable falls within a range between ‘too much’ and ‘too little’ with a region between where its function is ‘just right’; a concept captured by the Swedish term ‘Lagom’. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical phenomena of the Goldilocks/Lagom form including …
Human Electroencephalogram Based Biomarkers For Detection Of Alzheimer’S Disease, Ali H. Husseen Al-Nuaimi
Human Electroencephalogram Based Biomarkers For Detection Of Alzheimer’S Disease, Ali H. Husseen Al-Nuaimi
School of Engineering, Computing and Mathematics Theses
Alzheimer’s disease (AD) is a progressive disorder that affects cognitive brain functions and develops many years before there are any clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain in the early stages of AD would therefore be useful for early diagnosis. However, this would involve dealing with large numbers of people because up to 50% of dementia sufferers do not receive a formal diagnosis. Thus, there is a need for accurate, low-cost, robust, and easy to use biomarkers that can be used to detect AD in its early stages. Recent guidelines promote the use …
Beyond The Frontiers Of Timeline-Based Planning, Riccardo De Benedictis
Beyond The Frontiers Of Timeline-Based Planning, Riccardo De Benedictis
School of Engineering, Computing and Mathematics Theses
Any agent, either biological or artificial, understands how to behave in its environment according to its prior knowledge and to its prior experience. The process of deciding which actions to undertake and how to perform them so as to achieve some desired objective is called deliberation. In particular, planning is an abstract and explicit deliberation process that chooses and organizes actions, by anticipating their expected outcomes, with the aim to achieve, as best as possible, some pre-stated objectives called goals. Among the most widespread approaches to automated planning, the classical approach broadly pursues to the following definition of planning: starting …
Facial Identification For Digital Forensic, Hiba Al-Kawaz
Facial Identification For Digital Forensic, Hiba Al-Kawaz
School of Engineering, Computing and Mathematics Theses
Forensic facial recognition has become an essential requirement in criminal investigations as a result of the emergence of electronic devices, such as mobile phones and computers, and the huge volume of existing content. Forensic facial recognition goes beyond facial recognition in that it deals with facial images under unconstrained and non-ideal conditions, such as low image resolution, varying facial orientation, poor illumination, a wide range of facial expressions, and the presence of accessories. In addition, digital forensic challenges do not only concern identifying an individual but also include understanding the context, acknowledging the relationships between individuals, tracking, and numbers of …
Computational Study Of Neuronal Oscillations In Motor Control Circuits, Andrea Ferrario
Computational Study Of Neuronal Oscillations In Motor Control Circuits, Andrea Ferrario
School of Engineering, Computing and Mathematics Theses
In this thesis we used mathematical and computational models to study neuronal net- works that control motor behaviours. Specifically, we modelled two neuronal circuits from two opposite ends of the brain complexity spectrum: the swimming circuit of the hatchling Xenopus tadpole and the human basal ganglia. Due to its relative simplicity, tadpole is a unique animal for studying locomotion us- ing both experiments and models. This allowed us to define three biologically-realistic spiking models to clarify the interplay between the architecture of synaptic connections (structure) and the network’s ability to generate activities that correspond to its swim- ming behaviour (function). …
Computational Model Of Negotiation Skills In Virtual Artificial Agents, Daniela Pacella
Computational Model Of Negotiation Skills In Virtual Artificial Agents, Daniela Pacella
School of Engineering, Computing and Mathematics Theses
Negotiation skills represent crucial abilities for engaging in effective social interactions in formal and informal settings. Serious games, intelligent systems and virtual agents can provide solid tools upon which one-to-one training and assessment can be reliably made available. The aim of the present work is to fill the gap between the recent growing interest towards soft skills, and the lack of a robust and modern methodology for supporting their investigation. A computational model for the development of Enact, a 3D virtual intelligent platform for training and testing negotiation skills, will be presented. The serious game allows users to interact with …
The Manufacture And Testing Of Self-Sensing Cnts Nanocomposites For Damage Detecting Applications, Mohammed Al-Bahrani
The Manufacture And Testing Of Self-Sensing Cnts Nanocomposites For Damage Detecting Applications, Mohammed Al-Bahrani
School of Engineering, Computing and Mathematics Theses
Composite materials are widely used in various important applications due to their good engineering properties. However, these properties can be reduced when subjected to different type of loads. This thesis experimentally, theoretically and statistically investigates the possibility of using multi-walled carbon nanotubes (MWCNTs) as a filler to fabricate self-sensing nanocomposites for fracture and damage sensing applications. Self-sensing composite based MWCNTs can be used to diagnose early stage damage in order to prevent a fatal fracture that could occur in the structure during its working life. Here, different concentrations of MWCNTs were evenly distributed either in an epoxy resin using high …
Optimising Power Consumption For Smart Home Communities, Yaseen Saleem Yaseen
Optimising Power Consumption For Smart Home Communities, Yaseen Saleem Yaseen
School of Engineering, Computing and Mathematics Theses
Households’ demand-side energy management systems are considered as primary units for optimising power consumption in a community-based environment by peak load minimisation. These peak periods are expensive for energy providers and consumers. The power management in one community can reduce power consumption fluctuations and improve the response to power price variations per day. The fluctuation demand is not convenient in terms of planning, expenses, and logistics. Therefore, more stable demand will allow suppliers to use cheaper resources and avoid the need for additional resources, which are normally used to meet the load demand at peak times. In the current literature, …
Efficient Evolution Of Neural Networks, Paolo Pagliuca
Efficient Evolution Of Neural Networks, Paolo Pagliuca
School of Engineering, Computing and Mathematics Theses
This thesis addresses the study of evolutionary methods for the synthesis of neural network controllers. Chapter 1 introduces the research area, reviews the state of the art, discusses promising research directions, and presents the two major scientific objectives of the thesis. The first objective, which is covered in Chapter 2, is to verify the efficacy of some of the most promising neuro-evolutionary methods proposed in the literature, including two new methods that I elaborated. This has been made by designing extended version of the double-pole balancing problem, which can be used to more properly benchmark alternative algorithms, by studying the …
Active Stereo Vision For Manipulator Robot, Abdulla Mohamed
Active Stereo Vision For Manipulator Robot, Abdulla Mohamed
School of Engineering, Computing and Mathematics Theses
This thesis describes a novel active stereo vision platform that was developed to provide visual guidance to fruit harvesting robots. A five degree of freedom camera platform was built in order to identify and localize tomatoes grown in greenhouses in farms. A novel cognitive model of attention with three main features map is used to control the gaze of the camera system. The three feature maps are (A) an online epipolar geometry update to produce a disparity map and affordance of grasping, (B) a vergence controller to provide a map of the depth of tomatoes at high accuracy and (C) …
Widening Gyre: A Poetics Of Ocean Plastics, Mandy Bloomfield
Widening Gyre: A Poetics Of Ocean Plastics, Mandy Bloomfield
School of Law, Humanities and Social Sciences
By focusing on contemporary experimental poetry that engages with ocean plastics, this essay explores the capacity of ecopoetics to make distinctive interventions in the environmental humanities, and in particular the blue humanities. It examines work by Stephen Collis, Adam Dickinson, and Evelyn Reilly to show how poetry’s forms of juxtaposition, linkage, linguistic porosity, indeterminacy, and nonnarrative temporalities suggest fertile modes of cultural engagement with the more-than-human oceans. This poetry cultivates amplified modes of attention to more-than-human scales of space, time, agency, and modes of relation, and it performs highly material ways of understanding historical, economic, and aesthetic forces affecting the …
A Century Of Change In North Sea Plankton Communities Explored Through Integrating Historical Datasets, Abigail Mcquatters-Gollop, Jacob Bedford, David Johns
A Century Of Change In North Sea Plankton Communities Explored Through Integrating Historical Datasets, Abigail Mcquatters-Gollop, Jacob Bedford, David Johns
School of Biological and Marine Sciences
No abstract provided.
When Do We Cooperate With Robots?, Debora Zanatto
When Do We Cooperate With Robots?, Debora Zanatto
School of Engineering, Computing and Mathematics Theses
Robotic usage is entering the world into many diverse ways, from advanced surgical areas to assistive technologies for disabled persons. Robots are increasingly designed and developed to assist humans with everyday tasks. However, they are still perceived as tools to be manipulated and controlled by humans, rather than complete and autonomous helpers. One of the main reasons can be addressed to the development of their capabilities to appear credible and trustworthy. This dissertation explores the challenge of interactions with social robots, investigating which specific situations and environments lead to an increase in trust and cooperation between humans and robots. After …
Endo-Β-1,3-Glucanase (Gh16 Family) From Trichoderma Harzianum Participates In Cell Wall Biogenesis But Is Not Essential For Antagonism Against Plant Pathogens, Marcela Suriani Ribeiro, Renato Graciano De Paula, Aline Raquel Voltan, Raphaela Georg De Castro, Cláudia Batista Carraro, Leandro José De Assis, Andrei Stecca Steindorff, Gustavo Henrique Goldman, Roberto Nascimento Silva, Cirano José Ulhoa, Valdirene Neves Monteiro
Endo-Β-1,3-Glucanase (Gh16 Family) From Trichoderma Harzianum Participates In Cell Wall Biogenesis But Is Not Essential For Antagonism Against Plant Pathogens, Marcela Suriani Ribeiro, Renato Graciano De Paula, Aline Raquel Voltan, Raphaela Georg De Castro, Cláudia Batista Carraro, Leandro José De Assis, Andrei Stecca Steindorff, Gustavo Henrique Goldman, Roberto Nascimento Silva, Cirano José Ulhoa, Valdirene Neves Monteiro
Peninsula Medical School
Trichoderma species are known for their ability to produce lytic enzymes, such as exoglucanases, endoglucanases, chitinases, and proteases, which play important roles in cell wall degradation of phytopathogens. β-glucanases play crucial roles in the morphogenetic-morphological process during the development and differentiation processes in Trichoderma species, which have β-glucans as the primary components of their cell walls. Despite the importance of glucanases in the mycoparasitism of Trichoderma spp., only a few functional analysis studies have been conducted on glucanases. In the present study, we used a functional genomics approach to investigate the functional role of the gluc31 gene, which encodes an …
When Stakeholder Pressure Drives The Circular Economy: Measuring The Mediating Role Of Innovation Capabilities, J Suresh, S Kumar Mangla, L Sunil, S Kusi-Sarpong
When Stakeholder Pressure Drives The Circular Economy: Measuring The Mediating Role Of Innovation Capabilities, J Suresh, S Kumar Mangla, L Sunil, S Kusi-Sarpong
Plymouth Business School
Purpose The purpose of this paper is to explore the impact of stakeholder pressures on firm’s circular economy (CE) initiatives. The organizational responses are quite heterogeneous even when the firms face similar pressure. The authors have tried to explain this heterogeneity by using innovative capability as mediating variables. Design/methodology/approach Empirical survey data from Indian manufacturing firms are obtained to test the proposed hypotheses. The hypotheses are grounded in resource-based view of the firm. The authors used structural equation modeling approach with maximum likelihood methods of approximation. Findings The results indicate that exploratory innovation positively influences the firms to adopt CE …
Dietary Intake Of Inorganic Nitrate In Vegetarians And Omnivores And Its Impact On Blood Pressure, Resting Metabolic Rate And The Oral Microbiome, Ann Ashworth, Craig Clarke, Garry Farnham, Luke Liddle, Mia Burleigh, Ana Rodiles, Carla Sillitti, Michele Kiernan, Melanie Moore, Mary Hickson, Chris Easton, Raul Bescos
Dietary Intake Of Inorganic Nitrate In Vegetarians And Omnivores And Its Impact On Blood Pressure, Resting Metabolic Rate And The Oral Microbiome, Ann Ashworth, Craig Clarke, Garry Farnham, Luke Liddle, Mia Burleigh, Ana Rodiles, Carla Sillitti, Michele Kiernan, Melanie Moore, Mary Hickson, Chris Easton, Raul Bescos
School of Health Professions
No abstract provided.
Wild Entanglements: Exploring The Visions And Dilemmas Of ‘Renaturing’ Urban Britain, Cara Louisa Clancy
Wild Entanglements: Exploring The Visions And Dilemmas Of ‘Renaturing’ Urban Britain, Cara Louisa Clancy
School of Geography, Earth and Environmental Sciences Theses
In a rapidly urbanising world, where lands are increasingly repurposed for human endeavours, where seas and rivers carry the weight of mounting plastic, where species extinction is a common theme and where the effects of global climate change are a daily reality, there has never been a more pressing need to rethink nature-society relations and environmental ethics. This thesis draws insights from two cases of urban renaturing in Britain (London and Plymouth) to explore critical issues in contemporary environmental practice, including what matters for humans and nonhumans in such endeavours. Renaturing is here understood as an intentional, reflective attempt to …
Development Of Biomarker-Based Proxy Methods For Reconstructing The Late Quaternary Sea Ice History In The Barents Sea, Deniz Can Koseoglu
Development Of Biomarker-Based Proxy Methods For Reconstructing The Late Quaternary Sea Ice History In The Barents Sea, Deniz Can Koseoglu
School of Geography, Earth and Environmental Sciences Theses
Application of the sympagic diatom-produced, C25 highly branched isoprenoid (HBI) termed IP25 to paleo-sea ice reconstruction has confirmed its utility as a qualitative seasonal sea ice proxy. Combination of IP25 and a pelagic biomarker into the Phytoplankton-IP25 index (PIP25) has facilitated more detailed, semi-quantitative descriptions of sea ice conditions. Further work is motivated by challenges inherent to univariate methods (such as PIP25), and the availability of multiple HBIs characteristic of ice algal and pelagic production within sedimentary archives. This study investigated the potential of incorporating multiple biomarkers to characterise contrasting sea ice and productivity conditions in the contemporary Barents Sea, …
Brexit... A Lifetime Of Purgatory For The Uk's Environmental Laws - Or Is There A Stairway To Heaven?, Philip Connor
Brexit... A Lifetime Of Purgatory For The Uk's Environmental Laws - Or Is There A Stairway To Heaven?, Philip Connor
The Plymouth Law and Criminal Justice Review
This paper considers the prospect that the United Kingdom's decision to withdraw from the European Union may have a detrimental effect on its environmental protections. Brexit may provide the opportunity to pursue a more environmentally focused agenda, but it is argued that the UK's plan to transpose EU legislation underestimates the complexity of the task and that the UK lacks the resources to replicate the system it currently enjoys. On this basis it is thought that a reordering of environmental law is more likely than a radical re writing of it.
Socio-Legal Research: Looking Beyond Black Letter Law In The Context Of Birth Mothers' Rights In Adoption Proceedings, Lisamarie Deblasio
Socio-Legal Research: Looking Beyond Black Letter Law In The Context Of Birth Mothers' Rights In Adoption Proceedings, Lisamarie Deblasio
The Plymouth Law and Criminal Justice Review
This article explores the experiences that birth mothers face in adoption proceedings within a socio-legal context. With analysis of data from interviews with 32 birth mothers synthesised with the relevant provisions of the Adoption and Children Act 2002, it is argued that ingrained unfairness and a lack of accountability exists in the legal and administrative system where birth mothers' rights are concerned. Analysis extends to the social problems of blame and stigmatizing of birth mothers which originates from those agencies involved in the adoptions. It highlights the perspectives and voices of birth mothers, who are seldom the focus in leading …
Alternatives To The Common Fisheries Policy? The Future Of The Uk's Fisheries Post-Brexit, George Cass
Alternatives To The Common Fisheries Policy? The Future Of The Uk's Fisheries Post-Brexit, George Cass
The Plymouth Law and Criminal Justice Review
The Common Fisheries Policy (CFP) of the European Union has faced problems relating to sustainability since its conception. Subsequent reforms have offered some limited means of mitigating these problems yet ultimately they have not been adequately addressed and continue to cause critical damage to the European fisheries. Sound scientific advice has been continuously ignored resulting in catches in excess of the Total Allowable Catch (TAC), further compounding depleted stocks and reducing the chances of recovery. Despite the latest reform in 2013, European fisheries remain in a perilous condition. Brexit creates an opportunity for the UK to develop its own fisheries …
A Critical Analysis Of The Regulation Of Pornography, With Particular Attention To The Protection Of Adolescents, Natasha Owen
A Critical Analysis Of The Regulation Of Pornography, With Particular Attention To The Protection Of Adolescents, Natasha Owen
Plymouth Law Review
No abstract provided.
Live Wrasse Fishing In Southern England: The Legal Problems Surrounding A Biological Solution, Virginia Butcher
Live Wrasse Fishing In Southern England: The Legal Problems Surrounding A Biological Solution, Virginia Butcher
Plymouth Law Review
No abstract provided.
Investigation Of Ccn1 Role(S) In Mantle Cell Lymphoma (Mcl), Afak R S Zaidi
Investigation Of Ccn1 Role(S) In Mantle Cell Lymphoma (Mcl), Afak R S Zaidi
Other Faculty of Health Theses
Mantle Cell Lymphoma (MCL) is a comparatively rare non-Hodgkin`s lymphoma which is characterised by the overexpression of cyclin D1. Many patients present with or progress to advanced stage disease within three years. Disease progression involves down regulation of cyclin D1. Moreover, MCL is broadly considered as an incurable disease with median survival of patients being 3-4 years. CCN1, a matricellular protein involved in stem cell signalling within the haematopoietic microenvironment is highly expressed in early stage MCL cells and down-regulated in advanced stage disease. We have used the human MCL cell lines REC1
An Exploration Of Sharps Injuries Within A Nursing Student Population In The Uk, Kevin Hambridge
An Exploration Of Sharps Injuries Within A Nursing Student Population In The Uk, Kevin Hambridge
Other Faculty of Health Theses
Percutaneous injuries, such as sharps injuries, can transmit up to 60 different types of pathogen (Tarantola et al., 2006) to the injured party. Whilst up to 100% of some nursing student populations sustain sharps injuries (Trivedi et al., 2013), a dearth of research studies investigating the topic worldwide exist. It is unknown within the UK the devices contributing to sharps injuries, the incidence rates and the locations where they occur. The aims of this study were to identify the characteristics of sharps injuries within a nursing student population within the UK; to explore the experience of sharps injuries, concentrating on …
Drp1 Inhibition Is Protective Against Mitochondrial And Autophagic Impairment Induced By Alpha-Synuclein, Zhangqiuzi Fan
Drp1 Inhibition Is Protective Against Mitochondrial And Autophagic Impairment Induced By Alpha-Synuclein, Zhangqiuzi Fan
Other Faculty of Health Theses
Parkinson’s disease (PD) is the second most common neurodegenerative disorder with currently no effective neuroprotective or neurorestorative treatments available. Alpha-synuclein (α-syn) pathology is one of the key proteins involved in PD pathology, it has been found to induce mitochondrial dysfunction, yet the mechanism is not entirely understood. This thesis project tests the hypothesis that α-syn induces mitochondrial dysfunction through disruption of fission/fusion pathway. Using an inducible cell line, I successfully demonstrated that in a time-dependent manner α-syn overexpression induces mitochondrial fragmentation through disruption of fission/fusion dynamics, collapse of mitochondrial membrane potential, increased oxidative stress and impaired mitochondrial respiratory capacity. In …
The Role Of Cd133 In Mouse Incisor Tooth Epithelium, Donald Singer
The Role Of Cd133 In Mouse Incisor Tooth Epithelium, Donald Singer
Other Faculty of Health Theses
Since its discovery, CD133 has been used to identify, isolate and characterise many different stem cell types across a wide variety of tissues. Nonetheless, to date not much has been elucidated about its function in these cells. The continuously growing mouse incisor contains a large population of epithelial stem cells that drive the constant need for enamel generation. Using this model, this project aims to elucidate the role of CD133 in epithelial stem cell renewal and activation. After validating the presence of CD133 in the developing mouse incisor epithelium, this project compared the dental epithelial stem cell dynamics of wildtype …