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Quantifying The Release Of Tyre Wear Particles To The Marine Environment Via Multiple Pathways, Florence N.F. Parker-Jurd, Imogen E. Napper, Geoffrey D. Abbott, Simon Hann, Richard C. Thompson Jan 2021

Quantifying The Release Of Tyre Wear Particles To The Marine Environment Via Multiple Pathways, Florence N.F. Parker-Jurd, Imogen E. Napper, Geoffrey D. Abbott, Simon Hann, Richard C. Thompson

School of Biological and Marine Sciences

Desk-based studies have suggested tyre wear particles contribute a substantial portion of microplastic emissions to the environment, yet few empirical studies report finding tyre wear. Samples were collected from three pathways to the marine environment: atmospheric deposition, treated wastewater effluent, and untreated surface runoff. Pyrolysis coupled to gas chromatography–mass spectrometry was used to detect benzothiazole, a molecular marker for tyres. Benzothiazole was detected in each pathway, emitting tyre wear in addition to other sources of microplastics. Release via surface water drainage was the principle pathway in the regions examined. Laboratory tests indicated larger particles likely settle close to their entry …


Amazon Tree Dominance Across Forest Strata, Frederick C. Draper, Flavia R.C. Costa, Gabriel Arellano, Oliver L. Phillips, Alvaro Duque, Manuel J. Macía, Steege H Ter, Gregory P. Asner, Erika Berenguer, Juliana Schietti, Jacob B. Socolar, Souza Fc De, Kyle G. Dexter, Peter M. Jørgensen, J. Sebastian Tello, William E. Magnusson, Timothy R. Baker, Carolina V. Castilho, Abel Monteagudo-Mendoza, Paul V.A. Fine, Kalle Ruokolainen, Euridice N.Honorio Coronado, Gerardo Aymard, Nállarett Dávila, Mauricio Sánchez Sáenz, Marcos A.Rios Paredes, Julien Engel, Claire Fortunel, C. E.Timothy Paine, Jean Yves Goret, Aurelie Dourdain, Pascal Petronelli, Elodie Allie, Juan E.Guevara Andino, Roel J.W. Brienen, Leslie Cayola Pérez, Ângelo G. Manzatto, Narel Y.Paniagua Zambrana, Jean François Molino, Daniel Sabatier, Jerôme Chave, Sophie Fauset, Roosevelt Garcia Villacorta, Maxime Réjou-Méchain, Paul E. Berry, Karina Melgaço, Ted R. Feldpausch, Elvis Valderamma Sandoval, Rodolfo Vasquez Martinez, Italo Mesones, André B. Junqueira, Katherine H. Roucoux, Toledo Jj De, Ana C. Andrade, José Luís Camargo, Aguila Pasquel J Del, Flávia D. Santana, Wf Laurance, Sg Laurance, Thomas E. Lovejoy, James A. Comiskey, David R. Galbraith, Michelle Kalamandeen, Gilberto E.Navarro Aguilar, Jim Vega Arenas, Carlos A.Amasifuen Guerra, Manuel Flores, Gerardo Flores Llampazo, Luis A.Torres Montenegro, Ricardo Zarate Gomez, Marcelo P. Pansonato, Victor Chama Moscoso, Jason Vleminckx, Oscar J.Valverde Barrantes, Joost F. Duivenvoorden, Sousa Sa De, Luzmila Arroyo, Ricardo O. Perdiz, Jessica Soares Cravo, Beatriz S. Marimon, N/A Junio Jan 2021

Amazon Tree Dominance Across Forest Strata, Frederick C. Draper, Flavia R.C. Costa, Gabriel Arellano, Oliver L. Phillips, Alvaro Duque, Manuel J. Macía, Steege H Ter, Gregory P. Asner, Erika Berenguer, Juliana Schietti, Jacob B. Socolar, Souza Fc De, Kyle G. Dexter, Peter M. Jørgensen, J. Sebastian Tello, William E. Magnusson, Timothy R. Baker, Carolina V. Castilho, Abel Monteagudo-Mendoza, Paul V.A. Fine, Kalle Ruokolainen, Euridice N.Honorio Coronado, Gerardo Aymard, Nállarett Dávila, Mauricio Sánchez Sáenz, Marcos A.Rios Paredes, Julien Engel, Claire Fortunel, C. E.Timothy Paine, Jean Yves Goret, Aurelie Dourdain, Pascal Petronelli, Elodie Allie, Juan E.Guevara Andino, Roel J.W. Brienen, Leslie Cayola Pérez, Ângelo G. Manzatto, Narel Y.Paniagua Zambrana, Jean François Molino, Daniel Sabatier, Jerôme Chave, Sophie Fauset, Roosevelt Garcia Villacorta, Maxime Réjou-Méchain, Paul E. Berry, Karina Melgaço, Ted R. Feldpausch, Elvis Valderamma Sandoval, Rodolfo Vasquez Martinez, Italo Mesones, André B. Junqueira, Katherine H. Roucoux, Toledo Jj De, Ana C. Andrade, José Luís Camargo, Aguila Pasquel J Del, Flávia D. Santana, Wf Laurance, Sg Laurance, Thomas E. Lovejoy, James A. Comiskey, David R. Galbraith, Michelle Kalamandeen, Gilberto E.Navarro Aguilar, Jim Vega Arenas, Carlos A.Amasifuen Guerra, Manuel Flores, Gerardo Flores Llampazo, Luis A.Torres Montenegro, Ricardo Zarate Gomez, Marcelo P. Pansonato, Victor Chama Moscoso, Jason Vleminckx, Oscar J.Valverde Barrantes, Joost F. Duivenvoorden, Sousa Sa De, Luzmila Arroyo, Ricardo O. Perdiz, Jessica Soares Cravo, Beatriz S. Marimon, N/A Junio

School of Geography, Earth and Environmental Sciences

The forests of Amazonia are among the most biodiverse plant communities on Earth. Given the immediate threats posed by climate and land-use change, an improved understanding of how this extraordinary biodiversity is spatially organized is urgently required to develop effective conservation strategies. Most Amazonian tree species are extremely rare but a few are common across the region. Indeed, just 227 ‘hyperdominant’ species account for >50% of all individuals >10 cm diameter at 1.3 m in height. Yet, the degree to which the phenomenon of hyperdominance is sensitive to tree size, the extent to which the composition of dominant species changes …


Intraspecific Variation In Leaf Traits Facilitates The Occurrence Of Trees At The Amazonia–Cerrado Transition, Igor Araújo, Beatriz S. Marimon, Marina C. Scalon, Wesley J.A. Cruz, Sophie Fauset, Tiffani C.S. Vieira, David R. Galbraith, Manuel U. Gloor Jan 2021

Intraspecific Variation In Leaf Traits Facilitates The Occurrence Of Trees At The Amazonia–Cerrado Transition, Igor Araújo, Beatriz S. Marimon, Marina C. Scalon, Wesley J.A. Cruz, Sophie Fauset, Tiffani C.S. Vieira, David R. Galbraith, Manuel U. Gloor

School of Geography, Earth and Environmental Sciences

The ability of plant species to adjust key functional traits through intraspecific variation may determine their success in persisting on our planet in the future, especially in unstable habitats, such as the Amazonia–Cerrado transition zone. We assessed intraspecific variation in 12 leaf morphological and anatomical traits for four tree species along a savanna–forest gradient, including rocky cerrado, typical cerrado and woodland savanna. Generally, all evaluated species showed great intraspecific variation. Our findings demonstrate that trees occurring in the woodland savanna are potentially more vulnerable to climate change, while in the cerrado the individuals presented higher tolerance to water deficit and …


Using Dartmoor Ponies In Conservation Grazing To Reduce Molinia Caerulea Dominance And Encourage Germination Of Calluna Vulgaris In Heathland Vegetation On Dartmoor, Uk, Paul H. Lunt, Jakob L. Leigh, Samantha A. Mcneil, Malcolm J. Gibb Jan 2021

Using Dartmoor Ponies In Conservation Grazing To Reduce Molinia Caerulea Dominance And Encourage Germination Of Calluna Vulgaris In Heathland Vegetation On Dartmoor, Uk, Paul H. Lunt, Jakob L. Leigh, Samantha A. Mcneil, Malcolm J. Gibb

School of Geography, Earth and Environmental Sciences

The increasing dominance of purple moor-grass Molinia caerulea in heathland ecosystems in the UK is of growing concern due to its detrimental impact on plant and animal diversity on sites of nature conservation interest. The use of free-ranging ponies to reduce Molinia dominance was investigated from 2017 to 2019 within a 425 ha site on Dartmoor, UK. Salt blocks were used to attract the ponies to a Molinia-dominated area of heath within the site, away from their previously-preferred grazing areas. The impact of pony grazing was assessed by measurements of vegetation structure and plant species composition. The increased presence of …


Children And Crime: In The Moment, K Haines, S Case, R Smith, Laidler K Joe, N Hughes, C Webster, T Goddard, J Deakin, D Johns, K Richards, P Gray Jan 2021

Children And Crime: In The Moment, K Haines, S Case, R Smith, Laidler K Joe, N Hughes, C Webster, T Goddard, J Deakin, D Johns, K Richards, P Gray

School of Law, Humanities and Social Sciences

Traditional approaches to understanding and responding to children and crime are fundamentally based on ‘miniaturised’ adult models. The assumption appears to be that children are adults in the making, essentially just smaller, developing versions of grown-ups. This view of children is increasingly being challenged. Children are not simply putative adults, they are different, distinct and developing. This article sets out to explore the notion that children essentially think and behave ‘in the moment’. The implications of this for our understanding of children and crime are also explored.


Early Detection Of Alzheimer's Disease With Blood Plasma Proteins Using Support Vector Machines, Chima S. Eke, Emmanuel Jammeh, Xinzhong Li, Camille Carroll, Stephen Pearson, Emmanuel Ifeachor Jan 2021

Early Detection Of Alzheimer's Disease With Blood Plasma Proteins Using Support Vector Machines, Chima S. Eke, Emmanuel Jammeh, Xinzhong Li, Camille Carroll, Stephen Pearson, Emmanuel Ifeachor

Peninsula Medical School

No abstract provided.


Marine Fungi And The Biological Carbon Pump - A Quest For Novel Biomarkers For Key Players In The Carbon Cycle, E Cooper, S Thomas, S Ussher, D Rush, M Cunliffe, S Lengger Jan 2021

Marine Fungi And The Biological Carbon Pump - A Quest For Novel Biomarkers For Key Players In The Carbon Cycle, E Cooper, S Thomas, S Ussher, D Rush, M Cunliffe, S Lengger

School of Geography, Earth and Environmental Sciences

The biological carbon pump (BCP) has a major role in the ability of the oceans to control the global climate and carbon cycle. Inorganic carbon is assimilated by phytoplankton in the surface ocean and converted into organic matter. The organic matter is transported to the deeper ocean interior by the BCP and degraded by microbes en route or sequestered to the deep ocean [1]. Marine fungi are understudied compared to other marine microbes, yet can account for as much biomass as prokaryotes on sinking organic matter in the BCP [2]. Fungi, both unicellular and filamentous, are active in carbon degradation …


A Novel Multimodal Biometric Authentication System Using Machine Learning And Blockchain, Richard Brown, Gueltoum Bendiab, Stavros Shiaeles, Bogdan Ghita Jan 2021

A Novel Multimodal Biometric Authentication System Using Machine Learning And Blockchain, Richard Brown, Gueltoum Bendiab, Stavros Shiaeles, Bogdan Ghita

School of Engineering, Computing and Mathematics

No abstract provided.


Galleria Mellonella Larvae Exhibit A Weight-Dependent Lethal Median Dose When Infected With Methicillin-Resistant Staphylococcus Aureus, Poppy J. Hesketh-Best, Michelle V. Mouritzen, Kayleigh Shandley-Edwards, Richard A. Billington, Mathew Upton Jan 2021

Galleria Mellonella Larvae Exhibit A Weight-Dependent Lethal Median Dose When Infected With Methicillin-Resistant Staphylococcus Aureus, Poppy J. Hesketh-Best, Michelle V. Mouritzen, Kayleigh Shandley-Edwards, Richard A. Billington, Mathew Upton

School of Biological and Marine Sciences

ABSTRACT Galleria mellonella is a recognised model to study antimicrobial efficacy; however, standardisation across the scientific field and investigations of methodological components are needed. Here, we investigate the impact of weight on mortality following infection with Methicillin-resistant Staphylococcus aureus (MRSA). Larvae were separated into six weight groups (180–300 mg at 20 mg intervals) and infected with a range of doses of MRSA to determine the 50% lethal dose (LD50), and the ‘lipid weight’ of larvae post-infection was quantified. A model of LD50 values correlated with weight was developed. The LD50 values, as estimated by our model, were further tested in …


Beyond Spider Personality: The Relationships Between Behavioral, Physiological, And Environmental Factors, Duran L Hernández, David Thomas Wilson, Mark Briffa, Tasmin Lee Rymer Jan 2021

Beyond Spider Personality: The Relationships Between Behavioral, Physiological, And Environmental Factors, Duran L Hernández, David Thomas Wilson, Mark Briffa, Tasmin Lee Rymer

School of Biological and Marine Sciences

No abstract provided.


Accounting For Benefits From Natural Capital: Applying A Novel Composite Indicator Framework To The Marine Environment, Emily Stebbings, Tara Hooper, Melanie C. Austen, Eleni Papathanasopoulou, Xiaoyu Yan Jan 2021

Accounting For Benefits From Natural Capital: Applying A Novel Composite Indicator Framework To The Marine Environment, Emily Stebbings, Tara Hooper, Melanie C. Austen, Eleni Papathanasopoulou, Xiaoyu Yan

School of Biological and Marine Sciences

No abstract provided.


Evaluating Lamp Assays For Detection Of Phytoplasmas Classified In Different Ribosomal Groups, Naofel Aljafer, Mathew Dickinson Jan 2021

Evaluating Lamp Assays For Detection Of Phytoplasmas Classified In Different Ribosomal Groups, Naofel Aljafer, Mathew Dickinson

School of Biological and Marine Sciences

A new set of loop-mediated isothermal amplification assays was developed for detection of phytoplasmas associated with plant diseases and optimised for rapid laboratory detection. This set of assays was designed based on the leucyl tRNA synthetase gene expressed in most of the phytoplasmas and showing a good level of sequence divergence among strains from different 16Sr groups. This makes it a good target for developing discrete assays that can detect specific phytoplasma 16Sr groups. In this study, unique sets of LAMP assays were designed and validated for seven phytoplasma ribosomal groups (16SrI, 16SrII, 16SrIII, 16SrV, 16SrVI, 16SrX, and 16SrXII). These …


Bright Spots As Climate‐Smart Marine Spatial Planning Tools For Conservation And Blue Growth, Ana M. Queirós, Elizabeth Talbot, Nicola J. Beaumont, Paul J. Somerfield, Susan Kay, Christine Pascoe, Simon Dedman, Jose A. Fernandes, Alexander Jueterbock, Peter I. Miller, Sevrine F. Sailley, Gianluca Sará, Liam M. Carr, Melanie C. Austen, Steve Widdicombe, Gil Rilov, Lisa A. Levin, Stephen C. Hull, Suzannah F. Walmsley, Aonghusa C Nic Jan 2021

Bright Spots As Climate‐Smart Marine Spatial Planning Tools For Conservation And Blue Growth, Ana M. Queirós, Elizabeth Talbot, Nicola J. Beaumont, Paul J. Somerfield, Susan Kay, Christine Pascoe, Simon Dedman, Jose A. Fernandes, Alexander Jueterbock, Peter I. Miller, Sevrine F. Sailley, Gianluca Sará, Liam M. Carr, Melanie C. Austen, Steve Widdicombe, Gil Rilov, Lisa A. Levin, Stephen C. Hull, Suzannah F. Walmsley, Aonghusa C Nic

School of Biological and Marine Sciences

No abstract provided.


Seeing Lockdown Through The Eyes Of Children From Around The World: Reflecting On A Children's Artwork Project, S Neill, Mj Foster, M Al-Motlaq, B Carter, T O'Sullivan, A Quaye, M Majamanda, K Abdullah, Ik Hallstrom, C English, A Vickers, I Coyne, E Adama, E Morelius Jan 2021

Seeing Lockdown Through The Eyes Of Children From Around The World: Reflecting On A Children's Artwork Project, S Neill, Mj Foster, M Al-Motlaq, B Carter, T O'Sullivan, A Quaye, M Majamanda, K Abdullah, Ik Hallstrom, C English, A Vickers, I Coyne, E Adama, E Morelius

School of Nursing and Midwifery

The COVID-19 pandemic created new challenges for children including access to education and limiting social and emotional connections to extended family, friends, and the community. Globally, opportunities for sharing children’s self-reported experiences during lockdown were limited. The primary aim of this project was to create an art-E-Book that reflects children’s experiences of life during the COVID-19 pandemic that could be shared with other children around the world. Secondly, we wanted to reflect on the consultation undertaken within the International Network of Child and Family Centered Care (INCFCC) using Gibbs (1988) reflective cycle framework. Children from around the world were invited …


Exmed: An Ai Tool For Experimenting Explainable Ai Techniques On Medical Data Analytics, Marcin Kapcia, Hassan Eshkiki, Jamie Duell, Xiuyi Fan, Shangming Zhou, Benjamin Mora Jan 2021

Exmed: An Ai Tool For Experimenting Explainable Ai Techniques On Medical Data Analytics, Marcin Kapcia, Hassan Eshkiki, Jamie Duell, Xiuyi Fan, Shangming Zhou, Benjamin Mora

School of Nursing and Midwifery

No abstract provided.


Generation Of A Conjoint Surface Plasmon By An Infrared Nano‐Antenna Array, T Allsop, C Mou, R Neal, V Kundrát, C Wang, K Kalli, D Webb, X Liu, P Davey, P Culverhouse, Ania-Castañón J Diego Jan 2021

Generation Of A Conjoint Surface Plasmon By An Infrared Nano‐Antenna Array, T Allsop, C Mou, R Neal, V Kundrát, C Wang, K Kalli, D Webb, X Liu, P Davey, P Culverhouse, Ania-Castañón J Diego

School of Engineering, Computing and Mathematics

Localized surface plasmons (LSP) excited by optical fields have many potential applications resulting from their ability in detecting ultra-small, ambient refractive index change. Current methods using surface nano-patterning by means of lithography have given rise to LSP of limited propagation and interaction lengths, meaning that practical applications remain challenging. This article describes a new all-optical method of generating LSP by means of a carefully fabricated low-dimensional nano-structured material using a direct-write photochemical lithography. It is shown that the resulting array of localized SPs combine or “Conjoin” to have an unprecedented large interaction length, via coupled evanescent fields, giving rise to …


Type-1 Owa Operators In Aggregating Multiple Sources Of Uncertain Information: Properties And Real-World Applications In Integrated Diagnosis, Shang Ming Zhou, Francisco Chiclana, Robert I. John, Jonathan M. Garibaldi, Lin Huo Jan 2021

Type-1 Owa Operators In Aggregating Multiple Sources Of Uncertain Information: Properties And Real-World Applications In Integrated Diagnosis, Shang Ming Zhou, Francisco Chiclana, Robert I. John, Jonathan M. Garibaldi, Lin Huo

School of Nursing and Midwifery

No abstract provided.


Environmental Risks To Freshwater Organisms From The Mycotoxins Deoxynivalenol And Zearalenone Using Species Sensitivity Distributions, Ej Eagles, R Benstead, S Macdonald, Rd Handy, Th Hutchinson Jan 2021

Environmental Risks To Freshwater Organisms From The Mycotoxins Deoxynivalenol And Zearalenone Using Species Sensitivity Distributions, Ej Eagles, R Benstead, S Macdonald, Rd Handy, Th Hutchinson

School of Biological and Marine Sciences

No abstract provided.


Policy Brief - Implementing Nature-Based Solutions For Enhancing Coastal Resilience In Malaysia, Abigail Mcquatters-Gollop, Louise Firth Jan 2021

Policy Brief - Implementing Nature-Based Solutions For Enhancing Coastal Resilience In Malaysia, Abigail Mcquatters-Gollop, Louise Firth

School of Biological and Marine Sciences

No abstract provided.


The Remote Assessment Of Parkinsonism Supporting The Ongoing Development Of Interventions In Gaucher Disease, Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony H.V. Schapira Jan 2021

The Remote Assessment Of Parkinsonism Supporting The Ongoing Development Of Interventions In Gaucher Disease, Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony H.V. Schapira

Peninsula Medical School

Mutations in GBA which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of PD relies upon clinically defined motor features which appear after irreversible neurodegeneration. Prodromal symptoms of PD may provide a means to predict latent pathology, years before the onset of motor features. Previous work has reported prodromal features of PD in GBA mutation carriers, however this has been insufficiently sensitive to identify those that will develop PD. The Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease (RAPSODI GD) study assesses …


A Multicentre Prospective Double Blinded Randomised Controlled Trial Of Intravenous Iron (Ferric Derisomaltose (Fdi)) In Iron Deficient But Not Anaemic Patients With Chronic Kidney Disease On Functional Status, S. Bhandari, V. Allgar, A. Lamplugh, I. Macdougall, P. A. Kalra Jan 2021

A Multicentre Prospective Double Blinded Randomised Controlled Trial Of Intravenous Iron (Ferric Derisomaltose (Fdi)) In Iron Deficient But Not Anaemic Patients With Chronic Kidney Disease On Functional Status, S. Bhandari, V. Allgar, A. Lamplugh, I. Macdougall, P. A. Kalra

Peninsula Medical School

Abstract Background Iron deficiency (ID) is common in patients with chronic kidney disease (CKD). Intravenous (IV) iron in heart failure leads to improvement in exercise capacity and improvement in quality-of-life measurements; however, data in patients with CKD are lacking. Methods The Iron and the Heart Study was a prospective double blinded randomised study in non-anaemic CKD stages 3b-5 patients with ID which investigated whether 1000 mg of IV iron (ferric derisomaltose (FDI)) could improve exercise capacity in comparison to placebo measured at 1 and 3 months post infusion. Secondary objectives included effects on haematinic profiles and haemoglobin, safety analysis and …


Wind Speed And Mesoscale Features Drive Net Autotrophy In The South Atlantic Ocean, Daniel Ford, Gavin H. Tilstone, Jamie D. Shutler, Vassilis Kitidis, Polina Lobanova, Jill Schwarz, Alex J. Poulton, Pablo Serret, Tarron Lamont, Mateus Chuqui, Ray Barlow, Jose Lozano, Milton Kampel, Frederico Brandini Jan 2021

Wind Speed And Mesoscale Features Drive Net Autotrophy In The South Atlantic Ocean, Daniel Ford, Gavin H. Tilstone, Jamie D. Shutler, Vassilis Kitidis, Polina Lobanova, Jill Schwarz, Alex J. Poulton, Pablo Serret, Tarron Lamont, Mateus Chuqui, Ray Barlow, Jose Lozano, Milton Kampel, Frederico Brandini

School of Biological and Marine Sciences

A comprehensive in situ dataset of chlorophyll a (Chl a; N = 18,001), net primary production (NPP; N = 165) and net community production (NCP; N = 95), were used to evaluate the performance of Moderate Resolution Imaging Spectroradiometer on Aqua (MODIS-A) algorithms for these parameters, in the South Atlantic Ocean, to facilitate the accurate generation of satellite NCP time series. For Chl a, five algorithms were tested using MODIS-A data, and OC3-CI performed best, which was subsequently used to compute NPP. Of three NPP algorithms tested, a Wavelength Resolved Model (WRM) was the most accurate, and was therefore used …


An International Genome-Wide Meta-Analysis Of Primary Biliary Cholangitis: Novel Risk Loci And Candidate Drugs, Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Andrade M De, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Steven Flack Jan 2021

An International Genome-Wide Meta-Analysis Of Primary Biliary Cholangitis: Novel Risk Loci And Candidate Drugs, Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Andrade M De, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Steven Flack

Peninsula Medical School

No abstract provided.


Impact Of Direct‐Acting Antiviral Agents On Liver Function In Patients With Chronic Hepatitis C Virus Infection, Philip J. Johnson, Sarah Berhane, Alex J. Walker, Fh Gordon, Sd Ryder, S Mcpherson, A Sreedharan, Aa Ustianowski, K Agarwal, D Mutimer, Takeshi Kumada, Hidenori Toyoda, William L. Irving, K Agarwal, M. Aldersley, A. Ala, R. Aspinall, E. Barnes, A. Brown, L. Corless, M. Cramp, D. Forton, G. Foster, M. Foxton, W. Gelson, D. Gorard, F Gordon, S. Khakoo, A. Lawson, M. Prince, S. Moreea, D Mutimer, M. Prince, P. Richardson, W. Rosenberg, S Ryder, A Sreedharan, B. Stone, A Ustianowski, S. Verma, M. Wiselka Jan 2021

Impact Of Direct‐Acting Antiviral Agents On Liver Function In Patients With Chronic Hepatitis C Virus Infection, Philip J. Johnson, Sarah Berhane, Alex J. Walker, Fh Gordon, Sd Ryder, S Mcpherson, A Sreedharan, Aa Ustianowski, K Agarwal, D Mutimer, Takeshi Kumada, Hidenori Toyoda, William L. Irving, K Agarwal, M. Aldersley, A. Ala, R. Aspinall, E. Barnes, A. Brown, L. Corless, M. Cramp, D. Forton, G. Foster, M. Foxton, W. Gelson, D. Gorard, F Gordon, S. Khakoo, A. Lawson, M. Prince, S. Moreea, D Mutimer, M. Prince, P. Richardson, W. Rosenberg, S Ryder, A Sreedharan, B. Stone, A Ustianowski, S. Verma, M. Wiselka

Peninsula Medical School

No abstract provided.


Current State-Of-The-Art Diagnostics For Norovirus Detection: Model Approaches For Point-Of-Care Analysis, Maja A. Zaczek-Moczydlowska, Azadeh Beizaei, Michael Dillon, Katrina Campbell Jan 2021

Current State-Of-The-Art Diagnostics For Norovirus Detection: Model Approaches For Point-Of-Care Analysis, Maja A. Zaczek-Moczydlowska, Azadeh Beizaei, Michael Dillon, Katrina Campbell

Peninsula Medical School

No abstract provided.


Talin Mechanosensitivity Is Modulated By A Direct Interaction With Cyclin-Dependent Kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jd Humphries, Claus Jørgensen, Mj Humphries, Benjamin T. Goult Jan 2021

Talin Mechanosensitivity Is Modulated By A Direct Interaction With Cyclin-Dependent Kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jd Humphries, Claus Jørgensen, Mj Humphries, Benjamin T. Goult

Peninsula Medical School

Talin (TLN1) is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behavior of its multiple rod domains that modulate interactions with its binding partners. Cyclin-dependent kinase-1 (CDK1) is a key regulator of the cell cycle, exerting its effects through synchronized phosphorylation of a large number of protein targets. CDK1 activity maintains adhesion during interphase, and its inhibition is a prerequisite for the tightly choreographed changes in cell shape and adhesion that are required for successful mitosis. Using a combination of biochemical, structural, and cell biological approaches, we …


Dynamic Structural Colour Increases Photosynthetic Performance In The Alga Ericaria Selaginoides, Barry Pettifor, Lina M. Rasmusson, Jason M. Hall-Spencer Jan 2021

Dynamic Structural Colour Increases Photosynthetic Performance In The Alga Ericaria Selaginoides, Barry Pettifor, Lina M. Rasmusson, Jason M. Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.


To The Bitter End: Affect, Experience And Chemical Ecology, H Drayson Jan 2021

To The Bitter End: Affect, Experience And Chemical Ecology, H Drayson

School of Art, Design and Architecture

This article explores taste in its chemical, gustemological and affective senses, asking what we speak of when we talk about “bitter experience.” Drawing lines of connection between human affect and chemical ecology, it suggests a way of thinking about taste as a chemical entanglement of affective qualities and ecological relations. Two observations underpin the argument. First, the ambiguous resonance of bitter-tasting compounds in human culture is grounded in their ambiguous medical meaning, the same drug may serve as poison or cure. Second, plants interact with many other life-forms by producing chemical compounds, many of which are bitter tasting, that have …


Radiome: Challenges During The Development Of A Real Time Tool To Support People With Dementia, G Shakeri, S Brewster, S Venkatesh, D Moffat, A Kirke, E Miranda, S Banerjee, A Street, J Fachner, H Odell-Miller Jan 2021

Radiome: Challenges During The Development Of A Real Time Tool To Support People With Dementia, G Shakeri, S Brewster, S Venkatesh, D Moffat, A Kirke, E Miranda, S Banerjee, A Street, J Fachner, H Odell-Miller

School of Art, Design and Architecture

No abstract provided.


Guided Tissue Regeneration Techniques Involving Blood-Derived Products In Periradicular Surgery: A Systematic Review And Meta-Analysis Protocol, G Baniulyte, K Ali, L Burns Jan 2021

Guided Tissue Regeneration Techniques Involving Blood-Derived Products In Periradicular Surgery: A Systematic Review And Meta-Analysis Protocol, G Baniulyte, K Ali, L Burns

Peninsula Dental School

No abstract provided.