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Articles 1591 - 1620 of 6794
Full-Text Articles in Entire DC Network
Heartcv: A Tool For Transferrable, Automated Measurement Of Heart Rate And Heart Rate Variability In Transparent Animals, Ziad Ibbini, John I. Spicer, Manuela Truebano, John Bishop, Oliver Tills
Heartcv: A Tool For Transferrable, Automated Measurement Of Heart Rate And Heart Rate Variability In Transparent Animals, Ziad Ibbini, John I. Spicer, Manuela Truebano, John Bishop, Oliver Tills
School of Biological and Marine Sciences
Heart function is a key component of whole-organismal physiology. Bioimaging is commonly, but not exclusively, used for quantifying heart function in transparent individuals, including early developmental stages of aquatic animals, many of which are transparent. However, a central limitation of many imaging-related methods is the lack of transferability between species, life-history stages and experimental approaches. Furthermore, locating the heart in mobile individuals remains challenging. Here, we present HeartCV: an open-source Python package for automated measurement of heart rate and heart rate variability that integrates automated localization and is transferrable across a wide range of species. We demonstrate the efficacy of …
Reconstructing Sedimentary Processes In A Permian Channel–Lobe Transition Zone: An Outcrop Study In The Karoo Basin, South Africa, F Pohl, Jt Eggenhuisen, J De Leeuw, Et Al
Reconstructing Sedimentary Processes In A Permian Channel–Lobe Transition Zone: An Outcrop Study In The Karoo Basin, South Africa, F Pohl, Jt Eggenhuisen, J De Leeuw, Et Al
School of Biological and Marine Sciences
Turbidity currents commonly bypass sediment in submarine channels on the continental slope, and deposit sediment lobes farther down-dip on the flat and unconfined abyssal plain. Seafloor and outcrop data have shown that the transition from bypass to deposition usually occurs over complex zones referred to as channel–lobe transition zones (CLTZs). Recognition of these zones in cores and outcrop remains challenging due to a lack of characteristic sedimentary facies and structures. This paper focuses on Unit E of the Permian Fort Brown Formation in the Karoo Basin, South Africa, in the Slagtersfontein outcrop complex, which has previously been interpreted as a …
New Microsatellite Markers For The Shallow Coral Madracis Auretenra From The Caribbean, Diana Carolina Ballesteros-Contreras, Lina Maria Barrios, Richard Preziosi
New Microsatellite Markers For The Shallow Coral Madracis Auretenra From The Caribbean, Diana Carolina Ballesteros-Contreras, Lina Maria Barrios, Richard Preziosi
School of Biological and Marine Sciences
Coral reefs species represent one-third of all marine species described in the ocean. They are also responsible for providing habitat and support to different species. Recently, Caribbean coral reefs ecosystems have suffered an alarming decrease in their populations as a result of overexploitation. Madracis auretenra in particular, is a widespread shallow coral in marine protected areas (MPAs) of the Caribbean. Due to the important role of MPAs as a biodiversity conservation tool, this species can be used as a model to estimate its dispersion/migration among Caribbean reefs through the use of informative genetic markers (microsatellites) specifically designed for it. Seventeen …
Cold Water And Harmful Algal Blooms Linked To Coral Reef Collapse In The Eastern Tropical Pacific, Caroline Palmer, J Carlos, Giovanni Bassey, Eleazar Ruiz, T Villalobos, Mm Chavarria, Xavier A. Harrison, Robert Puschendorf
Cold Water And Harmful Algal Blooms Linked To Coral Reef Collapse In The Eastern Tropical Pacific, Caroline Palmer, J Carlos, Giovanni Bassey, Eleazar Ruiz, T Villalobos, Mm Chavarria, Xavier A. Harrison, Robert Puschendorf
School of Biological and Marine Sciences
Background: With conventional coral reef conservation methods proving ineffective against intensifying climate change, efforts have focussed on augmenting coral tolerance to warmer water—the primary driver of coral declines. We document coral cover and composition in relation to sea surface temperature (SST) over 25-years, of six marginal reefs in an upwelling area of Costa Rica’s Eastern Tropical Pacific. Methods: Using reef survey data and sea surface temperature (SST) dating back over 25-years, we document coral cover and composition of six marginal reefs in an upwelling area of Costa Rica’s Eastern Tropical Pacific in relation to thermal highs and lows. Results.: A …
Tauroursodeoxycholic Acid In Patients With Amyotrophic Lateral Sclerosis: The Tudca-Als Trial Protocol, Tudca-Als Study Group, Alberto Albanese, Albert Christian Ludolph, Christopher J. Mcdermott, Philippe Corcia, Philip Van Damme, Leonard H. Van Den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, Paolo Tornese, Antoniangela Cocco, Maria Lo Giudice, Michela Matteoli, Eliana Lauranzano, Maria Luisa Malosio, Chiara Adriana Elia, Flavia Lombardo, Flavia Mayer, Maria Puopolo, Stefania Spila Alegiani, Adriano Chiò, Umberto Manera, Cristina Moglia, Andrea Calvo, Paolina Salamone, Giuseppe Fuda, Carlo Colosimo, Giuseppe Stipa, Domenico Frondizi, Christian Lunetta, Valeria Sansone, Claudia Tarlarini, Francesca Gerardi, Vincenzo Silani, Alberto Doretti, Eleonora Colombo, Gianluca Demirtzidis, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Stefania Ballestrero, Johannes Dorst, Ulrike Weiland, Andrea Fromm, Maximilian Wiesenfarth, Katharina Kandler, Simon Witzel, Oliver Hanemann
Tauroursodeoxycholic Acid In Patients With Amyotrophic Lateral Sclerosis: The Tudca-Als Trial Protocol, Tudca-Als Study Group, Alberto Albanese, Albert Christian Ludolph, Christopher J. Mcdermott, Philippe Corcia, Philip Van Damme, Leonard H. Van Den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, Paolo Tornese, Antoniangela Cocco, Maria Lo Giudice, Michela Matteoli, Eliana Lauranzano, Maria Luisa Malosio, Chiara Adriana Elia, Flavia Lombardo, Flavia Mayer, Maria Puopolo, Stefania Spila Alegiani, Adriano Chiò, Umberto Manera, Cristina Moglia, Andrea Calvo, Paolina Salamone, Giuseppe Fuda, Carlo Colosimo, Giuseppe Stipa, Domenico Frondizi, Christian Lunetta, Valeria Sansone, Claudia Tarlarini, Francesca Gerardi, Vincenzo Silani, Alberto Doretti, Eleonora Colombo, Gianluca Demirtzidis, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Stefania Ballestrero, Johannes Dorst, Ulrike Weiland, Andrea Fromm, Maximilian Wiesenfarth, Katharina Kandler, Simon Witzel, Oliver Hanemann
Peninsula Medical School
Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that affects motor neurons in the brain, brainstem, and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. Although much has been achieved in understanding the disease pathogenesis, treatment options are limited, and in Europe, riluzole is the only approved drug. Recently, some other drugs showed minor effects. Methods: The TUDCA-ALS trial is a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial. The study aims to enroll 320 patients in 25 centers across seven countries in Europe. Enrolled patients are randomized to one of two …
Anthropogenic Contaminants In Glacial Environments Ii: Release And Downstream Consequences, Dylan B. Beard, Caroline C. Clason, Sally Rangecroft, Ewa Poniecka, Kim J. Ward, Will H. Blake
Anthropogenic Contaminants In Glacial Environments Ii: Release And Downstream Consequences, Dylan B. Beard, Caroline C. Clason, Sally Rangecroft, Ewa Poniecka, Kim J. Ward, Will H. Blake
School of Geography, Earth and Environmental Sciences
Anthropogenic contamination has been detected in glacial and proglacial environments around the globe. Through mechanisms of secondary release, these contaminants are finding their way into glacial hydrological systems and downstream environments, with potential to impact hundreds of millions of people who rely on glacial meltwater for water, food and energy security worldwide. The first part of our progress report outlined the sources and accumulation mechanisms of contaminants in glacial environments (Part I: Inputs and accumulation). Here we assess processes of contaminant release, pathways to downstream environments, and socio-environmental consequences. We reflect on the potential impacts these contaminants could have for …
Green Synthesis Of Silver Nanoparticles From Diospyros Villosa Extracts And Evaluation Of Antioxidant, Antimicrobial And Anti-Quorum Sensing Potential, Ot Adu, Farzana Mohamed, Yougasphree Naidoo, Ts Adu, Hafizah Chenia, Yaser Hassan Dewir, Hail Rihan
Green Synthesis Of Silver Nanoparticles From Diospyros Villosa Extracts And Evaluation Of Antioxidant, Antimicrobial And Anti-Quorum Sensing Potential, Ot Adu, Farzana Mohamed, Yougasphree Naidoo, Ts Adu, Hafizah Chenia, Yaser Hassan Dewir, Hail Rihan
School of Biological and Marine Sciences
The biosynthesis of silver nanoparticles (AgNPs) from Diospyros villosa leaves and stem bark extracts is described. The stem bark AgNPs of D. villosa synthesized at 80 °C (S80) showed good scavenging activity with a lower IC50 value of 8.75 µg·mL−1 compared to ascorbic acid (9.58 µg·mL−1). The total phenol content of the S80 AgNPs was measured and found to be 10.22 ± 0.14 mg.g−1 gallic acid equivalence (GAE). Bacterial growth inhibition (% GI) and violacein inhibition (% VI) of 10.08% and 58.83%, respectively, was observed against C.subtsugae CV017 with leaf AgNPs synthesized at 80 °C (L80) at 80 μg·mL−1. Stem …
The Mood Of The Silver Economy: A Data Science Analysis Of The Mood States Of Older Adults And The Implications On Their Wellbeing, M Palomino, R Allen, F Aider, Fa Tirotto, I Giorgi, H Alexander, G Masala
The Mood Of The Silver Economy: A Data Science Analysis Of The Mood States Of Older Adults And The Implications On Their Wellbeing, M Palomino, R Allen, F Aider, Fa Tirotto, I Giorgi, H Alexander, G Masala
School of Engineering, Computing and Mathematics
For the first time in the history of humanity, the number of people over 65 surpassed those under 5 in 2018. Undoubtedly, older people will play a significant role in the future of the economy and society in general, and technological innovation will be indispensable to support them. Thus, we were interested in learning how home automation could enable older people to live independently for longer. To better understand this, we held focus groups with UK senior citizens in 2021, and we analyzed the data derived from them from the perspective of affective computing. We have trained a machine learning …
Ecological Consequences Of Historic Moorland ‘Improvement’, Francis M. Rowney, Ralph M. Fyfe, Philip Anderson, Robert Barnett, William Blake, Tim Daley, Katie Head, Alison Macleod, Ian Matthews, David N. Smith
Ecological Consequences Of Historic Moorland ‘Improvement’, Francis M. Rowney, Ralph M. Fyfe, Philip Anderson, Robert Barnett, William Blake, Tim Daley, Katie Head, Alison Macleod, Ian Matthews, David N. Smith
School of Geography, Earth and Environmental Sciences
No abstract provided.
Forecasting Postoperative Delirium In Older Adult Patients With Fast-And-Frugal Decision Trees, Maria Heinrich, Jan K. Woike, Claudia D. Spies, Odette Wegwarth
Forecasting Postoperative Delirium In Older Adult Patients With Fast-And-Frugal Decision Trees, Maria Heinrich, Jan K. Woike, Claudia D. Spies, Odette Wegwarth
School of Psychology
Postoperative delirium (POD) is associated with increased complication and mortality rates, particularly among older adult patients. However, guideline recommendations for POD detection and management are poorly implemented. Fast-and-frugal trees (FFTrees), which are simple prediction algorithms, may be useful in this context. We compared the capacity of simple FFTrees with two more complex models—namely, unconstrained classification trees (UDTs) and logistic regression (LogReg)—for the prediction of POD among older surgical patients in the perioperative setting. Models were trained and tested on the European BioCog project clinical dataset. Based on the entire dataset, two different FFTrees were developed for the pre-operative and postoperative …
Longitudinal Study Of ‘Retraining’ Non-Maths Specialist Teachers To Become Capable, Confident Teachers Of Mathematics, Naomi Sani, David Burghes
Longitudinal Study Of ‘Retraining’ Non-Maths Specialist Teachers To Become Capable, Confident Teachers Of Mathematics, Naomi Sani, David Burghes
Plymouth Institute of Education
One of the key problems to be solved in mathematics education in England is that the demand for mathematics teachers is far in excess of the supply. Acknowledging that there are simply too few mathematics teachers, the UK government has invested significantly in retraining programmes. These programmes ‘retrain’ out-of-field teachers, that is, teachers of other subjects or from other phases, to teach secondary mathematics. The increased mathematical demand of the reformed GCSE courses coupled with the expectation that most post-16 students will engage with some mathematics (studying for A and AS levels, a Core Maths qualification or re-sitting GCSE) means …
Aptamer Functionalized Zno Thin-Film Transistor Based Multiplexed Detection Of Pb And E. Coli In Water, Sk Honnali, Raghavan V Srinivasa, R Ashwath, G Saravanavel, Kr Gunasekhar, S Sambandan, Ss Gorthi, B O'Driscoll, D Jenkins
Aptamer Functionalized Zno Thin-Film Transistor Based Multiplexed Detection Of Pb And E. Coli In Water, Sk Honnali, Raghavan V Srinivasa, R Ashwath, G Saravanavel, Kr Gunasekhar, S Sambandan, Ss Gorthi, B O'Driscoll, D Jenkins
School of Engineering, Computing and Mathematics
No abstract provided.
Micromorphology And Histology Of The Secretory Apparatus Of Diospyros Villosa (L.) De Winter Leaves And Stem Bark, Ot Adu, Yougasphree Naidoo, Ts Adu, Venkataramegowda Sivaram, Yaser Hassan Dewir, Hail Rihan
Micromorphology And Histology Of The Secretory Apparatus Of Diospyros Villosa (L.) De Winter Leaves And Stem Bark, Ot Adu, Yougasphree Naidoo, Ts Adu, Venkataramegowda Sivaram, Yaser Hassan Dewir, Hail Rihan
School of Biological and Marine Sciences
Diospyros villosa is a perennial species prominently acknowledged for its local medicinal applications. The native utilisation of this species in traditional medicine may be ascribed to the presence of secretory structures and their exudate (comprised of phytochemicals). However, the morphological nature and optical features of the secretory structures in D. villosa remain largely unclear. This study was directed to ascertain the occurrence and adaptive features of structures found within the leaves and stem bark of D. villosa using light and electron microscopy techniques. The current study notes the existence of trichomes, and other secretory structures were noted. SEM indicated the …
The Colonization Of Saline Waters Is Associated With Lowered Immune Responses In Aquatic Beetles, María Botella-Cruz, S Pallares, Josefa Velasco, A. John Moody, Richard Billington, A Millan, David T. Bilton
The Colonization Of Saline Waters Is Associated With Lowered Immune Responses In Aquatic Beetles, María Botella-Cruz, S Pallares, Josefa Velasco, A. John Moody, Richard Billington, A Millan, David T. Bilton
School of Biological and Marine Sciences
No abstract provided.
Linking Species Functional Traits To Specific Biogeochemical Processes Under Trawling Pressure, Irini Tsikopoulou, Christopher J. Smith, Konstantia Nadia Papadopoulou, Melanie C. Austen
Linking Species Functional Traits To Specific Biogeochemical Processes Under Trawling Pressure, Irini Tsikopoulou, Christopher J. Smith, Konstantia Nadia Papadopoulou, Melanie C. Austen
School of Biological and Marine Sciences
The impact of otter trawling on the relationship between functional traits of benthic invertebrates and specific biogeochemical processes were investigated in the oligotrophic Cretan Sea. The fishery is managed through a seasonal closure during the summer. During two seasons (winter and summer) replicate samples were taken from the field from a commercial trawl ground and an adjacent control area. Environmental parameters related to sediment biogeochemistry were measured including particulate organic carbon, sedimentary organic carbon, bottom water and sedimentary chlorophyll a and phaeopigment concentrations as well as benthic oxygen consumption. A significant impact of trawling was recorded only for bottom water …
The Presence Of Silver Nanoparticles Reduces Demand For Dissolved Phosphorus To The Benefit Of Biological Nitrogen Fixation In The Coastal Eastern Mediterranean Sea, Ap Rees, E Faraggiana, K Tait, M Celussi, E Dafnomilli, V Manna, A Manning, P Pitta, A Tsiola, S Živanović
The Presence Of Silver Nanoparticles Reduces Demand For Dissolved Phosphorus To The Benefit Of Biological Nitrogen Fixation In The Coastal Eastern Mediterranean Sea, Ap Rees, E Faraggiana, K Tait, M Celussi, E Dafnomilli, V Manna, A Manning, P Pitta, A Tsiola, S Živanović
School of Biological and Marine Sciences
The release of silver into the marine environment is of growing concern as its impact on marine life is not fully understood. Despite previous experiments that have shown toxic effects of silver as nanoparticles (AgNPs) and as free ions (Ag+) on microbial organisms, the impact on important biogeochemical processes, such as marine nitrogen fixation, remains relatively unexplored. The present study investigated the impact of AgNPs and Ag+ on nitrogen fixation activity in oligotrophic coastal ecosystems. Nine mesocosm enclosures were set-up in Crete, Greece, for twelve days during May 2019. Three mesocosms were left unamended at ambient light and temperature; three …
A Novel Method For Identifying Coded Tags Recorded On Aquatic Acoustic Monitoring Systems, Christopher D. Lowe, Nicolas J.C. Tregenza, Claudia J. Allen, Georgina E. Blow, Hanna Nuuttila, Chiara M. Bertelli, Anouska F. Mendzil, Thomas Stamp, Emma V. Sheehan, Peter Davies, Jonathan C.D. Gordon, Jonathan D. Bolland, J. Robert Britton, Robert Main, Randolph Velterop, Charles Crundwell, Andrew Schofield, David R.K. Clarke
A Novel Method For Identifying Coded Tags Recorded On Aquatic Acoustic Monitoring Systems, Christopher D. Lowe, Nicolas J.C. Tregenza, Claudia J. Allen, Georgina E. Blow, Hanna Nuuttila, Chiara M. Bertelli, Anouska F. Mendzil, Thomas Stamp, Emma V. Sheehan, Peter Davies, Jonathan C.D. Gordon, Jonathan D. Bolland, J. Robert Britton, Robert Main, Randolph Velterop, Charles Crundwell, Andrew Schofield, David R.K. Clarke
School of Biological and Marine Sciences
AbstractAquatic biotelemetry increasingly relies on using acoustic transmitters (‘tags’) that enable passive detection of tagged animals using fixed or mobile receivers. Both tracking methods are resource-limited, restricting the spatial area in which movements of highly mobile animals can be measured using proprietary detection systems. Transmissions from tags are recorded by underwater noise monitoring systems designed for other purposes, such as cetacean monitoring devices, which have been widely deployed in the marine environment; however, no tools currently exist to decode these detections, and thus valuable additional information on animal movements may be missed. Here, we describe simple hybrid methods, with potentially …
Boys Don’T Cry: Trauma, Trauma Narrative And Masculine Practice Among Young Male Who Engaged In Harmful Sexual Behaviour, B Zaniewski, R Dallos, J Stedmon, P Welbourne
Boys Don’T Cry: Trauma, Trauma Narrative And Masculine Practice Among Young Male Who Engaged In Harmful Sexual Behaviour, B Zaniewski, R Dallos, J Stedmon, P Welbourne
School of Health Professions
Compelling evidence suggests that majority of young men who engaged in harmful sexual behaviour (HSB) were subjected to various forms of trauma and adverse childhood experiences. This research explores lived experience of a group of young men who engaged in HSB, what sense they made of it and how their positioned themselves towards these events including HSB, so they are able to maintain their self-integrity. It also explores impact of lived experience with consideration for broader family and cultural discourses. Transition to Adulthood Attachment Interview and Semi-structured interview were employed and Dynamic- Maturation Model of attachment were utilised for this …
Integration Of Remote Sensing And Offshore Geophysical Data For Monitoring The Short-Term Morphological Evolution Of An Active Volcanic Flank: A Case Study From Stromboli Island, Daniele Casalbore, Traglia F Di, Claudia Romagnoli, Massimiliano Favalli, Teresa Gracchi, Stefanelli C Tacconi, Teresa Nolesini, Guglielmo Rossi, Soldato M Del, Irene Manzella, Paul Cole, Nicola Casagli, Francesco Latino Chiocci
Integration Of Remote Sensing And Offshore Geophysical Data For Monitoring The Short-Term Morphological Evolution Of An Active Volcanic Flank: A Case Study From Stromboli Island, Daniele Casalbore, Traglia F Di, Claudia Romagnoli, Massimiliano Favalli, Teresa Gracchi, Stefanelli C Tacconi, Teresa Nolesini, Guglielmo Rossi, Soldato M Del, Irene Manzella, Paul Cole, Nicola Casagli, Francesco Latino Chiocci
School of Geography, Earth and Environmental Sciences
The Sciara del Fuoco (SdF) collapse scar at Stromboli is an active volcanic area affected by rapid morphological changes due to explosive/effusive eruptions and mass-wasting processes. The aim of this paper is to demonstrate the importance of an integrated analysis of multi-temporal remote sensing (photogrammetry, COSMO-SkyMed Synthetic Aperture Radar amplitude image) and marine geophysical data (multibeam and side scan sonar data) to characterize the main morphological, textural, and volumetric changes that occurred along the SdF slope in the 2020–2021 period. The analysis showed the marked erosive potential of the 19 May 2021 pyroclastic density current generated by a crater rim …
Uk Perspective Research Landscape For Offshore Renewable Energy And Its Role In Delivering Net Zero, Deborah Greaves, Siya Jin, Puiwah Wong, Dave White, Henry Jeffrey, Beth Scott, Ross Wigg
Uk Perspective Research Landscape For Offshore Renewable Energy And Its Role In Delivering Net Zero, Deborah Greaves, Siya Jin, Puiwah Wong, Dave White, Henry Jeffrey, Beth Scott, Ross Wigg
School of Engineering, Computing and Mathematics
Abstract This paper sets out the role of offshore renewable energy (ORE) in UK targets for Net Zero greenhouse gas emissions by 2050 and provides a review of the research challenges that face the sector as it grows to meet these targets. The research challenges are set out in a Research Landscape that was established by the ORE Supergen Hub following extensive consultation with the ORE community. The challenges are divided into eight themes, each challenge is described, and current progress is summarised. The progress of the ORE sector in recent years has seen huge cost reductions, which have encouraged …
Word Embeddings For Automatic Equalization In Audio Mixing, Satvik Venkatesh, David Moffat, Eduardo Reck Miranda
Word Embeddings For Automatic Equalization In Audio Mixing, Satvik Venkatesh, David Moffat, Eduardo Reck Miranda
School of Art, Design and Architecture
In recent years, machine learning has been widely adopted to automate the audio mixing process. Automatic mixing systems have been applied to various audio effects such as gain-adjustment, equalization, and reverberation. These systems can be controlled through visual interfaces, providing audio examples, using knobs, and semantic descriptors. Using semantic descriptors or textual information to control these systems is an effective way for artists to communicate their creative goals. In this paper, we explore the novel idea of using word embeddings to represent semantic descriptors. Word embeddings are generally obtained by training neural networks on large corpora of written text. These …
Dexamethasone Reduces Vascular Endothelial Growth Factor In Comparison To Placebo In Post-Operative Chronic Subdural Hematoma Samples: A Target For Future Drug Therapy?, Ellie Edlmann, Susan Giorgi-Coll, Eric P. Thelin, Peter J. Hutchinson, Keri L.H. Carpenter
Dexamethasone Reduces Vascular Endothelial Growth Factor In Comparison To Placebo In Post-Operative Chronic Subdural Hematoma Samples: A Target For Future Drug Therapy?, Ellie Edlmann, Susan Giorgi-Coll, Eric P. Thelin, Peter J. Hutchinson, Keri L.H. Carpenter
Peninsula Medical School
BackgroundChronic subdural hematoma (CSDH) is a collection of blood and fluid that arises on the brain surface due to a combination of trauma and/or inflammation. The mainstay of treatment is surgical drainage, but CSDH can recur. Dexamethasone has been shown to reduce CSDH recurrence, but its mechanism of action has not been fully elucidated. Understanding the inflammatory mediators driving CSDH formation and recurrence and how dexamethasone alters this can help develop new therapeutic strategies.MethodsA subgroup of adult patients recruited to the Dex-CSDH trial, randomized to dexamethasone or placebo, who had surgery for their CSDH, were included. CSDH fluid and peripheral …
Exposure Of Escherichia Coli To Cadmium Telluride Quantum Dots, Silver Nanoparticles Or Cupric Oxide Nanoparticles During Aerobic Respiratory Versus Anaerobic Fermentative Growth On D-(+)-Glucose, Joanne Vassallo, Rich Boden, Richard D. Handy
Exposure Of Escherichia Coli To Cadmium Telluride Quantum Dots, Silver Nanoparticles Or Cupric Oxide Nanoparticles During Aerobic Respiratory Versus Anaerobic Fermentative Growth On D-(+)-Glucose, Joanne Vassallo, Rich Boden, Richard D. Handy
School of Biological and Marine Sciences
More harmful response to Escherichia coli in the presence of nanomaterials during anaerobic fermentation as compared to aerobic respiration.
From Microbes To Ecosystems: A Review Of The Ecological Effects Of Biodegradable Plastics, Winnie Courtene-Jones, Rodríguez A Martínez, Richard D. Handy
From Microbes To Ecosystems: A Review Of The Ecological Effects Of Biodegradable Plastics, Winnie Courtene-Jones, Rodríguez A Martínez, Richard D. Handy
School of Biological and Marine Sciences
Biodegradable plastics have been proposed as a potential solution to plastic pollution, as they can be biodegraded into their elemental components by microbial action. However, the degradation rate of biodegradable plastics is highly variable across environments, leading to the potential for accumulation of plastic particles, chemical co-contaminants and/or degradation products. This paper reviews the toxicological effects of biodegradable plastics on species and ecosystems, and contextualises these impacts with those previously reported for conventional polymers. While the impacts of biodegradable plastics and their co-contaminants across levels of biological organisation are poorly researched compared with conventional plastics, evidence suggests that individual-level effects …
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, A Ververi, S Zagaglia, Sm Sisodiya, Ja Hurst, Et Al
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, A Ververi, S Zagaglia, Sm Sisodiya, Ja Hurst, Et Al
Peninsula Medical School
DEPDC5 (DEP Domain-Containing Protein 5) encodes an inhibitory component of the mammalian target of rapamycin (mTOR) pathway and is commonly implicated in sporadic and familial focal epilepsies, both non-lesional and in association with focal cortical dysplasia. Germline pathogenic variants are typically heterozygous and inactivating. We describe a novel phenotype caused by germline biallelic missense variants in DEPDC5. Cases were identified clinically. Available records, including magnetic resonance imaging and electroencephalography, were reviewed. Genetic testing was performed by whole exome and whole-genome sequencing and cascade screening. In addition, immunohistochemistry was performed on skin biopsy. The phenotype was identified in nine children, eight …
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Catherine Devile, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, Jane A. Hurst
Germline Homozygous Missense Depdc5 Variants Cause Severe Refractory Early-Onset Epilepsy, Macrocephaly And Bilateral Polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Catherine Devile, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, Jane A. Hurst
Peninsula Medical School
Abstract DEPDC5 (DEP Domain-Containing Protein 5) encodes an inhibitory component of the mammalian target of rapamycin (mTOR) pathway and is commonly implicated in sporadic and familial focal epilepsies, both non-lesional and in association with focal cortical dysplasia. Germline pathogenic variants are typically heterozygous and inactivating. We describe a novel phenotype caused by germline biallelic missense variants in DEPDC5. Cases were identified clinically. Available records, including magnetic resonance imaging and electroencephalography, were reviewed. Genetic testing was performed by whole exome and whole-genome sequencing and cascade screening. In addition, immunohistochemistry was performed on skin biopsy. The phenotype was identified in nine children, …
Editorial: Biological Invasions In The Mediterranean Sea, Francesco Tiralongo, Jason Michael Hall-Spencer, Ioannis Giovos, Periklis Kleitou
Editorial: Biological Invasions In The Mediterranean Sea, Francesco Tiralongo, Jason Michael Hall-Spencer, Ioannis Giovos, Periklis Kleitou
School of Biological and Marine Sciences
No abstract provided.
Multiplex Lateral Flow Assay And The Sample Preparation Method For The Simultaneous Detection Of Three Marine Toxins, Clare Mills, Michael J. Dillon, Prabir Kumar Kulabhusan, Diana Senovilla-Herrero, Katrina Campbell
Multiplex Lateral Flow Assay And The Sample Preparation Method For The Simultaneous Detection Of Three Marine Toxins, Clare Mills, Michael J. Dillon, Prabir Kumar Kulabhusan, Diana Senovilla-Herrero, Katrina Campbell
Peninsula Medical School
A multiplex lateral flow immunoassay (LFA) has been developed to detect the primary marine biotoxin groups: amnesic shellfish poisoning toxins, paralytic shellfish poisoning toxins, and diarrhetic shellfish poisoning toxins. The performance characteristics of the multiplex LFA were evaluated for its suitability as a screening method for the detection of toxins in shellfish. The marine toxin-specific antibodies were class-specific, and there was no cross-reactivity between the three toxin groups. The test is capable of detecting all three marine toxin groups, with working ranges of 0.2–1.5, 2.5–65.0, and 8.2–140.3 ng/mL for okadaic acid, saxitoxin, and domoic acid, respectively. This allows the multiplex …
Herbivory And Functional Traits Suggest That Enemy Release Is Not An Important Mechanism Driving Invasion Success Of Brown Seaweeds, Al Mabey, Ja Catford, M Rius, A Foggo, Da Smale
Herbivory And Functional Traits Suggest That Enemy Release Is Not An Important Mechanism Driving Invasion Success Of Brown Seaweeds, Al Mabey, Ja Catford, M Rius, A Foggo, Da Smale
School of Biological and Marine Sciences
AbstractInvasive species are a global threat to biodiversity and there is a pressing need to better understand why some species become invasive outside of their native range, and others do not. One explanation for invasive species success is their release from concurrent natural enemies upon introduction to the non-native range. The so-called enemy release hypothesis (ERH) has conflicting support, depending upon the ecosystem and species investigated. To date, most studies testing the generality of the ERH have focused on terrestrial ecosystems. Here, we tested whether enemy release might contribute to the success of the invasive non-native brown seaweeds Undaria pinnatifida …
Data Report: Iodp Site U1523 Composite Section And Stratigraphic Splice Based On X-Ray Fluorescence Data, D Kulhanek, C Prunella, J Mclaughlin, B Griffin, R Mckay, M Patterson, J Gales, A Shevenell, Peer T Van, Iodp Expedition 374 Scientists
Data Report: Iodp Site U1523 Composite Section And Stratigraphic Splice Based On X-Ray Fluorescence Data, D Kulhanek, C Prunella, J Mclaughlin, B Griffin, R Mckay, M Patterson, J Gales, A Shevenell, Peer T Van, Iodp Expedition 374 Scientists
School of Biological and Marine Sciences
Contribution of melting Antarctic Ice Sheets (AIS) to rising sea level remains one of the least quantified inputs to models for the future. To improve these estimates, International Ocean Discovery Program (IODP) Expedition 374 cored five sites in the Ross Sea, Antarctica to examine the stability of the AIS to past intervals of global warmth. While most sites consisted of a single hole, Site U1523 cored 3 holes with overlapping stratigraphy in an attempt to recover as complete of a stratigraphic section as possible despite challenging coring conditions due to the presence of gravel lags and indurated intervals. Given these …