Digital Commons Network^™

Influence Of Exercise Training On Nitric Oxide Pathways And Their Physiological Effects, Jonas Benjamim, Stephen J Bailey, Leonardo Da Silva Gonçalves, Mia Burleigh, Mario Siervo, Andrew R Coggan, Raúl Bescos

School of Health Professions

Nitric oxide (NO) is a critical signalling molecule in cardiovascular, metabolic, and muscular function. Endogenous NO production occurs via two primary metabolic pathways: 1) the classical nitric oxide synthases (NOS) pathway, and 2) the alternative (nitrate-nitrite-NO) pathway, in which inorganic nitrate (NO 3 -) is sequentially reduced to nitrite (NO 2 -) and other NO intermediates (e.g., S-nitrosothiol). The latter pathway relies heavily on the oral microbiota, which catalyze the two-electron partial reduction of NO 3 - to NO 2 -, which is influenced by oral physiology, microbial composition and salivary flow. While the role of exercise training in enhancing …

Microplastics, Nanoplastics And Liver Disease: An Emerging Health Concern?, Shilpa Chokshi, Ashwin Dhanda, Matthew E. Cramp, Richard Thompson

Peninsula Medical School

Human liver tissue has been found to contain microplastics and nanoplastics (MNPs), with evidence that hepatic MNP accumulation has markedly increased over the past 10 years, prompting critical questions regarding their potential causal role in liver disease. In cell-based and murine models, MNP exposure can trigger oxidative stress, fibrogenesis and inflammation, pathological features that resemble those of advanced liver disease, suggesting shared mechanistic pathways. Furthermore, the capacity for MNPs to act as vectors for microbial pathogens, antimicrobial resistance, endocrine-disrupting chemicals and carcinogenic additives might have important implications for liver pathology. This Perspective examines emerging evidence on the consequences of MNPs …

Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer

School of Health Professions

Importance: In recent decades there has been an expansion in the quantity and quality of scientific findings and guidelines on different health topics to promote individual and public health status. Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns. At the same time, personal health behavior is well-known as efficient and cost-free, holding four times the potential to prevent early death compared to health care. Despite this knowledge, data show that the increasing prevalence of unhealthy …

Microplastics In Urine, Sputum And Lung Lavage Fluid From Patients With Respiratory Illnesses, Faezeh Jahedi, Neamatollah Jaafarzadeh Haghighi Fard, Mehdi Ahmadi, Afshin Takdastan, Maryam Haddadzadeh Shoushtari, Reza Dehbandi, Andrew Turner

School of Geography, Earth and Environmental Sciences

Because of the ubiquity of microplastics (MPs) in the environment there are concerns regarding human exposure. In this study, MPs have been determined in three physiological fluids: urine, sputum and bronchoalveolar fluid (BALF); from 30 adult patients in Iran with respiratory conditions. A total of nine small (20–100 μm) and mainly green and red fibres of polyethylene, polypropylene and polystyrene construction were detected in urine samples of eight participants. By contrast, 358 MPs that were dominated by small, white and transparent fibres, but also included larger (100–500 μm) fibres and fragments and spherules of various sizes, were detected in sputum …

Assessing Perioperative Risks In A Mixed Elderly Surgical Population Using Machine Learning: A Multi-Objective Symbolic Regression Approach To Cardiorespiratory Fitness Derived From Cardiopulmonary Exercise Testing, Pietro Arina, Davide Ferrari, Maciej R Kaczorek, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, Ramani Moonesinghe, Mervyn Singer, John Whittle, Evangelos B Mazomenos

Peninsula Medical School

Accurate preoperative risk assessment is of great value to both patients and clinical teams. Several risk scores have been developed but are often not calibrated to the local institution, limited in terms of data input into the underlying models, and/or lack individual precision. Machine Learning (ML) models have the potential to address limitations in existing scoring systems. A database of 1190 elderly patients who underwent major elective surgery was analyzed retrospectively. Preoperative cardiorespiratory fitness data from cardiopulmonary exercise testing (CPET), demographic and clinical data were extracted and integrated into advanced machine learning (ML) algorithms. Multi-Objective-Symbolic-Regression (MOSR), a novel algorithm utilizing …

Sustainability Considerations For End-Of-Life Fibre-Reinforced Plastic Boats, Ruadan Geraghty, Jasper Graham-Jones, Richard Pemberton, John Summerscales, Simon Bray

School of Engineering, Computing and Mathematics

In the 1950s, glass fibre-reinforced polyester resin (GRP, also known as fibreglass or glassfibre) composites replaced wood and metal as the material for small recreational and work boats. The changes resulted from relative ease of manufacture, durability, and low maintenance. New fibres and resins then became available to create a wider range of Fibre-Reinforced Plastics (FRP). Vessels remain serviceable beyond design life: 10 years for inflatables, 20 years for motorboats and 30 years plus for sailboats. Many vessels have now reached end-of-life (EoL) and become Abandoned or Derelict Vessels (ADV). Given that thermosetting resin is not easy to recycle, these …

A New Approach: Using Biometric Technology To Explore The Physiological Stress Of Working In Child Welfare, Austin Griffiths, Kim Link, Kara Haughtigan, Oliver Beer, Lindsey Powell, David Royse

School of Health Professions

Job stress among child welfare professionals affects their mental and physical health and is associated with negative outcomes. Researchers have used self-report measures to document the stress experienced by those in the child welfare field, and this is the first study to use biometric technology across 72 h to identify physiological indicators of stress, recovery, and sleep in frontline child welfare workers in mostly rural areas (n = 32). A stress profile of the participants is presented on their heart rates, mean time-stressed, percent of time stressed, mean time relaxed, percent of time relaxed, mean sleep time, mean RMSSD in …

Mortality Prediction After Major Surgery In A Mixed Population Through Machine Learning: A Multi-Objective Symbolic Regression Approach, Pietro Arina, Davide Ferrari, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, Ramani Moonesinghe, Vasa Curcin, Mervyn Singer, John Whittle, Evangelos B Mazomenos

Peninsula Medical School

INTRODUCTION: Understanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression.

METHODS: A single-institution database of patients undergoing major elective surgery with previous cardiopulmonary exercise testing was divided into three datasets: pre-operative clinical data; cardiorespiratory and physiological data; and combined. A multi-objective symbolic regression model was developed and compared against existing models. Model performance was evaluated using the …

Enhancing Human Well-Being Through Cognitive And Affective Pathways Linking Landscape Sensation To Cultural Ecosystem Services, Yashi Wu, Lina Tang, Chang‑Bing Huang, Guofan Shao, Jundong Hou, Clive E. Sabel

School of Geography, Earth and Environmental Sciences

Context: Landscape sensation is essential for the delivery of cultural ecosystem services (CESs), yet the pathways through which these services are delivered remain inadequately understood. Exploring how people obtain CESs from landscapes facilitates better understanding of the tradeoffs and synergies between ecosystem services and landscape sustainability. Objectives: This study aimed to elucidate the sensory pathways that links landscape attributes to CESs, focusing on the roles of cognitive and affective experiences. Methods: We analyzed social media comments for the measurement scale of cognition. We employed partial least squares structural equation modeling to integrate sensation, cognition, affect, and satisfaction, using questionnaire data …

Designing, Implementing And Testing An Intervention Of Affective Intelligent Agents In Nursing Virtual Reality Teaching Simulations—A Qualitative Study, Michael Loizou, Sylvester Arnab, Petros Lameras, Thomas Hartley, Fernando Loizides, Praveen Kumar, Dana Sumilo

School of Nursing and Midwifery

Emotions play an important role in human-computer interaction, but there is limited research on affective and emotional virtual agent design in the area of teaching simulations for healthcare provision. The purpose of this work is twofold: firstly, to describe the process for designing affective intelligent agents that are engaged in automated communications such as person to computer conversations, and secondly to test a bespoke prototype digital intervention which implements such agents. The presented study tests two distinct virtual learning environments, one of which was enhanced with affective virtual patients, with nine 3rd year nursing students specialising in mental health, during …

Integrating Natural Light For Wellbeing, Performance, And Quality Care Delivery In Healthcare Environments, Ademola Adebayo Akinbami

Other Faculty of Arts, Humanities and Business Theses

The global challenge of addressing human ill-health demands a re-evaluation of the multifaceted factors impacting health outcomes. Rising health issues in society impose significant burdens on healthcare professionals, affecting their comfort, overall well-being, and performance. While issues like inadequate funding and medical equipment shortages are frequently discussed, a growing recognition centres on the pivotal role that architecture and the built environment play in shaping health outcomes. Poorly designed healthcare facilities contribute to staff shortages and poor care outcomes. Consequently, architecture's transformative potential within the built environment becomes essential in advancing human health, well-being, and productivity. Interestingly, the impact of a …

Bridging The Gap: Technological Mediation And The Development Of Humanistic Skills In Medical Simulation: Lessons From Covid-19 And The Impact Of Immersive Media And Minimal Viable Simulation (Mvs), Nicholas Peres

School of Art, Design and Architecture Theses

This thesis provides a chronological account of the integration of innovation and technology within medical simulation and training from 2014 to 2023 at Torbay and South Devon NHS Foundation Trust (TSDFT). Responding to the backdrop of a constantly changing technological and clinical (epidemiological) landscape, it seeks to develop a methodology for assessing the role of technology in improving medical simulation and training. The research critically challenges the current trend towards high-fidelity simulations, driven by manufacturers' technology-centric marketing strategies that frequently impose cost constraints and limit perceived educational outcomes. Motivated by the Francis Report's (2013) findings, this practice-based study explores the …

Is There Clarity On The Horizon For Peri‐Operative Oxygen Therapy?, D. Martin, A. Cumpstey

Peninsula Medical School

No abstract provided.

The Effects Of Acute Hypoxia On Cognitive And Cardiovascular Parameters In Healthy Subjects, R Ravi, Mmf Subhan

School of Biomedical Sciences

Background: Hypoxia can affect the health and safety of patients and persons in various occupations. There is uncertainty surrounding the effect acute hypoxia may have on cognition and the cardiovascular system. Aims: The aim was to examine cognition using the Wechsler Abbreviated Scale of Intelligence – First Edition (WASI-I) and investigate heart rate variability (HRV) with varied fraction of inspired oxygen (FiO2) of 0.12, 0.165 and 0.21. Methods: Seventeen healthy volunteers participated in two tasks of the WASI-I; block design (BD) and matrix reasoning (MR). BD, MR and HRV were measured during randomized gas interventions. A subset had their cerebral …

Assessing The Association Between Overcrowding And Human Physiological Stress Response In Different Urban Contexts: A Case Study In Salzburg, Austria, Zhaoxi Zhang, Kristýna Měchurová, Bernd Resch, Prince Amegbor, Clive E. Sabel

School of Geography, Earth and Environmental Sciences

Overcrowding in densely populated urban areas is increasingly becoming an issue for mental health disorders. Yet, only few studies have examined the association between overcrowding in cities and physiological stress responses. Thus, this study employed wearable sensors (a wearable camera, an Empatica E4 wristband and a smartphone-based GPS) to assess the association between overcrowding and human physiological stress response in four types of urban contexts (green space, transit space, commercial space, and blue space). A case study with 26 participants was conducted in Salzburg, Austria. We used Mask R-CNN to detect elements related to overcrowding such as human crowds, sitting …

Long Nineteenth Century Ephemera, J Gregory

School of Law, Humanities and Social Sciences

No abstract provided.

Nitrite Lowers The Oxygen Cost Of Atp Supply In Cultured Skeletal Muscle Cells By Stimulating The Rate Of Glycolytic Atp Synthesis, Anthony G. Wynne, Charles Affourtit

School of Biomedical Sciences

Dietary nitrate lowers the oxygen cost of human exercise. This effect has been suggested to result from stimulation of coupling efficiency of skeletal muscle oxidative phosphorylation by reduced nitrate derivatives. In this paper, we report the acute effects of sodium nitrite on the bioenergetic behaviour of cultured rat (L6) myocytes. At odds with improved efficiency of mitochondrial ATP synthesis, extracellular flux analysis reveals that a ½-hour exposure to NaNO2 (0.1–5 μM) does not affect mitochondrial coupling efficiency in static myoblasts or in spontaneously contracting myotubes. Unexpectedly, NaNO2 stimulates the rate of glycolytic ATP production in both myoblasts and myotubes. Increased …

Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency At High Altitude – Further Results From The Xtreme Alps Study, Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O’Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Pöhnl, Monty G. Mythen, Michael P.W. Grocott, Denny Z.H. Levett, Daniel S. Martin, Martin Feelisch

Peninsula Medical School

IntroductionNitrate supplementation in the form of beetroot juice (BRJ) ingestion has been shown to improve exercise tolerance during acute hypoxia, but its effect on exercise physiology remains unstudied during sustained terrestrial high altitude exposure. We hypothesized that performing exercise at high altitude would lower circulating nitrate and nitrite levels and that BRJ ingestion would reverse this phenomenon while concomitantly improving key determinants of aerobic exercise performance.MethodsTwenty seven healthy volunteers (21 male) underwent a series of exercise tests at sea level (SL, London, 75 m) and again after 5–8 days at high altitude (HA, Capanna Regina Margherita or “Margherita Hut,” 4,559 …

A Neural Network-Based Model For Lower Limb Continuous Estimation Against The Disturbance Of Uncertainty, Wanting Li, Keping Liu, Zhongbo Sun, C Li, Yuanyuan Chai, Jian Gu

School of Engineering, Computing and Mathematics

In this paper, a novel prediction model is proposed to estimate human continuous motion intention using a fuzzy wavelet neural network (FWNN) and a zeroing neural network (ZNN). During walking, seven channel surface electromyography (sEMG) signals and motion data of hip and knee are collected, and two signals are selected and processed from the seven muscles based on physiological and correlation analysis. Then, FWNN is built as an intention recognition model, with sEMG signals as input and physical hip and knee information as output. Meanwhile, ZNN is exploited into the FWNN model, forming a hybrid model to eliminate the prediction …

Crowdsourcing Platform For Qoe Evaluation For Cloud Multimedia Services, A Laghari, Hui He, Asiya Khan, R Laghari, Shoulin Yin, Jiachi Wang

School of Engineering, Computing and Mathematics

This paper presents a novel web-based crowdsourcing platform for the assessment of the subjective and objective quality of experience (QoE) of the video service in the cloud-server environment. The user has the option to enter subjective QoE data for video service by filling out a web questionnaire. The objective QoE data of the cloud-server, network condition, and the user device is automatically captured by the crowdsourcing platform. Our proposed system collects both objective and subjective QoE simultaneously in real-time. The paper presents the key technologies used in the development of the platform and describes the functional requirements and design ideas …

The Elephant In The Room: How Neoliberal Architecture Education Undermines Wellbeing, I Troiani

School of Art, Design and Architecture

This essay examines the performative space of neoliberal architectural education in the United Kingdom, its history, attributes and values, focusing on staff and student wellbeing in relation to work-time. In so doing, it addresses the vertical unit studio as the ‘elephant in the room’. As a site in which unhealthy work practices are acculturated, and which, when learned at university, can be perpetuated throughout an architect’s work life, the vertical unit system encourages a competitive ego culture at the expense of a balanced work life. In a neoliberal market economy, how might the architecture design studio /education be reframed to …

To The Bitter End: Affect, Experience And Chemical Ecology, H Drayson

School of Art, Design and Architecture

This article explores taste in its chemical, gustemological and affective senses, asking what we speak of when we talk about “bitter experience.” Drawing lines of connection between human affect and chemical ecology, it suggests a way of thinking about taste as a chemical entanglement of affective qualities and ecological relations. Two observations underpin the argument. First, the ambiguous resonance of bitter-tasting compounds in human culture is grounded in their ambiguous medical meaning, the same drug may serve as poison or cure. Second, plants interact with many other life-forms by producing chemical compounds, many of which are bitter tasting, that have …

Human Adaptation To Hypoxia In Critical Illness, Helen T. Mckenna, Andrew J. Murray, Daniel S. Martin

Peninsula Medical School

The syndrome of critical illness is a complex physiological stressor that can be triggered by diverse pathologies. It is widely believed that organ dysfunction and death result from bioenergetic failure caused by inadequate cellular oxygen supply. Teleologically, life has evolved to survive in the face of stressors by undergoing a suite of adaptive changes. Adaptation not only comprises alterations in systemic physiology but also involves molecular reprogramming within cells. The concept of cellular adaptation in critically ill patients is a matter of contention in part because medical interventions mask underlying physiology, creating the artificial construct of “chronic critical illness,” without …

Dissociable Learning Processes, Associative Theory, And Testimonial Reviews: A Comment On Smith And Church (2018, Andy J. Wills, Charlotte E.R. Edmunds, Pelley M Le, Fraser Milton, Ben R. Newell, Dominic M. Dwyer, David R. Shanks

School of Psychology

No abstract provided.

Understanding Biomechanical Constraints For Modelling Expressive Performance: A Guitar Case Study, Leandro L. Costalonga, Marcelo S. Pimenta, Eduardo R. Miranda

School of Art, Design and Architecture

No abstract provided.

Mitochondrial Activity And Skeletal Muscle Insulin Resistance In Kidney Disease, Jane E. Carré, C Affourtit

School of Biomedical Sciences

Insulin resistance is a key feature of the metabolic syndrome, a cluster of medical disorders that together increase the chance of developing type 2 diabetes and cardiovascular disease. In turn, type 2 diabetes may cause complications such as diabetic kidney disease (DKD). Obesity is a major risk factor for developing systemic insulin resistance, and skeletal muscle is the first tissue in susceptible individuals to lose its insulin responsiveness. Interestingly, lean individuals are not immune to insulin resistance either. Non-obese, non-diabetic subjects with chronic kidney disease (CKD), for example, exhibit insulin resistance at the very onset of CKD, even before clinical …

A Comparison Of Exercise Interventions From Bed Rest Studies For The Prevention Of Musculoskeletal Loss, Nagarjun N. Konda, Rama S. Karri, Andrew Winnard, Mona Nasser, Simon Evetts, Eilis Boudreau, Nick Caplan, David Gradwell, Rochelle M. Velho

More Faculty of Health Research

Musculoskeletal loss in actual or simulated microgravity occurs at a high rate. Bed rest studies are a reliable ground-based spaceflight analogue that allow for direct comparison of intervention and control participants. The aim of this review was to investigate the impact of exercise compared to no intervention on bone mineral density (BMD) and muscle cross-sectional area (muscle CSA) in bed rest studies relative to other terrestrial models. Eligible bed rest studies with healthy participants had an intervention arm with an exercise countermeasure and a control arm. A search strategy was implemented for MEDLINE. After screening, eight studies were identified for …

Quality Of Experience (Qoe) And Quality Of Service (Qos) In Uav Systems, A Laghari, Ai Khan, H Hui

School of Engineering, Computing and Mathematics

No abstract provided.

Transparent Authentication Utilising Gait Recognition, Hind K Al-Obaidi

School of Engineering, Computing and Mathematics Theses

Securing smartphones has increasingly become inevitable due to their massive popularity and significant storage and access to sensitive information. The gatekeeper of securing the device is authenticating the user. Amongst the many solutions proposed, gait recognition has been suggested to provide a reliable yet non-intrusive authentication approach – enabling both security and usability. While several studies exploring mobile-based gait recognition have taken place, studies have been mainly preliminary, with various methodological restrictions that have limited the number of participants, samples, and type of features; in addition, prior studies have depended on limited datasets, actual controlled experimental environments, and many activities. …

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …