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A Nordic Perspective On Patient Online Record Access And The European Health Data Space, Maria Hägglund, Anna Kharko, Annika Bärkås, Charlotte Blease, Åsa Cajander, Catherine Desroches, Asbjørn Johansen Fagerlund, Josefin Hagström, Isto Huvila, Iiris Hörhammer, Bridget Kane, Gunnar O. Klein, Eli Kristiansen, Jonas Moll, Irene Muli, Hanife Rexhepi, Sara Riggare, Peeter Ross, Isabella Scandurra, Saija Simola, Hedvig Soone, Bo Wang, Maedeh Ghorbanian Zolbin, Rose Mharie Åhlfeldt, Sari Kujala, Monika Alise Johansen Jun 2024

A Nordic Perspective On Patient Online Record Access And The European Health Data Space, Maria Hägglund, Anna Kharko, Annika Bärkås, Charlotte Blease, Åsa Cajander, Catherine Desroches, Asbjørn Johansen Fagerlund, Josefin Hagström, Isto Huvila, Iiris Hörhammer, Bridget Kane, Gunnar O. Klein, Eli Kristiansen, Jonas Moll, Irene Muli, Hanife Rexhepi, Sara Riggare, Peeter Ross, Isabella Scandurra, Saija Simola, Hedvig Soone, Bo Wang, Maedeh Ghorbanian Zolbin, Rose Mharie Åhlfeldt, Sari Kujala, Monika Alise Johansen

School of Psychology

The Nordic countries are, together with the United States, forerunners in online record access (ORA), which has now become widespread. The importance of accessible and structured health data has also been highlighted by policy makers internationally. To ensure the full realization of ORA’s potential in the short and long term, there is a pressing need to study ORA from a cross-disciplinary, clinical, humanistic, and social sciences perspective that looks beyond strictly technical aspects. In this viewpoint paper, we explore the policy changes in the European Health Data Space (EHDS) proposal to advance ORA across the European Union, informed by our …

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Successfully Initiating An Escalation Of Care In Acute Ward Settings—A Qualitative Observational Study, J. Ede, B. Kent, P. Watkinson, R. Endacott Jun 2024

Successfully Initiating An Escalation Of Care In Acute Ward Settings—A Qualitative Observational Study, J. Ede, B. Kent, P. Watkinson, R. Endacott

School of Nursing and Midwifery

Aims: To address knowledge gaps by (i) developing a theoretical understanding of escalation and (ii) identifying escalation success factors. Design: Non-participant observations were used to examine deteriorating patient escalation events. Methods: Escalation event data were collected by a researcher who shadowed clinical staff, between February 16th 2021 and March 17th 2022 from two National Health Service Trusts. Events were analysed using Framework Analysis. Escalation tasks were mapped using a Hierarchical Task Analysis diagram and data presented as percentages, frequency and 95% CI. Results: A total of 38 observation sessions were conducted, totaling 105 h, during which 151 escalation events were …

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Gc Insights: Lessons From Participatory Water Quality Research In The Upper Santa River Basin, Peru, Sally Rangecroft, Caroline Clason, Rosa Maria Dextre, Isabel Richter, Claire Kelly, Cecilia Turin, Claudia V. Grados-Bueno, Beatriz Fuentealba, Mirtha Camacho Hernandez, Sergio Morera Julca, John Martin, John Adam Guy Jun 2024

Gc Insights: Lessons From Participatory Water Quality Research In The Upper Santa River Basin, Peru, Sally Rangecroft, Caroline Clason, Rosa Maria Dextre, Isabel Richter, Claire Kelly, Cecilia Turin, Claudia V. Grados-Bueno, Beatriz Fuentealba, Mirtha Camacho Hernandez, Sergio Morera Julca, John Martin, John Adam Guy

School of Geography, Earth and Environmental Sciences

Here we share four key lessons from an interdisciplinary project (Nuestro Rio) that gathered community perspectives on local water quality in the Santa River basin (Peru) utilising a digital technological approach where we collected data via a novel photo elicitation app, supported by a field work campaign. The lessons explored in this article provide insights into challenges and opportunities for researchers considering developing technological tools for encouraging participation and engagement in marginalised communities.

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Obituary: Prof. Donovan P Kelly (1940-2024), With A Review Of His Life's Work In Microbial Sulfur Metabolism, Autotrophy And C1 Metabolism, Rich Boden Jun 2024

Obituary: Prof. Donovan P Kelly (1940-2024), With A Review Of His Life's Work In Microbial Sulfur Metabolism, Autotrophy And C1 Metabolism, Rich Boden

School of Biological and Marine Sciences

No abstract provided.

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Evaluating The Use Of The Mobile Electrocardiogram Technology Kardiamobile™ In Community Settings: An Online Survey, Aimee Emmett, Bridie Kent, Alison James, Jane March-Mcdonald Jun 2024

Evaluating The Use Of The Mobile Electrocardiogram Technology Kardiamobile™ In Community Settings: An Online Survey, Aimee Emmett, Bridie Kent, Alison James, Jane March-Mcdonald

School of Nursing and Midwifery

Background: In response to issues identified by community healthcare professionals (HCPs), including difficulty in routinely recording electrocardiograms (ECGs) at the time of their assessments with the population of patients referred to as ‘housebound’, one National Health Service (NHS) Trust adopted the mobile ECG technology; KardiaMobile™, supported by the Academic Health and Science Network (AHSN), in 2017–2018. The use and uptake of this technology were evaluated and are reported in this paper. Methods: A cross-sectional, mixed-methods online survey was conducted from August 2021 to October 2021. The respondents were a convenience sample of HCPs using KardiaMobile™ to detect atrial fibrillation (AF) …

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Distinct Basal Ganglia Contributions To Learning From Implicit And Explicit Value Signals In Perceptual Decision-Making, Tarryn Balsdon, M. Andrea Pisauro, Marios G. Philiastides Jun 2024

Distinct Basal Ganglia Contributions To Learning From Implicit And Explicit Value Signals In Perceptual Decision-Making, Tarryn Balsdon, M. Andrea Pisauro, Marios G. Philiastides

School of Psychology

Metacognitive evaluations of confidence provide an estimate of decision accuracy that could guide learning in the absence of explicit feedback. We examine how humans might learn from this implicit feedback in direct comparison with that of explicit feedback, using simultaneous EEG-fMRI. Participants performed a motion direction discrimination task where stimulus difficulty was increased to maintain performance, with intermixed explicit- and no-feedback trials. We isolate single-trial estimates of post-decision confidence using EEG decoding, and find these neural signatures re-emerge at the time of feedback together with separable signatures of explicit feedback. We identified these signatures of implicit versus explicit feedback along …

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The Case(S) Of Environmental And Sustainability Education In The United Kingdom, Alun Morgan, Paul Warwick Jun 2024

The Case(S) Of Environmental And Sustainability Education In The United Kingdom, Alun Morgan, Paul Warwick

School of Law, Humanities and Social Sciences

The story of Environmental and Sustainability Education (ESE) in the United Kingdom (UK) is manifold in nature – with multiple initiatives interacting in the ebb and flow of its progress. The UK remains dis-united at an educational policy level, with Scotland, Wales and Northern Ireland leading the way in their recent emphasis on the importance of ESE in comparison to England.The exciting potential for ESE change has historically been more consistently harnessed across the UK through the Third Sector helping to catalyse change across the public Education Sector. Charities, voluntary and community organisations, social enterprises and cooperatives have partnered with …

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“She’S Been A Rock”: The Function And Importance Of “Holding” By Social Prescribing Link Workers In Primary Care In England—Findings From A Realist Evaluation, Debra Westlake, Geoffrey Wong, Steven Markham, Amadea Turk, Jordan Gorenberg, Catherine Pope, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Anthony Meacock, Kamal R. Mahtani, Stephanie Tierney Jun 2024

“She’S Been A Rock”: The Function And Importance Of “Holding” By Social Prescribing Link Workers In Primary Care In England—Findings From A Realist Evaluation, Debra Westlake, Geoffrey Wong, Steven Markham, Amadea Turk, Jordan Gorenberg, Catherine Pope, Joanne Reeve, Caroline Mitchell, Kerryn Husk, Sabi Redwood, Anthony Meacock, Kamal R. Mahtani, Stephanie Tierney

Peninsula Medical School

Social prescribing link workers are recently introduced roles in English primary care. One of their intended functions is to support patients with conditions influenced by the wider, social determinants of health. Their main purpose is to connect people to community resources to meet their nonmedical needs. However, our research reveals that link workers provide not only connections but also what we have described as “holding” for individuals with complex needs, who lack informal networks of support or who are waiting to access services. We explore the concept of holding, its meaning and significance in this context, and consider its consequences. …

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Transformation From E-Voting To E-Cheque, Yun Xing Kho, Swee Huay Heng, Syh Yuan Tan, Ji Jian Chin Jun 2024

Transformation From E-Voting To E-Cheque, Yun Xing Kho, Swee Huay Heng, Syh Yuan Tan, Ji Jian Chin

School of Engineering, Computing and Mathematics

Although e-voting scheme and e-cheque scheme are two different applications, they have similarities in the scheme definitions and security properties. This inspires us to establish a relationship between the two schemes by formalising a generic transformation from e-voting to e-cheque scheme. Firstly, we define the scheme definitions and security models for both e-voting scheme and e-cheque scheme. Subsequently, we demonstrate a generic transformation framework from e-voting to e-cheque with asymptotic complexity of O n and design a formal proof to show that a secure e-voting scheme can be transformed into a secure echeque scheme. As a proof of concept, we …

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Knowledge, Attitudes And Practices Of Psychiatrists In India Regarding Sudden Unexpected Death In Epilepsy (Sudep) And Seizure-Related Harm, Surobhi Chatterjee, Shivangini Singh, Sujita Kumar Kar, Rohit Shankar Jun 2024

Knowledge, Attitudes And Practices Of Psychiatrists In India Regarding Sudden Unexpected Death In Epilepsy (Sudep) And Seizure-Related Harm, Surobhi Chatterjee, Shivangini Singh, Sujita Kumar Kar, Rohit Shankar

Peninsula Medical School

BackgroundSudden unexpected death in Epilepsy (SUDEP) is one of the leading causes of death in people with epilepsy (PWE). Awareness and taking adequate preventive measures are pivotal to reducing SUDEP. Nearly 80% of PWE live in lower-middle-income countries (LMICs) such as India where for many, epilepsy management is by psychiatrists.AimTo evaluates the knowledge, attitude and practices of Indian psychiatrists on SUDEP and seizure risk.MethodsA cross-sectional online survey of 12 Likert response questions using validated themes, was circulated among Indian Psychiatric Society members. Non-discriminatory exponential snowballing technique leading to convenience non-probability sampling was used. The inquiry involved SUDEP-related topics including the …

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New Valproate Regulations, Informed Choice And Seizure Risk, Heather Angus-Leppan, Rachel Arkell, Lance Watkins, Dominic Heaney, Paul Cooper, Rohit Shankar Jun 2024

New Valproate Regulations, Informed Choice And Seizure Risk, Heather Angus-Leppan, Rachel Arkell, Lance Watkins, Dominic Heaney, Paul Cooper, Rohit Shankar

Peninsula Medical School

Valproate is the most effective medication for generalised epilepsies, and several specific epilepsy syndromes. For some people, it will be the only medication to establish seizure remission, and withdrawing it carries risks of seizure recurrence and Sudden Unexpected Death in Epilepsy (SUDEP). It is also of proven efficacy for bipolar disorder and migraine prevention.Guidelines based on observational and epidemiological studies stress that maternal valproate related teratogenicity and neurodevelopmental effects are significantly higher than for other antiseizure medications (ASMs). It should, therefore, only be used if other medications are ineffective and after balancing the teratogenicity risk. Regulatory restrictions have changed prescribing …

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Student Academic Representation In The Uk: An Exploration Of Recruitment, Training, And Impacts, Jennie Winter, Rebecca Turner, Oliver Webb, Luciana Dalla Valle, Claire Benwell Jun 2024

Student Academic Representation In The Uk: An Exploration Of Recruitment, Training, And Impacts, Jennie Winter, Rebecca Turner, Oliver Webb, Luciana Dalla Valle, Claire Benwell

Professional Services

Student academic representation is a staple feature in UK and international higher education. It provides a vital quality function whereby students, who are elected representatives of their programme, canvas the opinions of peers to inform quality assurance processes. In the UK, there is increasing regulatory pressure for universities and student unions to be dual owners of representation activity and much work has been done to enact this model. Nonetheless, little is known about the experiences of those serving as student representatives, despite this being a community of thousands of students across the UK, who hold an instrumental position in institutional …

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The Development Of Speech And Gesture In Sesotho Narratives, Heather Brookes, Dorothy Agyepong, Michelle White, Sefela Yalala Jun 2024

The Development Of Speech And Gesture In Sesotho Narratives, Heather Brookes, Dorothy Agyepong, Michelle White, Sefela Yalala

School of Psychology

Studies show that speech and gesture develop together with age, and the nature of gestures changes with increasing cognitive and discursive abilities. While there are common developmental trends, cultural differences may also impact development. We examined gesture development in narratives of Sesotho speaking children aged 5 to 6 years (n = 12), 9 to 10 years (n = 12) and adults (n = 12), who watched a wordless cartoon and narrated the story back to an interlocutor. Our results show that narrative ability develops with age. Speech and gesture become more complex. Representational and pragmatic gestures increase, but the proportion …

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#Disgusted: Identifying Potential Sub-Factors Of Moral Disgust Through Reflexive Thematic Analysis Of Tweets, Ryan Statton, Alison Bacon, Jaysan Charlesford, Sylvia Terbeck Jun 2024

#Disgusted: Identifying Potential Sub-Factors Of Moral Disgust Through Reflexive Thematic Analysis Of Tweets, Ryan Statton, Alison Bacon, Jaysan Charlesford, Sylvia Terbeck

School of Psychology

Social media provides an untapped resource for exploring Moral Disgust. We therefore drew on ‘tweets’ about Moral Disgust (k=526) to better conceptualise the situations, people, and concepts users found Disgusting. Our Reflexive Thematic Analysis identified two themes and accompanying subthemes: Hierarchical Disgust and Third-Party Disgust. Hierarchical Disgust was constructed from expressions of Disgust directed to power structures, abuses of power, and leaders, whereas Third-Party Disgust comprised expressions directed at negative outcomes for others, often in the form of discrimination or harm. Both themes served as a form of group protection through out-group distancing and normative in-group policing. Importantly, this research …

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Codesign Principles For The Effective Development Of Digital Heritage Extended Reality Systems For Health Interventions In Rural Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter, Ray B. Jones, Daniel Maudlin Jun 2024

Codesign Principles For The Effective Development Of Digital Heritage Extended Reality Systems For Health Interventions In Rural Communities, Alejandro Veliz Reyes, Marius N. Varga, Hannah Bradwell, Rory Baxter, Ray B. Jones, Daniel Maudlin

School of Art, Design and Architecture

We present a methodological, theoretical, and technological outline of codesign principles for the effective development of digital heritage extended reality systems for health and care. The paper is based on two large-scale research projects involving ageing in rural and coastal communities, focused on the codesign of extended reality systems to stimulate new forms of access to local heritage sites with potential impact on health outcomes. Our approach stems from a multi-disciplinary collaboration between health, digital design, and heritage specialists, and suggests ways to reconcile diverging forms of knowledge production, such as our ‘researcher in residence’ methodology and the place-based complexities …

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The Effects Of A Breathing Exercise-Based Intervention On Low Back Pain And Anxiety Symptoms, Jamie O'Neill Jun 2024

The Effects Of A Breathing Exercise-Based Intervention On Low Back Pain And Anxiety Symptoms, Jamie O'Neill

South West Clinical School Journal

#400WORDS: RESEARCH + ACTION

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Comparing Child Word Associations To Adult Associative Norms: Evidence For Child-Specific Associations With A Strong Priming Effect In 3-Year-Olds, Nadine Fitzpatrick, Caroline Floccia Jun 2024

Comparing Child Word Associations To Adult Associative Norms: Evidence For Child-Specific Associations With A Strong Priming Effect In 3-Year-Olds, Nadine Fitzpatrick, Caroline Floccia

School of Psychology

Investigating how infants first establish relationships between words is a necessary step towards understanding how an interconnected network of semantic relationships develops in the adult lexical-semantic system. Stimuli selection for these child studies is critical since words must be both familiar and highly imageable. However, there has been a reliance on adult word association norms to inform stimuli selection in English infant studies to date, as no resource currently exists for child-specific word associations. We present three experiments that explore the strength of word–word relationships in 3-year-olds. Experiment 1 collected children’s word associations (WA) (N = 150; female = 84, …

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Gpt-Enabled Cybersecurity Training: A Tailored Approach For Effective Awareness, Nabil Al-Dhamari, Nathan Clarke Jun 2024

Gpt-Enabled Cybersecurity Training: A Tailored Approach For Effective Awareness, Nabil Al-Dhamari, Nathan Clarke

School of Engineering, Computing and Mathematics

This study explores the limitations of traditional Cybersecurity Awareness and Training (CSAT) programs and proposes an innovative solution using Generative Pre-Trained Transformers (GPT) to address these shortcomings. Traditional approaches lack personalization and adaptability to individual learning styles. To overcome these challenges, the study integrates GPT models to deliver highly tailored and dynamic cybersecurity learning experiences. Leveraging natural language processing capabilities, the proposed approach personalizes training modules based on individual trainee profiles, helping to ensure engagement and effectiveness. An experiment using a GPT model to provide a real-time and adaptive CSAT experience through generating customized training content. The findings have demonstrated …

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Elucidating The Migrations Of European Seabass From The Southern North Sea Using Mark-Recapture Data, Acoustic Telemetry And Data Storage Tags, Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, Jan Reubens Jun 2024

Elucidating The Migrations Of European Seabass From The Southern North Sea Using Mark-Recapture Data, Acoustic Telemetry And Data Storage Tags, Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, Jan Reubens

School of Biological and Marine Sciences

The movement ecology of European seabass, Dicentrarchus labrax, remains poorly understood, especially in the northern ranges of its distribution. To investigate migration patterns of seabass from the southern North Sea, we combined data from different projects from four countries using various tagging techniques. This resulted in 146 recaptures (out of 5598 externally marked seabass), 138 detected animals (out of 162 seabass fitted with an acoustic transmitter) and 76 archived depth and temperature series (out of 323 seabass with an archival tag). Using geolocation modelling, we distinguished different migration strategies, whereby individual fish migrated to the eastern English Channel (15.1%), the …

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Hauntological Form: Where We Might Find The New In Contemporary Videogames, James Sweeting Jun 2024

Hauntological Form: Where We Might Find The New In Contemporary Videogames, James Sweeting

School of Art, Design and Architecture

This paper will examine a means by which contemporary videogames can recover a Lost Future. Central to this is expanding upon Mark Fisher’s (2022) and Simon Reynolds’ (2012) insights provided around hauntology in the context of popular music. Hauntology begins to provide an answer to the question surrounding the viability of the future, in that nostalgia is instead a symptom of hauntology, a byproduct of media’s increasing unwillingness to escape its past compounded by an inability to imagine a different future. This is where my concept of “Hauntological Form” is significant. It serves two core purposes; the first is to …

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Men’S Perceptions Of Beardedness In A Hispanic And Iranian Sample: The Role Of Intrasexual Competition On Evaluations Of Attractiveness, Masculinity, And Fighting Ability, Ray Garza, Reza Afhami, Farid Pazhoohi Jun 2024

Men’S Perceptions Of Beardedness In A Hispanic And Iranian Sample: The Role Of Intrasexual Competition On Evaluations Of Attractiveness, Masculinity, And Fighting Ability, Ray Garza, Reza Afhami, Farid Pazhoohi

School of Psychology

Facial hair is suggested to have evolved partly through female mate choice, enhancing men's attractiveness, and is also linked to forms of intrasexual competition, including aggression, masculinity, and dominance. The current research investigated how these perceptions vary across cultures, focusing on Iranian and Hispanic men's views on beardedness. The findings revealed a preference for shorter beards when considering a man's attractiveness, whereas longer beards were associated with masculinity and fighting ability. Cultural differences significantly influenced these perceptions, with Hispanic men rating beards of all lengths more favorably than Iranian men. The study also explored men’s dispositional level of intrasexual competition …

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Drivers Of Formal And Informal Retail Patronage In Emerging Markets, Rajesh Rajaguru, Margaret Matanda, Christopher Agyapong Siaw Jun 2024

Drivers Of Formal And Informal Retail Patronage In Emerging Markets, Rajesh Rajaguru, Margaret Matanda, Christopher Agyapong Siaw

Plymouth Business School

Purpose: This study examines how formal retail formats (FRFs), and informal retail formats (IRFs) may coexist as substitutes and complements in emerging markets because of store patronage driven by customers’ chronic shopping orientations, and differences in salesperson consultation in the two retail formats.Design/methodology/approach: Using a shopping motivational orientation framework, we develop and test a moderated mediation model using survey data from 515 shoppers of formal and informal grocery retail outlets in India.Findings: While task-focused and experiential-focused shopping orientations influence both FRF and IRF patronage, store satisfaction mediates these relationships and crucially attenuates the negative impact of task-focused orientation on FRF …

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Mutual Recognition Of Qualifications, Health Workforce Migration, And Graduate Outcomes: A Comparative Mapping Study Of Undergraduate Dental Education In Europe, Marie Bryce, Sally Hanks, Lorna Burns, Daniel Zahra, Tom Gale Jun 2024

Mutual Recognition Of Qualifications, Health Workforce Migration, And Graduate Outcomes: A Comparative Mapping Study Of Undergraduate Dental Education In Europe, Marie Bryce, Sally Hanks, Lorna Burns, Daniel Zahra, Tom Gale

Peninsula Dental School

BackgroundThe resource needs of health services are served by the recognition of qualifications across borders which allows professionals to migrate between countries. The movement of dentists across the European Union (EU), especially into the United Kingdom (UK), has provided a valuable boost to workforce supply. Recent changes to policy recognising overseas qualifications have brought attention to the equivalence of qualifications awarded in EU countries. Professional regulators need to be confident that dentists who qualified elsewhere have the appropriate knowledge, skills and experience to practise safely and effectively. The aim of this study was to compare UK and EU dental curricula, …

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Epilepsy Professionals' Views On Sudden Unexpected Death In Epilepsy Counselling: A Tale Of Two Countries, Lance Watkins, Oliver Henning, Paul Bassett, Samantha Ashby, Samuel Tromans, Rohit Shankar Jun 2024

Epilepsy Professionals' Views On Sudden Unexpected Death In Epilepsy Counselling: A Tale Of Two Countries, Lance Watkins, Oliver Henning, Paul Bassett, Samantha Ashby, Samuel Tromans, Rohit Shankar

Peninsula Medical School

Background and purpose: Sudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy mortality. All international guidance strongly advocates for clinicians working with people with epilepsy (PWE) to discuss SUDEP. Clinician views working with PWE in the UK and Norway on SUDEP counselling are compared. Methods: A cross-sectional online mixed methodology survey of 17 Likert and free-text response questions using validated themes was circulated via International League against Epilepsy/Epilepsy Specialist Nurses Association in the UK and International League against Epilepsy/Epilepsinet in Norway using a non-discriminatory exponential snowballing technique leading to non-probability sampling. Quantitative data were analysed using descriptive …

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Patient And Public Involvement And Engagement In The Development Of A Platform Clinical Trial For Parkinson's Disease: An Evaluation Protocol, Marie Louise Zeissler, Nikul Bakshi, Michèle Bartlett, Amit Batla, David Byrom, Rebecca Chapman, Sally Collins, Elaine Cowd, Eric Deeson, Romy Ellis-Doyle, Jodie Forbes, Cristina Gonzalez-Robles, Anna Jewell, Emma L. Lane, Nancy R. Lapelle, Keith Martin, Helen Matthews, Laurel Miller, Georgia Mills, Antony Morgan, Miriam Parry, Kuhan Pushparatnam, Natasha Ratcliffe, Dorothy Salathiel, Paula Scurfield, Carroll Siu, Sue Whipps, Sheila Wonnacott, Thomas Foltynie, Camille B. Carroll Jun 2024

Patient And Public Involvement And Engagement In The Development Of A Platform Clinical Trial For Parkinson's Disease: An Evaluation Protocol, Marie Louise Zeissler, Nikul Bakshi, Michèle Bartlett, Amit Batla, David Byrom, Rebecca Chapman, Sally Collins, Elaine Cowd, Eric Deeson, Romy Ellis-Doyle, Jodie Forbes, Cristina Gonzalez-Robles, Anna Jewell, Emma L. Lane, Nancy R. Lapelle, Keith Martin, Helen Matthews, Laurel Miller, Georgia Mills, Antony Morgan, Miriam Parry, Kuhan Pushparatnam, Natasha Ratcliffe, Dorothy Salathiel, Paula Scurfield, Carroll Siu, Sue Whipps, Sheila Wonnacott, Thomas Foltynie, Camille B. Carroll

Peninsula Medical School

Background: Patient and public involvement and engagement (PPIE) in the design of trials is important, as participant experience critically impacts delivery. The Edmond J Safra Accelerating Clinical Trials in PD (EJS ACT-PD) initiative is a UK consortium designing a platform trial for disease modifying therapies in PD. Objective: The integration of PPIE in all aspects of trial design and its evaluation throughout the project. Methods: PwP and care partners were recruited to a PPIE working group (WG) via UK Parkinson's charities, investigator patient groups and participants of a Delphi study on trial design. They are supported by charity representatives, trial …

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Twelve Years Of Drug Prioritization To Help Accelerate Disease Modification Trials In Parkinson’S Disease: The International Linked Clinical Trials Initiative, Camille Carroll Jun 2024

Twelve Years Of Drug Prioritization To Help Accelerate Disease Modification Trials In Parkinson’S Disease: The International Linked Clinical Trials Initiative, Camille Carroll

Peninsula Medical School

In 2011, the UK medical research charity Cure Parkinson’s set up the international Linked Clinical Trials (iLCT) committee to help expedite the clinical testing of potentially disease modifying therapies for Parkinson’s disease (PD). The first committee meeting was held at the Van Andel Institute in Grand Rapids, Michigan in 2012. This group of PD experts has subsequently met annually to assess and prioritize agents that may slow the progression of this neurodegenerative condition, using a systematic approach based on preclinical, epidemiological and, where possible, clinical data. Over the last 12 years, 171 unique agents have been evaluated by the iLCT …

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Early Threads Of Connection. Probing Infants' Understanding Of Caregiving Relationships, Christina Steele, Megan Richardson, Denis Tatone, Ashley Thomas Jun 2024

Early Threads Of Connection. Probing Infants' Understanding Of Caregiving Relationships, Christina Steele, Megan Richardson, Denis Tatone, Ashley Thomas

School of Psychology

Despite the centrality of caregiving relationships in the lives of infants, little is known about whether and how infants represent these relationships characterized by strong attachment and asymmetry in obligation and skills. The current studies (N=95) investigate whether 8-to-10-month-old infants attend to two cues‚Äîaffiliative touch and physical size‚Äîto predict who will respond to distress. In Study 1 (n=49), infants expected larger characters to respond to the emotional needs of smaller characters, only when they saw affiliative touch (proportion looking time at large character: BF10=6.72). In Study 2 (n=46), they did not expect smaller characters to respond to larger characters (proportion …

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Higher Education And Ableism: Experiences Of Disabled Students’ In England During The Covid-19 Pandemic – Stepping Into Inclusion, Suanne Gibson, Zeta Brown, Jen Shute, Mette Westander Jun 2024

Higher Education And Ableism: Experiences Of Disabled Students’ In England During The Covid-19 Pandemic – Stepping Into Inclusion, Suanne Gibson, Zeta Brown, Jen Shute, Mette Westander

School of Law, Humanities and Social Sciences

This paper details the persistent and continuous struggles disabled students experience studying in HE, and how these were exaggerated during the Covid-19 pandemic (DSUK, 2020). We critically consider progress made by Widening Participation and related equality policy, determining that higher education (HE) continues to be an ableist system and space because inclusion is not understood, nor prioritised, at either strategic or practitioner levels. Furthermore, orthodox pathological positions on disability continue and are re-created via hegemony, ignorance, and fear (Madriaga, 2007; Gibson, 2020). Attempts at practices for the inclusion and equality of disabled students take place within the constraints of other …

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Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper Jun 2024

Acceptance And Commitment Therapy Plus Usual Care For Improving Quality Of Life In People With Motor Neuron Disease (Commend): A Multicentre, Parallel, Randomised Controlled Trial In The Uk, Rebecca L. Gould, Christopher J. Mcdermott, Benjamin J. Thompson, Charlotte V. Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J. Turton, David A. White, Marc A. Serfaty, Christopher D. Graham, Lance M. Mccracken, Laura H. Goldstein, Ammar Al-Chalabi, Richard W. Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K. Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H. Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper

Peninsula Medical School

Background: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour change techniques. We aimed to evaluate the effectiveness of ACT plus usual care, compared with usual care alone, for improving quality of life in people with motor neuron disease. Methods: We conducted a parallel, multicentre, two-arm randomised controlled trial in 16 UK motor neuron disease care centres or clinics. Eligible participants were aged 18 years or older with a diagnosis of definite or laboratory-supported probable, clinically probable, or possible familial …

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Physicochemical And Metagenomic Analysis Of Samples From The Roman Baths (Bath, Uk) Reveals High Bacterial And Archaeal Diversity And A Potential For Antimicrobial Discovery, Enus Fina, Michele Kiernan, Bonnie Whatmough, Nathaniel J. Clark, Jazmin Conway, Iga W. Wieczorek, Laura Carey, Zofia Matyjaszkiewicz, Philip J. Warburton, Mathew Upton, Lee P. Hutt Jun 2024

Physicochemical And Metagenomic Analysis Of Samples From The Roman Baths (Bath, Uk) Reveals High Bacterial And Archaeal Diversity And A Potential For Antimicrobial Discovery, Enus Fina, Michele Kiernan, Bonnie Whatmough, Nathaniel J. Clark, Jazmin Conway, Iga W. Wieczorek, Laura Carey, Zofia Matyjaszkiewicz, Philip J. Warburton, Mathew Upton, Lee P. Hutt

School of Biological and Marine Sciences

Antimicrobial resistance of pathogenic bacteria to currently used antibiotics killed an estimated 1.27 million people in 2019 and it is believed that this toll will increase to 10 million per year by 2050. This remains one of the most urgent threats to human health and the hunt for novel antimicrobial natural products (NPs) from microorganisms is essential in efforts to combat this threat, but recent efforts have been unsuccessful. The investigation of extreme ecological niches, such as hot springs, has gained recent interest due to their unique ecosystems, increasing the chance for novel antimicrobial NP discovery. The Roman Baths (Bath) …

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